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The RRDi Legal Disclaimer explains our policy on commercial links, so here are a few links in case you need information on rosacea.
NIH/NIAMS Questions and Answers About Rosacea
The NIH spends over $31 Billion dollars on research and very little if any on rosacea research - for more information (requires subscription)If you have no idea what rosacea looks like, it looks like acne. You may find hundreds of images of rosacea in a Google Search.
Other Non Profit Rosacea Organizations (if the RRDi dissolves due to a lack of funds you will always have the ones below since these non profits receive lots of donations from the skin industry, i.e., pharmaceutical corporations and only a small percentage from rosaceans). Learn more watching Rosacea Episodes S1:E3. All the extant rosacea non profit organizations below are comprised of dermatologists and businessmen who have a vested interest in rosacea treatments and serve on their board of directors. Also look at how they spend donations from the public. Why not investigate this for yourself? (Links below are for members only)Acne and Rosacea Society of Canada
(No financial public records available so we have no data on any rosacea research)American Acne and Rosacea Society (AARS) 501 (c) (3) non-profit
(Spends most of it donations on conventions for its prestigious members and very little on rosacea research)
National Rosacea Society (NRS) 501 (c) (3) non-profit
(Spends 60% of its donations on two private contractors owned by the NRS board members, and 10% of its donations on rosacea research)
Rosacea Research Foundation [DISSOLVED]
(Spent $16K of its donations to the NRS)
Originally formed in January 2005 by Dr. Chuck Young, Jr., David Pascoe, Geoffrey Nase, PhD, Artist Cloutier and Andrew Reid and dissolved in December 2005.Other Non Profit Organizations (may spend a tiny bit on rosacea research)
The American Academy of Dermatology
(Spent 3% in 2015 on research [very little if any on rosacea research] and spent most of its donations on employee salaries/benefits and payroll taxes and the second largest expence on sponsoring conventions for dermatologists)Et Cetera (members only)
What is your idea of what a rosacea non profit should be doing?
Comparing Non Profit Organizations with their Mission
Grassroots Rosacea Non Profit Organization
Why Form Another Non Profit for Rosacea Sufferers?
If you are receiving an error message to the above links it is probably because you have not subscribed as an RRDi member (minimum donation of $2/month) to access the knowledge you are searching for.
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Posts
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Dermatologie (Heidelb). 2023 Mar 7. doi: 10.1007/s00105-023-05123-8. Online ahead of print. ABSTRACT Dermoscopy is an easily accessible, noninvasive diagnostic tool, originally used in the differentiation of benign and malignant skin tumors. Other structures beside pigment content observed by dermoscopy, e.g., scaling, follicles, or vessels, may present in a specific pattern in different dermatoses. Recognition of these patterns may aid the diagnosis of inflammatory and infectious dermatological conditions. The aim of this article is to review the distinct dermoscopic features of granulomatous and autoimmune skin diseases. Diagnosis of granulomatous skin disorders is based on the histopathological examination. The dermoscopic picture of these diseases (cutaneous sarcoidosis, granuloma annulare, necrobiosis lipoidica, and granulomatous rosacea) show many similarities; however, there are some differences to note between the dermatoses, mainly in granuloma annulare. The cornerstones of the diagnostic process of autoimmune skin diseases (morphea, systemic sclerosis, dermatomyositis, cutaneous lupus erythematosus) include the clinical picture, immunoserology, and histology; however, dermoscopy may aid the diagnostic process and follow-up of the patients. For those diseases, where vascular abnormalities play an important role in the pathogenesis, videocapillaroscopy is used for examination of the microcirculation at the nailfold capillaries. Dermoscopy can be an easy-to-use everyday diagnostic tool in clinical practice regarding granulomatous and autoimmune skin diseases. Although punch biopsy is inevitable in many cases, the distinct dermoscopic structures can aid the diagnostic process. PMID:36881125 | DOI:10.1007/s00105-023-05123-8 {url} = URL to article -
Front Pharmacol. 2023 Feb 15;14:1037925. doi: 10.3389/fphar.2023.1037925. eCollection 2023. ABSTRACT TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases. PMID:36874007 | PMC:PMC9975512 | DOI:10.3389/fphar.2023.1037925 {url} = URL to article
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Indian J Dermatol. 2022 Sep-Oct;67(5):625. doi: 10.4103/ijd.ijd_353_21. ABSTRACT BACKGROUND: Thirty per cent supramolecular salicylic acid (SSA) is a water-soluble, sustained release salicylic acid (SA) modality, which is well tolerated by sensitive skin. Anti-inflammatory therapy plays an important role in papulopustular rosacea (PPR) treatment. SSA at a 30% concentration has a natural antiinflammatory property. AIMS: This study aims to investigate the efficacy and safety of 30% SSA peeling for PPR treatment. METHODS: Sixty PPR patients were randomly divided into two groups: SSA group (30 cases) and control group (30 cases). Patients of the SSA group were treated with 30% SSA peeling three times every 3 weeks. Patients in both groups were instructed to topically apply 0.75% metronidazole gel twice daily. Transdermal water loss (TEWL), skin hydration and erythema index were assessed after 9 weeks. RESULTS: Fifty-eight patients completed the study. The improvement of erythema index in the SSA group was significantly better than that in the control group. No significant difference was found in terms of TEWL between the two groups. The content of skin hydration in both the groups increased, but there was no statistical significance. No severe adverse events were observed in both the groups. CONCLUSION: SSA can significantly improve the erythema index and overall appearance of skin in rosacea patients. It has a good therapeutic effect, good tolerance and high safety. PMID:36865859 | PMC:PMC9971792 | DOI:10.4103/ijd.ijd_353_21 {url} = URL to article
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Medicine (Baltimore). 2023 Mar 3;102(9):e33023. doi: 10.1097/MD.0000000000033023. ABSTRACT Rosacea is a chronic erythematous disease with telangiectasia that affects the central area of the face. However, because of the ambiguity in the pathophysiology of rosacea, its treatment has not been clearly elucidated; therefore, new therapeutic options need to be developed. Gyejibokryeong-hwan (GBH) is widely used in clinical practice for various blood circulation disorders, including hot flushes. Therefore, we explored the potential pharmaceutical mechanism of GBH on rosacea and investigated the therapeutic points exclusive to GBH through comparative analysis with chemical drugs recommended in 4 guidelines for rosacea based on network analysis. The active compounds in GBH were identified, and the proteins targeted by these compounds and the genes related to rosacea were searched. Additionally, the proteins targeted by the guideline drugs were also searched to compare their effects. And the pathway/term analysis of common genes was conducted. Ten active compounds were obtained for rosacea. There were 14 rosacea-related genes targeted by GBH, with VEGFA, TNF, and IL-4, which were suggested as core genes. The pathway/term analysis of the 14 common genes revealed that GBH could potentially act on rosacea via 2 pathways: the "interleukin 17 signaling pathway" and the "neuroinflammatory response." Comparison and analysis of the protein targets between GBH and guideline drugs revealed that only GBH separately acts on the "vascular wound healing pathway." GBH has the potential to act on IL-17 signaling pathway, neuroinflammatory response and vascular wound healing pathway. Further studies are needed to determine the potential mechanism of GBH in rosacea. PMID:36862896 | PMC:PMC9981404 | DOI:10.1097/MD.0000000000033023 {url} = URL to article
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Eur J Dermatol. 2022 Nov 1;32(6):716-723. doi: 10.1684/ejd.2022.4358. ABSTRACT BACKGROUND: Contact hypersensitivity or Demodex mite infestation is commonly reported in patients with rosacea. However, the associations and clinical implications of these two phenomena are poorly described in the literature. OBJECTIVES: This study aimed to investigate the association between clinical characteristics, contact sensitization profiles, and Demodex mite infestation in patients with rosacea. MATERIALS & METHODS: We retrospectively reviewed 189 patients diagnosed with rosacea, and categorized the patients into a rosacea-contact hypersensitivity or rosacea-non-contact hypersensitivity group. RESULTS: The rosaceacontact hypersensitivity group had older age (median: 45.5 vs. 37.0 years; p = 0.006), a higher frequency of itching (63.0% vs. 45.1%; p = 0.040), and a higher Demodex mite density (15.0/cm2 vs. 7.0/cm2; p = 0.002) than the rosacea-non-contact hypersensitivity group. Nickel sensitization was correlated with a higher Demodex mite density, female sex, and papulopustular subtype of rosacea. Based on the multivariate regression model, a favourable clinical outcome was correlated with nickel sensitization alone (odds ratio: 2.20, 95% confidence interval: 1.01-4.81). CONCLUSION: Patients with rosacea and contact hypersensitivity showed distinctive clinical features and a higher Demodex mite density. The association between nickel sensitization, Demodex mite infestation, and treatment response may reflect the role of allergen-specific TH polarization in the pathogenesis of rosacea. PMID:36856381 | DOI:10.1684/ejd.2022.4358 {url} = URL to article
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