MENLO PARK, Calif., July 27, 2017 /PRNewswire/ -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical company developing products for the dermatology market, today announced that a panel of prominent dermatologists will discuss BPX-01, a unique topical hydrophilic gel formulation of minocycline at the 2017 AAD Summer Meeting tomorrow. BPX-01 is an investigational drug for the treatment of acne and rosacea. Summer AAD Panel to Discuss BPX-01 for Acne and Rosacea, NEWS PROVIDED BY BioPharmX Corporation, Cision, PR Newswire 

Rosacea is considered the UK’s most common skin complaint. But what causes its red, itchy patches and how can you get rid of it? Why your diet could be causing rosacea, By Carla Challis, BT Carla doesn't mention sugar or carbohydrate as a rosacea trigger. The NRS still doesn't list sugar or carbohydrate as a rosacea trigger and articles like this one parrot the NRS trigger list. 

Rosacea’s red cheeks and nose aren’t caused by heavy drinking, and nor is it down to poor hygiene. We dispel the myths surrounding this common skin condition. Rosacea: the causes and triggers of the skin condition explained, By Carla Challis, BT

Phenotype 6 - Ocular manifestations

Ocular rosacea is common but often not recognized by the clinician.[1] It may precede, follow, or occur simultaneously with the skin changes typical of rosacea. In the absence of accompanying skin changes, ocular rosacea can be difficult to diagnose, and there is no test that will confirm the diagnosis. Patients usually have mild, nonspecific symptoms, such as burning or stinging of the eyes. A sensation of dryness is common, and tear secretion is frequently decreased. [2] Mild-to-moderate ocular rosacea (including blepharoconjunctivitis, chalazia, and hordeola) occurs frequently, whereas serious disease with the potential for visual loss, such as that which results from keratitis, occurs rarely.

Ocular problems occur in at least 50 percent of patients with rosacea. [3] "Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity." [14]

One report said, "Patients with rosacea have thinner corneas, which could be attributed to the observed deteriorated tear function parameters." [12]

For images of Ocular Rosacea click here:

http://goo.gl/ESG4n

Links to get you started [5]

Dry Eye: Awareness, Diagnosis, and Management

All of the ocular rosacea articles at rosacea news

Ocular Rosacea: Dr. Eric Jones, MD

Ocular Rosacea: Dr. Mark J. Mannis, MD

Ocular Rosacea: Curse of the Celts and Celebs, Heather Potter, MD, University of Wisconsin, School of Medicine and Public Health

Treatment

Treating ocular rosacea (from the AAO)

Topical Cyclosporine Proves Beneficial For Ocular Rosacea [6]

Avermectin Milbemycin Eyewash for Ocular Rosacea [7]

Might consider demodex mite treatment. [8]

Terpinen-4-ol (T4O) Pass [11]

One report states, "We suggest that a clinically acceptable dosage of PRP provides the ocular surface with the components necessary to restore normal cellular tensegrity and provides a foundation to eliminate the recurrence of the inflammation associated with DES [Dry eye syndrome]." [13] Cliradex [15] Optimel [16]

Diagnostic Test 

There may be a clinical diagnositic test now available for ocular rosacea. [4] One paper suggests, "The abundance of highly fucosylated N-glycans in the control samples and sulfated O-glycans in ocular rosacea patient samples may lead to the discovery of an objective diagnostic marker for the disease." [9] Another paper suggests, "The high abundance of oligosaccharides in the tear fluid of patients with rosacea may lead to an objective diagnostic marker for the disease." [10] "There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent." [14]

End notes

[1] Arch Dermatol 1997;133:89-90.[CrossRef][iSI] [Medline] 
Ocular rosacea: current concepts and therapy.
Kligman AM

[2] J Am Acad Dermatol 1992;26:211-214.[iSI] [Medline]
 Schirmer testing for dry eyes in patients with rosacea.
Gudmundsen KJ, O'Donnell BF, Powell FC. 
[3] Rosacea: A Common, Yet Commonly Overlooked, Condition
B. WAYNE BLOUNT, M.D., M.P.H. and ALLEN L. PELLETIER, M.D.
Am Fam Physician. 2002 Aug 1;66(3):435-441.

[4] Glycomics Analyses of Tear Fluid for the Diagnostic Detection of Ocular Rosacea
Hyun Joo An, Milady Ninonuevo, Jennifer Aguilan, Hao Liu,‡ Carlito B. Lebrilla, Lenio S. Alvarenga, and Mark J. Mannis
J. Proteome Res., 2005, 4 (6), pp 1981–1987, October 6, 2005, American Chemical Society

Trail of Tears May Lead to the First Diagnostic Test for Ocular Rosacea
Ocular Rosacea Test
Updated: 6/21/2006 9:16:46 AM Dental Care & Health Care Articles

[5] Link list courtesy of David Pascoe

[6] Topical Cyclosporine Proves Beneficial For Ocular Rosacea
Skin and Allergy News, Medical Dermatology
BRUCE JANCIN, Skin & Allergy News Digital Network

[7] Patent applied for by Galderma
David Pascoe's comment on the above patent

[8] In vitro and in vivo killing of ocular Demodex by tea tree oil.
Gao YY, Di Pascuale MA, Li W, Baradaran-Rafii A, Elizondo A, Kuo CL, Raju VK, Tseng SC.
Ocular Surface Center, 7000 SW 97 Avenue, Suite 213, Miami, FL 33173, USA.
Br J Ophthalmol. 2005 Nov;89(11):1468-73.

[9] Glycomic analysis of tear and saliva in ocular rosacea patients: the search for a biomarker.
Vieira AC, An HJ, Ozcan S, Kim JH, Lebrilla CB, Mannis MJ.
Ocul Surf. 2012 Jul;10(3):184-92. Epub 2012 May 3.

[10] Glycomics Analyses of Tear Fluid for the Diagnostic Detection of Ocular Rosacea
Hyun Joo An, Milady Ninonuevo, Jennifer Aguilan,Hao Liu, Carlito B. Lebrilla, Lenio S. Alvarenga,and Mark J. Mannis
J. Proteome Res., 2005, 4 (6), pp 1981–1987, DOI: 10.1021/pr0501620, Publication Date (Web): October 6, 2005

[11] In clinical trials as of August 2012:
Demodex Blepharitis Treatment Study (DBTS)

[12] Can J Ophthalmol. 2012 Dec;47(6):504-8. doi: 10.1016/j.jcjo.2012.07.009.
Central corneal thickness in patients with mild to moderate rosacea.
Onaran Z, Karabulut AA, Usta G, Ornek K.

[13] Optometry. 2012 Mar 30;83(3):111-3.
Dry-eye--is inflammation just the tip of the iceberg?
Jarka ES, Kahrhoff M, Crane JB. [14] Arq Bras Oftalmol. 2012 Oct;75(5):363-9. Ocular rosacea: a review. Vieira AC, Höfling-Lima AL, Mannis MJ.   [15] One report on Cliradex is from yoegan on 5th April 2013 10:01 PM Post #467   [16] judworth says, "For those of you plagued by ocular rosacea (I have MGD) and very red and sore outer lash line, I have been using Optimel for just over 2 weeks, together with a cream cleanser Ilast and the results are very encouraging! I would say the above products have improved my issues by about 70% already (Optimel says improvement by 4 weeks)."

CocaCola has announced a new Coke Zero Sugar brand (a different formula from Coke Zero) today which has been marketed in other countries and will be now marketed in the USA. For you CocaCola lovers who want to avoid sugar you may want to try it out. CocaCola will be eventually drop Coke Zero from its line of products replace it with Coke Zero Sugar. Read this in the Los Angeles Times.  I have listed for your convenience the ingredients of Diet Coke, Coke Zero, and Coke Zero Sugar if you are interested in knowing:  Diet Coke 
Ingredients: Carbonated Water, Caramel Color, Aspartame, Phosphoric Acid, Potassium Benzoate (To Protect Taste), Natural Flavors, Citric Acid, Caffeine. Coke Zero
Ingredients: Carbonated Water, Caramel Color, Phosphoric Acid, Aspartame, Potassium Benzoate (To Protect Taste), Natural Flavors, Potassium Citrate, Acesulfame Potassium, Caffeine.  Coke Zero Sugar
Ingredients: Water, Colour (Caramel E150d), Phosphoric Acid, Sweeteners (Aspartame, Acesulfame K), Natural Flavourings Including Caffeine, Acidity Regulator (Sodium Citrate). Contains a Source of Phenylalanine