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    • J Dtsch Dermatol Ges. 2022 Aug;20(8):1147-1167. doi: 10.1111/ddg.14849_g. NO ABSTRACT PMID:35971589 | DOI:10.1111/ddg.14849_g {url} = URL to article
    • J Cutan Aesthet Surg. 2022 Apr-Jun;15(2):101-107. doi: 10.4103/JCAS.JCAS_162_21. ABSTRACT Microbotox is the administration of multiple microdroplets of botulinum toxin in intradermal plane. It is increasingly becoming popular owing to its more favorable outcome and better safety profile than the conventional technique. The intention is to treat fine lines and wrinkles without imparting an undesired "frozen face like" appearance. Besides facial rejuvenation, it has found its way into the management of other indications such as rosacea, hyperhidrosis, keloid, and seborrhea. Being a relatively newer method, knowledge about the various dilution methods, desired volume, and correct depth of injection involved in this technique remain scarce. In this article, the authors have highlighted various indications, procedures, adverse effects, and contraindications of microbotox. PMID:35965899 | PMC:PMC9364467 | DOI:10.4103/JCAS.JCAS_162_21 {url} = URL to article
    • Cutis. 2022 Jun;109(6):310-313. doi: 10.12788/cutis.0541. ABSTRACT It is well established that many common skin diseases may result in mild to severe cosmetic disfigurement. Similarly, patients with these conditions have an increased risk for depression, anxiety, feelings of stigmatization, and self-harm ideation. There also is an increased risk for hospitalizations for mental health in patients with acne, rosacea, and hidradenitis suppurativa (HS). Cutaneous body image (CBI) is an individual's mental perception of the condition of their hair, nails, and skin. A positive CBI may be related to increased quality of life, and a negative CBI may be associated with poorer outcomes, such as insomnia, worsened overall morbidity of dermatologic disease, and intentional self-injury. For military service members who face a multitude of operational demands and who must be ready to "fight tonight," a holistic approach that addresses both physical and mental health is critical. Military dermatologists have the tools and expertise available to treat cutaneous disease, which by extension may improve body image, quality of life, and morale in military service members. Herein, we discuss how dermatologic treatments that often are thought of as nonessential cosmetic therapies can positively influence CBI and thus increase military readiness. PMID:35960965 | DOI:10.12788/cutis.0541 {url} = URL to article
    • Redox Biol. 2022 Aug 5;55:102427. doi: 10.1016/j.redox.2022.102427. Online ahead of print. ABSTRACT Reactive oxygen species (ROS)-activated proinflammatory signals in keratinocytes play a crucial role in the immunoregulation of inflammatory skin diseases, including rosacea and psoriasis. Nav1.8 is a voltage-gated sodium ion channel, and its abnormal expression in the epidermal layer contributes to pain hypersensitivity in the skin. However, whether and how epidermal Nav1.8 is involved in skin immunoregulation remains unclear. This study was performed to identify the therapeutic role of Nav1.8 in inflammatory skin disorders. We found that Nav1.8 expression was significantly upregulated in the epidermis of rosacea and psoriasis skin lesions. Nav1.8 knockdown ameliorated skin inflammation in LL37-and imiquimod-induced inflammation mouse models. Transcriptome sequencing results indicated that Nav1.8 regulated the expression of pro-inflammatory mediators (IL1β and IL6) in keratinocytes, thereby contributing to immune infiltration in inflammatory skin disorders. In vitro, tumor necrosis factor alpha (TNFα), a cytokine that drives the development of various inflammatory skin disorders, increased Nav1.8 expression in keratinocytes. Knockdown of Nav1.8 eliminated excess ROS production, thereby attenuating the TNFα-induced production of inflammatory mediators; however, a Nav1.8 blocker did not have the same effect. Mechanistically, Nav1.8 reduced superoxide dismutase 2 (SOD2) activity by directly binding to SOD2 to prevent its deacetylation and mitochondrial localization, subsequently inducing ROS accumulation. Collectively, our study describes a central role for Nav1.8 in regulating pro-inflammatory responses in the skin and indicates a novel therapeutic strategy for rosacea and psoriasis. PMID:35952475 | DOI:10.1016/j.redox.2022.102427 {url} = URL to article
    • Ann Dermatol. 2022 Aug;34(4):261-269. doi: 10.5021/ad.21.223. ABSTRACT BACKGROUND: Rosacea is a chronic inflammatory skin disease with a pathophysiological mechanism that remains unclear. Recently, dysregulation of the sensory nerve system has been implicated in the development of this condition. OBJECTIVE: This study aimed to investigate the effect of capsaicin on neuroinflammatory mediators in rosacea. In addition, this study aimed to evaluate the attenuating effects of capsazepine, a transient receptor potential vanilloid type 1 (TRPV1) antagonist. METHODS: We obtained skin tissue from both rosacea patients and normal individuals for an in vivo study. In addition, normal human epidermal keratinocytes (NHEKs) were cultured, and treated with capsaicin and capsazepine for an in vitro study. Quantitative changes in neuroinflammatory mediators were evaluated by semi-quantitative reverse transcription-polymerase chain reaction (PCR), real-time PCR, enzyme-linked immunosorbent assay, and immunofluorescence staining. RESULTS: The data showed the increase of TRPV1, TRPV4, cathelicidin (LL37) and tumor necrosis factor-α (TNF-α) in skin tissue by real-time PCR. In addition, the data showed that cathelicidin (LL37), kallikrein-5 (KLK-5), TNF-α, vascular endothelial growth factor (VEGF), interleukin (IL)-1α, IL-1β, IL-8, and protease-activated receptor 2 (PAR2) increased in capsaicin-treated NHEKs. Capsazepine attenuated the expression of TRPV1 and other mediators, except for IL-8, in capsaicin-treated NHEKs. CONCLUSION: We confirmed that TRPV1, TRPV4, cathelicidin (LL37) and TNF-α are increased in rosacea skin, and that capsaicin is associated with increase of neuroinflammatory mediators such as LL37, KLK-5, TNF-α, VEGF, IL-1α, IL-1β, IL-8, and PAR2. Modulators or inhibitors of neuroinflammatory mediators including TRPV1 could be potential therapeutic option in the treatment of patients with rosacea. PMID:35948328 | DOI:10.5021/ad.21.223 {url} = URL to article If you want to deep dive into this subject it is related to the Immune System Disorder Theory which one of many theories on the cause of rosacea. Find more information here (requires subscription😞 https://irosacea.org/forums/forum/67-immune-system-disorder-theory/
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