Butyric Acid in the Gut and Probiotics

[Guide]

Butyric Acid*

"To date, oral and topical probiotics for the skin microbiome play an important role in treating inflammatory skin diseases, atopic dermatitis, acne, rosacea, wound healing, and skin cancer." [1]

"These results demonstrate that butyric acid (BA) in the metabolites of fermenting skin probiotic bacteria mediates FFaR2 to induce the synthesis of collagen through p-ERK activation. We hereby imply that metabolites from the probiotic S. epidermidis fermentation of CIN as a potential carbon source could restore impaired collagen in the dermal extracellular matrix (ECM), providing integrity and elasticity to skin." [1]

"Butyric acid (from Ancient Greek: βούτῡρον, meaning "butter"), also known under the systematic name butanoic acid, is a straight-chain alkyl carboxylic acid with the chemical formula CH3CH2CH2CO2H. It is an oily, colorless liquid with an unpleasant odor. Isobutyric acid (2-methylpropanoic acid) is an isomer. Salts and esters of butyric acid are known as butyrates or butanoates. The acid does not occur widely in nature, but its esters are widespread. It is a common industrial chemical[7] and an important component in the mammalian gut." [2] (bold added) Do You Have a Gut Feeling About Rosacea? 

"Salts and esters of butyric acid are known as butyrates or butanoates." [2]

"Although the role and importance of butyrate in the gut is not fully understood, many researchers argue that a depletion of butyrate-producing bacteria in patients with several vasculitic conditions is essential to the pathogenesis of these disorders. A depletion of butyrate in the gut is typically caused by an absence or depletion of butyrate-producing-bacteria (BPB). This depletion in BPB leads to microbial dysbiosis." [2]

"Metabolites from the human probiotic bacteria Staphylococcus epidermidis (S. epidermidis) fermentation of different carbon sources such as sugar or polymers have been found to protect skin from inflammation in response to stress. The oral administration of probiotics could effectively heal wounds through the deposition of collagen on them." [1]

"Studies have evidenced that probiotics accelerate the fibrosis process, causing the deposition of collagen." [1]

Topical and Oral Probiotics Available in the RRDi Affiliate Store

Butyric Acid Supplements

End Notes

*Space filling model of butyric acid image courtesy of Wikimedia Commons

[1] Int J Mol Sciv.22(3); 2021 Feb PMC7866835
Probiotic Activity of Staphylococcus epidermidis Induces Collagen Type I Production through FFaR2/p-ERK Signaling
Indira Putri Negari, Sunita Keshari, and Chun-Ming Huang

]2] Butyric acid, Wikipedia