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Horse Paste for Rosacea?

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The RRDi recommends you discuss with your physician any questions before using a veterinary treatment for horses on your rosacea. However, the positive reports of using horse paste are growing exponentially and we would be remiss if we didn't discuss it in this thread. Please read through every post in this thread to be up to date on this subject. Add your experience using horse paste in this thread or complete our poll

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"Rosacea appears to be the first human skin disease to be treated with a veterinary medication....Doctors and researchers have growing concerns about the widespread use of this homegrown treatment." [1]

First and foremost is to understand that you apply the horse paste TOPICALLY on your face at night just before bed and leave it on all night and wash it off in the am. During the day you can apply your favorite moisturizer if you have dry skin or use nothing if you have oily skin. Even though this horse paste is to be used for horses orally, just remember it is for a 1250 pound horse, so it would probably be a terrible idea to ingest the horse paste in a human, so please apply treatment topically. We have a post about taking oral ivermectin, so this thread is about using the horse paste topically. There is one published paper that compares the treatment of using oral ivermectin alone with taking oral ivermectin and oral metronidazole for rosacea which you may not know about. Ivermectin is one of the 'wonder drugs' and a Nobel Prize was awarded for this discovery. 

Many report topical horse paste improves Phenotype 2 and Phenotype 4

Why Horse Paste Rather than Soolantra
The chief reasons Rosaceans are using horse paste are the following; (1) cheaper, a gram of horse paste cost approximately $1.16/gram while Soolantra costs approximately $13/gram (Six doses of Durvet Horse Paste at Amazon costs about $20 [six doses include 36 grams which is only 55 cents per gram] and lasts approximately six weeks which should be enough to know if it works better than Soolantra), (2) Horse paste is stronger than Soolantra, horse paste is 1.87% ivermectin while Soolantra is 1% ivermectin, (3) the inactive ingredients in certain brands of horse paste are generally more tolerated than the inactive ingredients in Soolantra (some complain of the 'Cetaphil' base ingredients of Soolantra called the 'basis for the vehicle') and, (4) there are way more positive reports using horse paste that the positive reports of using Soolantra, but, of course, no real data on this, just a cursory overall view of the reports indicate that horse paste is working better than Sooantra. Galderma may see this success and make an ivermectin gel similar to horse paste with fewer inactive ingredients than Soolantra. 

History
The first reports of using horse paste for rosacea may have occurred in 2017 or 2018, but an investigation into this hasn't found any earlier references. 

A typical example is a post at Facebook,  who writes, "I did a full 12 week course of horse paste and yes if you don't dilute it with moisturizer, some do experience headaches. I did not. I also took it by the recommendation of my primary care and dermatologist. My dermatologist recommends it to all of his patients that can not afford Soolantra or have health insurance. He has had many patients that have had success stories with it. And says that horse paste and Soolantra are basically the same thing except hp is a tad stronger and the base ingredients are not as toxic as Soolantra. If you want to try it, I suggest doing a test spot first for a couple days."

A Reddit a poster writes, "I called my dermatologist to ask about switching from metronidazole to ivermectin and she actually brought up the idea of trying horse paste before I even mentioned anything! She said she doesn't like to prescribe Soolantra because it's so expensive and recommends the horse paste to patients very often. So relieved to have dermatologist approval on this and thought I'd share because I know there are a lot of folks who are skeptical about trying this method since it isn't 'pharmaceutical grade.' "

 A poster at Facebook posts, "So I went for my routine Botox session and the staff was amazed at how clear my face was from 3 months ago. My doc was so intrigued by me telling her it was horse paste. She was in shock by the results. She took me around the office showing everyone that this horse paste had cleared my skin. She said she is going to tell a few of her patients about it on the down low! She very excited for me!"

You can read about all this in a Reddit group r/rosacea or in the Facebook Group Rosacea (English) and this is spreading in other groups. Therefore, the rosaceans who are trying this over-the-counter treatment for horses on their rosacea while reporting success will be the first guinea pigs in this group who have valiantly gone where no rosaceans have gone before and will eventually in the future report back any of the side effects and long term results or risks associated with using a veterinary oral medication for horses on their rosacea topically. It would be ironic that using a horse paste for rosacea that costs a few dollars is just as valid as using Soolantra which has cost millions of dollars for Galderma to go through the hoops to get FDA approval for human use topically. The results are speaking for themselves, horse paste is improving rosacea and the news is spreading like wildfire. 

Topical Application
This post is about topical horse paste for rosacea, NOT oral ivermectin.

Brands
There are many brands of horse paste and many who report using HP don't mention which brand they are using. Some of more popular brands are Durvet (on the box it says 'paste' but is appears to be a gel), Agri-Mectin, Zimecterin, Noromectin, Horse Health, Durmectin, Bimectin and the list keeps growing. 

Inactive Ingredients
As Tom Busby, mentions in a post at RF referred to in the next comment in this thread (scroll to the next comment) that a valid point is, "The biggest problem with horse paste is that no one knows what the other 98.13% of the ingredients are." The MSDS lists from some brands of horse paste usually do not list the inactive ingredients but some do. We have been investigating and found two brands that actually publish the inactive ingredients, Agri-Mectin and Eqvalan.  

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AGRI-MECTIN (ivermectin) Paste 1.87% Inactive Ingredients
The MSDS sheet for AGRI-MECTIN (ivermectin) Paste 1.87% are the following: 
Corn Oil, Polysorbate 80, Apple Flavor, and Aerosil. 

horsepaste.png

Durvet Inactive Ingredients
The box on Durvet clearly says the active ingredient is 1.87% Ivermectin. The MSDS sheet for Durvet Ivermectin Paste does NOT list the inactive ingredients, nor does the detail sheet provided by Durvet. This sheet provided by Bimeda, the parent company of Durvet, simply says the inactive ingredients are Proprietary Component A (80.98%), Proprietary Component B (7.65%), and Proprietary Component C (7.5%). At least we know there are three inactive ingredients but what these ingredients are exactly is still a mystery. 

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Horse Health Equine Ivermectin Paste 1.87%
The MSDS sheet for Horse Health Equine Ivermectin Paste 1.87% doesn't show the inactive ingredients. 

eqvalan.png

Eqvalan
However, in the third post in this thread we now have the inactive ingredient list for another horse paste, Eqvalan which are listed below: 

Eqvalan Oral Paste for Horses Ingredients: 
Ivermectin: 1.87% w/w. 
Titanium Dioxide (E171) 2.0% w/w.
Hyprolose
Hydrogenated Castor Oil
Propylene Glycol

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Bimectin
The inactive ingredients are listed as 
Proprietary Component A (80.98%), Proprietary Component B (7.65%), and Proprietary Component C (7.5%) on this data sheetBimectin-Paste_Bimeda_112015_SDS.pdf

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Duramectin
The data sheet for Durvet DuraMectin Ivermectin Paste 1.87% does NOT list the inactive ingredients:
duramectinMSDS.pdf

zimecterin.png

Zimecterin
The inactive ingredients are not known. 

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First Companion Iverchoice Equine Paste
The inactive ingredients are not known. 

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Farnam IverCare (ivermectin paste) 
The inactive ingredients are not known.

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Vetrimec Paste (Ivermectin 1.87%)
The inactive ingredients are not known.

noromectin.gif

Noromectin (available in the UK)

Noromectin is available in the UK (the inactive ingredients are not available)

Do It Yourself
ElaineA has a Homemade Ivermectin Cream Recipe

End Notes

[1] Articles on the internet from reputable sources are publishing news on this subject. The quote is from the first article below. 

People are turning to medication made for horses to treat rosacea, and dermatologists are concerned, J.K. Trotter, Insider

Br J Dermatol. 2018 Dec 30. doi: 10.1111/bjd.17540.
Misuse of veterinary wormers in self-medication of rosacea and scabies.
Hellen R, Ní Raghallaigh S.

Here are other articles mentioning this subject from other reputable sources:
"In a recent bulletin in the peer-reviewed British Journal of Dermatology, two Irish dermatologists, Rebecca Hellen and Siona Ni Raghallaigh, described a patient who 'enquired about the use of horse wormer as a cheaper alternative.' "
People are turning to medication made for horses to treat rosacea, and dermatologists are concerned, J.K. TROTTER, Business Insider

Two dermatologists are quoted as concerned about using horse paste in the following article: 

People are treating their rosacea with cheap horse medicine, and dermatologists are saying, 'Whoa!', by Bailey King, FEBRUARY 06, 2019. Philly Voice

"Physicians are growing concerned about horse paste’s rising popularity. Although it’s cheaper, it hasn’t been tested on humans, and it contains almost double the dosage of ivermectin (1.87 percent versus Soolantra’s 1 percent). Margo Weishar, MD, a cosmetic dermatologist based outside of Philadelphia, says that horse paste “may be irritating, cause allergy, or worse when applied to skin.”
People are Using Horse Paste to Treat Rosacea, Julie Morse on February 8, 2019, dermRounds, Dermatology Network

"Dermatologists are alarmed with the growing popularity of the inexpensive horse medicine. People cannot be blamed because healthcare is becoming very expensive."
Instead Of Makeup, People Are Treating Rosacea With Horse Medicine, Christopher Levay, MiseryWatch

Can You Use $5 Horse Paste to Treat Rosacea?, Blog, Leslie Baumann, MD, Cosmetic Dermatologist

[2] Clin Cosmet Investig Dermatol. 2016; 9: 71–77.
New developments in the treatment of rosacea – role of once-daily ivermectin cream
Leah A Cardwell, Hossein Alinia, Sara Moradi Tuchayi, and Steven R Feldman

Cost
Durvet Ivermectin costs less than $7 for 6 grams ($1.16/gram) while Soolantra costs $390 for 30 grams ($13/gram).

Horse Paste brand price varies but typically between $5 and $12 per 6 gram dose. You can save money if you purchase multiple doses (see pricing on three, six and twelve doses by scrolling to the bottom of this post and looking for the Amazon banners). For example, six doses of Durvet costs about $20 which includes 36 grams which is a cost per gram of about 55 cents per gram (a fifty percent savings over buying one dose). 

The cost savings over Soolantra is one of the principle reasons rosaceans are reporting using horse paste, not to mention the reports that is works better or just as good as Soolantra. Here are the links: 

Save on Multiple Doses

Three Doses                  Six Doses                   12 Doses

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Tom Busby, SD poster extraordinare at RF, mentioned in a post on this subject at RF, "an alternative source of ivermectin, on eBay" which is ivermectin powder. I asked Tom whether this would be a good idea since it seems a lot safer to use the horse paste than have to concoct a paste with grain alcohol and his comment is, "horse paste is fairly expensive for a really tiny amount of product.... I have to assume that someone who has some experience formulating hot emulsions (oil in water) could make a non-greasy cream with this ivermectin powder."

You might prefer the horse paste for a trial run before purchasing a chemistry set to make this. And of course you would have to know the formulae to be able to take a gram of ivermectin and dilute it to 1% with grain alcohol which is 100 parts grain alcohol to 1 part ivermectin and be able to dissolve it correctly into a cream base. Most rosaceans are not into a laboratory approach to treatment preferring a pill or a topical than experimenting with such treatments in a lab coat. But, of course, this is the internet, and guess what? Watch Mr. Wizard concoct a new rosacea treatment on YouTube (maybe we will hear reports of this). Also, if you haven't heard of the new TXA treatment, it also requires concocting a rosacea treatment yourself by purchasing powder from Amazon or your local chemical store. The RRDi recommends you check with your physician before using ivermectin for rosacea. 

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As mentioned earlier in this thread, one of the issues with using an oral horse paste TOPICALLY for rosacea sufferers is usually there is no inactive ingredient list to see what is actually in the paste or gel. However, one poster at Reddit found the list for one of the products, Eqvalan, which is listed for your convenience below:

Eqvalan Oral Paste for Horses Ingredients: 
Ivermectin: 1.87% w/w. 
Titanium Dioxide (E171) 2.0% w/w.
Hyprolose
Hydrogenated Castor Oil
Propylene Glycol
 

Source
Eqvalan_SPC_214477.pdf

Link for the above:
http://www.vmd.defra.gov.uk/productinformationdatabase/SPC_Documents/SPC_214477.DOC

Eqvalan MSDS

EqvalanMSDS.pdf

Link for the above:
https://www.statelinetack.com/ContentFiles/Associated_Content/EqvalanMSDS.pdf

If anyone finds the ingredients in any other horse paste/gel please post in this thread. 

eqvalan.png

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Warning Concerning Brands of Horse Paste/Gel

There are a number of horse paste/gel brands that also contain praziquentel (PZQ), an anthelmintic, which Wikipedia reports "is a medication used to treat a number of types of parasitic worm infections." Some brands are Pfizer Equimax Horse Wormer, Merial Zimecterin Gold, Bimeda Equimax and others. Praziquantel as far as we know has never been used to treat rosacea. Another horse paste, UltraCruz Equine Bio-Absorb Paste contains dioctahedral smectite (dio) which is used to treat acute diarrhoea. There may be other horse pastes that contain other active ingredients that you should carefully read the label on the horse paste and know what you are buying. Using treatments for horses or other animals which have not been FDA approved for humans may have some serious risks. 

The horse paste that everyone is reporting using is horse paste that only contains 1.87% ivermectin as the active ingredient. Read the label of the brand you are buying and if the active ingredient includes ivermectin and ANYTHING else, you may be in serious health risk applying this topically. Stick to the brands that ONLY have 1.87% ivermectin as the active ingredient. Always check with your physician before using ivermectin for your rosacea. 

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NOTE: The reports on using horse paste is to apply it TOPICALLY,  and NOT orally. 

However there is an anecdotal report posted on Facebook who requests anonymity (who gave permission for this screen shot) says her friend ingests horse paste for Lyme disease on the advice of her 'tropical disease consultant.'  Here is a screen shot of the post: 

lymediseasefacebookhorsepaste.png

We have a post on oral ivermectin

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image.png

positive.pngPositive Anecdotal Reports of Using Horse Paste for Rosacea

There are many, many positive reports at Facebook Groups, i.e., Rosacea (English), Rosacea Tips and Support Groups, as well as Reddit r/Rosacea,  but you will have to join these groups to read the anecdotal reports. 

The RRDi complies with requests for removal of certain published material on the internet from our website. However, for those of you who may not understand the legality of this issue, you may want to read the following post:

The Legality of Quoting a Post at Facebook or Another Internet Source

Here are some public statements at Facebook about using horse paste for rosacea:

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negative.pngNegative Anecdotal Reports of Using Horse Paste for Rosacea

There are a few negative reports at Facebook Groups, i.e., Rosacea (English), Rosacea (English), Rosacea Tips and Support Groups, as well as Reddit r/Rosacea,  but you will have to join these groups to find the negative anecdotal reports since they are few and far between, and very difficult to find. Of course, you will always find negative reports, just like you do with Soolantra and any other rosacea treatment. The negative posts are way less than the positive reports for horse paste. 

If there are more negative ones or a significant number of them then you should be wary. So far, with horse paste the negative ones are few. 

The RRDi complies with requests for removal of certain published material on the internet from our website. However, for those of you who may not understand the legality of this issue, you may want to read the following post:

The Legality of Quoting a Post at Facebook or Another Internet Source

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neutral.pngAnecdotal Reports of Using Horse Paste for Rosacea - You Decide Positive or Negative?

Found one neutral anecdotal report at Rosacea Tips and Support Group, Facebook but you will just have to find it. 

The RRDi complies with requests for removal of certain published material on the internet from our website. However, for those of you who may not understand the legality of this issue, you may want to read the following post:

The Legality of Quoting a Post at Facebook or Another Internet Source

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I never used horse paste or any ivermectin during my medications. I have type I followed by type 2 rosacea but most of the time type I only with the coexisting condition of seborrheic blepharitis and antibiotics work wonder if you take it orally and apply it topically as well and it completely cured me of seborrheic blepharitis and does not exacerbate the rosacea.

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17 hours ago, Apurva Tathe said:

I never used horse paste or any ivermectin during my medications. I have type I followed by type 2 rosacea but most of the time type I only with the coexisting condition of seborrheic blepharitis and antibiotics work wonder if you take it orally and apply it topically as well and it completely cured me of seborrheic blepharitis and does not exacerbate the rosacea.

Thanks for you post. Never heard of seborrheic blepharitis. I have heard of seborrheic dermatitis. When I used the search feature at Wikipedia for seborrheic blepharitis, it redirected me to 'blepharitis' and I found this quote, "Different variations of blepharitis can be classified as seborrheic, staphylococcal, mixed, posterior or meibomitis, or parasitic." 

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1 hour ago, Admin said:

Thanks for you post. Never heard of seborrheic blepharitis. I have heard of seborrheic dermatitis. When I used the search feature at Wikipedia for seborrheic blepharitis, it redirected me to 'blepharitis' and I found this quote, "Different variations of blepharitis can be classified as seborrheic, staphylococcal, mixed, posterior or meibomitis, or parasitic." 

Yes I had seborrheic dermatitis and blepharitis both with rosacea. So when  I researched about it thoroughly I found that when you have SD that causes blepharitis it is sometimes combinedly called seborrheic blepharitis.

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There are a lot of comments on Amazon from people who have taken it orally for Scabies. Most of the rosacea comments are using it topically but i did see a couple who use it successfully by mouth. The problem for some people maybe propylene glycol (PG), which is an ingredient in both Soolantra and the horse paste. For some people PG can cause allergic reactions, dryness and inflammation. Taking the horse paste orally may be an alternative. But i don't recommend it. 

What do you think Brady? Have you ever thought about ingesting it? I know you're an oily like me which according to studies means that we most likely harbour a lot more demodex mites than normal skin. 

 

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Haven't heard of this lutein stuff Brady. Havent really been around much lately. So youre still using zz, using some topical peroxide, low carb diet and lutein. Hell of a life, eh. 

Topical ivermectin may be the best option but some of us cant tolerate it. Im not sure any derm would be able to answer that question. Probably better to ask a vet.

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20 hours ago, Rory said:

Haven't heard of this lutein stuff Brady. Havent really been around much lately. So youre still using zz, using some topical peroxide, low carb diet and lutein. Hell of a life, eh. 

Topical ivermectin may be the best option but some of us cant tolerate it. Im not sure any derm would be able to answer that question. Probably better to ask a vet.

Rory, 

Soolantra is 1% ivermectin and the active ingredient. 

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I've tried Soolantra a couple of times. Lasted at best about 2 months but my face couldn't handle it. No idea why maybe its the propylene glycol in it. Im going to try the oral route and see what happens. I've ordered the paste. 

One thing i noticed each time I used Soolantra was that my face was in good condition for a while after i stopped using it. So i do think demodex has some part to play for me. 

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On 6/16/2019 at 10:18 AM, Rory said:

I've tried Soolantra a couple of times. Lasted at best about 2 months but my face couldn't handle it. No idea why maybe its the propylene glycol in it. Im going to try the oral route and see what happens. I've ordered the paste. 

One thing i noticed each time I used Soolantra was that my face was in good condition for a while after i stopped using it. So i do think demodex has some part to play for me. 

Rory, 
You will probably have better results using the horse paste over Soolantra, mainly because the horse paste is stronger ivermectin 1.87% over Soolantra's 1% and also because the inactive ingredients in the horse paste are simpler than Soolantra's list of inactive ingredients. So what brand of horse paste did you order? Also please be sure to post your results of taking oral ivermectin in the oral ivermectin post here. Just look at this comparison of horse paste inactive ingredients over Soolantra's inactive ingredients to see the difference: 

Eqvalan inactive ingredients:
Hydrogenated Castor Oil, Titanium Dioxide (E171) 2.0% w/w., Hyprolose, Propylene Glycol

Agri-Mectin inactive ingredients
Corn Oil, Polysorbate 80, Apple Flavor, and Aerosil. 

Soolantra's inactive ingredients:
carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.

This simple comparison explains why more positive results are with horse paste because of its simple inactive ingredient list compared to the huge number of inactive ingredients in Soolantra which may explain why some like you and me may have a side effect of dryness or whatever. Probably the other horse paste brands have few inactive ingredients just as the two we did find above. The most popular horse paste, Durvet Paste doesn't list the inactive ingredients but it probably is a list of only three "Proprietary Components".  Just about everyone reports it takes 12 weeks for clearance, but so do the positive reports using Soolantra, 12 weeks. 

 

 

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On 6/17/2019 at 1:48 AM, Rory said:

I've tried Soolantra a couple of times. Lasted at best about 2 months but my face couldn't handle it. No idea why maybe its the propylene glycol in it. Im going to try the oral route and see what happens. I've ordered the paste. 

One thing i noticed each time I used Soolantra was that my face was in good condition for a while after i stopped using it. So i do think demodex has some part to play for me. 

There are so many alcohols in Soolantra's inactive ingredients which cause dryness and flakiness of skin which in turn cause itching and irritation and redness. Parabens and propylene glycol are also there which tend to penetrate the skin to help allow other ingredients to enter and this may be the reason your skin reacted and couldn't handle because everyone's skin reacts differently to chemicals.

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2 hours ago, Apurva Tathe said:

There are so many alcohols in Soolantra's inactive ingredients which cause dryness and flakiness of skin which in turn cause itching and irritation and redness. Parabens and propylene glycol are also there which tend to penetrate the skin to help allow other ingredients to enter and this may be the reason your skin reacted and couldn't handle because everyone's skin reacts differently to chemicals.

What is interesting is that Galderma claims Soolantra's base is Cetaphil. However, we did an investigation and compared Cetaphil's ingredients with the list shown in Soolantra and discovered there is a difference. For more information: 

Soolantra mechanism of action (MOA) 

SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use.

SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.
Source

Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide
Source

Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet

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I ordered Bimectin Brady. It arrived 2 days ago. Not easy to get cause its not available in some european countries. I took a dose yesterday on an empty stomach with plenty of water. Not exactly sure when i should take the next dose, maybe in a few days or next week. So, all i can do now is wait and see what happens.

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9 hours ago, Rory said:

I ordered Bimectin Brady. It arrived 2 days ago. Not easy to get cause its not available in some european countries. I took a dose yesterday on an empty stomach with plenty of water. Not exactly sure when i should take the next dose, maybe in a few days or next week. So, all i can do now is wait and see what happens.

The Bimectin is topical, correct? Does it list the inactive ingredients?

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No, its the oral, apple flavoured horse paste with the syringe. You have a picture of it at the top of this page. The ingredients are not listed on the box. 

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6 hours ago, Rory said:

No, its the oral, apple flavoured horse paste with the syringe. You have a picture of it at the top of this page. The ingredients are not listed on the box. 

What I mean is, you are using the Bimectin topically, correct? 

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23 hours ago, Rory said:

No, its the oral, apple flavoured horse paste with the syringe. You have a picture of it at the top of this page. The ingredients are not listed on the box. 

Ok I guess you are ingesting it orally? and if you are ingesting it orally, it has residual effects means it is stored in body fat and then progressively released to work and taking too often will cause build up. So you have mentioned that you have already taken your first dose so wait for one week and see the results and then follow the next dose and the recommended dose is 200 mcg(micrograms) per kilogram body weight but slight point difference will be ok but ask and consult your physician before you take any treatment.

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Yes I'm ingesting it. I took a 250 lb dose. No, i dont weigh 250 lb. I just like the idea if a large dose. Each syringe has enough for a 1250 lb horse, so thats 5 doses per syringe. 

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