Soolantra News

[Guide]

Watch the RRDi Video on Soolantra (Please post in this thread your experience with Soolantra)

Cool Soolantra Video by Galderma 

The above Soolantra Savings Card has now been replaced by the CareConnect Savings Program

Galderma explains the CareConnect savings program (with some adjustments which you have to qualify for by reading below):

 

Official Soolantra Web Site  • Soolantra FAQs • Rosiver in Canada • Online Purchase Soolantra in UK

Soolantra Sales
Galderma has something that works for rosacea. Annual market sales for the 12 months ending May 2017 was $87 million. [1]

"In March 2017, Perrigo submitted an abbreviated new drug application, or ANDA, with a Paragraph IV certification for ivermectin cream, 1% to the FDA. In January 2018, this ANDA was tentatively approved by the FDA. Final approval from the FDA is subject to a 30-month stay under the Hatch-Waxman amendments to the Federal Food, Drug, and Cosmetic Act. Ivermectin cream, 1% is the active molecule in Soolantra, which is currently marketed in the United States by Galderma Laboratories LP. For the 12 months ended November 30, 2017, Soolantra achieved sales of  $113 million according to IQVIA." [2]

Cision, on Jan 30, 2018, states, "Annual market sales for the last 12 months were approximately $120 million, according to IMS Health."
Perrigo Announces Tentative FDA Approval For The Generic Version Of Soolantra® Cream, 1%, Cision

Anecdotal Reports
There have been very few reports that Soolantra doesn't work, and way more reports that it works, but you may want to read what the side effects are reported to be.  So this indicates a treatment for rosacea worth seriously considering to see if Soolantra works for your rosacea. It appears from the reports that it works for a significant number of rosaceans. One important note is that BEFORE your rosacea is controlled using Soolantra, there is ample evidence that it gets WORSE before it GETS BETTER and may take a couple of months of use to determine this! This 'worse before it gets better' syndrome may be the result of the killing of the mites. 

If you read the King of Soolantra threads then you will discover that there are reports that the Soolantra kills the mites and their dead bodies (with reports that contain a number of bacteria) cause a worsening of the rosacea symptoms before the rosacea gets better. Usually it takes two or more months before the demodectic rosacea is controlled by Soolantra. Your experience may be different since there are some who report that they do not get worse before it gets better and report success using Soolantra. The only way is to try it and find out yourself. You may be a candidate for Soolantra. Galderma would be pleased if you are a successful candidate. If you are please reply to this thread with your results. 

We have started a list of anecdotal reports in the fourth post of this thread (keep scrolling). You can add your report by finding the REPLY TO THIS TOPIC button and posting. 

Reports
"Topical ivermectin 1% cream acts by a dual, anti-inflammatory and anti-parasitic mode of action against rosacea by killing Demodex spp. in vivo, in addition to significantly improving clinical signs and symptoms in the skin." [3]

Galderma received European approval for releasing Soolantra in 28 European Union countries in March 2015. Source

Cetaphil Base
Galderma states the following about the 'basis for the vehicle':
"Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil^® Moisturizing Cream as the basis for the vehicle." 

There's no doubt that the actual base cream in Soolantra is not Cetaphil Cream, but on the other hand, it's roughly equivalent to the extent that they use a polymer-plus-emulsion cream. The evidence for this is in the footnote. [4]

Generic Soolantra
You may be interested in learning about generic Soolantra. 

Reply to this Topic

There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  

End Notes

[1] Perrigo Confirms Patent Challenge For Generic Version Of Soolantra® Cream, 1%, Cision PRNewswire, 

Cision, on Jan 30, 2018, states, "Annual market sales for the last 12 months were approximately $120 million, according to IMS Health."
Perrigo Announces Tentative FDA Approval For The Generic Version Of Soolantra® Cream, 1%, Cision

"For the 12 months ended November 30, 2017, Soolantra achieved sales of  $113 million according to IQVIA." 
As filed with the Securities and Exchange Commission on January 30, 2018, Registration No. 333-220234

[2] F-1/A 1 tv483839-f1a.htm AMENDMENT NO. 5 TO FORM F-1, US Securities and Exchange Commission

[3] J Eur Acad Dermatol Venereol. 2017 Jun 27. doi: 10.1111/jdv.14437. [Epub ahead of print]
Dual anti-inflammatory and anti-parasitic action of topical ivermectin 1% in papulopustular rosacea.
Schaller M, Gonser L, Belge K, Braunsdorf C, Nordin R, Scheu A, Borelli C.

Etc. 

CareConnectPriceCard_GCC-00020d_v13-TearSheetContent.pdf

The King of the Soolantra Threads (a wealth of data on Soolantra use)

[4] Soolantra mechanism of action (MOA) and BASIS FOR VEHICLE

SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use.

SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.
Source

Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide
Source

Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet

Superior Comparison of Soolantra inactive ingredients with Cetaphil Moisturing Cream ingredients:

Soolantra cream comparison.pdf

Soolantra Mechanism of Action & Basis for the Vehicle

Please post in this thread your experience with Soolantra

[Guide]

Dimethicone in Soolantra

Someone at Reddit points out an article published in the Tropical Medical Health by Hermann Feldmeier that concludes, "Dimeticones are a family of compounds with a physical mode of action, targeting an Achilles heel of ectoparasites." I found another article that state dimethicone is a pediculocide. I did find this article that says "dimethicone lotion is not an insecticide and instead kills lice by suffocation," which may explain it.

Dimeticone redirects to Polydimethylsiloxane. 

Dimethicone redirects to Polydimethylsiloxane. 

The Wikipedia article on Polydimethylsiloxane says it is used in medicine "in over-the-counter drugs as an antifoaming agent and carminative" with no mention of it being used as an insecticide or kills parasites. 

"Perhaps dimethicone is an old fashioned treatment for head lice, because like you, I can't find a reliable reference for using it as a miticide or arachnicide or insecticide. With lice, sometimes treatments are called any of these 3 terms. "Mite" is an old-fashioned English word, "arachnid" is the scientific term, and "insect" is just plain wrong, for referring to head lice or demodex. Watch out too for chemical names, as there are silicones that are oil soluble, water soluble, and not soluble in either oil or water.  And, I can't find the recommended concentration for treating head lice with dimethicone -- if, ,for example, it's 15%, that would be far too messy to be cosmetically acceptable for trying it on the face. From my personal point of view in formulating, I like only water soluble silicones, because some of them wash out easily with water, but still provide some "slip" (ease of combing hair, or detangling). The other silicones just sit there on the skin or on the hair, and don't do anything useful from an aesthetic point of view." Tom Busby, Post no 7, Rosacea Forum

"Dimethicone doesn't have any biocidal properties. The mode of action on the treatment of headlice is to prevent the adhesion of lice and the louse eggs on to the hair shaft. Headlice produce a strongly adhesive mucus secretion to stick their eggs (nits) to hair. Dimethicone prevents this adhesion and also interferes with the 'foothold' that the adult lice have on the scalp. Dimethicone is not immediate acting and requires several days for its effect to be apparent. It requires thorough combing of the hair after use to remove loosened lice and nits." johnabetts, Post no 8, Rosacea Forum

"Dimethicone was also the main ingredient (first in list) in the Dermalogica Close Shave Oil, no longer available. I have no signs of rosacea in my shaving area - only on the ears and nose, where clearly I didn't apply the shaving oil. The point with a shaving oil is, assuming you shave every day or two, it is very easy to fully cover the area on a very regular basis. I also thought Soolantra cream had good moisturising properties when I used it. Unfortunately it seemed to stop working on killing mites after a while, and I've had longer term success with Zhongzhou cream." antwantsclear, Post no 9, Rosacea Forum

[Guide]

Soolantra prices may vary but a 45 gram tube costs approximately $12.91/gram if you don't have insurance to cover it. Check with your insurance provider for your actual cost. The price below is a screen shot from GoodRx. 

[Guide]

Anecdotal Reports of using Soolantra

josephung [post no 5] "I am using Solantra for the past 6 month and the results are stunning. Didn't have any problems or irritation..."