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Soolantra Mechanism of Action & Basis for the Vehicle

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Mechanism of Action
Galderma has published two different statements about this (screenshots shown below): 

(1) "The mechanism of action (MOA) is not confirmed."

(2) "The mechanism of action (MOA) of Soolantra® (ivermectin) Cream, 1% in treating rosacea lesions is unknown."

Basis for the Vehicle
However, we are concentrating on an investigation into the 'basis for the vehicle' statement by Galderma regarding Soolantra, which in the Soolantra News post if you scroll down to Cetaphil Base, Galderma in FOOT NOTE 4, we report about the 'basis for vehicle' which Galderma states the following:  

"Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle." However, the original page is no longer available, but we have a screen shot of the Way Back Machine on August 21, 2018 which shows you the statement below: 


Soolantra mechanism of action (MOA) (Way Back Machine url) 

Actually after a careful search, Galderma has moved the statement that Cetaphil is the 'basis for the vehicle' statement to this page: 



Therefore, the current correct statement provided by Galderma is: 

"Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle."

SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use.

While the claim by Galderma that utilizing Cetaphil is 'basis for the vehicle' we have investigated and notice the differences with the inactive ingredients in Soolantra with the ingredients in Cetaphil below. 

SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.

Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide

Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet

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