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Topical Calcineurin Inhibitors (TCIs) for Rosacea


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Immunosuppressants are chemical agents (such as pimecrolimus or tacrolimus) that suppresses the immune response. Pimecrolimus (Elidel) and Tacrolimus(Protopic) are known as calcineurin inhibitors (TCIs) acting on immunophilins. Tacrolimus is a fungal product (Streptomyces tsukubaensis) and a macrolide lactoneand acts by inhibiting calcineurin with trade names such as Prograf, Advagraf, Protopic, and others. 

“The topical calcineurin inhibitors (TCIs) pimecrolimus and tacrolimus are approved for atopic dermatitis but have additional potential in other inflammatory skin diseases … whereas the response in rosacea and rosacea-like eruptions has been mixed.”

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