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Atopic Dermatitis (Eczema) is a rosacea mimic that can be quite confusing to differentiate from rosacea since if you click on Google images of eczema, it certainly looks like rosacea, so be sure to rule out atopic dermatitis (eczema). Eczema can be anywhere on the body but if it on your face, it is a rosacea mimic. Furthermore, you may have rosacea along with atopic dermatitis, therefore exczema can be a co-existing condition with rosacea. 

Medline Plus says, "Eczema is a term for several different types of skin swelling. Eczema is also called dermatitis. It is not dangerous, but most types cause red, swollen and itchy skin. Factors that can cause eczema include other diseases, irritating substances, allergies and your genetic makeup. Eczema is not contagious." [1]

Click here for an image of eczema.

Eczema is due to a hypersensitivity reaction (similar to an allergy) in the skin, which leads to long-term inflammation. The inflammation causes the skin to become itchy and scaly. Long-term irritation and scratching can cause the skin to thicken and an have a leather-like texture. One report shows a hypersensitivity to gluten. [2]

Nummular Eczema

"Staphylococcus aureus plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis." [3]

Allergic Eczema, aka Contact Dermatitis
"Allergic eczema, also known as contact dermatitis, is a skin condition that occurs when a person's skin comes into contact with an allergen." [4] This could be any allergic reaction that manifests on the facial area which looks like rosacea, i.e., countdracula's post about an allergic reaction to onions and garlic

"Our results showed that there may be an association between nickel sensitivity and rosacea. Nickel sensitivity may be one of the underlying pathology or a triggering factor of the rosacea." [5]


"Today, topical agents like emollients and corticosteroids are the mainstay of AD therapy, and patients with lesions that are resistant to optimally administered topical treatment can also receive phototherapy or systemic therapy with ciclosporin. Dr Fougerousse discusses her hopes for the future of AD therapy with the recent development of biologicals like dupilumab, which may provide improvements in clinical outcomes and quality of life for patients with moderate-to-severe AD. In the next few years, the therapeutic arsenal for AD will likely expand to include more systemic therapies providing sustained symptom control." [6]



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End Notes

*Allergic Dermatitis image courtesy of WikiMedia Commons

[1] Medline Plus

[2] Cutaneous hypersensitivity to gluten.
Tammaro A, Narcisi A, De Marco G, Persechino S.
Dermatitis. 2012 Sep;23(5):220-1.

[3] Case Rep Dermatol. 2017 May-Aug; 9(2): 19–25.
Published online 2017 May 22. doi:  10.1159/000473872
PMCID: PMC5465516
Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases
Joan E.E. Totté, Martijn B. van Doorn, and Suzanne G.M.A. Pasmans

[4] Everything you need to know about allergic eczema, MedicalNewsToday
Last reviewed Mon 18 June 2018 By Rachel Nall, RN, BSN, CCRN 
Reviewed by Debra Sullivan, PhD, MSN, RN, CNE, COI   

[5] Endocr Metab Immune Disord Drug Targets. 2019 Jan 01;:
Nickel Sensitivity In Rosacea Patients: A Prospective Case Control Study.
Çifci N

[6] Dermatol Ther (Heidelb). 2021 Feb 1 : 1–8. doi: 10.1007/s13555-021-00489-w 
At the Dawn of a Therapeutic Revolution for Atopic Dermatitis: An Interview with Dr Anne-Claire Fougerousse
Anne-Claire Fougerousse

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  • 5 years later...
  • Root Admin

Crisaborole Ointment for Atopic Dermatitis (Eczema)

Am J Clin Dermatol. 2016; 17(5): 519–526.
Published online 2016 Jun 22. doi:  10.1007/s40257-016-0204-6, PMCID: PMC5045489
Tolerability of Crisaborole Ointment for Application on Sensitive Skin Areas: A Randomized, Double-Blind, Vehicle-Controlled Study in Healthy Volunteers
Lee T. Zane, Matilda H. Hughes, and Sepehr Shakib

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  • 7 months later...
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  • 4 weeks later...
  • Root Admin

Grant Genereux, an engineer and geologist, who no longer suffers from eczema, has an interesting theory that Vitamin A toxicity is the culprit for eczema and a long list of autoimmune diseases and has written a free ebook, Poisoning for Profits.  His website has more information on this.  For example, note his long post on Connecting Eczema, Crohn’s and Alzheimer’s.

You can also read another book Genereux wrote, Extinguishing the Fires of Hell, Ending Autoimmune Disease, which the author says is "somewhat more relevant to topics of eczema, and rosacea." 

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There is a clinical trial going on using PAC-14028 Cream for Atopic Dermatitis (Eczema) being done by Amorepacific Corporation. Initial results seem promising [1]. 

End Notes 

[1] British Journal of Dermatology
Efficacy and safety of PAC‐14028 cream – a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild‐to‐moderate atopic dermatitis: a phase IIb randomized trial
Y.W. Lee  C.‐H. Won  K. Jung  H.‐J. Nam  G. Choi  Y.‐H. Park  M. Park  B. Kim

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