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Raynaud syndrome and Rosacea?


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213px-Raynaud_syndrome_on_female_airman's_hand.jpg

Raynaud syndrome on female airman's hand image courtesy of Wikimedia Commons

Eilleen66 [post no 5] points out at RF, "I was pointing out the coincidence that a lot of people who have rosacea also have Raynauds type symptoms."  So I thought I would do a little research on this using the search tool here at the RRDi website by simply typing in 'Raynaud' and see what comes up. Didn't do a Google search, since that takes more time and effort. Are you up to the task of really investigating this subject, googling it, and then add to this thread?  Not many are really into doing rosacea research but would rather 'rely on social media groups' to 'help them deal with this disease' [rosacea]. If you do find some point related to this subject, wouldn't it be incredible if you volunteered to post your search results in this thread to help other rosaceans who may be searching this same subject?  Be sure to rely on social media groups for your information as most rosaceans do instead of published clinical papers in medical journals. Just kidding. 

First off, while exposure to heat and cold is listed on most rosacea trigger lists, i.e., the NRS trigger factor list, there hasn't really been any clinical papers on this subject, as far as known, with double blind, placebo controlled, peer reviewed studies. Also it is not established in any known papers that a lot of rosaceans have Raynaud type symptoms. There are some papers that says 'some' rosaceans have Raynaud syndrome. Wouldn't it be nice to know in a huge study of say 2000 rosaceans what percentage have Raynaud syndrome?  Who would pay for such a study?

Wouldn't it be incredible if a rosacea patient advocacy group like the RRDi got 10K members together who all agreed that this should be investigated whether 'a lot of rosaceans have Raynaud type symptoms' and decided they wanted this investigated with an actual double blind, placebo controlled peer reviewed clinical study. If 10K members each gave ONE DOLLAR and everyone agreed this should be done, do you think we could offer this money to some worthy, reputable clinician to actually investigate this subject, i.e., possibly one of the RRDi MAC members or some other reputable authority?

So what are the results of my search using the RRDi search tool on our website? Note below my results with bold added for emphasis: 

"A notably high percentage of patients had neurologic (43% [6 of 14]) or neuropsychiatric (50% [7 of 14]) conditions, including complex regional pain syndrome, essential tremor, depression, and obsessive-compulsive disorder. Neurovascular disorders, including headaches (71% [10 of 14]) and Raynaud phenomenon (29% [4 of 14]), as well as rheumatologic disorders (36% [5 of 14]), including lupus, rheumatoid arthritis, fibromyalgia, mixed connective tissue disease, and psoriatic arthritis, were also common." Neurogenic Rosacea

"There is a clear subset of patients seen by both neurologists and dermatologists, whose main complaints are facial pain and dysesthesias. These patients often have a history of prominent facial flushing and blushing in response to various stimuli such as emotional stress, hot beverages, alcohol, spicy foods, exercise, heat, and sun exposure. They may also have erythematous papules and pustules. This cluster of features is most consistent with a diagnosis of rosacea but, when combined with the pain and dysesthesias, a form of complex regional pain syndrome must also be considered. In addition, some patients may have concurrent erythromelalgia and Raynaud's disease, suggesting that the etiology is perhaps more complex." Neuropathic Rosacea

"The role of Helicobacter pylori (HP) in some digestive diseases (gastritis, ulcer, gastric cancer, MALT lymphoma) is well known. It has been suggested relatively recently that infection with HP can be involved in various extra-digestive conditions: respiratory disorders (chronic obstructive pulmonary disease, bronchiectasis, lung cancer, pulmonary tuberculosis, bronchial asthma); vascular disorders (ischaemic heart disease, stroke, primary Raynaud phenomena, primary headache); autoimmune disorders (Sjogren syndrome, Henoch-Schonlein purpura, autoimmune thrombocytopenia, autoimmune thyroiditis, Parkinson's disease, idiopathic chronic urticaria, rosacea, alopecia areata); other disorders (iron deficiency anaemia, growth retardations, liver cirrhosis). Case studies, small patient series and non-randomized trials that have shown a beneficial effect of HP eradication in different conditions are not convincing."
Extragastric manifestations of Helicobacter pylori infection.

"Biofeedback can improve cutaneous problems that have an autonomic nervous system component. Examples include biofeedback of galvanic skin resistance (GSR) for hyperhidrosis and biofeedback of skin temperature for Raynaud's disease."
Biofeedback, cognitive-behavioral methods, and hypnosis in dermatology: is it all in your mind?

"In the capillaroscopic examination in all patients with rosacea atypical capillaries were found. The abnormal capillaries were present in 10 volunteers (63%). In the rosacea group the most common occurred: Raynaud loops in 10 cases (62.5%), meandering capillaries and their elongation also in 10 patients (62.5%) and increasing number of the capillaries in 13 examined persons (81.25%). In the control group the presence of stenosed capillaries was confirmed in 3 examined persons (18.75%) with good visualized subpapillary venous plexus also in 3 cases (18.75%)."
Assessment of microcirculatory system with conventional capillaroscopy in patients with rosacea--preliminary study

"Mirvaso gel should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans, scleroderma, or Sjögrens syndrome. Alpha-2 adrenergic agents can lower blood pressure."
FDA OKs Topical Gel to Take Red Out of Rosacea - (Mirvaso)

"Use with caution in patients with cerebral or coronary insufficiency, Raynaud’s phenomenon, thromboangiitis obliterans, scleroderma, or Sjögren’s syndrome and advise patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop.' Warning About Using Rhofade With Cardiovascular Disease

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"Arthralgia and myalgia had the same percentage as reported by the control group and in normal populations; however, Raynaud's phenomenon was slightly greater than reported in the 2 control group and the general populations. There could be an inverse relationship between Raynaud's treatment with vasodilators and rosacea flushing symptom."
A Clinico-Pathological Investigation of Rosacea with Particular Regard to Systemic Diseases, Dr. Mustafa Hassan Marai

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