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Warning About Using Rhofade With Cardiovascular Disease


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  • Root Admin

"RHOFADE should be used with caution in patients with severe or unstable or uncontrolled cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension/hypotension." [1]

"As the 5-HT2B receptor is potentially involved in drug-induced valvulopathy, the benefit/risk ratio should be carefully considered, especially in patients with cardiovascular disease or other comorbidities." [2]

"Alpha-adrenergic agonists as a class may impact blood pressure. Advise patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek medical care if their condition worsens. 
Use with caution in patients with cerebralo rcoronary insufficiency, Raynaud’s phenomenon, thromboangiitis obliterans, scleroderma, or Sjögren’s syndrome and advise patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop. 

Advise patients to seek immediate medical care if signs and symptoms of acute narrow-angle glaucoma develop." [3]

End Notes
[1] Once-Daily Treatment Reduces Persistent Facial Erythema (Redness) Associated With Rosacea Through 12 Hours, Allergan, 01.19.2017 | Investors

[2] Drugs in R&D, March 2018, Volume 18, Issue 1, pp 87–90 
In Vitro Safety Pharmacology Profiling of Topical α-Adrenergic Agonist Treatments for Erythema of Rosacea
David Piwnica, Atul Pathak, Gregor Schäfer. James R. Docherty

[3] Allergan Prescribing Information for Rhofade

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