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    • Surgical Treatment Strategy for Severe Rhinophyma With Bilateral Pedicled Nasolabial Flaps. J Craniofac Surg. 2019 Apr 12;: Authors: Cui MY, Guo S, Wang CC, Lv MZ, Jin SF Abstract BACKGROUND: Rhinophyma is a rare disease characterized by chronic inflammation and hypertrophy of sebaceous glands, blood vessels, and fibrous tissue, associated with end-stage severe acne rosacea. There are multiple approaches to treatment and repair, including dermal shaving, secondary intention healing, free skin graft, and skin flaps. However, these methods have various disadvantages, such as prolonged healing, obvious scarring, and skin texture mismatch. Therefore, the authors adopted surgical excision with bilateral pedicled nasolabial flaps, which have better color, texture, thickness, and symmetry. METHODS: The authors present a case of severe nasal tip rhinophyma successfully treated by excision and repair with bilateral pedicled nasolabial flaps. This procedure combines deep excision of the focal lesion and coverage with bilateral nasolabial flaps. RESULTS: The bilateral pedicled nasolabial flaps were used for severe rhinophyma in a patient. After the operation, the flaps survived uneventfully in this study. Both functional and aesthetic results were satisfactory at 3 months. CONCLUSION: The authors offer an effective method for surgical treatment of rhinophyma. Excision of hypertrophic nasal tissue is an acknowledged effective treatment for patients with severe rhinophyma. After excision, reconstruction with nasolabial flaps results in satisfactory outcomes both functionally and aesthetically. Therefore, this approach should be considered an appropriate alternative in cases of severe rhinophyma. PMID: 30998589 [PubMed - as supplied by publisher] {url} = URL to article
    • A detailed report on cannabinoid signaling in the skin had this to say:  "It has recently been shown that abuse of synthetic, hyperpotent cannabinoids (e.g., “Bonsai”, “fake weed”, “K2”, and “Jamaica”) can result in dermatological disorders, such as premature skin aging, hair loss and graying, or acne [88], indicating that cannabinoid signaling can profoundly influence skin biology." "Importantly, with respect to the efficiency of PEA, human clinical data are also available. Indeed, the PEA containing Physiogel® A.I. Cream was found to alleviate itch in 14 out of 22 patients suffering from prurigo, lichen simplex and other pruritic diseases. Importantly, the same formulation was found to be effective in alleviating erythema, excoriation, scaling, lichenification, dryness, as well as pruritus in AD patients (ATOPA study). However, another vehicle controlled, randomized clinical trial involving a total of 100 subjects suffering from pruritic dry skin (ClinicalTrials.gov ID: NCT00663364) found that a PEA containing lotion was not significantly superior in alleviating itch as compared to its emollient vehicle." PEA is Palmitamide MEA, a naturally occurring lipid compound that may act as an anti-oxidant and anti-irritant. Molecules. 2019 Mar; 24(5): 918. Published online 2019 Mar 6. doi: 10.3390/molecules24050918 Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System Kinga Fanni Tóth, Dorottya Ádám, Tamás Bíró, Attila Oláh
    • Related Articles [The value of reflectance confocal microscopy in detection of Demodex mites]. Ann Dermatol Venereol. 2017 Jun - Jul;144(6-7):459-461 Authors: Harmelin Y, Le Duff F, Passeron T, Lacour JP, Bahadoran P PMID: 28347561 [PubMed - indexed for MEDLINE] {url} = URL to article
    • A sample of food-grade diatomaceous Earth  Courtesy of Wikimedia Commons Diatomaceous earth - also known as D.E., diatomite, or kieselgur/kieselguhr – is a naturally occurring, soft, siliceous sedimentary rock that is easily crumbled into a fine white to off-white powder. Wikipedia Can it be used to treat demodectic rosacea?  At least one person thinks so.  This was posted initially at Facebook, Rosacea Tips and Support Group, by Karli Walton who writes, "People are using horsepaste (ivermectin) for their mites, ivermectin is also in sooIantra. I haven’t tried either. You can also use diatomaceous earth powder mixed with honey. I use the powder on my dogs for their mites and fleas. It’s natural and won’t hurt you. Just keep in mind with any of these things, that it will get better before it gets worse. When you put it on, the mites start freaking out before they die." Karli probably meant it 'gets worse before it gets better.' Without a doubt, since it was posted on Facebook, others will try this and we receive more reports  since you can obtain food grade diatomaceous earth below and other mediums besides honey will be attempted and the results will be coming in. 
    • Related Articles Do Dermatologic Diagnosis Change in Hot vs. Cold Periods of The Year? A Sub-Analysis of the DIADERM National Sample (Spain 2016). Actas Dermosifiliogr. 2019 Apr 11;: Authors: Gonzalez-Cantero A, Arias-Santiago S, Buendía-Eisman A, Molina-Leyva A, Gilaberte Y, Fernández-Crehuet P, Husein-ElAhmed H, Viera-Ramírez A, Fernández-Peñas P, Taberner R, Descalzo MA, García-Doval I Abstract BACKGROUND: Knowledge of seasonal variation of cutaneous disorder may be useful for heath planning and disease management. To date, however, descriptions of seasonality including all diagnoses in a representative country sample are very scarce. OBJECTIVES: To evaluate if clinical dermatologic diagnosis in Spain change in the hot vs. cold periods. MATERIALS AND METHODS: Survey based on a random sample of dermatologists in Spain, stratified by area. Each participant collected data during 6 days of clinical activity in 2016 (3 in the cold period of the year, 3 in the hot period). Clinical diagnoses were coded using ICD-10. RESULTS: With a 62% response proportion, we got data on 10999 clinical diagnoses. ICD-10 diagnostic groups that showed changes were: other benign neoplasms of skin (D23), rosacea (L71) and other follicular disorders (L73), which were more common in the hot period and acne (L70) which was more frequent in the cold period. We describe differences in the paediatric population and in private vs. public practice. Some of these differences might be associated to differences in the population demanding consultations in different periods. CONCLUSIONS: The frequency of most clinical diagnosis made by dermatologists does not change over the year. Just a few of the clinical diagnoses made by dermatologists show a variation in hot vs. cold periods. These variations could be due to the diseases themselves or to seasonal changes in the demand for consultation. PMID: 30982569 [PubMed - as supplied by publisher] {url} = URL to article
    • Treatment of Rhinophyma With Surgical Excision and Amniotic Membrane. J Craniofac Surg. 2019 Apr 10;: Authors: Yoo JJ, Thaller SR Abstract Rhinophyma is a phenotypic subtype of rosacea affecting the nose. It is characterized by phymatous changes, skin thickening/fibrosis, glandular hyperplasia, and chronic inflammation. Treatment of severe rhinophyma is predominantly surgical excision with closure by secondary intention. Amniotic membrane has been used to promote wound healing, fibrosis, and inflammation. In this case study, the authors present a 63-year-old male with longstanding rhinophyma treated with surgical excision with intraoperative placement of amniotic membrane. PMID: 30985502 [PubMed - as supplied by publisher] {url} = URL to article
    • A number of anecdotal reports are using diaper rash treatments for rosacea. A typical example is Sarah Ann, Rosacea Tips and Support Group, Facebook,  who posts "This is gonna sound kinda crazy but I’ve tried almost everything for my rosacea and finally a couple days ago I was got so desperate I tried using my daughters diaper rash cream lol. It must be the zinc in it but after 2 days of it my skin is better than ever! The brand is Weleda Baby. Any one else try anything like this? I’m amazed!" There are hundreds of others who report trying this treatment and using different brands and rave about it. Just search 'diaper rash treatment for rosacea.' Here are two more examples:  Chris Kosier, Rosacea Tips and Support Group, Facebook, posts, "This is the one I use [Honest Diaper Rash Cream] and recommend all the time in this group. It's for healing dehydrated skin. I also use it to calm irritation from a flare, and I apply a very thin layer under my makeup which keeps my skin soothed until washing it off. The opaque color also masks redness. I see so many people recommending this brand now so I must have started a revolution." Angie Pattillo, Rosacea Tips and Support Group, Facebook, posts, "I started Boudreaux's Butt Paste today. It has the highest Zinc content at 40%." If you try this treatment, please post your results in this thread. 
    • "Quite simply, “groat” is the old Scottish word for the entire oat kernel minus the husk....Oat Groats are the whole grain - germ, bran, and endosperm - without having been rolled or steel cut!....Steel Cut Oats: Steel cut oats are whole oat groats that have been cut into two or three pieces. That's it." The Oatmeal Compendium There is discussion at RF started by butler that making a paste from oat groats or steel cut oats will clear your Rosacea/Seborrheic Dermatitis. It is a long thread but some report that it works, especially if you are into a natural treatment for your Rosacea/Seborrheic Dermatitis. Some prominent posters like Tom Busby. sejon, MrRed77, rednasstor are really into this. One method used to make the paste is to put the oats into a coffee grinder and add water to make the paste. 
    • Thanks for the tip Apurva. Finding a SUN BLOCK is not easy, however, I found one:  You may find this sunscreen interesting even though you said sunscreens tend to dry your skin, probably one like this?    The Neutrogena Hydro Boost may be better for your skin or the Neutrogena Clear Face Sunscreen? I tried to find 'sun block' at Amazon and I just get a list of sunscreens and only found that one. I will keep searching.  
    • Rosaceans always try to use products which can protect their skin from sun rays and try to find the specific products of their needs. It has been said that sunblock is best for rosaceans with sensitive skin than sunscreen because sunblock has mineral composition which is less irritant to skin and protects the skin from UVB rays providing physical barrier so I also started using zinc oxide cream and after a while my skin started becoming very dry, flaky and rough and I could not understand what was causing my skin to get dry and rough and then I found that zinc oxide was the cause of extreme dryness and flaky skin. I know many of you will have suffered from this thing even thinking of doing nothing wrong. So, I have come up with few things : Zinc oxide is an astringent, means it tends to constrict soft organic tissues and so stops secretions like sebum and sweat.So when you apply sunblock cream directly onto your skin since it has thick creamy consistency so we tend to apply it directly onto our skin and it constricts the tissues and stops absorption and secretion because it sits on the top layer of our skin. So what you can do to prevent your skin from excess drying is apply a good amount of moisturizer which suits your skin best and wait for few minutes let it absorb properly and then apply sunblock cream and avoid using frequently when you do not go out and after applying one time you do not need to reapply it. So avoid using frequently and with this practice within one week the excess dryness is less.
    • Thanks Apurva Tathe for your posts. 
    • Hey Admin, It's completely nothing like that. Whenever I have anything to share and post, I always do. Today I found your post on fasting and I shared my experience with this post and was browsing something and I found NRS designated this month as rosacea month. SO I just shared that news in this forum and after posting that I found this post. I do not know about the donation and support to any organization, I only love to share and spread my knowledge.
    • Hello all my friends who have been experiencing and dealing with rosacea,  National Rosacea society(NRS) has assigned April month as rosacea awareness month to help educate public and spread awareness on the impact of this chronic condition and to seek medical help with acceptance and understanding. Now, What they have asked us to do to participate and get involved in this awareness month to spread this knowledge to everyone who is new to this condition. You can find this on the following link : https://www.rosacea.org/patients/rosacea-awareness-month
    • Thank you admin for this post. Yes, This is true to some extent that fasting improves skin condition. In Indian culture, fasting is a religious thing that we devote to god and there are different types of fasting which we perform. Whole fasting in which you can have only water no food items and intermittent fasting in which you can have only one time meal and one more fasting in which you can have only fast related food items like fruits or veggies all day. I have done all the different fasting techniques and I am always doing this and I have found a lot of times that when I fast my visible blood capillaries get constricted and my skin quality looks improved and the puffiness due to rosacea is reduced to some extent. Calories restriction and flushing out of toxins due to having only water in fasting are few things which we can count on but at the cellular and molecular level what happens inside the cell when we fast which contributes to the improvement of skin condition needs to be researched.  
    • Would fasting improve rosacea? One recent report says, "Another study performed by Smith et al. in 2008 has shown the beneficial impact of caloric restriction on acne vulgaris lesions. This was explained by decreased sebum production, which thereby counterbalances one of the main factors in the pathogenesis of acne vulgaris.....Despite such important practical implications, this topic has been neglected in the existing scholarly literature, when it deserves further research. High-quality randomized controlled trials (RCTs) should be conducted to systematically explore and compare different fasting protocols, including the use of vegetables and fruits for caloric and metabolic manipulations."  Wouldn't it be a novel idea to get 10K RRDi members together and each donate one dollar and offer $10K to one of our RRDi MAC members to conduct a clinical trial on this.  End Notes [1] Fasting and Its Impact on Skin Anatomy, Physiology, and Physiopathology: A Comprehensive Review of the Literature
    • Abnormal glucocorticoid synthesis in the lesional skin of erythematotelangiectatic rosacea. J Invest Dermatol. 2019 Apr 09;: Authors: Hong JS, Han S, Lee JS, Lee C, Choi MH, Kim YK, Seo EY, Chung JH, Cho S PMID: 30978355 [PubMed - as supplied by publisher] {url} = URL to article
    • Prevalence of cutaneous comorbidities in psoriatic patients and their impact on quality of life. Eur J Dermatol. 2019 Apr 10;: Authors: Caldarola G, De Simone C, Talamonti M, Moretta G, Fossati B, Bianchi L, Fargnoli MC, Peris K Abstract In contrast to the evidence for systemic co-morbidities, relatively few studies have examined the prevalence of cutaneous inflammatory co-morbidities in psoriatic patients. We conducted an observational multi-site study to measure the prevalence of cutaneous co-morbidities in adult patients with plaque psoriasis and to assess the relative impact on quality of life (QOL). Each patient attending one of the study clinics over a period of six months was evaluated to assess the presence of any concomitant skin inflammatory disease other than psoriasis at the time of the visit. Patients were also asked to complete QOL surveys at the initial visit, using DLQI, SF36, Skindex 29, and PDI. A total of 118 study participants (21.1%) had a cutaneous comorbidity. The most common cutaneous co-morbidities were rosacea (23 cases; 4.1%) and acne vulgaris (22 cases; 3.9%). Psoriatic patients with co-existing skin diseases had a worse QOL than those without, as evidenced by DLQI, Skindex 29, and PDI scores. Dermatologists should take a global approach to manage psoriatic patients by carefully evaluating the skin for any disorder and providing treatment to achieve "clean" skin. PMID: 30973328 [PubMed - as supplied by publisher] {url} = URL to article
    • Irina Kikena‎, Facebook, Rosacea Tips and Support Group, started a thread about using Ichthammol for her rosacea, and reports, "it made a huge difference for me instantly! The next day after using the Ichthammol ointment, I woke up, looked at myself in the mirror and just cried because I did not see such a clear face for a long time."  Ichthammol is Ammonium bituminosulfonate, "a product of natural origin obtained in the first step by dry distillation of sulfur-rich oil shale (bituminous schists)....has anti-inflammatory, bactericidal, and fungicidal properties. It is used to treat eczema, psoriasis, Acne rosacea and acne, and it decreases microorganisms in the area surrounding a skin condition. It is commonly used in 10% or 20% concentrate ointment, applied topically." Wikipedia "Materials made in China (Pinyin transcription: yushizhi and yushizhi ruangao) and offered outside China as Ichthammol or Ammonium Bituminosulfonate are not in line with the definition given for this substance in the United States Pharmacopoeia (USP) or European Pharmacopoeia (Ph.Eur)." Wikipedia <iframe style="width:120px;height:240px;" marginwidth="0" marginheight="0" scrolling="no" frameborder="0" src="//ws-na.amazon-adsystem.com/widgets/q?ServiceVersion=20070822&OneJS=1&Operation=GetAdHtml&MarketPlace=US&source=ac&ref=tf_til&ad_type=product_link&tracking_id=rosaresedevei-20&marketplace=amazon&region=US&placement=B014MRR7NY&asins=B014MRR7NY&linkId=4269b7a89ac4cfe9d8f5173ec24d28e2&show_border=false&link_opens_in_new_window=false&price_color=333333&title_color=0066c0&bg_color=ffffff">
    • Romeo Milea has since resigned from the board. Sent from my iPad using Tapatalk
    • [Teledermatology in Switzerland : Set-up for and examples of dermatological treatment from a telemedicine center]. Hautarzt. 2019 Apr 10;: Authors: Maltagliati-Holzner P Abstract BACKGROUND AND OBJECTIVES: In Switzerland, telemedicine has been an integral part of the health care system for many years and plays a significant role in basic medical care. Telemedicine is particularly suitable for skin diseases, thanks to the possibility of diagnostic imaging. The aim of this article is to point to services and structures needed using the example of a successful telemedicine center (Medgate Tele Clinic, Basel, Switzerland) and to illustrate the wide range of applications of telemedicine available in Switzerland based on examples from teledermatology. MATERIALS AND METHODS: This article describes how a telemedicine center functions, with particular emphasis on teledermatology. As examples, some of the dermatological disorders that have been treated only using teledermatology will be presented. RESULTS AND DISCUSSION: In about half of all cases, physicians working at the above-mentioned telemedicine center can complete treatment of their patients over the phone or video, so that no further appointment with a doctor is necessary. Many dermatological problems (such as pityriasis versicolor, perioral dermatitis or rosacea without eye involvement) can be treated particularly well with telemedicine. PMID: 30969351 [PubMed - as supplied by publisher] {url} = URL to article
    • mac5400 at Reddit, gives a tip to avoid flushing, of taking a supplement, Diamine oxidase (DAO), and writes, "I now take an OTC supplement called UmbrelluxDAO before i eat or drink. It contain the enzymes responsible for metabolizing histamine. And I barely flush anymore. The chronic rosiness on my cheeks has significantly reduced; more than any cream I've ever tried. In combination with a low histamine diet, i think i finally found the "cure" to my "rosacea." It's such a breakthrough for me. This supplement is life-changing." "Diamine oxidase (DAO), also known as histaminase, is an enzyme (EC involved in the metabolism, oxidation, and inactivation of histamine and other polyamines such as putrescine or spermidine in animals." Wikipedia Added DAO to the list of anti-flushing treatments. 
    • Dimethicone in Soolantra Someone at Reddit points out an article published in the Tropical Medical Health by Hermann Feldmeier that concludes, "Dimeticones are a family of compounds with a physical mode of action, targeting an Achilles heel of ectoparasites." I found another article that state dimethicone is a pediculocide. I did find this article that says "dimethicone lotion is not an insecticide and instead kills lice by suffocation," which may explain it. Dimeticone redirects to Polydimethylsiloxane.  Dimethicone redirects to Polydimethylsiloxane. The Wikipedia article on Polydimethylsiloxane says it is used in medicine "in over-the-counter drugs as an antifoaming agent and carminative" with no mention of it being used as an insecticide or kills parasites.  "Perhaps dimethicone is an old fashioned treatment for head lice, because like you, I can't find a reliable reference for using it as a miticide or arachnicide or insecticide. With lice, sometimes treatments are called any of these 3 terms. "Mite" is an old-fashioned English word, "arachnid" is the scientific term, and "insect" is just plain wrong, for referring to head lice or demodex. Watch out too for chemical names, as there are silicones that are oil soluble, water soluble, and not soluble in either oil or water.  And, I can't find the recommended concentration for treating head lice with dimethicone -- if, ,for example, it's 15%, that would be far too messy to be cosmetically acceptable for trying it on the face. From my personal point of view in formulating, I like only water soluble silicones, because some of them wash out easily with water, but still provide some "slip" (ease of combing hair, or detangling). The other silicones just sit there on the skin or on the hair, and don't do anything useful from an aesthetic point of view." Tom Busby, Post no 7, Rosacea Forum "Dimethicone doesn't have any biocidal properties. The mode of action on the treatment of headlice is to prevent the adhesion of lice and the louse eggs on to the hair shaft. Headlice produce a strongly adhesive mucus secretion to stick their eggs (nits) to hair. Dimethicone prevents this adhesion and also interferes with the 'foothold' that the adult lice have on the scalp. Dimethicone is not immediate acting and requires several days for its effect to be apparent. It requires thorough combing of the hair after use to remove loosened lice and nits." johnabetts, Post no 8, Rosacea Forum "Dimethicone was also the main ingredient (first in list) in the Dermalogica Close Shave Oil, no longer available. I have no signs of rosacea in my shaving area - only on the ears and nose, where clearly I didn't apply the shaving oil. The point with a shaving oil is, assuming you shave every day or two, it is very easy to fully cover the area on a very regular basis. I also thought Soolantra cream had good moisturising properties when I used it. Unfortunately it seemed to stop working on killing mites after a while, and I've had longer term success with Zhongzhou cream." antwantsclear, Post no 9, Rosacea Forum
    • Preparation of in situ hydrogels loaded with azelaic acid nanocrystals and their dermal application performance study. Int J Pharm. 2019 Apr 06;: Authors: Tomić I, Juretić M, Jug M, Pepić I, Čižmek BC, Filipović-Grčić J Abstract Azelaic acid (AZA) is a dicarboxylic acid that is topically used in the treatment of acne and rosacea since it possesses antibacterial and keratolytic activity. The primary objective of this study was to develop an AZA nanocrystal suspension. It is expected that improved solubility and dissolution rate will result in advanced biopharmaceutical properties, primarily the dermal bioavailability. Furthermore, a topical nanocrystal AZA-loaded hydrogels composed of Pluronic® F127 and hyaluronic acid mixture that are able to deliver AZA into the stratum corneum and deeper skin layers were considered. This study was conducted in order to: 1) determine the effect of non-ionic Polysorbate 60 on the stabilization and particle size of the AZA nanocrystals, as well as the effect of Pluronic® F127, used as an in situ gelation agent, and hyaluronic acid on the viscoelastic properties and the drug release of composed hydrogels, 2) determine the relationship between the rheological properties of the gels and the penetration of AZA into the stratum corneum. The composed hydrogels revealed pseudoplastic flow behaviour. The increase in Pluronic® F127 concentration induced a domination of elastic over viscous behaviour of the gels. The gel containing 15% of Pluronic® F127, 1% of hyaluronic acid and lyophilised 10% nanocrystal AZA suspension was considered to be an optimal formulation, since it possessed the rheological and drug delivery properties desirable for an in situ gelling platform for dermal application. PMID: 30965120 [PubMed - as supplied by publisher] {url} = URL to article
    • [THE RATIONALE FOR THE POSSIBLE ROLE OF DEMODEX FOLLICULORUM IN THE PATHOGENESIS OF ROSACEA]. Georgian Med News. 2019 Feb;(287):95-98 Authors: Tsiskarishvili T, Katsitadze A, Tsiskarishvili N, Chitanava L Abstract The purpose of the study was to study the frequency of detection and population density of the mite in rosacea patients depending on the clinical form, the location of the morphological elements on the face and some parameters of the functional state of the skin. We observed 55 patients (38 women and 17 men) aged from 30 to 65 years old with disease duration from 6 months to 10 years. According to clinical forms, 35 had PPR and 20 - ETR (erythematous - telangiectatic rosacea). By location of the rash elements, the following types are distinguished: central, medial, asymmetric, lateral, and total. The mite was identified by a microscopic method. The functions of the skin barrier of the face skin: moisture, oiliness, dryness were determined using a bio-impedance analyzer (BIA). As shown by the results of the study of the above parameters in the observed patients, a high density of the mite population (> 5 per cm2) was noted in cases of total, medial and central type of their location. This indicator was in direct correlation with parameters such as skin fat content and moisture. 75% of patients in this group were diagnosed with PPR. In the group of patients with medium and low population density of mites (<5 per cm2), the lateral, asymmetric and central type of their location were dominated in 65% ​​of patients with ETNR. This group of patients showed low levels of skin fat and moisture, relatively high rates of dryness. Thus, the population density of the mites is dependent on the intensity of the anatomical location of the sebaceous glands of the face skin. An analysis of the results obtained in the study of the role of mite in the pathogenesis of rosacea led us to the conclusion: in rosacea patients, a correlation was found between the increase in the population density of mites, the type of element arrangement and the severity of dermatosis, which proves the role of the mite as one of the most frequent but not obligatory pathogenetic factors in the development of this dermatosis, especially its papulopustular form. PMID: 30958297 [PubMed - in process] {url} = URL to article
    • Just thought I would vent a little since, after all, I founded the RRDi, and no one hardly ever posts, even though there are over 1200+ members, and we know  that many are viewing the posts since we have counters showing the number of views, so we know that rosacea sufferers are learning about rosacea from our website. So I posted about this a while back, Where Have All the Rosaceans Gone?, back in February 2018, which did elicit one reply from RedMage, which is much appreciated, and has as of this date 96 views, so the odds are 1 in 96 that someone will reply to this post. So I have been posting some at Reddit and Facebook to see what is going on, and am appalled at the lack of basic rosacea knowledge, so I have been trying to educate rosaceans and, got  a disparaging post from a Reddit poster who I had commended for some good investigative reporting on finding that Soolantra isn't really using Cetaphil as  its 'vehicle base' [1] and was told that "the Rosacea Research & Development Institute (RRDi) is a sham 'institute' operating from a PO Box that conducts no research or development, hasn't published a journal since 2010, and doesn't even publish its 990s like any reputable 501(c)(3) public charity would be expected to. You're not fooling anyone." That really made my day. Here I have devoted countless volunteer hours trying to make the RRDi a non profit rosacea patient advocacy organization and this certainly made me feel blue. It still boggles my mind that rosaceans continue to support and donate to the National Rosacea Society, which is the chief reason we formed the RRDi in 2004 (read this in case you haven't clue about this). Rosaceans actually prefer the NRS and how it spends its donations. Mind boggling to me.  So just want you to know, that is the 96 that may view this post, that if some of you don't step up to the plate and start volunteering, posting and doing something as a member of the  RRDi that this non profit organization for rosacea may indeed have to close. Then all you got is the NRS, the AARS, and the ARSC. It really is up to you. And I don't mean up to others, I mean up to you. Oh, you will still have your Facebook and Reddit rosacea groups which is what most rosaceans prefer so you will be in good company. Is that really what you prefer? [1] See end note [3] in this post
    • Dapsone for Unresponsive Granulomatous Rosacea. Am J Ther. 2019 Apr 01;: Authors: Merlo G, Cozzani E, Russo R, Parodi A PMID: 30946045 [PubMed - as supplied by publisher] {url} = URL to article
    • In Rosacea News, we have the post about this subject in detail for your information. Please post in this thread your experience using the horse paste, what brand you use, how often you are applying it, and other details and hopefully photos of before and after. 
    • As mentioned earlier in this thread, one of the issues with using an oral horse paste TOPICALLY for rosacea sufferers is usually there is no inactive ingredient list to see what is actually in the paste or gel. However, one poster at Reddit found the list for one of the products, Eqvalan, which is listed for your convenience below: Eqvalan Oral Paste for Horses Ingredients:  Ivermectin: 1.87% w/w.  Titanium Dioxide (E171) 2.0% w/w. Hyprolose Hydrogenated Castor Oil Propylene Glycol   Source Eqvalan_SPC_214477.pdf Link for the above: http://www.vmd.defra.gov.uk/productinformationdatabase/SPC_Documents/SPC_214477.DOC Eqvalan MSDS EqvalanMSDS.pdf Link for the above: https://www.statelinetack.com/ContentFiles/Associated_Content/EqvalanMSDS.pdf If anyone finds the ingredients in any other horse paste/gel please post in this thread. 
    • Related Articles A Case Report of Fulminant Type 1 Diabetes Mellitus Caused by Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Complicated by Iodine-Induced Thyrotoxicosis. Diabetes Ther. 2019 Apr 01;: Authors: Wang J, Gao X, Li Y, Ping F Abstract A 46-year-old woman presented with rash, fever, lymphadenopathy, eosinophilia and liver dysfunction. She had been treated with ornidazole for facial rosacea 2 months previously. Two weeks following presentation, she developed diabetic ketoacidosis with exhausted beta islets (2 h postprandial laboratory values: glucose 22.0 mmol/L, C-peptide < 0.017 nmol/L, proinsulin < 0.23 pmol/L) and negative autoantibodies. Several days thereafter, after having undergone an enhanced computed tomography examination to screen for malignancy, the patient developed thyrotoxicosis with a low iodine absorption rate and super-high urine and serum levels of iodine. The patient was ultimately diagnosed with drug reaction with eosinophilia and systemic symptoms (DRESS), a hypersensitivity reaction to drugs. Studies have shown that immune dysregulation during DRESS renders patients susceptible to new diseases. Here we report a patient who recovered from DRESS but developed fulminant type 1 diabetes complicated with iodine-induced thyrotoxicosis. This case report sheds light on the pathogenesis of DRESS and its sequelae and illustrates that patients with DRESS require long-term care and follow-up. PMID: 30937841 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Effect of recombinant bovine basic fibroblast growth factor gel on repair of rosacea skin lesions: A randomized, single-blind and vehicle-controlled study. Exp Ther Med. 2019 Apr;17(4):2725-2733 Authors: Luo Y, Luan XL, Sun YJ, Zhang L, Zhang JH Abstract The aim of the present study was to assess the effect of topical use of recombinant bovine basic fibroblast growth factor (rbFGF) gel on the repair of facial skin lesions in patients with rosacea. In the present single-blind study, a total of 1,287 patients with Demodex mite-induced rosacea who received treatment with ornidazole tablets were randomized to rbFGF gel treatment group (n=651) or control group (n=636) without revealing the group identity. Patients in the treatment group were treated with topical application of rbFGF gel over the skin lesions (0.2 g/cm2) for up to 8 weeks, whereas patients in the control group received gel vehicle treatment unless ulceration occurred. Skin lesions of all patients were scored prior to and following treatment with rbFGF gel and subjected to histological analysis. All patients were followed up for 6 months. Significant improvement in the total effective rates for erythema, papules, desquamation and dryness were observed in the rbFGF treatment group. At the end of the 2, 4 and 6 months of follow-up, the total effective rates for patients in the treatment group were significantly higher than those in the control group (81.67 vs. 28.84%; 85.11 vs. 40.81%, and 96.56 vs. 55.82%, respectively). Following treatment for 6 months, none of the patients in the rbFGF group exhibited ulceration or scar formation. In the control group, 61% of patients experienced exacerbation of skin lesions, of which, 12% exhibited ulceration and were treated with rbFGF gel to prevent scar formation. Histological analysis revealed gradual reduction in epidermal hyperplasia and resolution of dermal edema in skin lesions treated with rbFGF gel. In conclusion, rbFGF gel may improve the repair of facial rosacea skin lesions in patients treated with anti-Demodex. PMID: 30930972 [PubMed] {url} = URL to article
    • These recommendations are from ElaineA and Tom Busby at RF:  20 Muleteam Borax powder is available in US grocery stores in the laundry aisle. Price locally for me is currently about $5.59 per box. Borax is used as a water softener for laundry.  Try washing your washable clothes with some borax powder added to the wash load. Borax powder dissolves best in warm or hot water. For a cold wash, pre-disolving the borax powder in warm or hot water before adding to the wash, would be a good idea. Instructions on the box recommend adding 1/2 cup of borax powder per wash load. I don't know for sure that they can live for long on dry clothes, but they might - especially if there is enough oil or body lotion on the clothes or if the clothes are damp. I've read that they can live up to 54 hours on a wet towel. Wool has natural lanolin oil in it which may give them enough oil to survive when their human host is not available. The wool scarves are trickier. If you can wash these in cold water, diluting the borax powder first in hot water, allow it to cool enough, then add to the cold wash water for the scarf might be the best approach. Then as Tom said put the scarf in the sun to dry. Interesting that the Malessezia fungus is light sensitive. Demodex cannot be cultured in a lab (they die in an hour or two when removed from the host). They have such short lives, your clothes are not going to be a source of re-infestation of live demodex -- but as above though, the eggs should be washed off in soapy water.  As far as I know, no one knows how the long the eggs can survive, so to be certain, you can add a tiny amount of tee tree oil to the wash-cycle of your washing machine or wash basin -- rinse the TTO off completely so it doesn't stain your clothes (especially silk or wool), and you shouldn't have to worry. Normal "good housekeeping" for washing your clothing is sufficient in my opinion. This is a variable idea though, as winter clothing worn next to the skin, like a scarf or gloves, will probably need more washing than most people would consider "normal." About every 2-3 weeks should be enough. The hood and collar of coat (assuming the coat can't be washed) is more problematic though, and you might douse the collar and cuffs in 91% isopropyl alcohol every 2-3 weeks, and let it air dry until there's no smell. Isopropanol dries extremely quickly in a dry, winter climate. Color-test isopropanol in an inconspicuous place to be sure it doesn't lift the dye, first.
    • Related Articles Acne and Rosacea: Special Considerations in the Treatment of Patients With Latin American Ancestry J Drugs Dermatol. 2019 Mar 01;18(3):s124-126 Authors: Florez-White M Abstract Acne is a common disease among patients with Latin American ancestry. Its presentation is very similar to that in all skin types, but nodulocystic acne is more frequent in patients with oily and darker skin than in white Caucasians. Acne sequelae in patients with Latin American ancestry and with darker skin include postinflammatory hyperpigmentation (PIH) and atrophic and hypertrophic scars or keloids, with PIH being the most common complication affecting the quality of life of patients. Lately, more attention has been paid to rosacea in patients with darker skin. It has been seen that some of the patients, especially women, diagnosed with adult acne and who did not respond to treatment, were actually patients with rosacea. It is important to recognize the clinical characteristics of this disease in patients with darker skin in whom erythema and telangiectasia are difficult to observe. Here, we present the most relevant clinical characteristics of both diseases, as well as their treatment in patients with darker skin with Latin American ancestry. J Drugs Dermatol. 2019;18(3 Suppl):s124-126. PMID: 30909359 [PubMed - in process] {url} = URL to article
    • Rosácea infantil. Bol Med Hosp Infant Mex. 2019;76(2):95-99 Authors: Bernal LE, Zarco AP, Campos P, Arenas R Abstract Background: Rosacea is a chronic inflammatory skin condition that usually occurs in adults and rarely has been reported in children, although both subtypes share the same clinical characteristics. Case report: A 10-year-old female presented dermostosis on the face, affecting cheeks and nose, characterized by erythema, papules, pustules, scars of two years of evolution, as well as bilateral conjunctivitis, blepharitis and corneal opacity. She referred recurrent exacerbations and partial remission of cutaneous lesions and ocular symptoms related to sun exposure. She responded dramatically to systemic and topical antibiotics. Conclusions: Childhood rosacea should be distinguished from other most common erythematous facial disorders, such as acne, granulomatous perioral dermatitis, and sarcoidosis. The distribution of papulopustular facial lesions together with the presence of telangiectasia, flushing and the ocular findings allow the differentiation of rosacea from other facial eruptions. PMID: 30907384 [PubMed - in process] {url} = URL to article
    • Treating Acne With Topical Antibiotics: Current Obstacles and the Introduction of Topical Minocycline as a New Treatment Option J Drugs Dermatol. 2019 Mar 01;18(3):240-244 Authors: Bonati LM, Dover JS Abstract Oral antibiotics are well established treatments for acne vulgaris but are associated with undesirable side effects. Topical antibiotics offer an improved safety profile but have led to an alarming rise in worldwide P. acnes resistance. Fortunately, a new class of topical minocycline products has been developed for the treatment of acne and rosacea that decreases the risk for antibiotic resistance while maintaining safety and efficacy. Recent clinical studies have demonstrated that a hydrophilic minocycline gel (BPX-01) and a lipophilic minocycline foam (FMX101) both reduced acne lesion counts with negligible systemic absorption. Head-to-head studies have yet to be completed, but the hydrophilic gel studies reported greater treatment efficacy than the lipophilic foam studies. J Drugs Dermatol. 2019;18(3):240-244. PMID: 30909327 [PubMed - as supplied by publisher] {url} = URL to article
    • Comparative effectiveness of purpuragenic 595 nm pulsed dye laser versus sequential emission of 595 nm pulsed dye laser and 1,064 nm Nd:YAG laser: a double-blind randomized controlled study. Acta Dermatovenerol Alp Pannonica Adriat. 2019 Mar;28(1):1-5 Authors: Campos MA, Sousa AC, Varela P, Baptista A, Menezes N Abstract INTRODUCTION: Erythematotelangiectatic rosacea is a common condition in Caucasians. The most frequently used lasers to treat this condition are pulsed dye laser (PDL) and neodymium:yttrium-aluminum-garnet laser (Nd:YAG). This study compares the treatment efficacy of purpuragenic PDL with that of sequential emission of 595 nm PDL and 1,064 nm Nd:YAG (multiplexed PDL/Nd:YAG). METHODS: We performed a prospective, randomized, and controlled split-face study. Both cheeks were treated, with side randomization to receive treatment with PDL or multiplexed PDL/Nd:YAG. Efficacy was evaluated by spectrophotometric measurement, visual photograph evaluation, the Dermatology Quality of Life Index questionnaire, and a post-treatment questionnaire. RESULTS: Twenty-seven patients completed the study. Treatment was associated with a statistically significant improvement in quality of life (p < 0.001). PDL and multiplexed PDL/Nd:YAG modalities significantly reduced the erythema index (EI; p < 0.05). When comparing the degree of EI reduction, no differences were observed between the two treatment modalities. PDL was associated with a higher degree of pain and a higher percentage of purpura. Multiplexed PDL/Nd:YAG modality was associated with fewer side effects and greater global satisfaction, and 96.3% of the patients would recommend this treatment to a friend. CONCLUSIONS: Both laser modalities are efficacious in the treatment of erythematotelangiectatic rosacea. The multiplexed PDL/Nd:YAG modality was preferred by the patients. PMID: 30901061 [PubMed - in process] {url} = URL to article
    • Logo of the Human Microbiome Project, a program of the NIH Common Fund, National Institutes of Health, image courtesy of Wikimedia Commons This subject of microbiome-based therapeutic strategies for rosacea is one of my favorite subjects which I have done a great deal of research on. You may want to read the latest article I have written on this subject of the human microbiome. 
    • Related Articles Skin diseases are more common than we think: screening results of an unreferred population at the Munich Oktoberfest. J Eur Acad Dermatol Venereol. 2019 Mar 19;: Authors: Tizek L, Schielein MC, Seifert F, Biedermann T, Böhner A, Zink A Abstract BACKGROUND: Skin diseases are ranked as the fourth most common cause of human illness, resulting in an enormous non-fatal burden. Despite this, many affected people do not consult a physician. Accordingly, the actual skin disease burden might be even higher since reported prevalence rates are typically based on secondary data that exclude individuals who do not seek medical care. OBJECTIVE: The aim of the study was to investigate the prevalence of skin diseases in an unreferred population in a real-life setting. METHODS: A cross-sectional study of 9 days duration was performed in 2016 at the 'Bavarian Central Agricultural Festival', which is part of the Munich Oktoberfest. As part of a public health check-up, screening examinations were performed randomly on participating visitors. All participants were 18 years or older and provided written informed consent. RESULTS: A total of 2701 individuals (53.5% women, 46.2% men; mean age 51.9 ± 15.3 years) participated in the study. At least one skin abnormality was observed in 1662 of the participants (64.5%). The most common diagnoses were actinic keratosis (26.6%), rosacea (25.5%) and eczema (11.7%). Skin diseases increased with age and were more frequent in men (72.3%) than in women (58.0%). Clinical examinations showed that nearly two-thirds of the affected participants were unaware of their abnormal skin findings. CONCLUSION: Skin diseases might be more common than previously estimated based on the secondary data of some sub-populations. Further information and awareness campaigns are needed to improve people's knowledge and reduce the global burden associated with skin diseases. PMID: 30891839 [PubMed - as supplied by publisher] {url} = URL to article
    • Fractionated Carbon Dioxide Laser Resurfacing as an Ideal Treatment Option for Severe Rhinophyma: A Case Report and Discussion. J Clin Aesthet Dermatol. 2019 Jan;12(1):24-27 Authors: Comeau V, Goodman M, Kober MM, Buckley C Abstract Rhinophyma is a progressive, disfiguring condition that affects the nose and is caused by the hypertrophy of sebaceous glands and connective tissue. Although its exact pathogenesis remains unclear, it is generally thought to be a subtype of the chronic, inflammatory condition rosacea. To date, oral and topical treatments have been largely ineffective at treating rhinophyma. Laser resurfacing is an emerging treatment modality that offers hope for patients with severe rhinophyma. We present a case of rhinophyma treated via fractionated carbon dioxide laser resurfacing with impressive results, excellent tolerability, and minimal downtime. PMID: 30881573 [PubMed] {url} = URL to article
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