• The Only Non Profit Organization Founded by Rosaceans [rosacea sufferers] for Rosaceans

    Welcome to the RRDi official web site.

    The Rosacea Research & Development Institute [RRDi] is the first 501 (c) (3) non profit corporation established June 7, 2004 in the State of Hawaii, USA for the purpose of finding a cure for rosacea, researching rosacea, and to form a patient advocacy organization established by volunteer rosaceans for rosacea sufferers. State of Hawaii Certificate of Good Standing.

    Please take our 2016 Rosacea Survey now. This will take you 10 to 15 minutes. If you have any issues with taking the survey please contact us letting us know what issue you experienced.

    In 2015 we polled our members and the general public with a survey about their rosacea experience and you can view the results by clicking here.

    What is Rosacea?

    Rosacea is a chronic and sometimes progressive disorder of the face, characterized by some or all of the following symptoms:

    Extremely sensitive skin, blushing, flushing, permanent redness, burning, stinging, swelling, papules, pustules, broken red capillary veins, red gritty eyes (which can lead to visual disturbances) and in more advanced cases, a disfiguring bulbous nose. Men and women of all ages can be affected, with over 45 million estimated sufferers of Rosacea worldwide. For more info click here.

    "Rosacea is a multifactorial, hyper-reactivity, vascular and neural based disease with a broad range of facial and manifestations where normal vasodilation is greater and more persistent and involves an autoimmune component where microscopic amounts of extravasated plasma induce localized dermal inflammation where repeated external triggers lead vasodilation, telangiectasias, redness with eventual fibrosis and hypertrophic scarring of the dermis." Sandra Cremers, M.D., F.A.C.S., RRDi MAC Member.

    "Rosacea is probably a collection of many different diseases that are lumped together inappropriately." Zoe Diana Draelos, MD. Dr. Draelos is a member of the ROSIE [ROSacea International Expert] Group that says the current classification of rosacea is controversial. Dr. Draelos is also a member of the RRDi MAC. Just because you have a red face might mean you have another skin condition besides rosacea. Your physician should differentiate rosacea from a plethora of other skin conditions. If you need photos of rosacea click here.

    Sometimes rosacea is misdiagnosed. No one really knows what causes rosacea and there are a number of theories for your consideration. Rosacea, therefore, can be confusing, a bewilderment and a mystery (for more info click here). The number of cases of rosacea worldwide is conservatively around 74 million. 

    Check our FAQs about rosacea.

    What will the RRDi Do For Me?

    The RRDi is in the forefront of other rosacea non profit organizations with the digital medical revolution. Your rosacea is an individual case and you need to find what treatment will work for your rosacea and not a treatment aimed at the masses. Individuals can come together and share data, using collaboration tools that the RRDi offers for free. If you have the volunteer spirit and want to become part of this innovative non profit, learn how you can volunteer and be part of this digital medical revolution. You can post in our member forum if you register.

    Once you join you have a number of tools to collaborate with other members. You can create your own rosacea blog with our tools once you join, with easy step by step directions on how to do this. Our Gallery application lets members share photos and videos with the community. We have a chat tool available to members. Volunteers who contribute their time and energy may receive a free Google Apps for Work account.

    RRDI_Vol1No1_Journal-Cover300.jpg

    Your donation will assist us to continue to publish our journal, keep this web site going and sponsor rosacea research. Mahalo for your donation..

    The RRDi is a volunteeer member driven organization and invites rosacea sufferers to become involved. Volunteering is the force that drives the organization and is an integral spirit of the RRDi philosophy. The RRDi warmly invites rosacea sufferers to participate in this non profit which you can become a part of. You are not required to volunteer when you join, since we still want you to join even if you can't volunteer. If all you can do is become a member, that will increase our membership which is helpful in itself. But if you can volunteer, let us know on the application. Please join. For a limited time you may receive a free ebook, Rosacea 101: Includes the Rosacea Diet as a free gift from the founder/director. Just mention in the application that you want the free ebook (write in the volunteer box).

    If you can't volunteer and simply want to join to increase our membership that could be the least you do. 

    How to Join

    You can browse our web site and learn about rosacea. To post in our Member Forum or submit articles for publication you must register to join to become a member. The RRDi requires that you provide us with your contact info and mailing address and agree to our policies since you become a corporate member of the RRDi. Your privacy is our utmost concern and we will take precautions to ensure your privacy will not be violated. Our Privacy Policy is solid.

    Once you have joined you can post in our secure members forum which will allow you to post questions to the Medical Advisory Consultants (MAC) and to fellow members or to submit articles for our journal. Yes, members may have an article published in our journal. You may receive a free Google Apps account with our organization upon approval and you have the volunteer spirit. 

    The Charter of the Corporation states the purpose and Mission Statement which clearly outlines the goals of the non profit corporation. If you are interested in the history of how and why this non profit organization was formed click here for more information. Please take our Rosacea Survey.

    The RRDi is registered at GuideStar

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    • Demodex mites are usually on all adults and what they are doing there is up for debate since no one really knows. Some conjecture a symbiotic relationship but so far has not been discovered. Demodex do not appear on babies but show up later in life. Demodex feed on sebum and hang around hair follicles. They like warmth so they usually are on the face. They do not like light so they bury themselves deep into the skin during the day and come out at night and move around. They have no way to eliminate their waste and eventually die. This poses no problem for most humans who haven't a clue these demodex are on their face. The history of demodex is that there are only two kinds that appear on humans even though there are dozens of kinds and their connection to acne rosacea goes way back and has been debated by the medical authorities for over a hundred years. Recent studies confirm that a bacteria in the mites may have the clue to why rosacea appears. Whether the mites cause the rosacea or the rosacea increases the mite density count is a chicken or egg question. Most studies conclude that a higher demodex density count appears on humans who have rosacea. Treatment for demodectic rosacea, a variant of rosacea, is one way to confirm one has it if the rosacea improves. Not all cases of rosacea are demodectic. Dermatologists have been treating recently with Soolantra. 
    • Related Articles Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study. Dermatol Ther (Heidelb). 2016 Sep 22; Authors: Marshall VD, Moustafa F, Hawkins SD, Balkrishnan R, Feldman SR Abstract
      INTRODUCTION: Inflammation is an established component of cardiovascular disease (CVD) and an underlying factor of several dermatologic conditions including rosacea, atopic dermatitis, and psoriasis. Identifying potential associations between these dermatologic and cardiovascular diseases can better inform holistic healthcare approaches. The objective of this study was to determine whether rosacea, psoriasis or atopic dermatitis are independent risk factors for CVD 1 year following diagnosis.
      METHODS: Using a large commercial claims database of 21,801,147 lives, we employed a propensity-matched logistic regression to evaluate the association between diagnoses of rosacea, psoriasis, or atopic dermatitis and a 1-year risk of being diagnosed with cardiovascular disease. Control patients were matched based on health-care utilization, age and overall health status as defined by a modified Deyo-Charlson comorbidity index.
      RESULTS: The analysis included 2105 rosacea, 622 atopic dermatitis, 1536 psoriasis, and 4263 control patients. Compared to propensity-matched controls, the adjusted odds of cardiovascular disease were not higher in patients with rosacea (odds ratio: 0.894, p = 0.2713), atopic dermatitis (OR 1.032, p = 0.8489), or psoriasis (OR 1.087, p = 0.4210). In univariate analysis, the unadjusted odds of cardiovascular disease was higher in patients with psoriasis (OR 1.223, p = 0.0347).
      CONCLUSIONS: Limitations of this study include the short follow-up period and inclusion of only commercially insured patients limit the generalizability of these findings. In this large study of patients with rosacea, atopic dermatitis, and psoriasis, we did not detect an increased 1-year risk of cardiovascular disease after adjusting for confounders.
      PMID: 27659680 [PubMed - as supplied by publisher] {url} = URL to article
    • As of this date, there are no reports in medical literature researching contraceptives and rosacea, however, there are plenty of discussions, articles and posts on this subject. We will use this FAQ as a source to keep this discussion in this thread. If you have anything to add please post in this thread.  One of the rosacea triggers is menopause, so logically the hormones are somehow involved, but we have no clear understanding of how. [1] Some physicians prescribe antihistamines, antidepressants, low-estrogen birth control pills [2], diuretics, or an anti-dandruff shampoo containing zinc for the flushing that results from menopause. [3] Some anecdotal reports indicate that taking birth control pills improves rosacea. [4] Another anecdotal report indicates that going off birth control for one day improved rosacea. [5] Conversely, there are reports of women who go on birth control that increase rosacea flareups. [6] From an article posted at the dermatologist “We’re not certain of the clinical significance of the skin production of androgens because a lot is being made by the ovaries or testes. But, the skin is a large organ, so even if it’s involved in any respect in androgen metabolism, it could play a role in acne,” says Diane M. Thiboutot M.D., a Professor of Dermatology at the Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center. “It might be that women with acne may have greater local production of androgen in their skin that could in part account for the presence of acne. Many of our female patients with acne were found to have high levels of testosterone. Agents that block adrenal production of androgens are oral contraceptives and low-dose glucocorticoids. “Most times we use prednisone at a low dose because there seems to be increased risk of adrenal suppression with dexamethasone,” says Dr. Thiboutot. “While we have patients on treatment with dexamethasone or prednisone for congenital adrenal hyperplasia, it’s important to know whether your therapy is actually reducing those androgens, so you may want to check the serum dehydroepiandrosterone sulfate (DHEAS) to see if you’re bringing that down into the normal range.”  Even on low-dose prednisone, adrenal suppression could still occur, so you may want to refer to an endocrinologist or an internist to have cortisol checked or to check adrenal function in general." Oral contraceptives contain a low-dose of an estrogen and a progestin. Studies show that most oral contraceptives used to treat acne have similar effectiveness, around a 45% reduction in inflammatory lesions. However, a novel progestin has been introduced called drospirenone, which is a derivative of 17-spironolactone, and it is found in the Yasmin brand oral contraceptive, which contains about 30 µg of estrogen.  According to Dr. Thiboutot, a small trial for this contraceptive involving 128 women showed about a 60% lesion reduction over 9 months. Phase III trials for this therapy are in progress. Many patients are concerned about the interaction between oral contraceptives and antibiotics. “The gut flora is needed to cleave estrogen from the conjugated estrogen in the oral contraceptives, and the risk of an interaction is greatest with tetracyclines,” says Dr. Thiboutot. “But the number of reports in the literature is actually small. However, I think that we should discuss this with our patients.” [7] End Notes [1] birth control
      Q&A: Birth Control & Topical Medication, NRS  [2] "The oral contraceptives chlormadinon acetate/mestranol (Ovosiston) and the antiandrogen agent cyproterone have been suggested as being effective hormonal treatments for rosacea."
      P T. 2009 Jan; 34(1): 38–45.
      Rosacea: A Review
      Brittney Culp, BA and Noah Scheinfeld, MD [3] Women May Need Added Therapy
      Lynn Drake, MD, Editor, NRS Rosacea Revew [4] sunshine12, Rashadooks, cas, [5] lexiophile [6] amethystice215 [7] What's New for Treating Acne
      By Michael S. Krivda, the dermatologist
    • Exactly How to Get a Flawless Wedding Complexion, No Matter Your Skin Issues, by Kate Somerville, Popsugar
    • Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition. Int J Mol Sci. 2016;17(9) Authors: Woo YR, Lim JH, Cho DH, Park HJ Abstract
      Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid toward better comprehending its complex pathogenesis.
      PMID: 27649161 [PubMed - as supplied by publisher] {url} = URL to article
    • One of the theories of the cause of rosacea is an overactive immune system.  "In a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman-Yassky of Mount Sinai Medical School [RRDi MAC Member], discovered that an arm of the immune system -- the Th17 pathway -- in these patients is way too active, and the higher its activity, the worse the disease severity....The drug Paller will test, secukinumab, has already been highly effective in psoriasis, a more common skin disorder with an increase in this Th17 pathway, leading to inflammation and scaling. And with Paller's new discovery, she thinks the drug could be even more helpful in ichthyosis because the overactive immune pathway was actually more strongly correlated with ichthyosis than with psoriasis." Research finally reveals reason for perplexing red skin disease
      Science Daily, September 20, 2016  
    • The Rosacea X-Factor Syndrome is an interesting concept originated at a rosacea yahoo group over fifteen years ago . The X-Factor is 'the factor of a regimen of treatment for rosacea that is not fully understood when rosacea is controlled in one person, but the same regimen doesn't work for another rosacean.'  While one rosacean may report success in treating rosacea explaining their treatment in detail, another rosacean will try it and not find the same level of success. Why? What is the X-Factor? The X-Factor is rooted in what causes rosacea. There may be other reasons why a particular rosacea regimen for one rosacean that works to control rosacea will not work for another rosacean but for now the X-Factor is a good explanation to describe this phenomenon or syndrome.  Trigger factors are included in the X-Factor, since what may trigger a rosacea flare-up in one rosacean may not trigger another rosacean. Trigger factors only MAY trigger a rosacea flare-up no matter who makes up the trigger factor list.  One of the problems with the X-Factor is that there is the difficulty of defining rosacea and how rosacea is often misdiagnosed. When a physician says that you have rosacea (or one of the subtypes) this disease looks like so many other skin conditions that a rosacean may find later that it is SD, PF, PD, or demodectic rosacea. The disease has such a broad spectrum and looks way too much like acne, SD, lupus, PD, and a host of rosacea mimics. The point of all this is that when one is looking for a treatment for rosacea, assuming that the doctor is right about the diagnosis, and finds out way down the line that what is on the face is actually another skin disease or condition, the X-Factor goes into another realm, the Rosacea Twilight Zone. it really shows that we need research on this, and that is why this non profit organization was formed in the first place, to do just that.

      The real question is what is the X-Factor for you? The X-Factor is why treatment for rosacea is an individual thing. What works for one rosacean may not work for another. The X-Factor will not go away unless we find a cure for rosacea. The Rosacea X-Factor is with us until we know more.