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  • Rosacea Research & Development Institute

    We are rosaceans and this is a grassroots rosacea non profit organization. The entire board of directors are rosacea sufferers. Compare that with the other non profit rosacea organizations, run by NON rosaceans. Compare that with your favorite rosacea social media platform, i.e., Facebook, Reddit, Twitter, etc. Is your rosacea social media group a registered 501 c 3 non profit? 

    We used to allow guests to post here without registering an account.  Guests can no longer post.  However, to access 95% of our rosacea website data will require a donation of a minimum $2/month of access as a subscriber ($1/month for three or more months). Please donate and register.

    We have an Invision Community platform forum. A private member forum allows the public to view the subforum categories only,  while only members can view the posts and comment (registering an account with your email is required). What is odd is that this format, while older than the social media platforms, i.e., Reddit, Facebook, Instagram, Twitter, etc., requires no more than what the social media platforms require, an email address to register. There is way more rosacea content in the member forum and worth the effort to register.  You want a mobile app?  Mobile apps are in beta version (read below). 

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    You may view the Private Member Forum using the Invision Community Forum. (requires subscription)

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    Private Member Forum

    In a Private Member RRDi forum hosted at Invision Community and ALL posts are for members only. (requires subscriptionYou may access the private member forum url here: 

    https://irosacea.org/forums/

    Guests can comment in the Guest Forum(requires subscription)

    Mobile App?

    There was a beta version mobile app for Android (also there was a beta iOS version available for Apple devices but didn't work out)

    We also have a Tapatalk Private Forum hosted at Tapatalk available (scroll below for more information) but has not proved popular and no one engages with any posts but we have noticed some RRDi members have the Tapatalk app so that is why we tried using Tapatalk to host one of our domains. Private forums are just that, you cannot view the posts unless you join (the public can NOT view the posts).

    Tapatalk Enabled (private forum)

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    Tapatalk App
    You can download from the App Store or Google Playstore.  The Tapatalk app ONLY works for our private rosaceans forum hosted at Tapatalk. 

    Private Tapatalk Rosaceans Group - rosacea-control.com
    The RRDi rosaceans forum is affiliated with Tapatalk and is a PRIVATE Rosaceans [rosaceans are rosacea sufferers]. Tapatalk forum free for users is a private group. If you are not able to subscribe to our private member forum on the current site you are viewing now, and money is your issue, we do still support a Freemium private rosacea forum through Tapatalk but getting members to post is like pulling teeth. If you are not familiar with the difference between a private member forum and a PUBLIC forum, the posts in a private forum are only read if you join. Here is the official announcement about our Rosaceans Tapatalk Private Forum (requires subscriptionwhich explains an option about Tapatalk Gold Points (not required but available for your consideration). You may access the private Tapatalk which is totally run on Tapatalk servers and has no issues using the Tapatalk app. We do have a post in our guest forum which you learn more about the difference between a Freemium platform vs a Subscription platform



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  • Posts

    • "Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice....Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea." [1] "Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene." [2] "Aquaporins (AQPs) are water channels that facilitate transepithelial water transport across plasma membranes following an osmotic gradient [3]. AQPs are glycosylated integral membrane proteins and widely expressed in bacteria (for review [4]), yeast [5], plants [6] (for review [7]), and mammals..." [3] Obviously we need more rosacea research on this subject. Do you want to support such targeted research? Join the RRDi and post in this thread. A Graphical abstract of AQP3 [4] End Notes [1] PubMed RSS Feed - -Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea  [2] Aquaporin-3, Wikipedia [3] Aquaporin-3 in Cancer Saw Marlar, Helene H. Jensen, Frédéric H. Login, and Lene N. Nejsum Int J Mol Sci. 2017 Oct; 18(10): 2106. Published online 2017 Oct 7. doi: 10.3390/ijms18102106 [4] Biochimica et Biophysica Acta (BBA) - Biomembranes Volume 1861, Issue 4, 1 April 2019, Pages 768-775 Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3 Roberto A. Rodriguez, Huiyun Liang, Liao Y. Chen, Germán Plascencia-Villa, George Perry 
    • "In fact, rosacea might be underreported and underdiagnosed in populations with skin of color because of the difficulty of discerning erythema and telangiectasia in dark skin. The susceptibility of persons with highly pigmented skin to dermatologic conditions like rosacea, whose triggers include sun exposure, is probably underestimated. Many people with skin of color who have rosacea might experience delayed diagnosis, leading to inappropriate or inadequate treatment; greater morbidity; and uncontrolled, progressive disease with disfiguring manifestations, including phymatous rosacea." Global epidemiology and clinical spectrum of rosacea, highlighting skin of color: Review and clinical practice experience Andrew F. Alexis MD, MPH, Valerie D. Callender MD, Hilary E. Baldwin MD, Seemal R. Desai MD, Marta I. Rendon MD, Susan C. Taylor MD  Journal of the American Academy of Dermatology Volume 80, Issue 6, June 2019, Pages 1722-1729.e7
    • In  2004, it has been stated that "The economic burden of skin disease on the US healthcare was approximately $96 billion in 2004. [1] "In 2013, more than 85 million Americans were seen by a medical professional for skin diseases. The United States healthcare system alone is estimated to spend approximately 75 billion dollars annually to treat skin diseases. Additionally, the prevalence of skin disease increases to almost 50% in Americans 65 years of age or older). Moreover, it is estimated that the population over the age of 65 will almost double in the United States in the next 30 years, leading to an inevitable increase in annual healthcare costs for skin disease treatment." [2] This expenditure is on all skin conditions. A "Data Bridge Market Research analyses that the rosacea treatment market, which was USD 1.8 billion in 2022, would rocket up to USD 2.6 billion by 2030 and is expected to undergo a CAGR of 6.1% during the forecast period of 2023 to 2030." - Global Rosacea Treatment Market, DBMR  How much is spent on rosacea in the USA?  Rosacea How many of those billions are spent on rosacea? As the above figures shows it is in the millions of dollars.  "In 2013, the costs associated with the treatment and lost productivity among those who sought medical care for rosacea was $243 million." [2] Between 2002 and 2005, for an individual patient, "Of the total healthcare costs, annual rosacea-related expenditures were $276; approximately 70% of rosacea-related expenditures were due to prescription drugs. [3]  In 2013, "The treatment of rosacea incurred primarily pharmacy rather than medical costs. The median annual pharmacy costs, by type of therapy, were: $285 for combination therapy $142 for a topical medication $63 for an oral antibiotic agent." [4] In 2014, the NRS states, "The lack of health insurance or the amount of the required co-pay kept 47 percent of the survey respondents from obtaining medical care for their rosacea at some point.  And 56 percent reported they had paid out-of-pocket for a rosacea-related medication or procedure not covered by their insurance policy.  Of those answering the survey, the amount paid out of pocket was less than $100 for 33 percent, between $100 and $500 for 35 percent, between $500 and $1,000 for 12 percent and greater than $1,000 for 11 percent." [6] End Notes [1] Bickers DR, Lim HW, Margolis D, et al; for the American Academy of Dermatology Association, and the Society for Investigative Dermatology. The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol. 2006;55: 490-500. [2] Aquaporin-3 in the epidermis: more than skin deep Wendy B. Bollag, Lorry Aitkens, Joseph White, and Kelly A. Hyndman Am J Physiol Cell Physiol. 2020 Jun 1; 318(6): C1144–C1153. Published online 2020 Apr 8. doi: 10.1152/ajpcell.00075.2020 [3] SKIN CONDITIONS BY THE NUMBERS, AAD [4] Healthcare utilization and costs of patients with rosacea in an insured population Michael Romanowicz, Judith J Stephenson, James Q Del Rosso, Greg Lenhart Dermatol. 2008 Jan;7(1):41-9. Healthcare utilization and costs of patients with rosacea in an insured population [5] Cost and Drug Utilization Patterns Associated with the Management of Rosacea Caroline Helwick, Medical Writer Am Health Drug Benefits. 2013 Nov-Dec; 6(9): 583–584. [6] New Survey Shows Insurance Covers Medication For Most, NRS
    • Int J Dermatol. 2023 Nov 29. doi: 10.1111/ijd.16950. Online ahead of print. NO ABSTRACT PMID:38031285 | DOI:10.1111/ijd.16950 {url} = URL to article
    • PubMed RSS Feed - -Successful Treatment of Granulomatous Rosacea by JAK Inhibitor Abrocitinib: A Case Report If you are taking vandetanib read this:  PubMed RSS Feed - -Dark perifollicular macules and granulomatous rosacea secondary to vandetanib
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