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Rosacea Research & Development Institute
We are rosaceans and this is a grassroots rosacea non profit organization. The entire board of directors are rosacea sufferers. Compare that with the other non profit rosacea organizations, run by NON rosaceans. Compare that with your favorite rosacea social media platform, i.e., Facebook, Reddit, Twitter, etc. Is your rosacea social media group a registered 501 c 3 non profit?
We used to allow guests to post here without registering an account. Guests can no longer post. However, to access 95% of our rosacea website data and POST will require a donation of a minimum $2/month of access as a subscriber ($1/month for three or more months). Please donate and register to post. To view as a guest is free. Why not show your support and subscribe?
We have an Invision Community platform forum. A private member forum allows the public to view the subforum categories only, while only members can view the posts and comment (registering an account with your email is required). What is odd is that this format, while older than the social media platforms, i.e., Reddit, Facebook, Instagram, Twitter, etc., requires no more than what the social media platforms require, an email address to register. There is way more rosacea content in the member forum and worth the effort to register. You want a mobile app? Mobile apps are in beta version (read below).
You may view the Private Member Forum using the Invision Community Forum. (requires subscription)
Private Member Forum
In a Private Member RRDi forum hosted at Invision Community and ALL posts are for members only. (requires subscription) You may access the private member forum url here:
Guests can comment in the Guest Forum. (requires subscription)
Mobile App?
There was a beta version mobile app for Android (also there was a beta iOS version available for Apple devices but didn't work out)
We also have a Tapatalk Private Forum hosted at Tapatalk available (scroll below for more information) but has not proved popular and no one engages with any posts but we have noticed some RRDi members have the Tapatalk app so that is why we tried using Tapatalk to host one of our domains.
Tapatalk Enabled (private forum)
Tapatalk App
You can download from the App Store or Google Playstore. The Tapatalk app ONLY works for our private rosaceans forum hosted at Tapatalk.Private Tapatalk Rosaceans Group - rosacea-control.com
The RRDi rosaceans forum is affiliated with Tapatalk and is a PRIVATE Rosaceans [rosaceans are rosacea sufferers]. Tapatalk forum free for users is a private group. If you are not able to subscribe to our private member forum on the current site you are viewing now, and money is your issue, we do still support a Freemium private rosacea forum through Tapatalk but getting members to post is like pulling teeth. If you are not familiar with the difference between a private member forum and a PUBLIC forum, the posts in a private forum are only read if you join. Here is the official announcement about our Rosaceans Tapatalk Private Forum (requires subscription) which explains an option about Tapatalk Gold Points (not required but available for your consideration). You may access the private Tapatalk which is totally run on Tapatalk servers and has no issues using the Tapatalk app. We do have a post in our guest forum which you learn more about the difference between a Freemium platform vs a Subscription platform.
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Forum Statistics
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Total Topics6.6k
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Total Posts8.3k
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Posts
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J Dermatol. 2024 Aug 10. doi: 10.1111/1346-8138.17411. Online ahead of print. ABSTRACT Rosacea is a chronic inflammatory disorder primarily affecting the facial skin, prominently involving the cheeks, nose, chin, forehead, and periorbital area. Cutaneous manifestations encompass persistent facial erythema, phymas, papules, pustules, telangiectasia, and flushing. The pathogenesis of rosacea is associated with various exacerbating or triggering factors, including microbial infestation, temperature fluctuations, sunlight exposure, physical exertion, emotional stress, consumption of hot beverages and spicy foods, and exposure to airborne pollen. These environmental factors interact with genetic predispositions in the development of rosacea. The roles of the lipophilic microbiome, ultraviolet radiation, nociceptive responses, and vascular alterations have been proposed as significant factors in the pathogenesis. These insights contribute to understanding the anatomical specificity of facial involvement and the progressive nature of rosacea. East Asian skin, predominantly classified as Fitzpatrick skin phototypes III to IV, is characterized by relatively diminished skin barrier function and increased sensitivity to irritants. Airborne pollen exposure may particularly act as a trigger in East Asian individuals, possibly mediated through toll-like receptors. The lack of specificity in objective clinical and histopathological findings leads to diagnostic challenges for individuals with colored skin, including East Asians, particularly when erythema is the sole objective manifestation. An alternative diagnostic scheme may thus be necessary. A diagnostic approach emphasizing vascular manifestations and nociceptive symptoms potentially holds promise for individuals with darker skin tones. More research focusing on potential variations in skin physiology across different racial groups is essential to establish more effective diagnostic schemes applicable to both dark and light skin colors. PMID:39126257 | DOI:10.1111/1346-8138.17411 {url} = URL to article -
Indian J Dermatol. 2024 May-Jun;69(3):232-237. doi: 10.4103/ijd.ijd_470_23. Epub 2024 Jun 26. ABSTRACT BACKGROUND: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases. AIMS AND OBJECTIVES: The present study aims to evaluate the relationship of these cytokines with rosacea. MATERIALS AND METHODS: A total of 100 individuals, including 50 patients with rosacea and 50 healthy controls, were included in the study. IL-36, IL-37, and IL-38 levels were measured using the ELISA method by taking serum samples from all participants. RESULTS: The mean serum levels of IL-36, IL-37, and IL-38 in the patient group were 52.17 ± 24.07 pg/ml, 18.46 ± 8.18 pg/ml, and 25.74 ± 8.36 ng/l, respectively. The mean serum levels of IL-36, IL-37, and IL-38 in the control group were 32.99 ± 19.90 pg/ml, 44.61 ± 22.27 pg/ml, and 45.61 ± 17.32 ng/l, respectively. The difference between the serum levels of IL-36, IL-37, and IL-38 in the patient and control groups was statistically significant (P < 0.001). CONCLUSION: Based on these findings, an increase in IL-36 and a decrease in IL-37 and IL-38 may contribute to the pathogenesis of rosacea. Future rosacea treatments could target and/or interact with these possible steps in the pathogenesis of rosacea. PMID:39119329 | PMC:PMC11305503 | DOI:10.4103/ijd.ijd_470_23 {url} = URL to article
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Skin Res Technol. 2024 Aug;30(8):e13875. doi: 10.1111/srt.13875. ABSTRACT BACKGROUND: Recent studies increasingly suggest that microbial infections and the immune responses they elicit play significant roles in the pathogenesis of chronic inflammatory skin diseases. This study uses Mendelian randomization (MR) and Bayesian weighted Mendelian randomization (BWMR) to explore the causal relationships between immune antibody responses and four common skin diseases: psoriasis, atopic dermatitis (AD), rosacea, and vitiligo. METHODS: We utilized summary statistics from genome-wide association studies (GWAS) for antibody responses to 13 infectious pathogens and four skin diseases. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs) to assess causal relationships using multiple MR methods, including inverse variance weighted (IVW), MR Egger, and weighted median. BWMR was also employed to confirm findings and address potential pleiotropy. RESULTS: The IVW analysis identified significant associations between specific antibody responses and the skin diseases studied. Key findings include protective associations of anti-Epstein-Barr virus (EBV) IgG seropositivity and Helicobacter pylori UREA antibody levels with psoriasis and AD. anti-chlamydia trachomatis IgG seropositivity, anti-polyomavirus 2 IgG seropositivity, and varicella zoster virus glycoprotein E and I antibody levels were negatively associated with rosacea, while EBV Elevated levels of the early antigen (EA-D) antibody levels and HHV-6 IE1B antibody levels were positively associated with rosacea. H. pylori Catalase antibody levels were protectively associated with vitiligo, whereas anti-herpes simplex virus 2 (HSV-2) IgG seropositivity was positively associated with vitiligo. The BWMR analysis confirmed these associations. CONCLUSION: This study underscores the significant role of H. pylori and other pathogens in these skin diseases, suggesting both protective and exacerbating effects depending on the specific condition. Understanding these pathogen-immune interactions can lead to the development of more effective, personalized treatments and preventative strategies, ultimately improving patient outcomes and quality of life. PMID:39120064 | PMC:PMC11311118 | DOI:10.1111/srt.13875 {url} = URL to article
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J Invest Dermatol. 2024 Aug 7:S0022-202X(24)01982-1. doi: 10.1016/j.jid.2024.07.018. Online ahead of print. ABSTRACT Numerous recent evidence highlights epidemiological connections between rosacea and metabolic disorders. However, the precise path through which metabolic factors impact rosacea risk is still unclear. Therefore, this study aims to investigate the role of adiponectin, a crucial adipokine that regulates metabolic homeostasis, in the pathogenesis of rosacea. We elucidated a detrimental feedback loop between rosacea-like skin inflammation and decreased levels of skin adiponectin. To elaborate, rosacea lesional skin exhibits diminished adiponectin expression compared to non-lesional areas in the same patients. Induction of rosacea-like inflammation reduced adiponectin levels in the skin by generating inflammatory cytokines that suppress adiponectin production from subcutaneous adipocytes. Conversely, complete depletion of adiponectin exacerbated rosacea-like features in the mouse model. Mechanistically, adiponectin deficiency led to heightened S6 phosphorylation, a marker of the mTORC1 signaling pathway, in the epidermis. Adiponectin significantly inhibited S6 phosphorylation in cultured keratinocytes. Notably, replenishing adiponectin whole protein or topically applying an agonist for adiponectin receptor 1 successfully improved rosacea-like features in mice. This study contributes to understanding the role of adiponectin in skin inflammation associated with rosacea pathophysiology, suggesting that restoring adiponectin function in the skin could be a potential therapeutic strategy. PMID:39122145 | DOI:10.1016/j.jid.2024.07.018 {url} = URL to article
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Cutan Ocul Toxicol. 2024 Aug 8:1-5. doi: 10.1080/15569527.2024.2383242. Online ahead of print. ABSTRACT BACKGROUND/ OBJECTIVES: Rosacea is a common chronic inflammatory skin disorder. Endocrinedisrupting chemicals (EDC) are toxic substances, that may gain entry through the skin and subsequently interfere with hormonal and immune functions. Bisphenol A (BPA) and pentachlorophenol sodium (PCS) are two of these EDCs, incriminated in the pathogenesis of certain inflammatory skin disorders. We aimed to test the hypothesis that exposure to BPA and PCS might be involved in the pathogenesis of rosacea. METHODS: This prospective cross-sectional study involved 34 patients with rosacea (18F/16 M; mean age 48.5 ± 11 years) and 34 age and sex-matched healthy controls (20 F/14 M; mean age 48.2 ± 10.2 years). Main anthropometric measures, fasting plasma glucose (FPG), insulin, HOMA-IR, lipids, C-reactive protein (CRP), BPA, and PCS levels were quantified and recorded. RESULTS: Serum CRP (9.6 ± 3.4 vs. 3.7 ± 1.6 mg/L, respectively, p0.05 for all). Serum BPA levels were 55.8 ± 14.4 and 51.9 ± 19.2 ng/mL, and PCS levels were 63.3 ± 45.9 ng/mL and 68.6 ± 40.8 ng/mL for patients and healthy controls, respectively. There was no significant difference in BPA and PCS levels between the two groups (p > 0.05 for both). No significant association was found among HOMAIR, CRP, BPA, and PCS levels (p > 0.05 for all). CONCLUSIONS: Although the present study fails to provide presumptive evidence for the role of BPA and PCS in rosacea, the question as to other EDCs might be involved in its etiopathogenesis remains. This hypothesis requires confirmation in large-scale future prospective trials. PMID:39113570 | DOI:10.1080/15569527.2024.2383242 {url} = URL to article
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