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CHARACTERIZATION OF NOVEL O-GLYCANS ISOLATED FROM TEAR AND SALIVA OF OCULAR ROSACEA PATIENTS. J Proteome Res. 2013 Jan 8; Authors: Ozcan S, An HJ, Vieira AC, Park GW, Kim J, Mannis MJ, Lebrilla CB Abstract O-glycans in saliva and tear isolated from patients suffering from ocular rosacea, a form of inflammatory ocular surface disease, were profiled and their structures were elucidated using high resolution mass spectrometry. We have previously shown that certain structures, particularly sulfated oligosaccharides, increased in the tear and saliva of rosacea patients. In this study, the structures of these glycans were elucidated using primarily tandem mass spectrometry. There were important similarities in the glycan profiles of tears and saliva with the majority of the structures in common. The structures of the most abundant species common to both tear and saliva, which were also the most abundant species in both, were elucidated. For sulfated species, the positions of the sulfate groups were localized. The majority of the structures were new, with the sulfated glycans comprising of mucin core 1 and core 2-type structures. As both saliva and tear are rich in mucins, it is suggested that the O-glycans are mainly components of mucins. The study further illustrates the strong correspondence between the glycans in the tear and saliva of ocular rosacea patients. PMID: 23294139 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23294139?dopt=Abstract = URL to article

Related ArticlesRadiosurgery excision of rhinophyma. Dermatol Surg. 2012 Oct;38(10):1760 Authors: Garito J PMID: 23030374 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/23030374?dopt=Abstract = URL to article

Butterfly rash with periodontitis: A diagnostic dilemma. Contemp Clin Dent. 2012 Jul;3(3):356-8 Authors: Aggarwal M, Mittal M, Dwivedi S, Vashisth P, Jaiswal D Abstract Rashes can occur in any part of the body. But rash which appears on face has got both psychological and cosmetic effect on the patient. Rashes on face can sometimes be very challenging to physicians and dermatologists and those associated with oral manifestations pose a challenge to dentists. Butterfly rash is a red flat facial rash involving the malar region bilaterally and the bridge of the nose. The presence of a butterfly rash is generally a sign of lupus erythematosus (LE), but it can also include a plethora of conditions. The case presented here is of a female with butterfly rash along with typical bright red discoloration of gingiva. The clinical, histopathological and biochemical investigations suggested the presence of rosacea. PMID: 23293500 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23293500?dopt=Abstract = URL to article

Morbihan disease. Dermatol Online J. 2012;18(12):27 Authors: Hu SW, Robinson M, Meehan SA, Cohen DE Abstract Morbihan disease, which consists of solid facial edema, is a rare complication of rosacea, a common cutaneous disorder in middle-aged individuals. The characteristic features of Morbihan disease are its chronic course, typical clinical picture, lack of specific laboratory and histopathologic findings, and refractoriness to therapeutic measures. Since its initial description in 1957, only a small number of cases have been reported in the dermatologic literature. We report a 54-year-old man who developed a two-year duration of erythema and edema that affects the upper and mid face, with accentuation in the periorbital region. Patch tests excluded an allergic contact dermatitis and histopathologic investigation showed small, nodular clusters of epithelioid cells in the dermis that were consistent with sarcoidal granulomata. A diagnosis of Morbihan disease was made owing to the combination of clinical and histopathologic findings. Therapeutic options for the disease remain unsatisfactory and treatments reported in the literature include systemic glucocorticoids, oral tetracyclines, thalidomide, isotretinoin, ketotifen, and clofazimine. Our patient failed a six-to-seven months course of minocycline prior to presentation and has since experienced improvement on gradually-increasing doses of isotretinoin. PMID: 23286817 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23286817?dopt=Abstract = URL to article

Related ArticlesAcne, rosacea, psoriasis. Treat Guidel Med Lett. 2013 Jan;11(125):1-8 Authors: PMID: 23282734 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23282734?dopt=Abstract = URL to article

Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. Exp Dermatol. 2013 Jan;22(1):41-7 Authors: Briganti S, Flori E, Mastrofrancesco A, Kovacs D, Camera E, Ludovici M, Cardinali G, Picardo M Abstract Azelaic acid (AzA) has been used for the treatment for inflammatory skin diseases, such as acne and rosacea. Interestingly, an improvement in skin texture has been observed after long-time treatment with AzA. We previously unrevealed that anti-inflammatory activity of AzA involves a specific activation of PPARγ, a nuclear receptor that plays a relevant role in inflammation and even in ageing processes. As rosacea has been considered as a photo-aggravated disease, we investigated the ability of AzA to counteract stress-induced premature cell senescence (SIPS). We employed a SIPS model based on single exposure of human dermal fibroblasts (HDFs) to UVA and 8-methoxypsoralen (PUVA), previously reported to activate a senescence-like phenotype, including long-term growth arrest, flattened morphology and increased synthesis of matrix metalloproteinases (MMPs) and senescence-associated β-galactosidase (SA-β-gal). We found that PUVA-treated HDFs grown in the presence of AzA maintained their morphology and reduced MMP-1 release and SA-β-galactosidase-positive cells. Moreover, AzA induced a reduction in ROS generation, an up-modulation of antioxidant enzymes and a decrease in cell membrane lipid damages in PUVA-treated HDFs. Further evidences of AzA anti-senescence effect were repression of p53 and p21, increase in type I pro-collagen and abrogation of the enhanced expression of growth factors, such as HGF and SCF. Interestingly, PUVA-SIPS showed a decreased activation of PPARγ and AzA counteracted this effect, suggesting that AzA effect involves PPARγ modulation. All together these data showed that AzA interferes with PUVA-induced senescence-like phenotype and its ability to activate PPAR-γ provides relevant insights into the anti-senescence mechanism. PMID: 23278893 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23278893?dopt=Abstract = URL to article

The surgical treatment of rhinophyma-Complete excision and single-step reconstruction by use of a collagen-elastin matrix and an autologous non-meshed split-thickness skin graft. Int J Surg Case Rep. 2012 Nov 10;4(2):200-203 Authors: Selig HF, Lumenta DB, Kamolz LP Abstract INTRODUCTION: Rhinophyma is the most common clinical manifestation of phytamous rosacea. While conservative methods (e.g. topical or systemic antibiotics, retinoids) are effective for the treatment of acne rosacea, a surgical intervention is appropriate and required in established rhinophyma. A variety of surgical techniques to reduce proliferated tissue have been reported. However, a surgical "gold standard" for treating the distorting phymatous skin alterations has not yet been established. PRESENTATION OF CASE: This case report details a novel surgical approach: the combination of a bovine collagen-elastin with simultaneous autologous non-meshed split-thickness skin grafting. DISCUSSION: Our approach was based on the following considerations: deep excision facilitates complete removal of diseased tissue that ultimately reduces the risk of recurrence in contrast to commonly applied methods relying predominantly on superficial lesion removal with subsequent spontaneous re-epithelialization. The application of a dermal substitute to create a neodermis covered by split-thickness autologous skin grafting may serve as a functionally and aesthetically appropriate model without requiring the recruitment of donor sites for full-thickness skin grafts or even local flaps. CONCLUSION: The combination of deep excision and single-step replacement of epidermal-dermal components may ultimately avoid the recurrence of rhinophyma and contribute to a full skin repair leading to satisfactory functional and aesthetic outcome. PMID: 23276767 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23276767?dopt=Abstract = URL to article

Clinical application of development of nonantibiotic macrolides that correct inflammation-driven immune dysfunction in inflammatory skin diseases. Mediators Inflamm. 2012;2012:563709 Authors: Rodriguez-Cerdeira C, Sanchez-Blanco E, Molares-Vila A Abstract Background. Inflammation-driven immune dysfunction supports the development of several chronic human disorders including skin diseases. Nonantibiotic macrolides have anti-inflammatory and/or immunomodulatory activity that suggests the exploitation of these in the treatment of skin diseases characterized by inflammatory disorders. Materials and Methods. We performed an extensive review of the nonantibiotic macrolide literature published between 2005 and 2012, including cross-references of any retrieved articles. We also included some data from our own experience. Results. Calcineurin antagonists such as tacrolimus and ascomycins (e.g., pimecrolimus) act by inhibiting the activation of the nuclear factor for activated T cells (NFAT). There are new applications for these macrolides that have been available for several years and have been applied to skin and hair disorders such as atopic dermatitis, oral lichen planus, vitiligo, chronic autoimmune urticaria, rosacea, alopecia areata, pyoderma gangrenosum, Behcet's disease, neutrophilic dermatosis, and lupus erythematosus. We also reviewed new macrolides, like rapamycin, everolimus, and temsirolimus. In addition to the literature review, we report a novel class of nonantibiotic 14-member macrocycle with anti-inflammatory and immunomodulatory effects. Conclusions. This paper summarizes the most important clinical studies and case reports dealing with the potential benefits of nonantibiotic macrolides which have opened new avenues in the development of anti-inflammatory strategies in the treatment of cutaneous disorders. PMID: 23258954 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23258954?dopt=Abstract = URL to article

Dry-eye--is inflammation just the tip of the iceberg? Optometry. 2012;83(3):111-3 Authors: Jarka ES, Kahrhoff M, Crane JB Abstract BACKGROUND: Dry eye syndrome (DES) has been described by The International Dry Eye WorkShop as ''multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear instability with potential damage to the ocular surface.'' Inflammation has been recognized as a primary contributor to the disease and was a tremendous step forward in the description and treatment of DES. Although most treatments of DES treat inflammation, the signs and symptoms of DES usually return shortly after discontinuing the use of the anti-inflammatory agent; CASE: We present a case of a 70-year-old patient who presents with significant dry eye symptoms for 2 years. She reports the need to wear sunglasses during all waking hours, both indoors and out, and had discontinued her hobby of gardening. She had ocular rosacea diagnosed at a previous ophthalmology practice and did not respond to any past treatments. The patient was treated with 25% platelet-rich plasma (PRP) and experienced significant improvement and a return to a normal quality of life that has continued for more than a year after discontinuing treatment; CONCLUSION: Our group is investigating the use of biologic therapeutics in the treatment of various forms of DES. We suggest that a clinically acceptable dosage of PRP provides the ocular surface with the components necessary to restore normal cellular tensegrity and provides a foundation to eliminate the recurrence of the inflammation associated with DES. PMID: 23231408 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23231408?dopt=Abstract = URL to article

Rosacea: update on management and emerging therapies. Skin Therapy Lett. 2012 Dec;17(10):1-4 Authors: Fallen RS, Gooderham M Abstract Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in the context of an altered innate immune response, the available topical and systemic therapies function as immunomodulators to restore cutaneous homeostasis. The goals of therapy include reduction of papules, pustules, erythema and physical discomfort with improvement in quality of life. Standard topical treatments include metronidazole and azelaic acid, although many other agents and regimens have been presented. Subantimicrobial/antiinflammatory dose oral doxycycline was US FDA approved in 2006 for the management of rosacea, but Health Canada clearance was only recently granted for this indication. Furthermore, renewed research interest has led to the development of other emerging therapies including topical ivermectin, brimonidine and oxymetazoline that hold promise for patients suffering from this condition. PMID: 23223767 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23223767?dopt=Abstract = URL to article

Central corneal thickness in patients with mild to moderate rosacea. Can J Ophthalmol. 2012 Dec;47(6):504-8 Authors: Onaran Z, Karabulut AA, Usta G, Ornek K Abstract OBJECTIVE: We aimed to evaluate central corneal thickness (CCT) in patients with rosacea in comparison to a healthy control group and to investigate any correlations by using the Schirmer test, tear break-up time (TBUT), and disease severity. DESIGN: Prospective nonrandomized study. PARTICIPANTS: Patients with mild to moderate rosacea (n = 51) and a group of healthy individuals (n = 51) were included. METHOD: Patients were evaluated by a dermatologist; disease severity was determined and total rosacea severity score was calculated for each patient. CCT measurements were performed using ultrasonic pachymetry. Tear function tests, including Schirmer and TBUT, were also performed. RESULTS: The mean CCT value was significantly lower in patients with rosacea than in the control group (544.91 ± 29.41 μm vs 559.40 ± 24.18 μm, p = 0.003). The mean Schirmer test value was significantly lower in patients than in controls (10.54 ± 6.09 mm vs 19.13 ± 4.24 mm, p < 0.0001), and the mean TBUT was shorter in the group with rosacea than in the controls (8.32 ± 3.50 s vs 16.67 ± 5.76 s, p < 0.0001). CCT values were found to be correlated with the Schirmer test values in the rosacea group (r = 0.33, p = 0.01). CONCLUSIONS: Patients with rosacea have thinner corneas, which could be attributed to the observed deteriorated tear function parameters. Candidates for corneal photoablation surgery should be evaluated regarding rosacea disease because the postoperative period could be complicated by decreased ocular wetting and corneal thinning, even in overlooked mild forms. PMID: 23217504 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23217504?dopt=Abstract = URL to article

Related ArticlesImages in clinical medicine: Rhinophyma. N Engl J Med. 2012 Nov 8;367(19):1838 Authors: Macdonald JB, Nguyen XH Abstract A 42-year-old man presented with impaired nasal breathing and a slowly growing mass on the tip of the nose. Examination revealed a multilobulated sebaceous nodule protruding from the nasal tip. PMID: 23134384 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/23134384?dopt=Abstract = URL to article

Related ArticlesGnatophyma: a rare form of rosacea. An Bras Dermatol. 2012 Dec;87(6):903-5 Authors: Macedo AC, Sakai FD, Vasconcelos RC, Duarte AA Abstract Phyma is the last stage of rosacea and is due to chronic inflammation and edema. It can affect nose (rhinophyma), chin (gnatophyma), forehead (metophyma), ears (otophyma) and eyelids (blepharophyma). Rhinophyma is the most frequent location and there are few reports about gnatophyma. We report the case of a female patient, 41 years old, who had an infiltrated, erythematous, edematous plaque around the chin and lower lip for two years. Histopathology showed perivascular lymphocytic infiltrate, hypertrophied follicles and sebaceous glands, dilated vessels and fibrosis. She was treated with oral tetracycline, oral ivermectin and metronidazole cream with a satisfactory response. The clinical, histopathological and therapeutic response correlation confirmed the diagnosis of gnatophyma, a rare variant of phyma. PMID: 23197212 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23197212?dopt=Abstract = URL to article

Related ArticlesQuantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Exp Dermatol. 2012 Dec;21(12):906-10 Authors: Casas C, Paul C, Lahfa M, Livideanu B, Lejeune O, Alvarez-Georges S, Saint-Martory C, Degouy A, Mengeaud V, Ginisty H, Durbise E, Schmitt AM, Redoulès D Abstract The aim of this study is to quantify D. folliculorum colonisation in rosacea subtypes and age-matched controls and to determine the relationship between D. folliculorum load, rosacea subtype and skin innate immune system activation markers. We set up a multicentre, cross-sectional, prospective study in which 98 adults were included: 50 with facial rosacea, including 18 with erythematotelangiectatic rosacea (ETR), and 32 with papulopustular rosacea (PPR) and 48 age- and sex-matched healthy volunteers. Non-invasive facial samples were taken to quantify D. folliculorum infestation by quantitative PCR and evaluate inflammatory and immune markers. Analysis of the skin samples show that D. folliculorum was detected more frequently in rosacea patients than age-matched controls (96% vs 74%, P < 0.01). D. folliculorum density was 5.7 times higher in rosacea patients than in healthy volunteers. Skin sample analysis showed a higher expression of genes encoding pro-inflammatory cytokines (Il-8, Il-1b, TNF-a) and inflammasome-related genes (NALP-3 and CASP-1) in rosacea, especially PPR. Overexpression of LL-37 and VEGF, as well as CD45RO, MPO and CD163, was observed, indicating broad immune system activation in patients with rosacea. In conclusion, D. folliculorum density is highly increased in patients with rosacea, irrespective of rosacea subtype. There appears to be an inverse relationship between D. folliculorum density and inflammation markers in the skin of rosacea patients, with clear differences between rosacea subtypes. PMID: 23171449 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23171449?dopt=Abstract = URL to article

Emotional benefit of cosmetic camouflage in the treatment of facial skin conditions: personal experience and review. Clin Cosmet Investig Dermatol. 2012;5:173-182 Authors: Levy LL, Emer JJ Abstract BACKGROUND: Recent studies highlighting the psychological benefits of medical treatment for dermatological skin conditions have demonstrated a clear role for medical therapy in psychological health. Skin conditions, particularly those that are overtly visible, such as those located on the face, neck, and hands, often have a profound effect on the daily functioning of those affected. The literature documents significant emotional benefits using medical therapy in conditions such as acne, psoriasis, vitiligo, and rosacea, but there is little evidence documenting similar results with the use of cosmetic camouflage. Here we present a review highlighting the practical use of cosmetic camouflage makeup in patients with facial skin conditions and review its implications for psychological health. METHODS: A search of the Medline and Scopus databases was performed to identify articles documenting the emotional benefit of cosmetic camouflage. RESULTS: Cosmetic camouflage provides a significant emotional benefit for patients with facial skin conditions, and this is substantiated by a literature review and personal experience. More clinical studies are needed to assess and validate the findings reported here. CONCLUSION: Patients with visible skin conditions have increased rates of depression, anxiety, and decreased self-esteem. It is prudent for us to consider therapies that can offer rapid and dramatic results, such as cosmetic camouflage. PMID: 23152694 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23152694?dopt=Abstract = URL to article

Isotretinoin for the Treatment of Granulomatous Rosacea: Case Report and Review of the Literature. J Cutan Med Surg. 2012 Dec 1;16(6):438-441 Authors: Rallis E, Korfitis C Abstract Background:Granulomatous rosacea is considered a clinical variant of rosacea and is characterized by hard yellow, brown, red or flesh-colored cutaneous papules or nodules that may be severe and may lead to scarring. The lesions typically appear on the cheeks and periorificial lesions; they are monomorphic in each patient and sit on relatively normal-appearing skin. The diagnosis should be established by excluding other granulomatous disorders and rosacea-like eruptions such as sarcoidosis, tuberculosis, and lupus miliaris disseminatus faciei. The clinical course is chronic and unpredictable, and management can be very difficult.Case Report:We report the case of a 28-year-old female with granulomatous rosacea who responded successfully to oral isotretinoin. No recurrence was noticed 6 months after the completion of treatment. PMID: 23149202 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23149202?dopt=Abstract = URL to article

Elephantoid Eyelid Edema Associated With Continuous Positive Airway Pressure Treatment. Ophthal Plast Reconstr Surg. 2012 Nov 2; Authors: Chiam PJ, Hubbard AD Abstract A man with rosacea developed bilateral eyelid edema from wearing a continuous positive airway pressure nasal mask daily. The edema was refractory to steroid, diuretics, and lymphatic drainage massage. The effect may be related to cumulative venous congestion and lymphostasis due to the continuous positive airway pressure treatment. PMID: 23128530 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23128530?dopt=Abstract = URL to article

Related Articles[Acantholytic rosacea of the forehead and scalp in a patient with Hailey-Hailey disease]. Ann Dermatol Venereol. 2012 Oct;139(10):626-30 Authors: Mohr M, Kanter P, Cribier B, Lipsker D Abstract BACKGROUND: Rosacea is a common dermatosis that can involve the bald area of the scalp. We report the case of a man presenting clinical symptoms of rosacea of the forehead and the scalp, but with a histological picture of familial chronic benign pemphigus. PATIENTS AND METHODS: A 47-year-old man with a history of Hailey-Hailey disease had been presenting facial dermatosis for 5 years. The clinical features were erythema with pustules and scales located on the mid-forehead and the androgenic bald area of the frontal scalp. The histological aspect of the skin biopsy showed suprabasilar clefting and ancantholysis at all levels of the epidermis and sparse perivascular infiltrate. Direct immunofluorescence was negative. These findings were typical of Hailey-Hailey disease. Based on clinical findings, and without taking account of the skin biopsy results, treatment with doxycycline and a topical antifungal was administered for 3 months, leading to remission of symptoms. DISCUSSION: The site of rosacea on the bald area of the scalp in males is described in the literature, and when present, is probably enhanced by exposure to UV radiation. In this patient, the histological features were interpreted as histopathologically equivalent to Köbner phenomenon. PMID: 23122375 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23122375?dopt=Abstract = URL to article

Tranexamic acid solution soaking is an excellent approach for rosacea patients: A preliminary observation in six patients. J Dermatol. 2012 Nov 1; Authors: Kim MS, Chang SE, Haw S, Bak H, Kim YJ, Lee MW PMID: 23116067 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23116067?dopt=Abstract = URL to article

Related Articles[Rosacea fulminans: report of two cases]. Rev Med Chil. 2012 May;140(5):637-9 Authors: Sanz-Motilva V, Martorell Calatayud A, Rivera R, Vanaclocha-Sebastián F Abstract Background: Rosacea fulminans is a rare condition, characterized by a sudden onset of papulopustules, cysts, edema, and draining sinuses usually confined to the facial area. It is often accompanied by low-grade fever, myalgias and leukocytosis. Patients usually have a background of mild rosacea. We report two male patients aged 29 and 54 years, presenting with rosacea fulminans and ocular involvement, triggered by the use of topical steroids. Both responded to systemic treatment with corticosteroids, isotretinoin and metronidazole. Rosacea fulminans should be considered as a variant of rosacea that includes papulopustular, ocular, phymatous and erythematotelangiectatic types. PMID: 23096671 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23096671?dopt=Abstract = URL to article

Related ArticlesAcquired rhinophyma as a paraneoplastic manifestation of non-small cell lung cancer. Wien Klin Wochenschr. 2012 Apr;124(7-8):276-7 Authors: Rakusic N, Baricevic D, Rakusic N, Samarzija M, Jakopovic M, Baricevic M Abstract We report a case of a 58-year-old man who developed rhinophyma caused by non-small cell lung cancer. To the best of our knowledge, rhinophyma as paraneoplastic syndrome associated with non-small cell lung cancer has not been previously reported. PMID: 22527814 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/22527814?dopt=Abstract = URL to article

Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine. J Oral Microbiol. 2012;4 Authors: Gu Y, Walker C, Ryan ME, Payne JB, Golub LM Abstract In 1983, it was first reported that tetracyclines (TCs) can modulate the host response, including (but not limited to) inhibition of pathologic matrix metalloproteinase (MMP) activity, and by mechanisms unrelated to the antibacterial properties of these drugs. Soon thereafter, strategies were developed to generate non-antibacterial formulations (subantimicrobial-dose doxycycline; SDD) and compositions (chemically modified tetracyclines; CMTs) of TCs as host-modulating drugs to treat periodontal and other inflammatory diseases. This review focuses on the history and rationale for the development of: (a) SDD which led to two government-approved medications, one for periodontitis and the other for acne/rosacea and ( CMTs, which led to the identification of the active site of the drugs responsible for MMP inhibition and to studies demonstrating evidence of efficacy of the most potent of these, CMT-3, as an anti-angiogenesis agent in patients with the cancer, Kaposi's sarcoma, and as a potential treatment for a fatal lung disease (acute respiratory distress syndrome; ARDS). In addition, this review discusses a number of clinical studies, some up to 2 years' duration, demonstrating evidence of safety and efficacy of SDD formulations in humans with oral inflammatory diseases (periodontitis, pemphigoid) as well as medical diseases, including rheumatoid arthritis, post-menopausal osteopenia, type II diabetes, cardiovascular diseases, and a rare and fatal lung disease, lymphangioleiomyomatosis. PMID: 23071896 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23071896?dopt=Abstract = URL to article

Skin lesions in histoplasmosis. Clin Dermatol. 2012 Nov;30(6):592-8 Authors: Chang P, Rodas C Abstract Histoplasmosis is a granulomatous infection caused by Histoplasma capsulatum, a dimorphic fungus. It is distributed worldwide and prevalent in certain regions of North and Central America. Pulmonary involvement is the most common clinical presentation. Cutaneous manifestations are reported to occur in 10% to 25% of AIDS patients with disseminated histoplasmosis. The skin lesions are polymorphic papules, plaques with or without crusts, pustules, nodules, mucosal ulcers, erosions, punched out ulcers, lesions resembling molluscum contagiosum, acneiform eruptions, erythematosus papules and keratotic plaques, purpuric lesions, and localized and generalized vegetant forms of dermatitis, sometimes an eruption similar to rosacea, keratotic papules with transepidermal elimination, polymorphous erythema, erythroderma syndromes, pyoderma gangrenosum, panniculitis, diffuse hyperpigmentation, abscesses, and cellulitis. PMID: 23068146 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23068146?dopt=Abstract = URL to article

Meibomitis-related keratoconjunctivitis: implications and clinical significance of meibomian gland inflammation. Cornea. 2012 Nov;31 Suppl 1:S41-4 Authors: Suzuki T Abstract ABSTRACT:: Meibomian gland inflammation, "meibomitis," is associated with ocular surface inflammatory diseases. However, these diseases are poorly defined clinically, making effective treatment difficult. Herein, we propose a new disease subset, termed meibomitis-related keratoconjunctivitis (MRKC). The ocular surface features of MRKC include: meibomitis with redness and swelling of the eyelid margin and palpebral conjunctiva; superficial vascularization and granulomatous nodules in the cornea; and conjunctival hyperemia, similar or identical to that observed in phlyctenular keratitis. The characteristics of MRKC patients include a significantly higher prevalence in women, multiple history of chalazia, close association with meibomitis, the presence of specific human leukocyte antigen association, high Propionibacterium acnes detection rates in meibum culture, and the effectiveness of systemic antimicrobial therapy targeting P. acnes. MRKC may share many clinical features with ocular rosacea, especially during childhood. The clinical effectiveness of systemic antimicrobial agents in treating both diseases suggests the importance of focusing on the elimination of bacteria such as P. acnes. PMID: 23038034 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23038034?dopt=Abstract = URL to article

Interest of corrective makeup in the management of patients in dermatology. Clin Cosmet Investig Dermatol. 2012;5:123-8 Authors: Seité S, Deshayes P, Dréno B, Misery L, Reygagne P, Saiag P, Stengel F, Roguedas-Contios A, Rougier A Abstract BACKGROUND: Disfiguring dermatoses may have a significant impact on patients' quality of life, namely on their relationship with others, self image, and self esteem. Some previous studies have suggested that corrective foundation can improve the quality of life (QOL) of patients with facial dermatoses; in particular, in patients with acne vulgaris or pigmentary disorders. OBJECTIVE: The aim of this prospective study was to evaluate the impact of the skin conditions of patients with various skin diseases affecting their face (scars, acne, rosacea, melasma, vitiligo, hypo or hyperpigmentation, lentigines, etc) on their QOL and the improvement afforded by the use of corrective makeup for 1 month after being instructed on how to use it by a medical cosmetician during an initial medical consultation. METHODS: One hundred and twenty-nine patients with various skin diseases affecting the patients' face were investigated. The patients were instructed by a cosmetician on how to use corrective makeup (complexion, eyes, and lips) and applied it for 1 month. The safety of the makeup application was evaluated and the QOL was assessed via a questionnaire (DLQI) and using a 10-cm visual analog scale (VAS) completed before the first application and at the final visit. The amelioration of their appearance was documented by standardized photography. RESULTS: No side effects occurred during the course of the study. A comparison of the standardized photographs taken at each visit showed the patients' significant improvement in appearance due to the application of corrective makeup. The mean DLQI score dropped significantly from 9.90 ± 0.73 to 3.49 ± 0.40 (P < 0.0001). CONCLUSION: Our results suggest that dermatologists should encourage patients with disfiguring dermatoses to utilize appropriate and safe makeup to improve their appearance and their QOL. Corrective makeup can also complement the treatment of face dermatological diseases in order to improve patient's adherence. PMID: 23055760 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23055760?dopt=Abstract = URL to article