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Rosacea-like Cutaneous Lupus Erythematosus: An Atypical Presentation Responding to Antimalarials. Acta Derm Venereol. 2012 Oct 11; Authors: Marzano AV, Lazzari R, Polloni I, Boneschi V, Crosti C Abstract Abstract is missing (Letter). PMID: 23053047 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23053047?dopt=Abstract = URL to article

Rosacea. Treating facial redness. Mayo Clin Health Lett. 2012 Aug;30(8):6 Authors: PMID: 23045739 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23045739?dopt=Abstract = URL to article

Related ArticlesHighlights of thirty-year experience of CO2 laser use at the Florence (Italy) department of dermatology. ScientificWorldJournal. 2012;2012:546528 Authors: Campolmi P, Bonan P, Cannarozzo G, Bassi A, Bruscino N, Arunachalam M, Troiano M, Lotti T, Moretti S Abstract The CO(2) laser has been used extensively in dermatological surgery over the past 30 years and is now recognised as the gold standard for soft tissue vaporization. Considering that the continuous wave CO(2) laser delivery system and the newer "superpulsed" and scanned CO(2) systems have progressively changed our practice and patient satisfaction, a long range documentation can be useful. Our experience has demonstrated that the use of CO(2) laser involves a reduced healing time, an infrequent need for anaesthesia, reduced thermal damage, less bleeding, less inflammation, the possibility of intra-operative histologic and/or cytologic examination, and easy access to anatomically difficult areas. Immediate side effects have been pain, erythema, edema, typically see with older methods, using higher power. The percentage of after-treatment keloids and hypertrophic scars observed was very low (~1%) especially upon the usage of lower parameters. The recurrence of viral lesions (condylomas and warts) have been not more frequent than those due to other techniques. Tumor recurrence is minor compared with radiotherapy or surgery. This method is a valid alternative to surgery and/or diathermocoagulation for microsurgery of soft tissues. Our results are at times not consistent with those published in the literature, stressing the concept that multicentric studies that harmonization methodology and the patient selection are vital. PMID: 22593693 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/22593693?dopt=Abstract = URL to article

Related ArticlesRole of Helicobacter pylori in common rosacea subtypes: A genotypic comparative study of Egyptian patients. J Dermatol. 2012 Oct 5; Authors: El-Khalawany M, Mahmoud A, Mosbeh AS, Abd Alsalam F, Ghonaim N, Abou-Bakr A Abstract Helicobacter pylori was incriminated as an etiological factor of rosacea. However, there is still controversy about this association. We conducted a comparative study in order to assess the role of H. pylori in rosacea patients who had dyspeptic symptoms. The study included 68 patients and 54 controls. Screening for H. pylori was performed and positive cases were referred for gastric endoscopy. The inflammatory response and bacterial density were evaluated in gastric biopsy. H. pylori vacA alleles, cagA and iceA genotypes were assessed by polymerase chain reaction. We found that 49 rosacea (72%) and 25 controls (46.3%) were infected with H. pylori. Thirty-one rosacea cases were papulopustular (PPR) while 18 were erythematotelangiectatic (ETR). Gastric ulceration was higher in PPR cases (38.7%) than ETR (11.1%) and controls (12%). A significant inflammatory reaction was observed more in PPR cases (74.2%) compared with 44.4% in ETR (P = 0.04) and 44% in controls (P = 0.02). Analysis of H. pylori genotypes revealed that vacA s1m1 was more identified in PPR cases (54.8%) compared with 22.2% in ETR (P = 0.03) and 16% in controls (P = 0.003). There was a significant elevation of cagA/vacA s1m1 positivity in PPR cases. After the eradication regimen of H. pylori, a significant improvement (P < 0.05) was observed in 15 out of 27 PPR cases (55.6%) compared with three out of 17 ETR (17.6%). We concluded that H. pylori has a significant role in rosacea patients who had dyspeptic symptoms. The PPR type is more influenced by H. pylori and this is regarded as being because of certain virulent strains that increase the inflammatory response in gastric mucosa and also in cutaneous lesions. PMID: 23039081 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23039081?dopt=Abstract = URL to article

Related ArticlesIdiopathic Facial Aseptic Granuloma in a Child: A Possible Expression of Childhood Rosacea. Pediatr Dermatol. 2012 Sep 28; Authors: Baroni A, Russo T, Faccenda F, Piccolo V Abstract   Idiopathic facial aseptic granuloma is a chronic, benign, and painless facial nodule occurring exclusively in childhood. Its pathogenesis is unclear, although some interesting hypotheses have been advanced. On the basis of the relationship existing between this disease and recurrent chalazions and conjunctivitis, we hypothesize that it could be considered to be a possible marker of childhood rosacea. PMID: 23016512 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23016512?dopt=Abstract = URL to article

Isotretinoin: dose, duration and relapse. What does 30 years of usage tell us? Australas J Dermatol. 2012 Sep 26; Authors: Rademaker M Abstract With 30 years of clinical use, it is appropriate to review the use of isotretinoin. We now understand that retinoids influence cellular growth, differentiation, morphogenesis and apoptosis, inhibit tumour promotion and malignant cell growth, exert immuno-modulatory actions and alter cellular cohesiveness. This has expanded the indications of isotretinoin from just acne and rosacea to a wide range of inflammatory and malignant skin disorders. While the standard dose of 0.5 to 1 mg/kg per day for 4 months to a cumulative dose of 120-140 mg/kg per day has served us well in the management of acne vulgaris, there is emerging evidence that much lower dosages (as low as 5 mg/day) are just as effective but have significantly fewer adverse effects. Relapse of acne vulgaris continues to be a problem but we are beginning to recognise that this is related less to the cumulative dose and more to the length of sebaceous gland suppression. Other factors important for relapse include a macrocomedonal pattern of acne, smoking and age, both younger (under 14 years) and older (over 25 years). After 30 years of use, we now understand why isotretinoin is such an effective drug. Not only does it clear acne in almost all patients, long-term remission can be achieved in 70-80% of patients with a single course. Important changes in the use of isotretinoin include using a lower daily dose for a longer period of time. New indications continue to emerge, particularly as a potential treatment for both intrinsic and extrinsic (photo) aging. Teratogenicity however, remains a very significant concern. PMID: 23013115 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/23013115?dopt=Abstract = URL to article

No link between rosacea and Propionibacterium acnes. APMIS. 2012 Nov;120(11):922-5 Authors: Jahns AC, Lundskog B, Dahlberg I, Tamayo NC, McDowell A, Patrick S, Alexeyev OA Abstract Rosacea is a common skin disease in adults affecting mainly the facial skin. Although inflammation appears to play a pathogenic role in rosacea, initiating factors are largely unknown. Microbial involvement in the development of rosacea has been suggested previously. We aimed to visualize Propionibacterium acnes in the skin compartments of rosacea patients. Facial skin biopsies from 82 rosacea patients and 25 controls were stained with a P. acnes-specific monoclonal antibody (QUBPa3). Seven of 82 patients (8.5%) tested positive for P. acnes which was present either as a biofilm (57% of positive) or a microcolony (43%) in colonized patients. Our results suggest that P. acnes does not play a major role in the pathogenesis of rosacea. PMID: 23009116 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/23009116?dopt=Abstract = URL to article

Related ArticlesMiliarial-type perifollicular B-cell pseudolymphoma (lymphocytoma cutis): a misleading eruption in two women. J Cutan Pathol. 2012 Aug 29; Authors: Moulonguet I, Ghnassia M, Molina T, Fraitag S Abstract Disseminated miliarial-type lymphocytoma cutis is a rare clinicopathologic subtype of lymphocytoma, characterized by numerous translucent micropapules and located on the head and neck. We describe here the clinical, histological and immunological features of miliarial-type perifollicular B-cell pseudolymphoma in two women aged 32 and 49 years presenting with numerous 1-2 mm translucent papules on the head and neck. Microscopic examination revealed features typical of a miniature lymphocytoma cutis with a superficial nodular infiltrate housing small well-circumscribed germinal centers containing tingible body macrophages and surrounded by a distinct mantle zone. The immunohistological profile was also typical of lymphocytoma cutis, and polymerase chain reaction analysis of the IgH gene rearrangement did not show any clonal B-cell population. The lesions resolved spontaneously in one case and improved after treatment with hydroxychloroquine in the second patient. The presentation of this subtype of lymphocytoma is a formidable clinical diagnostic challenge. Rosacea, sarcoidosis, democidiosis, lupus miliaris disseminatus faciei and steroid acne are easy to exclude on the basis of histological profile. However, the miliarial form of primary cutaneous center lymphoma is difficult to rule out. Dermatologists and dermatopathologists should be aware of this unusual form of lymphocytoma cutis, which can be misleading during clinical diagnosis. PMID: 22998442 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/22998442?dopt=Abstract = URL to article

Rosacea with severe ophthalmic involvement and blindness - a rare occurrence. Int J Dermatol. 2012 Oct;51(10):1271-3 Authors: Subashini K, Pushpa G, Venugopal V, Murali N PMID: 22994677 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/22994677?dopt=Abstract = URL to article

Is it acne or is it rosacea? An important distinction. Cutis. 2012 Aug;90(2):59-61 Authors: Baldwin HE PMID: 22988645 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/22988645?dopt=Abstract = URL to article

Related ArticlesWhole genome comparisons of Fragaria, Prunus and Malus reveal different modes of evolution between Rosaceous subfamilies. BMC Genomics. 2012;13:129 Authors: Jung S, Cestaro A, Troggio M, Main D, Zheng P, Cho I, Folta KM, Sosinski B, Abbott A, Celton JM, Arús P, Shulaev V, Verde I, Morgante M, Rokhsar D, Velasco R, Sargent DJ Abstract BACKGROUND: Rosaceae include numerous economically important and morphologically diverse species. Comparative mapping between the member species in Rosaceae have indicated some level of synteny. Recently the whole genome of three crop species, peach, apple and strawberry, which belong to different genera of the Rosaceae family, have been sequenced, allowing in-depth comparison of these genomes. RESULTS: Our analysis using the whole genome sequences of peach, apple and strawberry identified 1399 orthologous regions between the three genomes, with a mean length of around 100 kb. Each peach chromosome showed major orthology mostly to one strawberry chromosome, but to more than two apple chromosomes, suggesting that the apple genome went through more chromosomal fissions in addition to the whole genome duplication after the divergence of the three genera. However, the distribution of contiguous ancestral regions, identified using the multiple genome rearrangements and ancestors (MGRA) algorithm, suggested that the Fragaria genome went through a greater number of small scale rearrangements compared to the other genomes since they diverged from a common ancestor. Using the contiguous ancestral regions, we reconstructed a hypothetical ancestral genome for the Rosaceae 7 composed of nine chromosomes and propose the evolutionary steps from the ancestral genome to the extant Fragaria, Prunus and Malus genomes. CONCLUSION: Our analysis shows that different modes of evolution may have played major roles in different subfamilies of Rosaceae. The hypothetical ancestral genome of Rosaceae and the evolutionary steps that lead to three different lineages of Rosaceae will facilitate our understanding of plant genome evolution as well as have a practical impact on knowledge transfer among member species of Rosaceae. PMID: 22475018 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/22475018?dopt=Abstract = URL to article

Related ArticlesSclerosing sweat duct carcinoma of the nose with multiple cervical lymph node metastasis. Auris Nasus Larynx. 2012 Aug;39(4):425-7 Authors: Moon MJ, Cho KS, Lee YS, Nam SB Abstract Sclerosing sweat duct carcinoma (SSDC) in the nose, a rare occurrence with no specific symptoms, is frequently confused with rhinophyma or other inflammatory disease. In this report, we describe a 64-year-old woman who presented with a mass on her nasal dorsum for 1 year. Initially, the tumor had been misdiagnosed as a rhinophyma and followed-up for 1 year. She was referred due to a persistent nasal and neck mass. Deep incisional biopsy was performed to produce sufficient tissue and the histopathologic results showed SSDC. We performed wide local excision and reconstruction using radial forearm musculocutaneous free flaps with a costal cartilage framework followed by bilateral neck dissection. SSDC is seldom recognized and is frequently clinically confused with benign syringoma prior to pathologic diagnosis. Wide and deep incisional biopsy is necessary for the correct diagnosis and successful treatment of SSDC. PMID: 21862254 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/21862254?dopt=Abstract = URL to article

[Efficacy of diuretics in the treatment of Morbihan's disease: Three cases]. Ann Dermatol Venereol. 2012 Aug;139(8-9):559-63 Authors: Messikh R, Try C, Bennani B, Humbert P Abstract BACKGROUND: Morbihan's disease (MD), also known as 'persistent facial oedema' or 'rosaceous lymphoedema', is an uncommon facial condition that is difficult to treat. Its cause remains unclear. AIM: We report three new cases of solid persistent facial oedema, which, after treatment with furosemide, showed dramatic improvement. PATIENTS AND METHODS: Three men (respectively aged 38, 66 and 76years) presented Morbihan's disease progressing respectively for 2, 5 and 8years. These patients presented with facial oedema, mainly affecting the eyelids. The diagnosis of MD was based on clinical and laboratory criteria (after exclusion of other aetiologies such as sarcoidosis, lupus erythematosus, facial demodicidosis and rosacea). After several unsuccessful treatments (tetracyclines, synthetic antimalarials, danazol, systemic steroids and isotretinoin), the patients received diuretics: furosemide (60mg/d) in two cases and spironolactone 75mg twice daily for the third patient. The patients were evaluated after 1month, then every 3months. RESULTS: Regression of oedema was complete or almost complete with follow-up of between 1 and 16 years. No adverse effects were reported. DISCUSSION: Treatment of Morbihan's disease remains difficult and empirical. Diuretics may be of value since they help significantly reduce swelling even if they do not definitely cure patients. PMID: 22963967 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/22963967?dopt=Abstract = URL to article

Laser use for cutaneous vascular alterations of cosmetic interest. Dermatol Ther. 2012 Jul;25(4):340-51 Authors: Bencini PL, Tourlaki A, De Giorgi V, Galimberti M Abstract In 1983, selective photothermolysis dramatically transformed vascular surgery, reducing the adverse effects and increasing its efficacy. As a result, laser surgery is now considered the gold standard treatment for many congenital and acquired skin vascular disorders. In this paper, the authors analyze the main laser sources for vascular surgery, the general parameters regarding laser-tissue interactions that can influence the treatment (such as hemodynamic features, anatomical areas, vessel depth, and diameters), and other aspects important for a good laser practice. Afterward, the main indications for laser treatment in vascular cutaneous disorders are discussed, with particular reference to port-wine stain, hemangioma, facial telangiectasia, rosacea, spider angioma, venous lake, varicose leg veins, and leg telangiectasias. PMID: 22950561 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/22950561?dopt=Abstract = URL to article

Related ArticlesClinical efficacy of a serum integrating multiple cosmetic ingredients in the management of erythema of the face in aging skin. J Cosmet Dermatol. 2012 Sep;11(3):207-12 Authors: Dupont E, Léveillé C, Gomez J, Loigeret M, Loing E, Bilodeau D Abstract Background  Skin redness is a common cosmetic concern affecting predominantly fair-skin individuals and often leading to rosacea. On the basis of the current scientific knowledge of the physiological mechanisms underlying the problem, a complex and integral skin care serum (100RXED2025) was developed and tested clinically for efficacy. Method  Forty-five healthy men and women volunteers, age 30-65, were recruited. All subjects had fair skin (phototype I, II, or III) and presented some degree of skin redness with telangiectasia on the cheeks, the nose, or the nose sides, at baseline. In the course of this open label study, subjects applied the test product on their face, twice daily for 56 days. For each subject, skin redness was evaluated through colorimetric and visual analysis of photographs taken under cross-polarized light at T = 28 (week 4) and T = 56 (week 8), then compared to baseline measurements obtained at day 0. Results  Forty-four volunteers completed the study. On visual evaluation, skin redness had decreased in average by 32.2% at T = 28 (P < 0.001) and by 48.0% at T = 56 (P < 0.001). Importantly, 91% of the subjects showed improvement of skin redness at T = 28, reaching 100% at T = 56. Colorimetric analysis gave an average reduction in redness of 11.6% at T = 28 (P < 0.001) and 13.7% at T = 56 (P < 0.001). Conclusion  The anti-redness efficacy of the test product was demonstrated after 28 days with further increase following 56 days of application. PMID: 22938005 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/22938005?dopt=Abstract = URL to article

The potential role of Demodex folliculorum mites and bacteria in the induction of rosacea. J Med Microbiol. 2012 Aug 29; Authors: Jarmuda S, O'Reilly N, Zaba R, Jakubowicz O, Szkaradkiewicz A, Kavanagh K Abstract Rosacea is a common dermatological condition that predominantly affects the central regions of the face. Rosacea affects up to 3% of the world's population and a number of subtypes are recognized. Rosacea can be treated with a variety of antibiotics (e.g. tetracycline or metronidazole) yet no role for bacteria or microbes in its aetiology has been conclusively established. The density of Demodex mites in the skin of rosacea patients is higher than in controls, suggesting a possible role for these mites in the induction of this condition. In addition, Bacillus oleronius, known to be sensitive to the antibiotics used to treat rosacea, has been isolated from a Demodex mite from a patient with papulopustular rosacea and a potential role for this bacterium in the induction of rosacea has been proposed. Staphylococcus epidermidis has been isolated predominantly from the pustules of rosacea patients but not from unaffected skin and may be transported around the face by Demodex mites. These findings raise the possibility that rosacea is fundamentally a bacterial disease resulting from the over proliferation of Demodex mites living in skin damaged as a result of adverse weathering, age or the production of sebum with an altered fatty acid content. This review surveys the literature relating to the role of Demodex mites and their associated bacteria in the induction and persistence of rosacea and highlights possible therapeutic options. PMID: 22933353 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/22933353?dopt=Abstract = URL to article

Related ArticlesModerate rhinophyma successfully treated with a Smoothbeam laser. J Dermatolog Treat. 2012 Apr;23(2):153-5 Authors: Chou CL, Chiang YY PMID: 20964564 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/20964564?dopt=Abstract = URL to article

Related ArticlesRhinophyma and non-melanoma skin cancer: an update. Ann Chir Plast Esthet. 2012 Apr;57(2):183-4 Authors: Lazzeri D, Agostini T, Pantaloni M, Spinelli G PMID: 22385825 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/22385825?dopt=Abstract = URL to article

Rosacea overview: patients require attention to skin care and self-esteem. Adv NPs PAs. 2012 Jul;3(7):31-2 Authors: Bellomo R PMID: 22856116 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/22856116?dopt=Abstract = URL to article

Intraductal Meibomian Gland Probing in the Management of Ocular Rosacea. Ophthal Plast Reconstr Surg. 2012 Jul 25; Authors: Wladis EJ Abstract PURPOSE:: Rosacea is a significant cause of ocular surface disease, and our current therapeutic armamentarium is often ineffective. Intraductal meibomian gland probing is a novel technique to address dry eye syndrome, although its use has not been described in the management of ocular surface disease from rosacea. METHODS:: Patients with ocular rosacea, meibomian gland dysfunction, and surface disease, which was refractory to conventional management, underwent intraductal meibomian gland probing. Each patient completed the Ocular Surface Disease Index (OSDI) questionnaire before the procedure and at the 1- and 6-month postoperative visits. RESULTS:: Forty eyelids of 10 patients (5 men, 5 women; mean age = 42.1 years) underwent intraductal meibomian gland probing. All patients reported subjective improvement in their symptoms of discomfort, tearing, and blurred vision. The mean preoperative, 1-month, and 6-month OSDI scores were 78.11 (standard deviation [sD] = 5.33), 37.54 (SD = 7.25), and 43.00 (SD = 5.49), respectively. The differences between the preoperative and one- and six-month scores were statistically significant (p < 0.05). Nine of the ten patients in this study were able to discontinue their doxycycline use after surgery, and 10 out of 10 patients reported decreased frequency of artificial tear use. No complications were identified in the 6-month follow-up period. CONCLUSIONS:: Intraductal meibomian gland probing is a safe, effective technique to address the ocular surface disease, tearing, and discomfort associated with ocular rosacea, and this intervention results in a dramatic improvement in these symptoms. This study provides the first documentation of these findings and represents the first quantitative demonstration of the use of intraductal meibomian gland probing in the peer-reviewed literature. PMID: 22836802 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/22836802?dopt=Abstract = URL to article

2513 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: rosacea These pubmed results were generated on 2012/07/25 PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=(((rosacea)%20AND%20%221900%2F01%2F01%2000.00%22%5BMHDA%5D%3A%222012%2F07%2F25%2016.19%22%5BMHDA%5D))%20NOT%20((%20(((%22rosacea%22%5BTIAB%5D%20OR%20%22rosacea%22%5BTIAB%5D)))%20AND%20%220001%22%5BEDAT%5D%3A%221900%2F01%2F01%2000.00%22%5BEDAT%5D)) = URL to article

Related ArticlesGlycomic analysis of tear and saliva in ocular rosacea patients: the search for a biomarker. Ocul Surf. 2012 Jul;10(3):184-92 Authors: Vieira AC, An HJ, Ozcan S, Kim JH, Lebrilla CB, Mannis MJ Abstract The purpose of this study was to study changes in glycosylation in tear and saliva obtained from control and ocular rosacea patients in order to identify potential biomarkers for rosacea. Tear fluid was collected from 51 subjects (28 healthy controls and 23 patients with ocular rosacea). Saliva was collected from 42 of the same subjects (25 controls and 17 patients). Pooled and individual samples were examined to determine overall glycan profiles and individual variations in glycosylation. O-and N- glycans were released from both patients and control subjects. Released glycans were purified and enriched by solid-phase extraction (SPE) with graphitized carbon. Glycans were eluted based on glycan size and polarity. SPE fractions were then analyzed by high-resolution mass spectrometry. Glycan compositions were assigned by accurate masses. Their structures were further elucidated by tandem mass spectrometric using collision-induced dissociation (CID), and specific linkage information was obtained by exoglycosidase digestion. N- and O-glycans were released from 20-μL samples without protein identification, separation, and purification. Approximately 50 N-glycans and 70 O-glycans were globally profiled by mass spectrometry. Most N-glycans were highly fucosylated, while O-glycans were sulfated. Normal tear fluid and saliva contain highly fucosylated glycans. The numbers of sulfated glycans were dramatically increased in tear and saliva of rosacea patients compared to controls. Glycans found in tear and saliva from roseatic patients present highly quantitative similarity. The abundance of highly fucosylated N-glycans in the control samples and sulfated O-glycans in ocular rosacea patient samples may lead to the discovery of an objective diagnostic marker for the disease. PMID: 22814645 [PubMed - in process] http://www.ncbi.nlm.nih.gov/PubMed/22814645?dopt=Abstract = URL to article

Related ArticlesRadiosurgical excision of rhinophyma. Dermatol Surg. 2012 May;38(5):816-7 Authors: Niamtu J PMID: 22563654 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/PubMed/22563654?dopt=Abstract = URL to article

Lack of "appropriately assessed" Patient-Reported Outcomes in randomised controlled trials assessing the effectiveness of interventions for rosacea. Br J Dermatol. 2012 Jul 14; Authors: van Zuuren EJ, Fedorowicz Z Abstract Rosacea is a chronic skin disease and psychological problems are fairly common in people affected by rosacea. The persistent red pimply rash on the face can be a source of embarrassment, anxiety and low self-esteem, may instil a lack of confidence and may even lead to depression or body dysmorphic disorder. Rosacea can also have a significant negative impact on health-related quality of life (HRQoL).We have documented the patient-reported outcomes (PRO) used in clinical trials identified in the Cochrane Review on the effectiveness of interventions for rosacea published in the Cochrane Library March 2011 and reported their measurement properties.(1) Here we discuss the results. PMID: 22803770 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/22803770?dopt=Abstract = URL to article

Intralymphatic granulomas in lymphoedema secondary to anogenital granulomatosis. Australas J Dermatol. 2012 Jul 11; Authors: Saracino A, Gordon K, Ffolkes L, Mortimer PS Abstract The granulomatous inflammation seen in filariasis, orofacial granulomatosis (OFG), rosacea and sarcoidosis can be associated with lymphoedema. In the setting of OFG, the finding of intralymphatic granulomas has been reported as a possible mechanism for lymphoedema. Anogenital granulomatosis (AGG) is a similar chronic inflammatory condition of unknown pathogenesis. It presents as granulomatous genital or anoperineal inflammation and associated lymphoedema, with histological findings of non-caseating granulomas and a perivascular infiltrate. We report a case of AGG and lymphoedema with intralymphatic granulomas seen on biopsy. This finding is unique and we propose that the intralymphatic granulomatous inflammation causes a partial or complete occlusion of lymphatic drainage, thus resulting in the clinical situation of lymphoedema. PMID: 22780576 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/PubMed/22780576?dopt=Abstract = URL to article