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About some red faces. Ann Dermatol Venereol. 2011 Nov;138 Suppl 3:S201-6 Authors: Doutre MS, Beylot-Barry M Abstract The term "red face" is reserved for lesions located exclusively or very predominantly on the face. Diagnosis is based on different data: date and mode of appearance, characteristics of the erythema, functional signs, and associated systemic manifestations. A case of red face can have an infectious origin, caused by vascular, congenital, or acquired lesions, or be caused by photodermatosis, or be the main location of inflammatory dermatosis or collagenosis, but depending on the clinical context, many other diagnoses can be suggested. A few observations are presented so as to discuss the management of red face in the atopic patient, the role played by ultraviolet rays in the cutaneous lesions of dermatomyositis, as well as the diagnostic criteria of polymorphous light eruption, and lupus erythematosus. PMID: 22183099 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22183099&dopt=Abstract = URL to article

Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line (hTCEpi). Invest Ophthalmol Vis Sci. 2012 Apr 24; Authors: O'Reilly N, Gallagher C, Katikireddy K, Clynes M, O'Sullivan F, Kavanagh K Abstract Purpose: The aim of the work presented here was to establish the response of a corneal epithelial cell line (hTCEpi) to protein extracted from a bacterium (Bacillus oleronius) previously isolated from a Demodex mite from a rosacea patient.Methods: The response of the corneal epithelial cell line to Bacillus proteins was measured in terms of alterations in cell migration and invasiveness. Changes in the expression of metalloproteinase genes and proteins were also assessed. Results: The results indicated increased cell migration (14.5 fold, p = 0.001) as measured using 8 µm PET inserts (BD Falcon) in a transwell assay and invasiveness (1.7 fold, p = 0.003) as measured using 8 µm Matrigel (BD Biocoat) invasion inserts in a 24 well plate assay format, following exposure to the Bacillus proteins. Cells exposed to the Bacillus protein showed a dose dependent increased in expression of genes coding for matrix metalloprotease-3 (MMP-3) (61 fold) and matrix metalloprotease-9 (MPP-9) (301 fold). This dose dependent increase in gene expression was also reflected in elevated levels of MMP-9 protein (1.34 fold, p = 0.033) and increased matrix metalloprotease activity (1.96 fold, p = 0.043) being present in the culture supernatent. Cells also displayed reduced levels of β-integrin (1.25 fold, p = 0.01), indicative of increased motility, and elevated levels of vinculin (2.7 fold, p = 0.0009), suggesting altered motility. Conclusion: The results indicate that exposure of corneal epithelial cells to Bacillus proteins results in an aberrant wound healing response as visualized using a scratch wound assay. PMID: 22531699 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22531699&dopt=Abstract = URL to article

[A woman with periocular swelling]. Ned Tijdschr Geneeskd. 2012;156(17):A2845 Authors: van Rappard DC, van der Linden MM, Faber WR Abstract We present a 37-year-old woman with an 8-year history of rosacea, who developed persistent swelling of the right lower eyelid, diagnosed as Morbihan's disease. Morbihan's disease is considered a rare complication of rosacea. PMID: 22531036 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22531036&dopt=Abstract = URL to article

An alternative micrographic method for decreasing bleeding and recurrence in the treatment of rhinophyma. Eur Rev Med Pharmacol Sci. 2012 Mar;16(3):418-21 Authors: Firat C, Erbatur S, Elmas O, Aytekin AH Abstract Rhinophyma is a subtype of rosacea which develops at the advanced stage of rosacea and is characterized by an excessive enlargement of the sebaceous glands. Its etiology is not well-defined beyond the following usual suspects: vitamin deficiencies, stress, hormonal factors and the Demodex folliculorum mite. Carcinoma may develop in rhinophyma patients. The first surgical process for rhinophyma was applied by Daniel Sennert in 1629. The ideal surgical method for treatment of rhinophyma is still unclear and controversial. Massive bleeding makes a controlled excision of the mass impossible, which contributes to the recurrence of rhinophyma. In this case, we combined trichloroacetic acid (TCA 45%) with dermabrasion, a treatment which hasn't been reported previously. Our method was suggested by the Mohs micrographic surgery technique, which employs serial excisions. PMID: 22530361 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22530361&dopt=Abstract = URL to article

Cutaneous B-Cell Neoplasms Mimicking Granulomatous Rosacea or Rhinophyma. Arch Dermatol. 2012 Apr 16; Authors: Barzilai A, Feuerman H, Quaglino P, David M, Feinmesser M, Halpern M, Feldberg E, Tomasini C, Tabibian-Keissar H, Amarilgio N, Hodak E Abstract BACKGROUND: Unlike T-cell neoplasms, B-cell lymphoproliferative disorders have a limited clinical spectrum of skin involvement. Cutaneous B-cell neoplasms mimicking rosacea or rhinophyma are rare. OBSERVATIONS: We described 12 patients with B-cell lymphoproliferative neoplasms presenting with a facial eruption clinically mimicking rosacea or rhinophyma. Eleven patients were women; ages ranged from 36 to 81 years. The clinical presentation included small papules on the nose and cheeks and around the eyes mimicking granulomatous rosacea; nodules on the nose, cheeks, chin, or forehead mimicking phymatous rosacea; or a combination of both. Three patients had preexisting erythematotelangiectatic rosacea and 1 had rhinophyma. Based on a clinicopathologic correlation and B-cell clonality analysis, the diagnosis was primary cutaneous follicular center B-cell lymphoma in 4 cases, primary cutaneous marginal zone lymphoma in 6, and skin involvement of chronic lymphocytic leukemia in 2. All patients had an indolent course as expected for their disease. CONCLUSIONS: Cutaneous involvement of B-cell neoplasms may mimic granulomatous rosacea or rhinophyma. This unusual clinical presentation is more common in women and appears in the setting of preexisting rosacea or as a new eruption. Proliferative B-cell disorders should be added to the differential diagnosis of symmetric papular or papulonodular eruptions of the face. PMID: 22508769 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22508769&dopt=Abstract = URL to article

Ruzicka T, Wolff H, Thomas P, Prinz J, editors: Fortschritte der praktischen Dermatologie und Venerologie 2010. Acta Dermatovenerol Croat. 2012 Apr;20(1):59-60 Authors: PaÅ¡ić A Abstract The edition Fortschritte der praktischen Dermatologie und Venerologie 2010, in English Advances in Practical Dermatology and Venereology 2010, emphasizes all aspects of Dermatology and Venereology, as traditionally presented every year at the Congress providing continuing education for German dermatologists and venereologists, during the jubilee week on July 25-30, 2010. The book has been written in German by 146 dermatologists as well as Dia-Klinik authors from Ludwig-Maximillian-University and Department of Dermatology and Allergology in Munich. As stated in the Preface, this tradition of continuing education for German speaking dermatologists has been well known for 60 years now, starting with Professor Alfred Marchionini, Professor Otto Braun-Falco, Professor Gerd Plewig and now Professor Thomas Ruzicka. There was special atmosphere at the Congress, as reported by all the participants. Plenary and oral presentations, courses, lunch seminars, satellite seminars, special courses like Ultrasound and Laser Courses and breakfast seminars were all highly attractive and interesting. The book has 646 pages, while chapters are illustrated with excellent color photographs, tables in blue and color schemes, including the following: 1. Newest knowledge and view in the future Acne and rosacea; Psoriasis, autoinflammation syndrome, new dermatotherapeutic options; The evolution of human skin color; Over pigmentation and segmental manifestation and steam cells - friend or enemy? 2. Pediatric dermatology Congenital nevi - when anything to do; Neutrophilic dermatoses in childhood; Bullous lesions in childhood - differential diagnosis and therapy. 3. Dermatooncology Dermatooncology - current knowledge; Melanoma - view in the future; Innovation in the therapy of metastatic melanoma; Sentinel lymph nodes - Munich experience and follow-up dates. 4. Dermatological problem zones Dermatological problem zones on the skin of the head; Genito-anal region; Soul. 5. Eczema and Allergology Hematogenetic contact eczema (systemic contact dermatitis): what is this?; Atopic eczema - view in the future; New development in the management of atopic eczema; Allergology: tolerance or no tolerance - this is the central question; Primary allergology prevention; Anaphylaxis - new aspects in pathophysiology and management. 6. Aesthetic Dermatology Newest knowledge in aesthetic dermatology; Beautiful skin through hormones and cosmeceuticals? Good-looking hair - possibility of hair transplantation; Complications in aesthetic medicine. 7. Update and new technical advance Update - autoimmune dermatoses; Update - photodermatology; Update - laser; New labor diagnostic methods; New picturesque methods. 8. Undesired question on the skin Insects and Borrelias; Staphylococci. 9. Cases, mistakes and practical decisions Wolf in the sheep fur…or reversely; Bad running - from mistakes to learn; Pigment disturbance - actual to vitiligo and melasma; Nail diseases; Urticaria. 10. Courses Acne and rosacea; Andrology; Occupational dermatoses; Botolinum toxin I: base support; Botulinum toxin II: advanced stages; Filler. 11. Recipes and dermatological galenic - practical tips and Examples Pediatric dermatology; Update in wound management in Germany; Mycology; Nail diseases; Food allergy; New diagnostic and therapeutic methods; Phlebology; Photodermatology; Photodynamic therapy and fluorescence diagnostics; Cardiologic and lung resuscitation; Nail problems with cicatrix - actual therapeutic possibilities; Proctology; Psychodermatology - update 2010; Sexually transmitted diseases; Sonography of the skin and subcutis including Subcutaneous lymph nodes; Specific immunotherapy; Structure and function of the skin; Trichoscopy and trichogram. 12. Dia-Clinic Churg-Strauss syndrome; Adiponecrosis subcutanea neonatorum; Infection with cowpox; Angiofibromata gigantea by Morbus Bourneville-Pringle; Skin changes in type IIa - hypercholesteronemia; Spiky hyperkeratosis associated with malignant melanoma; Erythema a computatro; Loefgren syndrome; Erythrodysesthesia within chemotherapy; Cutaneous actinomycose; Unilateral Morbus Favre-Racouchot; Progressive nodular histiocytosis; Granular parakeratosis; Contact eczema on carrot-brandy corn wheat; Whirpool dermatitis with 'hot hands'; Subcorneal bleeding by anticoagulation; 'Yellow dots' in alopecia areata diffusa; Bullous pemphigoid induced by zoster; Granulomatous syphilis lesions masked with prurigo-like scabies; Aurantiasis cutis; Becker-Naevus on leg with lipoatrophy; Birt-Hogg-Dubé syndrome; Linear IgA dermatosis of childhood; Monozygotic twins with papillomatosis confluence and reticularis Gougerot-Carteaud; Pemphigus vulgaris juvenilis with skin and mucosal involvement; Histoplasmosis; Diffuse dermal angiomatosis; Poppers dermatitis. This book is highly valuable for German speaking dermatologists and venereologists because it connects scientific update knowledge in dermatology and venereology with practical knowledge from the Munich dermatology school. In 2011, it achieved the same success with European attendees and the English version of the book. PMID: 22507481 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22507481&dopt=Abstract = URL to article

[Progress on whole genome sequencing in woody plants]. Yi Chuan. 2012 Feb;34(2):145-56 Authors: Shi JS, Wang ZJ, Chen JH Abstract In recent years, the number of sequencing data of plant whole genome have been increasing rapidly and the whole genome sequencing has been also performed widely in woody plants. However, there are a set of obstacles in investigating the whole genome sequencing in woody plants, which include larger genome, complex genome structure, limitations of assembly, annotation, functional analysis, and restriction of the funds for scientific research. Therefore, to promote the efficiency of the whole genome sequencing in woody plants, the development and defect of this field should be analyzed. The three-generation sequencing technologies (i.e., Sanger sequencing, synthesis sequencing, and single molecule sequencing) were compared in our studies. The progress mainly focused on the whole genome sequencing in four woody plants (Populus, Grapevine, Papaya, and Apple), and the application of sequencing results also was analyzed. The future of whole genome sequencing research in woody plants, consisting of material selection, establishment of genetic map and physical map, selection of sequencing technology, bioinformatic analysis, and application of sequencing results, was discussed. PMID: 22382056 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22382056&dopt=Abstract = URL to article

Giant rhinophyma of the nose. J Oral Maxillofac Surg. 2012 Feb;70(2):376-7 Authors: Mangal M, Agarwal A, Jain H, Gupta A PMID: 21798644 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21798644&dopt=Abstract = URL to article

Letter: Crowdsourcing for research data collection in rosacea. Dermatol Online J. 2012;18(3):15 Authors: Armstrong AW, Harskamp CT, Cheeney S, Schupp CW Abstract Several medical crowdsourcing sites are available to patients online, but few studies in the literature have compared crowdsourced data to clinical trials. Herein, we compare data from rosacea patients from a major medical crowdsourcing site with those from randomized controlled trials. PMID: 22483526 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22483526&dopt=Abstract = URL to article

Dermatologic manifestations in inflammatory bowel disease in Tunisia. Tunis Med. 2012 Mar;90(3):253-8 Authors: Mebazaa A, Aounallah A, Naija N, Cheikh Rouhou R, Kallel L, El Euch D, Boubaker J, Mokni M, Filali A, Ben Osman A Abstract Background: Cutaneous manifestations are the most common extra intestinal manifestations associated with inflammatory bowel disease (IBD). Aim: To assess the epidemio-clinical profile of skin manifestations in IBD. Methods: A prospective and descriptive study was conducted. We have examined skin, mucosa, hair and nails, of all patients with an IBD during one year. Results: One hundred-ninety-five patients were included. Crohn's disease (CD) was noted in 154 cases (79.8%), ulcerous rectocolitis (UC) in 39 cases (21.2%) and inclassable IBD in 2 cases. Cutaneous manifestations were found in 91% of Crohn's patients and in 92% of UC patients. Granulomatous perianal skin lesions were the main cutaneous manifestations of CD (53%). The most common affected sites were ano-perineal fistulae, perianal and perineal fissures and oedematous and infiltrated perianal and genital plaques. Reactive lesions (Erythema nodosum, Pyoderma gangrenosum, Aphthous stomatitis) were noted in 14 cases. Skin manifestations due to malabsorption were also frequently observed (101 cases: 51.7%).Other dermatoses implicating various mechanisms such as psoriasis, alopecia areata, vitiligo, rosacea, lichen planus, were also noted. Adverse skin manifestations due to treatment (folliculitis, acne, macula-papular rash and DRESS syndrome) were present in 16 cases. Conclusion: Our series is characterized by a high frequency of cutaneous manifestations associated to IBD. A better recognition of these skin manifestations by the physician may improve their management. PMID: 22481199 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22481199&dopt=Abstract = URL to article

Advances in understanding and managing rosacea: part 2: the central role, evaluation, and medical management of diffuse and persistent facial erythema of rosacea. J Clin Aesthet Dermatol. 2012 Mar;5(3):26-36 Authors: Del Rosso JQ Abstract In this article, the second part of a two-part series on rosacea, emphasis will be placed on persistent facial erythema. Despite variations in the intensity of visible redness, persistent facial erythema is a very common and consistent finding among patients with rosacea, including those with presentations classically defined as papulopustular rosacea, erythematotelangiectatic rosacea, and in many patients with phymatous rosacea. The underlying mechanisms of rosacea and their correlation with specific clinical features have been discussed in Part 1 and are referred to here where applicable. An overview of cutaneous vasculature, role of alpha-adrenoreceptors, and a discussion of available medical therapies and treatment selection are also presented, including emerging topical options for diffuse and persistent facial erythema of rosacea. PMID: 22468177 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22468177&dopt=Abstract = URL to article

Advances in understanding and managing rosacea: part 1: connecting the dots between pathophysiological mechanisms and common clinical features of rosacea with emphasis on vascular changes and facial erythema. J Clin Aesthet Dermatol. 2012 Mar;5(3):16-25 Authors: Del Rosso JQ Abstract Rosacea is a common inflammatory facial dermatoses affecting primarily adults with fair skin, although all skin types may be affected. The diagnostic term "rosacea" reflects a spectrum of clinical features with the more common presentations characterized by increased blood flow and vasodilation during disease flares, which accentuate central facial erythema. Inflammatory lesions, usually papules and/or pustules are present in some cases. Variations in magnitude of the associated features of rosacea are noted clinically. Over time, other clinical features emerge or may be further accentuated, such as diffuse facial erythema and telangiectasias, as fixed changes in cutaneous vasculature occur. These later findings account for persistent diffuse facial erythema usually accentuated centrally on the inner cheeks, chin, nose, and/or medial forehead. Some patients may also develop phymatous changes and/or have concurrent ocular rosacea. Augmented innate immune response to certain triggers (often exogenous) and neurovascular/neuroimmune dysregulation appear to be involved early in the pathophysiological sequence of cutaneous rosacea and appear to signal other downstream inflammatory or physiochemical cascades that contribute to the pathogenesis of the disorder. In this article, Part 1 of a two-part series, emphasis is placed upon the correlation of clinical features and underlying pathophysiological changes in the more common presentations of rosacea encountered by the clinician. The importance of this information is that some of these pathogenic mechanisms are modulated by available therapies, and others remain as targets for the development of new therapeutic agents or modalities. PMID: 22468176 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22468176&dopt=Abstract = URL to article

Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea. Int J Dermatol. 2012 Apr;51(4):459-62 Authors: Bamford JT, Gessert CE, Haller IV, Kruger K, Johnson BP Abstract A 2006 article published in the International Journal of Dermatology reported that oral zinc sulfate 100 mg three times daily was associated with improvement in the severity of facial rosacea (Sharquie et al. 2006; 45: 857-861). The current study was undertaken to further assess the role of zinc in the management of rosacea. This was a randomized, double-blind trial of 220 mg of zinc sulfate twice daily for 90 days in patients with moderately severe facial rosacea at baseline. Subjects were recruited in the Upper Midwest USA between August 2006 and April 2008, and followed until July 2008. Forty-four subjects completed the trial (22 in each arm). Rosacea improved in both groups. There were no differences in magnitude of improvement based on rosacea severity scores between subjects receiving zinc sulfate and subjects receiving placebo (P = 0.284). Serum zinc levels were higher in subjects receiving zinc (P < 0.001). Oral zinc sulfate was not associated with greater improvement in rosacea severity compared with placebo in this study. Additional studies are needed to determine what role oral zinc may have in the management of rosacea. PMID: 22435439 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22435439&dopt=Abstract = URL to article

Dermatophyte infections mimicking other skin diseases: a 154-person case survey of tinea atypica in the district of Cagliari (Italy). Int J Dermatol. 2012 Apr;51(4):410-5 Authors: Atzori L, Pau M, Aste N, Aste N Abstract Background  Although usually simple, the diagnosis of dermatophyte infection is sometimes neglected. An observational study has been realized to evaluate the role of corticosteroid exposure (tinea incognito) and of other primary characteristics of the dermatophytosis that from onset mimic other diseases and mislead an unexperienced physician. Materials and methods  Between 1990 and 2009, all cases of atypical dermatophytosis mimicking other skin diseases were collected from the more general number of dermatophyte infections diagnosed at the Dermatology Department of Cagliari University, Italy. Results  One-hundred and fifty-four cases (71 male/83 female, 2-81 years old) were studied, with a median of 7 cases/year. The most observed clinical forms were those mimicking impetigo, eczematous dermatitis, lupus erythematosus, polymorphous light eruption, psoriasis, and rosacea. The identified dermatophytes were: Microsporum canis (70 cases), Trichophyton rubrum (43 cases), Trichophyton mentagrophytes var. mentagrophytes (29 cases), Trichophyton mentagrophytes var. interdigitale (six cases), Microsporum gypseum (three cases), Epidermophyton floccosum (two cases), and Trichophyton verrucosum (one case). Diagnostic difficulties are discussed, with special attention to the origin of the pathomorphosis. Conclusions  In our experience, clinical atypia is not a mere consequence of corticosteroid therapy but present at the very onset of the illness, due to the variable dermatophyte invasive capacity, the site of invasion, physiological individual, and/or acquired condition, such as excessive washing or sun exposure. Therefore, we suggest using the term "tinea atypica" rather than "tinea incognito" to include all forms of dermatophytosis that do not present the classic features for both primary and secondary pathomorphosis. PMID: 22435428 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22435428&dopt=Abstract = URL to article

Prevalence of asymptomatic and symptomatic meibomian gland dysfunction in the general population of Spain. Invest Ophthalmol Vis Sci. 2012 Mar 16; Authors: Viso E, Rodríguez-Ares MT, Abelenda D, Oubiña B, Gude F Abstract Purpose: To describe epidemiological characteristics of asymptomatic and symptomatic meibomian gland dysfunction (MGD) in a general adult population in north-western Spain.Methods: A total of 1155 subjects ≥40 years were selected by an age-stratified random sample procedure in O Salnés (Spain). A standardized symptoms questionnaire was administered and a comprehensive ophthalmic evaluation which included ocular surface tests was carried out. Absent, viscous or waxy white secretion upon digital expression, lid margin telangiectasia or plugging of the meibomian gland orifices was considered evidence of MGD. The prevalence and associations of asymptomatic and symptomatic MGD, and their effects on the ocular surface, were investigated.Results: From 937 eligible subjects, 619 (66.1%) participated (mean age (SD): 63.4 (14.5) years, range: 40-96, 37.0% males). The prevalence of asymptomatic MGD was 21.9% (95%CI 18.8-25.3). This prevalence increased with aging (P=0.000) and was higher in men than in women (P=0.003). The prevalence of symptomatic MGD was 8.6% (95%CI 6.7-10.9). This prevalence also increased with aging (P=0.000) but was not associated with sex. Abnormal tear breakup time and fluorescein staining prevalence estimates were higher among asymptomatic subjects. After controlling for age and sex, asymptomatic MGD was associated with diabetes (ORa2.23) and cardiovascular disease (ORa1.80), and symptomatic MGD with rosacea (ORa3.50) and rheumatoid arthritis (ORa16.50). Conclusions: Asymptomatic MGD is more common than symptomatic MGD. Symptomatology is not associated with secondary damage to the ocular surface. Some systemic diseases may lower whereas others may raise the risk of developing symptoms. Symptom-based approaches do not seem appropriate for MGD estimation. PMID: 22427596 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22427596&dopt=Abstract = URL to article

Chronic Lymphocytic Leukemia Associated Leukemia Cutis Presenting as Acne Rosacea. Leuk Lymphoma. 2012 Mar 16; Authors: Ng E, Patel V, Engler D, Grossman M PMID: 22423601 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22423601&dopt=Abstract = URL to article

Antimicrobial peptides: agents of border protection for companion animals. Vet Dermatol. 2012 Mar 12; Authors: Leonard BC, Affolter VK, Bevins CL Abstract Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis. In addition to direct antimicrobial activity, these peptides participate in many cellular functions, including chemotaxis, wound healing and even determination of canine coat colour. Various biological and genetic approaches have helped to elucidate the role of antimicrobial peptides with respect to innate immunity and host defense. Associations of antimicrobial peptides with various skin diseases, including psoriasis, rosacea and atopic dermatitis, have been documented in humans. In the longer term, therapeutic modulation of antimicrobial peptide expression may provide effective new treatments for disease. This review highlights current knowledge about antimicrobial peptides of the skin and circulating leukocytes, with particular focus on relevance to physiology and disease in companion animals. PMID: 22409270 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22409270&dopt=Abstract = URL to article

[The impact of rosacea on patients' daily life: A transverse observational study among private dermatologists]. Ann Dermatol Venereol. 2012 Mar;139(3):222-4 Authors: Beaulieu P, Varlet JL, Savary J PMID: 22401690 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22401690&dopt=Abstract = URL to article

A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. J Drugs Dermatol. 2012 Mar 1;11(3):333-9 Authors: Chang AL, Alora-Palli M, Lima XT, Chang TC, Cheng C, Chung CM, Amir O, Kimball AB Abstract Background: Papulopustular acne rosacea is a chronic inflammatory condition which can be difficult to treat. Many patients are unwilling to use systemic medications, and single topical agents alone may not address all the symptoms of rosacea. A combination topical clindamycin phosphate 1.2% and tretinoin 0.025% gel is efficacious for acne vulgaris, and may be helpful for rosacea, since acne vulgaris and rosacea shares many similar clinical and histologic features. Objective: To assess the preliminary efficacy and safety of a combination gel consisting of clindamycin phosphate 1.2% and tretinoin 0.025% on papulopustular rosacea after 12 weeks of usage. Methods: Randomized, double-blind, placebo controlled two site study of 79 participants with moderate to severe papulopustular acne rosacea using both physician and subjects' validated assessment tools. Primary endpoint consisted of statistically significant reduction in absolute papule or pustule count after 12 weeks of usage. Results: There was no significant difference in papule/pustule count between placebo and treated groups after 12 weeks (P=0.10). However, there was nearly significant improvement in physicians' assessments of the telangiectasia component of rosacea (P=0.06) and erythematotelangiectatic rosacea subtype (P=0.05) in treated versus placebo group after 12 weeks. The only significant adverse event different was facial scaling, which was significantly increased in treated group (P=0.01), but this did not result in discontinuation of study drug. Conclusions: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025% may improve the telangiectatic component of rosacea and appears to better treat the erythemotelangiectatic subtype of rosacea rather than papulopustular subtype. Our preliminary study suggests that future studies with much larger sample size might confirm our findings. Clinical Trials: NCT00823901. J Drugs Dermatol. 2012;11(3):333-339. PMID: 22395584 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22395584&dopt=Abstract = URL to article

Lupus miliaris disseminatus faciei with extrafacial involvement in a 17-year-old white girl. J Cutan Med Surg. 2011 Nov-Dec;15(6):340-3 Authors: Mullan E, Green P, Pasternak S Abstract BACKGROUND: Lupus miliaris disseminatus faciei (LMDF) is a benign condition characterized by a papular eruption located in the central face. Histologic studies of the papules show granulomatous infiltrates with central necrosis. The condition is self-limited and usually resolves within 1 to 2 years yet can be cosmetically debilitating, given the location and potential for scarring. Granulomatous periorificial dermatitis similarly affects the face with granulomatous lesions and may overlap clinically with LMDF. CONCLUSION:This report highlights the challenge in differentiating and treating uncommon granulomatous facial dermatoses. PMID: 22202509 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22202509&dopt=Abstract = URL to article

The South-East Scotland Dermatology Workload Study: 30 years analysis. Br J Dermatol. 2012 Feb 28; Authors: Holme SA, Scott-Lang VE, Ooi ET, Matthews AG, Darling MI, Needham D, McCormack SK Abstract Background:  Dermatological activity data has been collected for the same region of south-east Scotland (population of 1.24 million), approximately every five years, since 1981. This has allowed assessment of trends in demand from primary and secondary care, and activity within secondary care dermatology services, assisting planning of dermatological services. Objectives:  To quantify dermatology outpatient workload across the same population to allow comparison with previous studies for trends in practice. Methods:  During November 2010, a standardised proforma was completed for all National Health Service and private practice dermatology outpatient consultations. Demographic data, source and reason for referral, diagnoses, investigations, treatments and disposal were recorded, and comparisons made with five previous studies. Results:  5470 consultations were recorded: 2882 new and 2588 review patients (new:review ratio 1:0.9, male:female 1:1.3, mean age 49 years, range 1 month - 101 years). Ninety one per cent of referrals came from primary care and 9% from secondary care. Fifty eight per cent of referrals were for diagnosis and 32% for hospital management. Diagnostic concordance between referrer and dermatologist ranged from 97% for acne to 14% for melanoma. Benign tumours accounted for 30% of referrals, malignant tumours 13%, dermatitis 13.3%, psoriasis 6.2%, and acne/rosacea 5%. The referral rate rose to 23.2 / 1000 population per annum, with the increase coming mainly from primary care. Conclusions:  Demand for dermatology continues to increase: new referrals have risen by 134% in 30 years, with a 36% increase in the last 5 years, despite corresponding population increases of 5.3% and 3% respectively. PMID: 22372993 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22372993&dopt=Abstract = URL to article

Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea. J Cosmet Dermatol. 2012 Mar;11(1):37-41 Authors: Berardesca E, Iorizzo M, Abril E, Guglielmini G, Caserini M, Palmieri R, Piérard GE Abstract Background  Rosacea is a chronic inflammatory skin disease affecting mostly facial skin. Its origin is multifactorial. Important steps in its treatment are avoidance of any triggering factor and control of skin inflammation. Aim  To assess the benefit of topical applications of a new product (P-3075). Patients/Methods  A randomized, multicenter, double-blind, placebo-controlled, parallel-group, pilot study was carried out to evaluate the efficacy and tolerability of a cream (P-3075) based on 5% potassium azeloyl diglycinate (PAD, Azeloglicina(®) ) and 1% hydroxypropyl chitosan (HPCH). Forty-two patients (rosacea stages I and II) were enrolled and randomized, 28 in the P-3075 group and 14 in the placebo group. They were asked to apply the cream twice daily for 4 weeks. The main assessments were the objective quantification of erythema and skin hydration using the Mexameter(®) and Corneometer(®) devices, respectively. Clinical signs and symptoms were evaluated on a four-point scale. Results  The P-3075 cream applied for 28 days was effective in skin protection by reducing erythema, evaluated both instrumentally and clinically. In addition, the clinical assessments of other symptoms such as flushing, stinging, and burning supported the beneficial effect of the P-3075 cream. Conclusions  The anti-inflammatory and moisturizing effects of potassium azeloyl diglycinate combined with the protective properties of HPCH allow the new product to be a good candidate for controlling signs and symptoms of rosacea. PMID: 22360333 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22360333&dopt=Abstract = URL to article

Neurogenic rosacea treated with endoscopic thoracic sympathectomy. Arch Dermatol. 2012 Feb;148(2):270-1 Authors: Schram AM, James WD PMID: 22351842 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22351842&dopt=Abstract = URL to article

Should Idiopathic Facial Aseptic Granuloma Be Considered Granulomatous Rosacea? Report of Three Pediatric Cases. Pediatr Dermatol. 2012 Feb 16; Authors: Neri I, Raone B, Dondi A, Misciali C, Patrizi A Abstract   Idiopathic facial aseptic granuloma (IFAG), or pyodermite froide du visage, is a skin disease reported only in children and characterized by painless red nodules usually located on the cheeks. Its etiology is still unclear, but some authors considered the possibility that IFAG might be included in the spectrum of granulomatous rosacea (GR). The histopathological features of IFAG and GR are quite similar, showing perifolliculitis, granulomas, folliculitis, and lymphocytes and plasmacells around epithelioid histiocytes. In the present article, we discuss three cases in which an association between a facial nodule, compatible with both IFAG and GR, and recurrent chalazia make us support the hypothesis that IFAG should be considered as GR. PMID: 22340024 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22340024&dopt=Abstract = URL to article

Doxycycline Indirectly Inhibits Proteolytic Activation of Tryptic Kallikrein-Related Peptidases and Activation of Cathelicidin. J Invest Dermatol. 2012 Feb 16; Authors: Kanada KN, Nakatsuji T, Gallo RL Abstract The increased abundance and activity of cathelicidin and kallikrein 5 (KLK5), a predominant trypsin-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesis of rosacea, a disorder treated by the use of low-dose doxycycline. Here we hypothesized that doxycycline can inhibit activation of tryptic KLKs through an indirect mechanism by inhibition of matrix metalloproteinases (MMPs) in keratinocytes. The capacity of doxycycline to directly inhibit enzyme activity was measured in surface collections of human facial skin and extracts of cultured keratinocytes by fluorescence polarization assay against fluorogenic substrates specific for MMPs or TLSPs. Doxycycline did inhibit MMP activity but did not directly inhibit serine protease activity against a fluorogenic substrate specific for TLSPs. However, when doxycycline or other MMP inhibitors were added to live keratinocytes during the production of tryptic KLKs, this treatment indirectly resulted in decreased TLSP activity. Furthermore, doxycycline under these conditions inhibited the generation of the cathelicidin peptide LL-37 from its precursor protein hCAP18, a process dependent on KLK activity. These results demonstrate that doxycycline can prevent cathelicidin activation, and suggest a previously unknown mechanism of action for doxycycline through inhibiting generation of active cathelicidin peptides.Journal of Investigative Dermatology advance online publication, 16 February 2012; doi:10.1038/jid.2012.14. PMID: 22336948 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22336948&dopt=Abstract = URL to article