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Treatment options for rosacea with concomitant conditions. Nurse Pract. 2011 Jan 11; Authors: Roebuck H Patients with rosacea frequently present with coexisting skin conditions, such as seborrheic dermatitis, acne, perioral dermatitis, and melasma, which may complicate diagnosis and treatment. This article discusses the presentation, pathophysiology, and management of rosacea with common concomitant skin disorders. PMID: 21228729 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21228729&dopt=Abstract = URL to article

Topical corticosteroid-induced rosacea-like dermatitis: A clinical study of 110 cases. Indian J Dermatol Venereol Leprol. 2011 Jan-Feb;77(1):42-6 Authors: Rathi SK, Kumrah L Background: Prolonged and continuous use of topical steroids leads to rosacea-like dermatitis with variable clinical presentations. Aims: To study the various clinical presentations of patients with topical corticosteroid-induced rosacea-like dermatitis (TCIRD), who had a history of prolonged and repeated use of topical steroids for reasons other than the known disease entities. Methods: A total of 110 patients were enrolled for the study over a period of 2 years, excluding all those with the known disease entity in which topical steroids were commonly used. Detailed history which also included the source and the type of topical steroid use was taken along with clinical examination. Results: There were 12 males and 98 females with their age ranging from 18 to 54 years. The duration of topical steroid use ranged from 4 months to 20 years. The most common clinical presentation was diffuse erythema of the face. Most of the patients had rebound phenomenon on discontinuation of the steroid. The most common topical steroid used was Betamethasone valerate, which could be due to its easy availability and low cost. Conclusion: Varied clinical presentations are seen with prolonged and continuous use of topical steroids. The treatment of this dermatitis is difficult, requiring complete cessation of the offending steroid, usually done in a tapering fashion. PMID: 21220878 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21220878&dopt=Abstract = URL to article

Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. Dermatol Surg. 2010 Dec;36(12):2075-8 Authors: Rubenzik M, Keller M, Humphreys T PMID: 21044227 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21044227&dopt=Abstract = URL to article

Management of rhinophyma with coblation. Dermatol Surg. 2010 Dec;36(12):2057-60 Authors: Roje Z, Racic G PMID: 21044222 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21044222&dopt=Abstract = URL to article

Restoration of Facial Form and Function After Severe Disfigurement from Burn Injury by a Composite Facial Allograft. Am J Transplant. 2011 Jan 7; Authors: Pomahac B, Pribaz J, Eriksson E, Annino D, Caterson S, Sampson C, Chun Y, Orgill D, Nowinski D, Tullius SG Composite facial allotransplantation is emerging as a treatment option for severe facial disfigurements. The technical feasibility of facial transplantation has been demonstrated, and the initial clinical outcomes have been encouraging. We report an excellent functional and anatomical restoration 1 year after face transplantation. A 59-year-old male with severe disfigurement from electrical burn injury was treated with a facial allograft composed of bone and soft tissues to restore midfacial form and function. An initial potent antirejection treatment was tapered to minimal dose of immunosuppression. There were no surgical complications. The patient demonstrated facial redness during the initial postoperative months. One acute rejection episode was reversed with a brief methylprednisolone bolus treatment. Pathological analysis and the donor's medical history suggested that rosacea transferred from the donor caused the erythema, successfully treated with topical metronidazol. Significant restoration of nasal breathing, speech, feeding, sensation and animation was achieved. The patient was highly satisfied with the esthetic result, and regained much of his capacity for normal social life. Composite facial allotransplantation, along with minimal and well-tolerated immunosuppression, was successfully utilized to restore facial form and function in a patient with severe disfigurement of the midface. PMID: 21214855 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21214855&dopt=Abstract = URL to article

Intensely Hypermetabolic Lipomatous Hypertrophy of the Interatrial Septum on 18-FDG PET With MRI and CT Correlation. Clin Nucl Med. 2010 Dec;35(12):972-3 Authors: Klein MA, Scalcione LR, Youn T, Shah RA, Katz DS, Sung WW, Yung EY We present a 69-year-old female patient with a history of emphysema, rosacea, and breast cancer. The patient was in remission for 4 years until a 15-pound weight loss prompted further evaluation with a computed tomography of the chest, abdomen, and pelvis, cardiac magnetic resonance imaging, as well as an 18-FDG-PET scan to evaluate for metastatic disease and potential cardiac abnormalities. There was an intensely hypermetabolic bilobed focus within the region of the interatrial septum, correlating with the patient's lipomatous hypertrophy of the interatrial septum (LHIS), which was identified on computed tomography and magnetic resonance imaging. LHIS is a relatively uncommon cardiac finding characterized by excessive deposition of adipocytes with varying quantities of brown fat. Brown fat in LHIS may be hypermetabolic on 18-FDG-PET examinations, and familiarity with the prevalence and features of LHIS will avoid misdiagnosis of metastatic disease. PMID: 21206236 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21206236&dopt=Abstract = URL to article

Otorhinophyma, pruritus and alopecia totalis syndrome; response to testosterone. Arch Dermatol Syph. 1947 Sep;56(3):379-93 Authors: AYRES S, JENSEN AK PMID: 20262878 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20262878&dopt=Abstract = URL to article

[Tobacco and skin]. Ann Dermatol Venereol. 2010 Aug-Sep;137(8-9):568-72; quiz 567 Authors: Biver-Dalle C, Humbert P PMID: 20804906 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20804906&dopt=Abstract = URL to article

Efficacy of 1% terbinafine cream in comparison with 0.75% metronidazole gel for the treatment of papulopustular rosacea. Cutan Ocul Toxicol. 2010 Dec 20; Authors: Serdar ZA, Yaşar S Background: Topical antifungals comprising imidazole derivatives have been used for the treatment of rosacea previously, owing to their anti-inflammatory activities. Terbinafine, an antifungal agent belongs to allylamine group, has also anti-inflammatory effects. Currently, there are only a few unpublished studies, in which terbinafine has been used systemically for rosacea treatment. Aims: In this single-blind, 8-week study, we investigated the potential efficacy and safety of terbinafine 1% cream for the treatment of mild and moderate papulopustular rosacea, and compared the results with those of 0.75% metronidazole gel. Patients/methods: Forty patients, 30 females and 10 males, with papulopustular rosacea were enrolled into the study between 2006 and 2007 years. Twenty of the patients were instructed to apply 1% terbinafine cream, whereas others patients of the study population were instructed to use 0.75% metronidazole gel. A total of 32 patients completed the study. Pre-treatment and post-treatment total severity score (TSS) of the disease were determined by assessing the severity of erythema/telangiectasia, and the number of papules/pustules of the whole face. The overall response rates, differences of pre-/post-treatment scores of each criterium and the percentages of the decrease in TSS of the study groups were compared statistically. Results: There was no statistically significant difference between the groups in terms of age, sex, and disease duration (P  =  0.937, 1.000, and 0.055, respectively). No significant difference was found between the mean post-treatment TSSs of the two groups (P  =  0.605). The percentage of clearance assessed by the differences between pre-treatment and post-treatment TSSs was 55% in terbinafine group, although the percentage was 45% in metronidazole group, with no statistically significant difference between the groups (P  =  0.496). Local side effects including erythema, pruritus, and burning were mild and transient in both groups, with similar frequencies (P  =  0.101). Conclusion: This preliminary study suggests that 1% terbinafine cream is an effective and safe treatment for papulopustular rosacea, and can be an option for patients who cannot tolerate other modalities. PMID: 21166608 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21166608&dopt=Abstract = URL to article

The role of Helicobacter pylori infection in skin diseases: facts and controversies. Clin Dermatol. 2010 Sep-Oct;28(5):478-82 Authors: Tüzün Y, Keskin S, Kote E Helicobacter pylori is a Gram-negative bacterium that is considered a causative agent of peptic ulcer disease, gastric lymphoma, and gastric carcinoma. H pylori triggers an intense leucocyte infiltration of the gastric submucosa, an action that is mediated by proinflammatory cytokines. Because this pathogenetic mechanism is common to many other diseases, H pylori seroprevalence has also been investigated in other diseases. H pylori seropositivity is associated with various dermatologic disorders. Although the precise role of H pylori is unknown in these diseases, the organism can be eradicated, using simple and reliable drug regimens. This contribution highlights the dermatologic diseases associated with H pylori seropositivity. PMID: 20797505 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20797505&dopt=Abstract = URL to article

Rosacea and rhinophyma in the elderly. Clin Dermatol. 2011 Jan-Feb;29(1):61-8 Authors: Wollina U Rosacea is a chronic inflammatory disease with a predominance of facial manifestations. The prevalence is increasing with age, peaking in the group aged older than 65 years. In 1997, one in eight Americans was aged 65 years and older. By 2030, more than 70 million individuals will be in this age group. This contribution reviews the current understanding of pathogenesis, aggravating factors, classification, comorbidities, and treatment options. Rosacea is a manageable disease that negatively affects quality of life. Rosacea increases the risk of depression and shows a significant proportion of extracutaneous manifestations, in particular ocular rosacea. PMID: 21146734 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21146734&dopt=Abstract = URL to article

Enhancing effect of pretreatment with topical niacin in the treatment of rosacea-associated erythema by 585-nm pulsed dye laser in Koreans: A randomized, prospective, split-face trial. Br J Dermatol. 2010 Dec 9; Authors: Kim TG, Roh HJ, Cho SB, Lee JH, Lee SJ, Oh SH Background  Rosacea is a chronic dermatosis that is usually confined to the face. A pulsed dye laser (PDL) system has been proven to be effective in treating rosacea-associated erythema and telangiectasias. Niacin is a cutaneous vasodilator that can increase the chromophore through increased blood flow. Objectives  We hypothesized that increased blood flow by pretreatment with topical niacin could enhance the effect of PDL in the treatment of rosacea. Methods  Eighteen Korean patients with rosacea were recruited. Three sessions of 585-nm PDL using a subpurpuragenic dose with and without pretreatment with niacin cream were performed on randomly-assigned half-faces at 3-week intervals. An objective erythema scale measurement was assessed by a polarization color imaging system, and evaluations by three blinded dermatologists were also taken. Patient satisfaction was evaluated using a 10-point visual analogue scale. Results  Fifteen total patients completed this study. All patients showed an improvement in erythema scale measurements after three sessions of PDL treatment both with and without niacin pretreatment (p=0.023 and 0.009, respectively). According to the amount of change in erythema scale measures, there was no significant difference in the improvement of objective erythema between the two sides. However, based on physician assessment, the overall clinical improvement on the niacin side was significantly higher (p=0.005) and patient satisfaction was also higher on the niacin-pretreated side (p=0.007). There were no remarkable side effects, with the exception of transient erythema and edema. Conclusions  Pretreatment with topical niacin safely enhanced the effect of 585-nm PDL treatment of rosacea-associated erythema in Koreans. Application of niacin can be helpful in overcoming the relatively lower effect of subpurpuragenic PDL in dark-skinned Asians. PMID: 21143465 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21143465&dopt=Abstract = URL to article

[Not available]. Actas Dermosifiliogr. 1946 Apr;37:951-63 Authors: CAMPOS MARTIN R, OLLER COROMINAS F, RUBIO ROIG J PMID: 20989569 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20989569&dopt=Abstract = URL to article

Rhinophyma operated with diathermic wire-loop. Acta Derm Venereol. 1945;26(1):102 Authors: DANBOLT N PMID: 21065387 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21065387&dopt=Abstract = URL to article

Related Articles[Ocular intolerance to antiglaucoma medications is underestimated]. Bull Soc Belge Ophtalmol. 2010;(315):47-53 Authors: Bresson-Dumont H Since about 20 years, the large panel of the antiglaucoma eyedrops has drastically changed the management of glaucoma. Indications for filtering surgery had decreased in frequency. A great number of patients are controlled only by medications. However ocular intolerance and side effects have been reported until in 50% of the cases with 10% of severe manifestations of intolerance. Ocular side effects to topical medications may very often alter compliance. Ocular intolerance had been shown to be secondary to immunological mechanisms and direct or indirect toxicity. The immunological or allergic mechanisms are induced by a type I or IV hypersensibility and only represent 3% to 10% of all the side effects induced by topical medications. Toxic effect can be a direct through different mechanisms: pure toxic effect, acid pH, osmolarity of the solution, photosensibilisation. This will induce inflammatory reaction that will produce fibrosis in the long term. This toxic effect can be worsened by eye dryness or rosacea. Toxicity can also be indirect through an alteration of the conjunctival microbial flora and/or the lacrymal secretion. Concomitant obstruction of the lacrymal ducts may also contribute to this effect. These mechanisms could have been elucidated thank to histological studies from conjunctival mark, and more recently with confocal HRT, which gives an analysis of the ocular surface in vivo. Appropriate and early detection of intolerance to antiglaucoma medications is mandatory to adjust management strategies accordingly. These are based on the suppression or the reduction of conservative agents whenever possible, the use of fixed combinations, the reduction of the number of the instillations and the associated treatment of the ocular surface. PMID: 21114054 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21114054&dopt=Abstract = URL to article

Related ArticlesTLR2 Expression Is Increased in Rosacea and Stimulates Enhanced Serine Protease Production by Keratinocytes. J Invest Dermatol. 2010 Nov 25; Authors: Yamasaki K, Kanada K, Macleod DT, Borkowski AW, Morizane S, Nakatsuji T, Cogen AL, Gallo RL A diverse environment challenges skin to maintain temperature, hydration, and electrolyte balance while also maintaining normal immunological function. Rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli. We hypothesized that abnormal function of innate immune pattern recognition could explain the enhanced sensitivity of patients with rosacea, and observed that the epidermis of patients with rosacea expressed higher amounts of Toll-like receptor 2 (TLR2) than normal patients. Increased expression of TLR2 was not seen in other inflammatory skin disorders such as atopic dermatitis or psoriasis. Overexpression of TLR2 on keratinocytes, treatment with TLR2 ligands, and analysis of TLR2-deficient mice resulted in a calcium-dependent release of kallikrein 5 from keratinocytes, a critical protease involved in the pathogenesis of rosacea. These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea.Journal of Investigative Dermatology advance online publication, 25 November 2010; doi:10.1038/jid.2010.351. PMID: 21107351 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21107351&dopt=Abstract = URL to article

Related ArticlesCase report: Chalazion and its features visualized by ultrahigh resolution optical coherence tomography. Cont Lens Anterior Eye. 2010 Nov 18; Authors: Sorbara L, Maram J, Bizheva K, Hutchings N, Simpson TL PURPOSE: The purpose of this case report is to highlight the clinical characteristics of a recurrent chalazion through the use of digital photography and ultra-high resolution optical coherence tomography (UHROCT). CASE REPORT: A single case is presented, along with digital biomicroscopic photographs and UHROCT images. DISCUSSION: A review of the literature describing the histopathological and associations of chalazia and other disorders, suggest it may be possible to differentiate different eyelid conditions based on their clinical manifestations and appearance on UHROCT tomograms. Based on the images presented here, it appears that this case is typical of a post-menopausal incidence of chalazion and risk for acne rosacea. PMID: 21094077 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21094077&dopt=Abstract = URL to article

Related ArticlesTreatment of rhinophyma with radiofrequency: a case report. B-ENT. 2010;6(3):209-13 Authors: Arikan OK, Muluk NB, Cirpar O PROBLEM: Rhinophyma is characterized by a slow progressive enlargement of the nasal skin that cannot resolve spontaneously. Clinically, the lower two-thirds of the nose becomes enlarged and hypervascular, developing a reddish-purple discoloration and a nodular appearance. It is believed that rhinophyma represents the end stage of acne rosacea. The treatment modalities are medical and surgical. CASE: This study describes a 62-year-old man with rhinophyma that was treated with a radiofrequency technique. The pathological examination was compatible with acne rosacea. After surgery, a broad-spectrum sunscreen was applied until reepithelialization was complete. CONCLUSION: We recommend the radiofrequency technique for treatment of rhinophyma. PMID: 21090165 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21090165&dopt=Abstract = URL to article

Related ArticlesChanges in rosacea comorbidities and treatment utilization over time. J Drugs Dermatol. 2010 Nov;9(11):1402-6 Authors: Yentzer BA, Fleischer AB BACKGROUND: Rosacea is a chronic skin condition that requires lifelong treatment. Given the rise in antibiotic-resistant bacteria, many physicians are re-evaluating their use of antibiotics for long-term treatment of rosacea. PURPOSE: To examine trends in the treatment of rosacea and the comorbidities associated with this skin condition. METHODS: From 2002-2006, the National Ambulatory Medical Care Survey queried drug mentions at rosacea visits and coexisting diagnoses. Prescribing patterns of dermatologists were compared to other physicians' patterns. RESULTS: Ten million physician visits had the diagnosis of rosacea; 74 percent were associated with co-morbidities. Metronidazole, tetracyclines, azelaic acid and sodium sulfacetamide were the top medications mentioned at rosacea visits. Prescriptions increased for azelaic acid and decreased for sodium sulfacetamide. Dermatologists decreased their prescribing of systemic medications. CONCLUSION: Dermatologists are reducing their use of systemic antibiotics for rosacea and turning to therapies, such as azelaic acid, that do not have potential to induce bacterial resistance. PMID: 21061763 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21061763&dopt=Abstract = URL to article

Related ArticlesThe potential role of microorganisms in the development of rosacea. J Dtsch Dermatol Ges. 2010 Nov 8; Authors: Lazaridou E, Giannopoulou C, Fotiadou C, Vakirlis E, Trigoni A, Ioannides D Rosacea is a chronic cutaneous disorder characterized by centrofacial persisting erythema, telangiectases, papules, pustules, edema, phymas and ocular involvement. Despite being one of the most common skin disorders, its pathogenesis remains unclear and controversial. Although the disease triggering factors are well recognized, the underlying causes of rosacea have not yet been identified. Several different postulates about its pathogenesis can be found in the medical literature. Abnormalities of the pilosebaceous unit, as well as genetic, vascular, inflammatory, environmental and microbial factors have been described. The microorganisms that have been associated include Helicobacter pylori, Demodex folliculorum, Staphylococcus epidermidis, and Chlamydia pneumonia; all the studies have been inconclusive. We review currently available scientific data on the potential pathogenetic role of microorganisms in the development of rosacea. PMID: 21059171 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21059171&dopt=Abstract = URL to article

Related ArticlesTHERAPEUTIC HOTLINE: Successful treatment of Morbihan's disease with oral prednisolone and doxycycline. Dermatol Ther. 2010 Nov;23(6):682-5 Authors: Ranu H, Lee J, Hee TH Persistent facial swelling can occur as a rare complication of rosacea. This finding is referred to as lymphedematous rosacea or Morbihan's disease. We report a case of a 45-year-old male with no previous history of rosacea who developed bilateral periorbital swelling associated with facial erythema and edema that responded to a combination of oral corticosteroids and doxycycline. Biopsy revealed changes of granulomatous rosacea. PMID: 21054712 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=21054712&dopt=Abstract = URL to article

Related Articles[Rosacea.] Postepy Hig Med Dosw (Online). 2010;64:439-450 Authors: Robak E, Kulczycka L TrÄ…dzik różowaty (rosacea) jest przewlekÅ‚Ä… zapalnÄ… chorobÄ… skóry twarzy spotykanÄ… najczęściej wÅ›ród mieszkaÅ„ców PóÅ‚nocnej i Zachodniej Europy, a także w Ameryce PóÅ‚nocnej. Rzadziej w innych grupach etnicznych. Rozpoczyna siÄ™ zwykle w wieku 20-30 lat skÅ‚onnoÅ›ciÄ… do czÄ™stego powstawania rumienia na skórze wypukÅ‚ych części twarzy, z wyraźnÄ… progresjÄ… w nastÄ™pnej dekadzie życia i peÅ‚nym rozwojem w wieku 40-50 lat. Patogeneza choroby nie jest jednorodna i do koÅ„ca wyjaÅ›niona, zależy od wielu czynników. Patomechanizm rozwoju trÄ…dziku różowatego jest zÅ‚ożony i ksztaÅ‚towany przez naturalnÄ… odporność immunologicznÄ…, zaburzenia naczyniowe, udziaÅ‚ reaktywnych form tlenu oraz enzymów proteolitycznych, promieniowanie UV, a także czynniki infekcyjne. ModulujÄ…cy wpÅ‚yw warunków Å›rodowiskowych na wrodzonÄ… odporność immunologicznÄ… może odpowiadać za rozwój różnych objawów choroby oraz wyznaczać sposób postÄ™powania terapeutycznego. Obraz kliniczny rosacea jest zróżnicowany. Obecnie wyróżnia siÄ™ cztery podtypy choroby: rumieniowo-teleangiektatycznÄ…, grudkowo-krostkowÄ…, guzkowÄ… oraz ocznÄ…. TrÄ…dzik różowaty przebiega z okresami remisji i zaostrzeÅ„ klinicznych, które wymagajÄ… przewlekÅ‚ego stosowania leków zarówno miejscowych, jak i ogólnych. Każde zaostrzenie przyczynia siÄ™ do postÄ™pujÄ…cego uszkodzenia skóry i nasilenia objawów choroby. W leczeniu wykorzystuje siÄ™ różne preparaty farmakologiczne miejscowe i ogólne, kierujÄ…c siÄ™ w dużym stopniu wytycznymi FDA. Istotne znaczenie odgrywa także odpowiednia pielÄ™gnacja i styl życia. W pracy przedstawiono wspóÅ‚czesne poglÄ…dy na patogenezÄ™, przebieg kliniczny i możliwoÅ›ci terapeutyczne trÄ…dziku różowatego.<br /> PMID: 20966501 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20966501&dopt=Abstract = URL to article

Related ArticlesStatins in dermatology. Int J Dermatol. 2010 Nov;49(11):1235-43 Authors: Jowkar F, Namazi MR Statins are competitive inhibitors of 3-hydroxy-3-methylyglutaryl-coenzyme A reductase and reduce low-density lipoprotein-C levels. Statins are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Statins possess anti-inflammatory, immunomodulatory, antioxidant, metabolic, and possible anticancer effects. Statins are reported to be effective against psoriasis, dermatitis, graft-versus-host disease, uremic pruritus, vitiligo, and hirsutism. Topical forms of statins are employed in the treatment of acne, seborrhea, rosacea, and rhinophyma. Animal studies show the beneficial effect of statins against contact dermatitis and wound healing. They have promising anti-HIV effects as well. This article succinctly reviews the various cellular and molecular effects of statins, their applications in cutaneous medicine and their side effects. PMID: 20964647 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20964647&dopt=Abstract = URL to article

Related ArticlesInfluence of climatic factors on the medical attentions of dermatologic diseases in a hospital of Lima, Peru. An Bras Dermatol. 2010 Aug;85(4):461-8 Authors: Gutierrez EL, Galarza C, Ramos W, Mendoza M, Smith ME, Ortega-Loayza AG BACKGROUND: Significant associations have been described between climatic factors and human health, which can occur in dermatologic diseases too. OBJECTIVE: To determine the influence of the climatic factors on the medical attentions of dermatologic diseases in a general hospital in Lima (Peru). PATIENTS AND METHODS: Observational study which was carried out in a national hospital between January 2004 and December 2007. The diagnoses were classified according to the ICD-10 system. The climate information was provided by the National Oceanographic and Atmospheric Administration from USA(NOAA). RESULTS: 3 294 patients were included in the study, the average age was 35.4 ± 20.7 years old, and 53.2% were females. The "El Niño" phenomenon was associated with an increase in the prevalence of actinic keratosis (p=0.002), viral warts (p=0.001) and rosacea (p=0.014). The "La Niña" phenomenon was associated with a reduction in viral warts (p=0.026). Spring was associated with an increase of dermatitis (p=0.003), and summer was associated with an increase of benign neoplasms (p=0.049). CONCLUSION: The climatic variations influenced the occurrence of certain dermatologic diseases. The present study may represent an orientation guide to specialists and general practitioners identifying the most common dermatologic diagnoses and thus enabling better preparation to treat these cases in determined seasons of the year. PMID: 20944906 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20944906&dopt=Abstract = URL to article

Related ArticlesStaphylococcus epidermidis: A possible role in the pustules of rosacea. J Am Acad Dermatol. 2010 Oct 11; Authors: Whitfeld M, Gunasingam N, Leow LJ, Shirato K, Preda V BACKGROUND: Rosacea is a common skin and ocular disease. Cutaneous rosacea is characterized by facial flushing, telangiectasia, papules, and pustules. It is generally regarded as inflammatory in nature. We believed that the role of bacteria as a contributory factor in pustular and ocular rosacea needed to be revisited. OBJECTIVES: We sought to ascertain whether there is an increase in the bacteria isolated from the (1) pustules of rosacea; and (2) eyelid margins of persons with cutaneous pustular rosacea. METHODS: Bacterial swabs were taken and cultured from an incised rosacea pustule, the ipsilateral cheek skin, and the eyelid margin of 15 patients with pustular rosacea. Swabs were also taken from the cheek skin and ipsilateral eyelid margin of 15 matched control subjects. RESULTS: A pure growth of Staphylococcus epidermidis was isolated from a pustule of 9 of 15 patients with pustular rosacea, and no pure growth of S epidermidis was isolated from their ipsilateral cheek skin. This was a highly statistically significant increase (P = .0003). A pure growth of S epidermidis was isolated from the eyelid margins of 4 of 15 patients with pustular rosacea, and no pure growth was isolated from the eyelids of age- and sex-matched control subjects. This was a statistically significant increase (P = .05). LIMITATIONS: This study focuses on the microbial basis of rosacea. CONCLUSION: Our findings suggest S epidermidis may play a role in pustular and ocular rosacea. PMID: 20943287 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20943287&dopt=Abstract = URL to article