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Related ArticlesA two-gene phylogeny shows the lichen genus Niebla (Lecanorales) is endemic to the New World and does not occur in Macaronesia nor in the Mediterranean basin. Fungal Biol. 2010 Jul;114(7):528-37 Authors: Sérusiaux E, van den Boom P, Ertz D The generic segregates of the widespread fruticose genus Ramalina (mostly based on empirical data on morphology, cortex anatomy and secondary metabolites) are studied using maximum parsimony, maximum likelihood and Bayesian analyses of nuclear LSU and ITS sequences. The species examined include the three species aggregates within Niebla from the western coasts of North America, all species except one assumed to belong to the same genus from Macaronesia and the Mediterranean basin, the type species of Dievernia and Ramalina, and representatives of the genus Fistulariella. The genus Niebla is strongly supported when restricted to species from the New World, and all species referred to it from Macaronesia and the Mediterranean basin belong to Ramalina (R. bourgeana, R. crispatula, R. cupularis, R. hamulosa, R. portosantana, R. rosacea, R. subwebbiana and R. webbii). No support is found for the genera Dievernia and Fistulariella. The internal topology of the large genus Ramalina is unresolved and needs further studies. PMID: 20943164 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20943164&dopt=Abstract = URL to article

Related ArticlesClinical Applications of Non-Antimicrobial Tetracyclines in Dermatology. Pharmacol Res. 2010 Oct 8; Authors: Monk E, Shalita A, Siegel D There are many proposed non-antimicrobial actions of tetracyclines. The pathways affected by these medications, such as those involving matrix metalloproteinase (MMP) activity, are often overexpressed in various dermatologic conditions. Non-antimicrobial effects of tetracyclines that are important in dermatology include inflammatory cytokine regulation, inhibition of leukocyte chemotaxis and activation, and anti-oxidation. Dermatologists have utilized the non-antimicrobial benefits of using tetracycline, through their success in treating disorders that do not have a primary infectious etiology such as rosacea. Even in acne, there is believed to be overactive inflammation to a normally commensal organism which is inhibited by tetracyclines. These medications have also been reported as successful in cases of less common skin conditions, such as pyoderma gangrenosum and bullous pemphigoid, both of which involve inflammation and dermal destruction which are inhibited by tetracyclines. In the Dermatology section, the pathologic mechanisms of several dermatologic conditions are reviewed, followed by evidence of how tetracyclines and its derivatives, including chemically modified tetracyclines (CMTs) affect these pathways. Clinical testing of sub-antimicrobial doxycycline, in both 20mg twice daily and 40mg once daily (controlled release; 30mg immediate release, 10mg delayed release) forms, in rosacea and acne is reviewed as evidence that non-antimicrobial actions are valuable for treatment. Chemically modifies tetracycline-3 (CMT-3) for Kaposi 's sarcoma is highlighted as the only clinical evidence available for CMTs. Certain evidence of success using antimicrobial tetracyclines in inflammatory conditions of the skin is reviewed as well, because they are likely working through non-antimicrobial properties. Finally, dermatologic side effects of non-antimicrobial tetracyclines are assessed. PMID: 20937386 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20937386&dopt=Abstract = URL to article

Related ArticlesRosacea in patients with skin of color: uncommon but not rare. Cutis. 2010 Aug;86(2):60-2 Authors: Alexis AF PMID: 20919596 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20919596&dopt=Abstract = URL to article

Related ArticlesA report from the 68th annual meeting of the American Academy of Dermatology (March 5-9, 2010 - Miami, Florida, USA). Drugs Today (Barc). 2010 Jun;46(6):437-48 Authors: Rabasseda X Although a study using eye-tracking technology to assess the focus of attention when evaluating the beauty of a face demonstrated a marked attentional preference for the eye area (Cula, G.O. et al., Abst P1636), the skin at large is a main factor that reveals information about a person to everyone else with whom he or she comes into contact. Be it because of disease or because of aging, improving the appearance of the skin is as important as relieving pain, itch or other troublesome symptoms caused by skin diseases. Moreover, this can be much more important in a place like South Miami Beach, where bare skin is revealed on much more than just the face ... at least under normal circumstances, when the weather is not as surprisingly chilly as it was in March 2010 during the AAD annual meeting However, if beauty is very important for many people, health is important for everybody, and important news was also discussed on treatments for common and less common cutaneous diseases, ranging from psoriasis, acne and atopic dermatitis to a broad range of blistering, papulosquamous and granulomatous diseases. These are among the most important issues reviewed in the following report, which in combination with expert insight interviews freely accessible from the Access Dermatology website and the full abstracts from the meeting, available for download from the AAD website, will hopefully improve dermatologists' approach to treating skin diseases through use of the most novel therapies. Treatment is important, but so is prevention, and in that sense an important issue discussed during the meeting, which was nicely covered in an interview with Dr. Darrell S. Riegel from the Ronald O. Perelman Department of Dermatology at the New York University School of Medicine, was that protecting the skin from sunlight and artificial tanning beds is essential for preventing malignancies such as melanoma, while not jeopardizing adequate availability of active vitamin D. A fitting message is: "It's cold, but even if it wasn't, cover your skin... even in Miami". PMID: 20571613 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20571613&dopt=Abstract = URL to article

Related ArticlesBluish pigmentation of face and sclera. J Fam Pract. 2010 Sep;59(9):519-22 Authors: Bayne-Poorman M, Shubrook J Was this a case of Addison's disease, hemochromatosis, or melanoma? Or did one of the patient's medications have something to do with it? PMID: 20824229 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20824229&dopt=Abstract = URL to article

Related ArticlesSurgical management of rhinophyma. Clin Otolaryngol. 2010 Apr;35(2):158-9 Authors: Greaney L, Singh NP, Roberts DN PMID: 20500598 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20500598&dopt=Abstract = URL to article

Related ArticlesChronic lymphedema of the eyelid: case series. Orbit. 2010 Aug;29(4):222-6 Authors: Chalasani R, McNab A Purpose: To evaluate the clinical features, management and outcomes of treatment of chronic lymphedema of the eyelid in a tertiary referral setting. Design: Retrospective case series. Participants: 15 patients referred to the authors with unilateral or bilateral eyelid swelling of greater than 3 months duration. Main Outcome Measures: Clinical features, patient management, response to treatment. Results: Chronic eyelid lymphedema was associated with acne rosacea in 9 patients, radiotherapy in 1 patient, trauma in 1 patient and post-vitrectomy silicone oil leak in 1 patient. In the remaining 4 patients no associated condition or factor was identified. Surgical debulking was performed in 9 cases with improvement in all cases and no complications. Conclusion: Chronic eyelid lymphedema is a rare condition most commonly associated with rosacea. In our experience, surgical resection of involved subcutaneous tissue was helpful. PMID: 20812843 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20812843&dopt=Abstract = URL to article

Related ArticlesPustular eruption on face. J Fam Pract. 2010 Jul;59(7):399-401 Authors: Kim NN, Wickless HW PMID: 20625570 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20625570&dopt=Abstract = URL to article

Related ArticlesInnovative use of topical calcineurin inhibitors. Dermatol Clin. 2010 Jul;28(3):535-45 Authors: Lin AN Topical tacrolimus and pimecrolimus are indicated for treatment of atopic dermatitis, but they have been studied in many off-label uses. Double-blind and open studies have shown favorable results with topical tacrolimus and pimecrolimus in oral lichen planus. In 1 study of oral lichen planus, blood tacrolimus was detected in 54% of patients, but there were no signs of systemic toxicity. Double-blind and open studies of vitiligo have shown favorable results with tacrolimus in combination with excimer laser, especially for lesions over bony prominences and on extremities. Similarly, double-blind studies of vitiligo have shown favorable results when pimecrolimus is combined with narrow-band UVB, especially for facial lesions. Double-blind and open studies of psoriasis have shown favorable results for tacrolimus and pimecrolimus, especially for inverse psoriasis. Topical calcineurin inhibitors have been effective in many other cutaneous disorders, and further studies would help clarify their roles. PMID: 20510763 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20510763&dopt=Abstract = URL to article

Related ArticlesSingle-stage forehead flap in nasal reconstruction. Ann Plast Surg. 2010 May;64(5):645-8 Authors: Fudem GM, Montilla RD, Vaughn CJ The paramedian forehead flap has become the standard of care for major nasal reconstruction. The classic procedure involves a second-stage operation to divide and inset the external pedicle. We present our experience in a clinical series using single-stage forehead flap reconstruction. Our indications include elderly patients, pediatric patients treated during mission trips, and any patient in whom an external pedicle or two-stage procedure is problematic. From 2008 to 2009, 9 patients underwent a single-stage forehead flap. The majority had defects after excision of skin cancer. Our modification involves removal of radix and proximal nasal skin and fat and deepithelialization of the proximal pedicle to allow inset without excess compression or kinking. This modification avoids the sequelae of an external pedicle, which include bleeding, dressings, the inability to wear eyeglasses, and the patient's reluctance to appear in public. It safely provides acceptable results and avoids a mandatory secondary procedure. PMID: 20395802 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20395802&dopt=Abstract = URL to article

Related ArticlesDemodex mites: Facts and controversies. Clin Dermatol. 2010 September - October;28(5):502-504 Authors: Elston DM Because Demodex mites are ubiquitous, their potential as human pathogens has often been ignored. This contribution focuses on the growing body of evidence linking Demodex mites with various skin disorders. Histologically, spongiosis and lymphoid inflammation are regularly seen in follicles containing Demodex mites. In animals, they are well established as a cause of mange, and a human counterpart-demodectic alopecia-appears to exist. There is also a statistical association between Demodex mite density and rosacea, facial itching, and chronic blepharitis. Papulovesicular rosacealike lesions and spiny blepharitis often respond to agents that reduce Demodex numbers. Although these observations are not sufficient to fulfill Koch's postulates, Koch's postulates are also not fulfilled for the association between brown recluse spiders and dermal necrosis or the association between streptococci and guttate psoriasis. The evidence linking Demodex mites to human disease has implications regarding treatment. PMID: 20797509 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20797509&dopt=Abstract = URL to article

Related ArticlesFibrosing Blepharo-conjunctivitis following Pyogenic Granuloma in Ocular Acne Rosacea. Ocul Immunol Inflamm. 2010 Aug 25; Authors: Rahman MQ, Lim Y, Roberts F, Ramaesh K Purpose: To report a case of pyogenic granuloma associated with ocular acne rosacea. Design: Case report. Methods: Interventional case report. Results: The patient developed an unusual lesion of the conjunctiva and limbus, histologically confirmed to be pyogenic granuloma. Excision of the lesion resulted in symblepharon formation, adhesions between lid margins, tarsal conjunctiva, and cornea, and reductions in visual acuity. The patient underwent surgical separation of the corneal lid adhesions with a mucosal autograft for the tarsal conjunctiva and an amniotic membrane graft for the cornea with good results. Conclusions: Ocular rosacea is a common condition but such excessive and unusual fibrotic healing responses following excision of pyogenic granulomas have not been previously reported. This case demonstrated significant morbidity and decreased visual acuity. However, early recognition and effective surgical management can lead to good visual outcomes. PMID: 20735292 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20735292&dopt=Abstract = URL to article

The use of sodium sulfacetamide 10%-sulfur 5% emollient foam in the treatment of acne vulgaris. J Clin Aesthet Dermatol. 2009 Aug;2(8):26-9 Authors: Del Rosso JQ Acne vulgaris is the most common disorder encountered in ambulatory clinical practice comprising 11.3 percent of office visits to dermatologists in 2005.(1) By comparison, eczematous dermatoses, psoriasis, and skin cancer accounted for 6.2, 3.5, and 10 percent of office visits, respectively.(1) A variety of topical therapeutic options are available for treatment of acne vulgaris, including benzoyl peroxide, antibiotics, retinoids, azelaic acid, and sodium sulfacetamide-sulfur.(2,3) Sodium sulfacetamide 10%-sulfur 5% has been used for the topical treatment of seborrheic dermatitis, acne vulgaris, and rosacea since the mid-1950s and is available in a variety of formulations, including lotions, creams, cleansers, and emollient foams.(4) Recently, an emollient foam sodium sulfacetamide 10%-sulfur 5% formulation indicated for topical therapy of acne vulgaris, rosacea, and seborrheic dermatitis has become available.(5) This article provides an overview of the sodium sulfacetamide 10%-sulfur 5% emollient foam and reports the results of a case report series of patients with acne vulgaris treated with sodium sulfacetamide 10%-sulfur 5% emollient foam as monotherapy or in combination with other topical acne products. PMID: 20729951 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20729951&dopt=Abstract = URL to article

Related ArticlesRetrospective analysis of the association between demodex infestation and rosacea. Arch Dermatol. 2010 Aug;146(8):896-902 Authors: Zhao YE, Wu LP, Peng Y, Cheng H Objectives To explore the association between Demodex infestation and rosacea and the pathogenesis of demodicosis rosacea by means of a meta-analysis. Data Sources Electronic searches of the ISI Web of Knowledge (Science Citation Index, ISTP [index to Scientific & Technical Proceedings], Journal Citation Reports, BP [bIOSIS Preview], INSPEC [ination Service in Physics, Electronics Technology, and Computer and Control], and DII [Derwent Innovation Index]), MEDLINE, and CNKI (China National Knowledge Infrastructure) databases (January 1, 1950, to December 31, 2009). We also performed hand searches of reference lists and conference proceedings. Study Selection Predefined selection criteria were applied to all published case-control studies that analyzed the association between Demodex infestation and rosacea. Data Extraction Two of us independently extracted data from the included studies. For disputed articles, a third party mediated whether to include the study. Data Synthesis Forty-eight English- and Chinese-language articles, which covered 10 different countries and 28 527 participants, were eligible. The pooled odds ratio in random-effects models is 7.57 (95% confidence interval, 5.39-10.62). Stability is good according to sensitivity analysis. The fail-safe number is 18 456 in the quantitative analysis of publication bias. CONCLUSIONS: A significant association exists between Demodex infestation and the development of rosacea. Demodex infestation is a vital risk factor for rosacea according to the time-to-event relationship, and the degree of infestation played a more important role than did the mite infestation rate in the development of rosacea. PMID: 20713824 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20713824&dopt=Abstract = URL to article

Related ArticlesRosacea: 244 Tunisian cases. Tunis Med. 2010 Aug;88(8):597-601 Authors: Khaled A, Hammami H, Zeglaoui F, Tounsi J, Zermani R, Kamoun MR, Fazaa B Background: Rosacea is a common, chronic facial dermatosis of uncertain etiology, several well-defined types and variable progression. There is a paucity of epidemiologic studies from North African countries especially in Tunisia. Aim: to determine epidemiological, clinical, histological features, treatment and outcome of rosacea in a Tunisian study. Methods: A retrospective study of all rosacea cases diagnosed in the outpatient Dermatology Department of Charles Nicolle hospital of Tunis was conducted between 1990, January and 2003, May. Results: Our study included 244 patients. The diagnosis of rosacea was made on symptoms and clinical features in 185 cases and on histological findings in 59 patients. The hospital prevalence of rosacea was 0.2%. The sex ratio M/F was 0,4. Patient's Mean age was of 49 years. Triggered factors mentioned included most often: sun exposure (64%) and thermal stimuli (25%). Mean duration between the onset of symptoms and the first consultation was about 20 months. The rosacea subtypes were: erythematotelangiectatic type (12%), papulopustular rosacea (69%), and rhinophyma (3.7%). Granulomatous rosacea was diagnosed in 8 patients and steroid rosacea in 28 cases. Ocular rosacea was observed in 41 cases. Treatment modalities included: topical treatment (1.6%), systemic treatment (85%), systemic and topical treatment (5%) and surgical procedures (1.2%). Conclusions: Rosacea seems to be a frequent dermatosis in Tunisia where most of the population is phenotype IV-V. It affects mostly middle-aged women. Most of our patients present with papulopustular rosacea (69%). More epidemiological and clinical studies in North African countries should be conducted to emphasize these results. PMID: 20711968 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20711968&dopt=Abstract = URL to article

Related ArticlesImmunohistochemical expression of matrix metalloproteinases in the granulomatous rosacea compared with the non-granulomatous rosacea. J Eur Acad Dermatol Venereol. 2010 Jul 31; Authors: Jang YH, Sim JH, Kang HY, Kim YC, Lee ES Background There is a granulomatous variant which is recognized in the rosacea spectrum. However, the pathogenesis of granuloma formation in rosacea has not been clearly demonstrated. Matrix metalloproteinases (MMPs) are required for recruitment of inflammatory cells and for tissue remodelling, making way for the development of well-organized granuloma. Objective The aim of this study was to investigate the expression of transforming growth factor (TGF)-beta, TGF-beta type II receptor (TbetaRII), Tumour necrosis factor (TNF)-alpha, MMP-1, 2 and 9 in the granulomatous rosacea (GR) compared with the non-granulomatous rosacea (NGR) and test the hypothesis that the changes of these profiles in GR would be related with chronic ultraviolet radiation (UVR)-exposure. Methods Facial skin samples were obtained from 20 patients with GR and NGR (control group). The sections were stained using haematoxylin and eosin, Verhoeff's elastic stain, and antibodies to TGF-beta, TbetaRII, TNF-alpha, MMP-1, -2 and -9. Results The amount of elastotic material was significantly increased in the dermis of GR lesions. Expression of TGF-beta was significantly decreased in the epidermis of GR lesions compared with NGR lesions. In addition, the expression of MMP-9 was significantly increased in the dermis of GR lesions compared with NGR lesions, especially at the centre of the granuloma on a semi-quantitative analysis. MMP-2 expression was also increased in GR lesions, although the difference between the two groups was not statistically significant. Conclusions The results of this study suggest that the increased expression of MMPs in the dermis may participate in granuloma formation of GR in association with UVR. PMID: 20698913 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20698913&dopt=Abstract = URL to article

Related ArticlesGranulomatous diseases of the nose. Int J Dermatol. 2009 Dec;48(12):1275-82; quiz 1282 Authors: Zargari O, Elpern DJ PMID: 20415668 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20415668&dopt=Abstract = URL to article

Related ArticlesMorphea, an unusual side effect of anti-TNF-alpha treatment. Eur J Dermatol. 2010 May-Jun;20(3):400-1 Authors: Mattozzi C, Richetta AG, Cantisani C, Giancristoforo S, D'Epiro S, Gonzalez Serva A, Viola F, Cucchiara S, Calvieri S PMID: 20299314 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20299314&dopt=Abstract = URL to article

Related Articles[Rosacea: pathogenesis, clinical forms and therapy.] Orv Hetil. 2010 Jul 25;151(30):1209-14 Authors: Preisz K, Kárpáti S Rosacea is one of the most common chronic dermatological diseases. It is characterized by transient or persistent facial erythema, teleangiectasias, papules and pustules, usually on the central portion of the face. Rosacea can be classified into four main subtypes: erythemato-teleangiectatic, papulopustular, phymatous, and ocular. These subtypes require different therapeutic approaches. Regarding to the pathomechanism, several hypotheses have been documented in the literature, including genetic and environmental factors, vascular abnormalities, dermal matrix degeneration, microorganisms such as Demodex folliculorum and Helicobacter pylori, but the cause of rosacea is still not known. Authors in this article review current literature on new classification system of rosacea, as well as the main pathogenetic theories and current therapeutic options. PMID: 20650811 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20650811&dopt=Abstract = URL to article

Related ArticlesLong-term efficacy and safety of topical PRK 124 (0.125%) lotion (Pyratine-XR) in the treatment of mild-to-moderate rosacea. J Drugs Dermatol. 2010 Jun;9(6):647-50 Authors: Tremaine AM, Ortiz A, Elkeeb L, Tran M, Weinstein G BACKGROUND: Many patients with rosacea cannot tolerate extended treatment periods with topical agents because their skin sensitivity is often increased. OBJECTIVE: To determine the long-term efficacy and tolerability of a new moisturizing lotion for improving the signs and symptoms of mild-to-moderate rosacea. METHODS: In a 48-week, open-label study, a moisturizing lotion containing furfuryl tetrahydropyranyladenine as PRK-124 (0.125%, Pyratine-XR, Senetek PLC, Napa, CA) was applied twice daily by 18 subjects with mild-to-moderate rosacea. Clinical improvements were assessed by the treating physician. Skin barrier function was measured by transepidermal water loss after treatment. Tolerability and cosmetic outcome were evaluated by subjects. RESULTS: Subjects experienced a mean 44 percent reduction in erythema severity and a mean 89 percent reduction in inflammatory lesion count at week 48. Reductions were significant (P < 0.05) in both erythema and lesions at weeks 24, 36 and 48. Statistically significant (P < or = 0.05) improvements in telangiectasias, transepidermal water loss and dryness were noted. Overall clinical improvement was observed in 81 percent of subjects and the investigator's global assessment steadily improved throughout the study. Treatments were well-tolerated and cosmetically acceptable. Treatment-induced skin irritation was not observed. CONCLUSION: The new moisturizing lotion containing furfuryl tetrahydropyranyladenine as PRK 124 is efficacious, does not irritate skin, and is well tolerated for at least 48 weeks. PMID: 20645526 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20645526&dopt=Abstract = URL to article

Related ArticlesEfficacy of topical azelaic acid (AzA) gel 15% plus oral doxycycline 40 mg versus metronidazole gel 1% plus oral doxycycline 40 mg in mild-to-moderate papulopustular rosacea. J Drugs Dermatol. 2010 Jun;9(6):607-13 Authors: Del Rosso JQ, Bruce S, Jarratt M, Menter A, Staedtler G Rosacea is a leading reason why people seek the care of a dermatologist, accounting for nearly 7 million office visits annually. Pharmacologic treatments include both topical and oral medications, which are increasingly being used in combination, especially at the outset of therapy. This exploratory study assesses the safety, effectiveness and speed of onset of two common topical agents for the treatment of rosacea--azelaic acid gel (AzA) 15% and metronidazole gel 1%--used in conjunction with anti-inflammatory dose doxycycline (40 mg once daily). Men and women (n = 207) with mild-to-moderate papulopustular rosacea were enrolled and randomized to receive either AzA gel 15% twice daily plus doxycycline 40 mg once daily (AzA group) or metronidazole gel 1% once daily plus doxycycline 40 mg once daily (Metro group) for 12 weeks. Both regimens were safe, efficacious and well tolerated. Efficacy parameters revealed a possible trend toward greater and earlier benefit with the AzA-based regimen than with the metronidazole-based regimen. These findings warrant further investigation in a sufficiently powered study. PMID: 20645521 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20645521&dopt=Abstract = URL to article

Related ArticlesWe are making progress with both acne and rosacea--but, let's face it! We still have a long way to go. J Drugs Dermatol. 2010 Jun;9(6):603-4 Authors: Del Rosso JQ PMID: 20645520 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20645520&dopt=Abstract = URL to article

Related ArticlesPimecrolimus cream 1% for the treatment of papulopustular eruption related to epidermal growth factor receptor inhibitors: a case series and a literature review of therapeutic approaches. Dermatology. 2010;220(3):243-8 Authors: Nikolaou V, Stratigos A, Antoniou C, Kiagia M, Nikolaou C, Katsambas A, Syrigos K BACKGROUND: Cutaneous side effects of epidermal growth factor receptor inhibitors (EGFRIs) are very frequent and well known. The aim of our study was to investigate the efficacy and safety of pimecrolimus 1% cream in the treatment of papulopustular eruption caused by EGFRIs and to review the relevant literature on therapeutic approaches. METHODS: Twenty cancer patients being treated with EGFRIs were included in the study. Nine of the patients showed grade 1 and 11 showed grade 2 papulopustular eruption. All patients were treated with pimecrolimus 1% cream, which was applied twice daily. Patients with grade 2 eruption also received systemic minocycline 100 mg/day. RESULTS: All patients with grade 1 eruption responded to treatment, with 4/9 experiencing complete resolution of the lesions 2 weeks after the initiation of treatment. Five out of 11 patients with grade 2 eruption had more than 50% improvement in erythema and pustules, and 1 had complete resolution of the skin lesions. Two patients did not respond to treatment but were significantly improved after substitution of pimecrolimus 1% cream with metronidazole 1% cream. No side effects were recorded. CONCLUSIONS: Our case series shows that pimecrolimus cream may be an effective and safe approach in the management of papulopustular eruption related to EGFRIs. PMID: 20110632 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20110632&dopt=Abstract = URL to article

Related ArticlesRosacea Treatments: What's New and What's on the Horizon? Am J Clin Dermatol. 2010;11(5):299-303 Authors: Gallo R, Drago F, Paolino S, Parodi A Rosacea is a common, chronic, cutaneous disorder presenting with recurrent episodes of facial flushing, erythema, papules, pustules and telangiectasias. It is a multifactorial disease and its various clinical presentations probably represent the consequence of combined different triggers upon a specific background. Its management is largely based on long-established treatments empirically tailored to the specific presenting symptoms and no real breakthrough has occurred to date. However, recent insights into the still rather obscure pathophysiology of rosacea seem to open the way for etiologically oriented treatments. These may include, on the one side, the more effective application of traditional drugs, such as tetracyclines and metronidazole, to specifically selected patients or, on the other side, new therapeutic options, such as vitamin D receptor antagonists. It is to be remarked that the quality of most studies evaluating rosacea treatment is rather poor, mainly due to a lack of proper standardization. For a major breakthrough to occur in the management of rosacea, we need both a better understanding of its pathogenesis and the adherence of future clinical trials to clearly defined grading and inclusion criteria, which are crucial for investigators to correctly compare and interpret the results of their work. PMID: 20642292 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20642292&dopt=Abstract = URL to article

Related ArticlesInnovations in natural ingredients and their use in skin care. J Drugs Dermatol. 2010 Jun;9(6 Suppl):S72-81; quiz s82-3 Authors: Fowler JF, Woolery-Lloyd H, Waldorf H, Saini R Natural ingredients have been used traditionally for millennia and their application in topical creams, lotions and preparations within the traditional medicines and healing traditions of many cultures has been observed. Over the last 20 years, clinical and laboratory studies have identified the benefits of an array of natural ingredients for skin care. Consequently, a number of these ingredients and compounds are today being developed, used or considered not only for anti-aging effects, but also for use in dermatologic disorders. Certain ingredients, such as colloidal oatmeal and aloe vera, have been identified as beneficial in the treatment of psoriasis and atopic dermatitis, respectively, due to their anti-inflammatory properties. For combating acne and rosacea, green tea, niacinamide and feverfew are considered efficacious. As to hyperpigmentation and antioxidative capabilities, licorice, green tea, arbutin, soy, acai berry, turmeric and pomegranate are among those plants and compounds found to be most beneficial. Additional research is needed to determine to confirm and elucidate the benefits of these ingredients in the prevention and management of skin disease. PMID: 20626172 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20626172&dopt=Abstract = URL to article