rss

Related ArticlesHARMONY IN DERMATOLOGY AND VENEREOLOGY HAS BEEN ACHIEVED! 7TH EADV SPRING SYMPOSIUM, Cavtat, Croatia, May 13-16, 2010. Acta Dermatovenerol Croat. 2010 Jul;18(2):131-2 Authors: Bukvić Mokos Z The 7th EADV Spring Symposium, with the motto <<Harmony in Dermatology and Venereology>>, was held in Cavtat, Croatia, on 13-16 May 2010, under the presidency of Prof Jasna Lipozencić and auspices of the President of the Republic oh Croatia Professor Ivo Josipović. The 7th EADV Spring Symposium brought together nearly 2,000 dermatologists-venereologists from 78 countries, from all over the world. The rich and varied scientific program was not only interesting in clinical but also in the academic-research point of view. The main topics included melanoma; psoriasis; syphilis; dermatological surgery; novel drugs in dermatovenereology; food allergies, dermatoscopy; cutaneous lymphomas; hair and nail diseases; skin diseases in the Mediterranean; bullous diseases; acne and rosacea; wound healing and leg veins; chronic urticaria; vitiligo and pigmentary disorders; skin clues of systemic and connective tissue diseases; photodermatology; atopic dermatitis; laser therapy; sexually transmitted infections; paediatric dermatology; non-melanoma skin cancer; dermatomycoses; aesthetic dermatology (Botulinum toxin, facial rejuvenation); skin conditions and endocrinology; and the skin and internal malignancy. The Symposia comprised four Case Report Sessions, Poster Forum, six Focus Sessions, four Forum Sessions, twelve Workshops, twelve Symposia, What's New Session, two Free Communications Sessions, and eight Satellite Symposia. Over 480 posters were presented and exhibited. An excellent beginning of scientific program was achieved by two outstanding opening lectures. Prof Amir Muzur overviewed the milestones in the history of Croatian dermatology and venereology; and Prof Stefan Beissert presented the highlights of present and future of dermatovenereological research. On Plenary Sessions, leading experts shared their experiences of particular topics. Prof Johannes Ring gave the excellent lecture on allergy, environment and the skin; Prof Christopher Griffits facilitated our understanding of brain-skin axis; Prof Georg Stingl gave an overview on immunotherapy for skin diseases in the molecular era; Prof Gregor Jemec emphasized novel imaging techniques for the diagnosis of skin disorders; Prof Jean-Hilaire Saurat overviewed exogenous acne; Prof Keith Radcliffe summarized progress, challenges and opportunities of STIs in Europe. All Focus Sessions were brilliantly accepted, bringing insightful presentations on Botulinum toxin (directed by Prof Ronni Wolf); dermatoscopy (Prof Harald Kittler); the skin and internal malignancy (Prof Bruce Thiers); STIs and adolescence (Assist Prof Suzana Ljubojević); acne and rosacea (Prof Gerd Plewig); and cutaneous lupus erythematosus (prof Percy Lehmann). Prof Andreas Katsambas, EADV President, led the excellent President's Symposium, which provided up-to-date data on different topics: metabolic co-morbidities and psoriasis (Prof Paolo Gisondi); genetic mechanisms in atopic eczema (Prof Sara Brown); and melanocytes and melanogenesis (Prof Marcus Böhm). Prof Irene Stefanki shared her extensive experiences from the STD Clinics. On What's New Session, Prof Rudolf Happle stressed on new diagnoses in Session what's new in clinical dermatology; Prof Erwin Tschachler presented what's new in venereology; and Prof Peter Steijlen overviewed the novelties in pediatric dermatology. It is important to mention a very active participation of Croatian dermatovenereologists who gave 15 excellent lectures concerning different fields: atopic dermatitis (Prof Jasna Lipozencić); bullous diseases (Assist Prof Branka Marinović); acne and rosacea (Prof Aleksandra Basta-Juzbasić and Assist Prof Zrinka Bukvić Mokos); pigmentary disorders (Prof Mirna Situm); chronic urticaria (Prof Visnja Milavec-Puretić), psoriasis (Prof Marija Kastelan, Assist Prof Romana Ceović), syphilis (Prof Franjo Gruber); HPV in dermatovenereology (Prof Mihael Skerlev); STIs in adolescence (Assist Prof Suzana Ljubojević); paediatric dermatology (Head Doctor Slobodna Murat-Susić); dermatological surgery (dr Daska Stulhofer Buzina); venous ulcers (dr Sandra Marinović Kulisić); and laser therapy (Assist Prof Zrinka Bukvić Mokos). In addition, domestic dermatovenerologists presented several free communications and case reports, as well as interesting posters. The Symposia was brilliantly organized. The elected scientific program was accompanied by the excellent technical support and impressive exhibition area. Furthermore, social program was unforgettable. During Opening Ceremony, Croatian ensembles presented a part of Croatian rich cultural heritage. It was followed by memorable Welcome Reception, which took place by hotel Croatia's swimming pool; so the participants could enjoy in the breathtaking view to nearby islands and crystalline blue sea in the sunset, pleasant live music, and Croatian gastronomic specialties. Equally unforgettable was President's Dinner which took place in Dubrovnik Art Gallery, with unique elegant atmosphere which was additionally accentuated by enjoyable view to the Old Town of Dubrovnik, considered as one of the most attractive on the planet. The charming beauty of Dubrovnik and its fascinating history attracted the most of the participants to visit this <<paradise on Earth>>. The remarkable success of this 7th EADV Spring Symposium in all its aspects could not be achieved without enormous effort of its chairperson Prof Jasna Lipozencić. Prof Lipozencić devoted her years of determined work to organize the EADV Spring Symposium of the highest scientific level, and to present Croatian dermatovenereology and our country in the best light. She unquestionably succeeded in all her aims and gave to this Symposium her personal touch. The long applause aimed to Prof Lipozencić by more than three hundred participants at the Closing Ceremony said more than a hundred words. Therefore Prof Lipozencić earns our cordial congratulations, admiration and respect. Our congratulations should be also addressed to Assist Prof Branka Marinović, Symposium Secretary General, who gave a huge contribution to the success of this meeting by her discrete, but hard and pedantic work. In conclusion, 7th EADV Spring Symposium was successful in its scientific contents and its organization, fully achieving its motto <<Harmony in Dermatology and Venereology>>! Congratulations! PMID: 20624366 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20624366&dopt=Abstract = URL to article

Related Articles[Facial dermatosis: acne, rosacea, seborrhoeic dermatitis] Rev Prat. 2010 Jun 20;60(6):849-55 Authors: Puzenat E, Riou-Gotta MO, Messikh R, Humbert P PMID: 20623910 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20623910&dopt=Abstract = URL to article

Related ArticlesSpontaneous corneal perforation in ocular rosacea. Middle East Afr J Ophthalmol. 2010 Apr;17(2):186-8 Authors: Al Arfaj K, Al Zamil W Rosacea is a dermatologic condition that affects the midfacial region. Ocular rosacea is most frequently diagnosed when cutaneous signs and symptoms are also present. Ocular manifestations are essentially confined to the eyelids and ocular surface. Ocular involvement ranges from minor irritation, dryness, and blurry vision to potentially severe ocular surface disruption including corneal ulcers, vascularization and rarely perforation. We present a 49-year-old Saudi Arabian female with the diagnosis of rosacea who presented with a peripheral corneal performation. The perforation was successfully managed by surgical repair, oral doxycycline and topical steroid. The final best corrected visual acuity was 20/30 after treatment. Early referral to an ophthalmologist and careful long-term follow-up are recommended. PMID: 20616930 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20616930&dopt=Abstract = URL to article

Related ArticlesRosacea and acne: topical or systemic treatment? Dtsch Med Wochenschr. 2010 Jul;135(28/29):1435-1439 Authors: Lehmann P Acne and Rosacea belong to the most common dermatoses of adolescents and adults. A good understanding of these diseases and its particularities is necessary for the differential diagnoses of the many clinical subtypes and in order to enable a stage and phase specific treatment approach. Topical treatments that are widely accepted in rosacea are metronidazole and azelaic acid; investigational agents that may have good therapeutic outcomes are Permethrin and Calcineurin-inhibitors. In acne topical retinoids, benzoylperoxide, antibiotics, and azelaic acid are applied to control the disease. Systemically, antibiotics such as tetracycline and macrolide antibiotics and in severe cases, isotretinoin, can be used in both diseases. PMID: 20614406 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20614406&dopt=Abstract = URL to article

Related ArticlesTetracyclines: A pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Jun 30; Authors: Griffin MO, Fricovsky E, Ceballos G, Villarreal FJ There must be something unique about a class of drugs (discovered and developed in the mid-1940's) where there are more than 130 ongoing clinical trials currently listed. Tetracyclines were developed as a result of the screening of soil samples for antibiotic organisms. The 1(st) of these compounds chlortetracycline was introduced in 1948. Soon after their development tetracyclines were found to be highly effective against various pathogens including rickettsiae, gram-positive and negative bacteria thus, becoming a class of broad spectrum antibiotics. The mechanism of action of tetracyclines is thought to be related to the inhibition of protein synthesis by binding to the 30S bacterial ribosome. Tetracyclines are also an effective anti-malarial drug. Over time, many other "protective" actions have been described for tetracyclines. Minocycline, which can readily cross cell membranes, is known to be a potent anti-apoptotic agent. Its mechanism of action appears to relate to specific effects exerted on apoptosis signaling pathways. Another tetracycline, doxycycline is known to exert anti-protease activities. Doxycycline can inhibit matrix metalloproteinases which contribute to tissue destruction activities in diseases such as gingivitis. A large body of literature has provided additional evidence for the "beneficial" actions of tetracyclines including their ability to act as oxygen radical scavengers and anti-inflammatory agents. This increasing volume of published work and ongoing clinical trials supports the notion that a more systematic examination of their possible therapeutic uses is warranted. This review provides a summary of tetracycline's multiple mechanisms of action and while using the effects on the heart as an example, the manuscript also notes their potential to benefit patients suffering from various pathologies such as cancer, Rosacea and Parkinson's disease. PMID: 20592239 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20592239&dopt=Abstract = URL to article

Related ArticlesBlepharitis. Semin Ophthalmol. 2010 May;25(3):79-83 Authors: Bernardes TF, Bonfioli AA Blepharitis is a chronic inflammatory process of the eyelid margin. It is a common eye disorder throughout the world and can affect any age group. It may be associated with several systemic diseases, particularly rosacea and seborrheic dermatitis, and is related to other ocular conditions like dry eye, chalazion, conjunctivitis, and keratitis. Common symptoms associated with blepharitis are burning sensation, irritation, tearing, photophobia, blurred vision, and red eyes. Clinical examination reveals the presence of scurf, telangiectatic vascular changes of the eyelid margin, inspissated meibomian glands, conjuntival hyperemia, punctuate keratopathy, cornea vascularization, and ulceration. Patients with longstanding chronic blepharitis may present hypertrophy of the lid margin, scars, madarosis, trichiasis, and poliosis. Treatment of blepharitis is long and unsatisfactory. Long-term commitment to eyelid hygiene is essential. Other treatment options are discussed. PMID: 20590417 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20590417&dopt=Abstract = URL to article

Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol. 2010 Jun 23; Authors: Elewski BE, Draelos Z, Dréno B, Jansen T, Layton A, Picardo M Abstract Background The absence of specific histological or serological markers, the gaps in understanding the aetiology and pathophysiology of rosacea, and the broad diversity in its clinical manifestations has made it difficult to reach international consensus on therapy guidelines. Objectives The main objective was to highlight the global diversity in current thinking about rosacea pathophysiology, classification and medical features, under particular consideration of the relevance of the findings to optimization of therapy. Methods The article presents findings, proposals and conclusions reached by the ROSacea International Expert group (ROSIE), comprising European and US rosacea experts. Results New findings on pathogenesis provide a rationale for the development of novel therapies. Thus, recent findings suggest a central role of the antimicrobial peptide cathelicidin and its activator kallikrein-5 by eliciting an exacerbated response of the innate immune system. Cathelicidin/kallikrein-5 also provide a rationale for the effect of tetracyclines and azelaic acid against rosacea. Clinically, the ROSIE group emphasized the need for a comprehensive therapy strategy - the triad of rosacea care - that integrates patient education including psychological and social aspects, skin care with dermo-cosmetics as well as drug- and physical therapies. Classification of rosacea into stages or subgroups, with or without progression, remained controversial. However, the ROSIE group proposed that therapy decision making should be in accordance with a treatment algorithm based on the signs and symptoms of rosacea rather than on a prior classification. Conclusion The ROSIE group reviewed rosacea pathophysiology and medical features and the impact on patients and treatment options. The group suggested a rational, evidence-based approach to treatment for the various symptoms of the condition. In daily practice this approach might be more easily handled than prior subtype classification, in particular since patients often may show clinical features of more than one subtype at the same time. PMID: 20586834 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20586834&dopt=Abstract = URL to article

Treatment of Extrafacial Rosacea with Low-dose Isotretinoin. Acta Derm Venereol. 2010 Jul;90(4):409-10 Authors: Bostanci OZ, Borelli C, Schaller M PMID: 20574608 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20574608&dopt=Abstract = URL to article

Related ArticlesRosacea-like eruption associated with nilotinib. J Eur Acad Dermatol Venereol. 2010 Jun 21; Authors: Yang JH, Lee DW, Won CH, Chang SE, Lee MW, Lee KH, Choi JH, Moon KC PMID: 20569294 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20569294&dopt=Abstract = URL to article

Related ArticlesAcne rosacea associated imatinib mesylate in a gastrointestinal stromal tumor patient. J Oncol Pharm Pract. 2010 Jun 15; Authors: Demirci U, Coskun U, Erdem O, Ozturk B, Yilmaz IB, Benekli M, Buyukberber S Tyrosine kinase inhibitors (TKIs) are targeted treatments for various cancers. Skin toxicities are one of the most common nonhematological side-effects of TKIs. We report an imatinib mesylate (IM) induced hyperpigmented acne rosacea (AR) and sunitinib-induced palmar hyperkeratosis in the case with gastrointestinal stromal tumor. AR was arisen due to the discontinuation of IM. To the best of our knowledge, this kind of cutaneous side-effect with IM has not been documented previously. PMID: 20551113 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20551113&dopt=Abstract = URL to article

Related ArticlesAzelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. Exp Dermatol. 2010 Jun 2; Authors: Mastrofrancesco A, Ottaviani M, Aspite N, Cardinali G, Izzo E, Graupe K, Zouboulis CC, Camera E, Picardo M Please cite this paper as: Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. Experimental Dermatology 2010. Abstract: Azelaic acid (AzA), a nine-carbon dicarboxylic acid, is an agent for the topical treatment of acne. It has also been shown to be effective in rosacea; however, the mechanism of action has not been clarified. Because inflammation is a common feature of both conditions, we investigated the effects of azelaic acid on the inflammatory response of normal human keratinocytes to ultraviolet B light, which is a photosensitizer agent in rosacea. AzA, at 20 mm, a concentration achievable following topical application of a 15% gel, suppresses ultraviolet B light-induced interleukins-1beta, -6 and tumor necrosis factor-alpha mRNA expression and protein secretion. Mechanistically, azelaic acid significantly reduced the ultraviolet B light-induced nuclear translocation of nuclear factor kB p65 subunit and the phosphorylation of the p38 mitogen and stress-activated protein kinase. Moreover, as peroxisome proliferators-activated receptor gamma, (PPARgamma) which has a crucial role in the control of inflammation, is activated by fatty acids and products of lipid peroxidation, we further investigated the effect of azelaic acid on the expression of this nuclear receptor. AzA induced peroxisome proliferators-activated receptor-gamma mRNA and its transcriptional activity. The PPARgamma antagonist GW9662 abrogated the inhibitory effects of AzA on the UVB-induced pro-inflammatory cytokines release and on the cell proliferation. Our study provides new insights into the molecular mechanisms of the activity of azelaic acid and lands additional evidences for its therapeutic effects on inflammatory skin diseases, such as rosacea. PMID: 20545756 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20545756&dopt=Abstract = URL to article

Related ArticlesTHE IMPACT OF ROSACEA ON LIFE QUALITY: Effects of demographic and clinical characteristics and various treatment modalities. Br J Dermatol. 2010 Jun 9; Authors: Aksoy B, Altaykan-Hapa A, Egemen D, Karagöz F, Atakan N ABSTRACT Background: Rosacea has a major psychosocial impact on a patient's life. Objective: The aims of this study were to determine the extent of impact of rosacea on patient's life quality, the relationship of life quality scores to clinical and demographic variables, and the change of life quality according to various treatment alternatives. Patients & Methods: Patients' demographic and clinical characteristics were recorded at their initial examination and their response to treatment alternatives and side effects were recorded additionally at their control examination. Rosacea severity was scored for each sign from 0 to 3. Patients were requested to fill out Dermatology Life Quality Index (DLQI). Results: A total of 308 patients took part in this study. Mean DLQI total score at the initial visit was 6.93+/-5.18 and related to patients' age, gender, disease starting age, subjective symptoms, triggering factors, previous treatments, rosacea severity scores and patients' self assessment of ease of living with rosacea. Of these 308 patients, 164 completed the DLQI following treatment as well. Post-treatment DLQI score was 4.36+/-4.82. Post-treatment scores were also related to gender, type of treatment modality, development of side effects, improvement of rosacea, rosacea severity scores and patients' self reported ease of living with rosacea. Topical metronidazole, oral tetracycline and oral isotretinoin were observed to reduce signs and symptoms of rosacea and DLQI scores significantly at this repeat examination. Conclusions: Rosacea affects patients' lives moderately and this could be assessed by using DLQI. DLQI is also sensitive to health quality changes brought about by treatment of rosacea. As a preliminary result we can say that topical metronidazole, oral tetracycline and oral isotretinoin seem to improve quality of life of patients by improving lesions of rosacea more efficiently than other therapeutic agents. PMID: 20545683 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20545683&dopt=Abstract = URL to article

Related Articles[Dermatological diseases in psychiatry] Soins Psychiatr. 2010 May-Jun;(268):26-9 Authors: Dubreuil A From Ekbom's syndrome to neurotic acne, from seborrheic dermatitis to psoriasis or rosacea, without forgetting atopic dermatitis in children, these dermatological illnesses all have a direct or indirect link with psychiatric pathology In the field of dermatological infections, treatment must be provided by both the dermatologist and psychiatrist. The skin is an interface, attacked by external factors, as well as expressing psychic conflicts. In this context, there is a real place for psychodermatology. PMID: 20540390 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20540390&dopt=Abstract = URL to article

Related ArticlesDescription of peripheral blood cells and differential blood analysis of captive female and male leopard grouper Mycteroperca rosacea as an approach for diagnosing diseases. Fish Physiol Biochem. 2010 Jun 5; Authors: Burgos-Aceves MA, Campos-Ramos R, Guerrero-Tortolero DA The peripheral blood cells and differential blood profile of captive female and male leopard grouper Mycteroperca rosacea are described for aquacultural purposes. Basophilic, polychromatic, and orthochromic erythroblasts were observed as immature erythrocytes that develop into mature erythrocytes. Young erythrocytes were not evident, and bi-lobed erythrocytes were extremely scarce. Types of leukocytes included lymphocytes; three types of granulocytes (basophiles, eosinophiles, and neutrophiles); monocytes; and a specialized amoeboid-like macrophage in the blood, which has not been previously described in fish-blood literature. Thrombocytes were commonly observed. There was significantly higher erythropoiesis in males. Granulocytes and lymphocytes of females were significantly higher than males, whereas monocytes and thrombocytes were not. PMID: 20526671 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20526671&dopt=Abstract = URL to article

Related ArticlesPrevalence of Rosacea in an Estonian Working Population Using a Standard Classification. Acta Derm Venereol. 2010 May;90(3):269-273 Authors: Abram K, Silm H, Oona M Data about the prevalence of rosacea are scarce. The aim of this study was to evaluate the prevalence rate of rosacea according to the American National Rosacea Society Expert Committee (NRSEC) classification. A cross-sectional study of 348 subjects randomly selected from a working population >/= 30 years of age was performed. All subjects completed a questionnaire. Skin status was examined according to NRSEC criteria. Of the 348 subjects, 78 (22%) had one or more primary features of rosacea. The most common features were erythema (21%) and telangiectasia (18%). Of the subjects with rosacea, 78% had erythematotelangiectatic rosacea and 22% had papulopustular rosacea. Fifteen percent of the study subjects had experienced frequent episodes of flushing without permanent features of rosacea. No significant gender-related differences were found between study groups. In conclusion, according to the NRSEC, rosacea is a more common skin condition over the age of 30 years than previously thought. PMID: 20526544 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20526544&dopt=Abstract = URL to article

Related Articles[Oxidative stress level in patients with rosacea and a rationale for the therapeutic use of an ozone-oxygen mixture] Klin Lab Diagn. 2010 Apr;(4):13-6 Authors: The paper gives information on the possible involvement of pro- and antioxidant imbalance in the pathogenesis of rosacea. Eighty patients with different clinical types of rosacea were examined; the parameters of primary and intermediate products of lipid peroxidation, superoxide dismutase, plasma total antioxidative activity, and protein oxidative modification were studied. Based on the findings, oxidative therapy options for rosacea, treatment with an ozone-oxygen mixture in particular, are proposed. PMID: 20524341 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20524341&dopt=Abstract = URL to article

Related ArticlesNovel photopneumatic therapy for the treatment of rosacea. Ann Dermatol. 2009 Aug;21(3):268-73 Authors: Kim JH, Chang SH, Cho MK, Kim BS BACKGROUND: Rosacea is a common skin condition, but the currently available treatments are not satisfactory. OBJECTIVE: We wanted to assess the efficacy and safety of photopneumatic therapy (PPx), which delivers pneumatic energy and broadband light (400~1,200 nm), for the treatment of erythematotelangiectatic rosacea. METHODS: Twenty two patients with erythematotelangiectatic rosacea were treated 3~5 times with PPx. Three independent dermatologists evaluated the efficacy of PPx by comparing the photographs taken before and after treatment. Patient self-assessment was also done by interviews. RESULTS: The photographic assessment by the dermatologists of the improvement showed that >50% improvement occurred in 64% (14/22) of the patients. The specific categories of improvement were as follows: poor (<25% improvement), 1 patient; fair (25~50% improvement), 7 patients; good (50~75% improvement), 11 patients; and excellent (>75% improvement), 3 patients. Based on the patients' self-assessment, 20 patients (91%) acknowledged an improvement. CONCLUSION: PPx is an effective and safe treatment option for erythematotelangiectatic rosacea. PMID: 20523801 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20523801&dopt=Abstract = URL to article

Related ArticlesClinical evaluation of 168 korean patients with rosacea: the sun exposure correlates with the erythematotelangiectatic subtype. Ann Dermatol. 2009 Aug;21(3):243-9 Authors: Bae YI, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC BACKGROUND: Although rosacea is a chronic cutaneous inflammatory disorder that's commonly seen in adults, the etiology and pathogenesis of the illness remain unclear. A well established diagnostic classification and grading system may play a critical role in performing research and it would serve as a diagnostic reference in the clinical field. OBJECTIVE: We sought to classify the patients with the new standard classification and grading system and we wanted determine the peculiar features and relationships of each subtype. We also analyzed the relationships between the degree of sun exposure and each subtype. METHODS: We reviewed the medical records and clinical photos of 168 patients who were diagnosed with rosacea from 2002 to 2007 at our hospital. The standard classification and grading system suggested by the National Rosacea Society (NRS) Expert Committee was adopted to evaluate each patient's subtype and the severity. RESULTS: The male:female ratio was 1:2.29. The mean age at the time of diagnosis was 47.8 years. The mean duration of disease was 3.5 years. Sun exposure and hot baths/exercise were the two most common precipitating factors, while the majority of patients did not have any specific factor that relieved their symptoms. According to the NRS classification and grading system, the patients were classified into four subtypes. One hundred sixty two (96.4%) patients were diagnosed with the erythematotelangiectatic subtype irrespective of severity. Eighty five (50.6%) patients had the papulopustular subtype and 24 (14.3%) patients had ocular rosacea. Eight (4.8%) patients displayed mild phymatous change. The degree of sun exposure had significant correlation with the development and severity of the erythematotelangiectatic subtype (p<0.05), while it had no correlation with the papulopustular, ocular and phymatous subtypes. CONCLUSION: Although the erythematotelangiectatic subtype was the most common subtype of rosacea, many patients also had other subtypes of rosacea simultaneously. Based on our results, we proved that ocular rosacea is an extension of the clinical spectrum of erythematotelangiectatic rosacea. In addition, the results of our study particularly suggest that sun exposure has a different influence on each subtype of rosacea. PMID: 20523797 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20523797&dopt=Abstract = URL to article

Related ArticlesRosacea fulminans with ocular involvement. Br J Dermatol. 2010 May 28; Authors: Kim TG, Noh SM, Do JE, Lee MG, Oh SH PMID: 20518777 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20518777&dopt=Abstract = URL to article

Related ArticlesInnovative Use of Topical Metronidazole. Dermatol Clin. 2010 Jul;28(3):525-534 Authors: Zip CM Metronidazole is a synthetic nitroimidazole derivative with antimicrobial and antiinflammatory properties. It was the first topical therapy approved solely for rosacea and remains a cornerstone of rosacea management. This article reviews the optimal use of topical metronidazole in the treatment of rosacea and other innovative but off-label dermatologic uses reported in the literature. PMID: 20510762 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20510762&dopt=Abstract = URL to article

Related ArticlesLupus Miliaris Disseminatus Faciei: A case report. Dermatol Online J. 2010;16(5):10 Authors: Esteves T, Faria A, Alves R, Marote J, Viana I, Vale E A 33-year-old man presented to our clinic with asymptomatic red-brown, dome-shaped papules, distributed bilaterally on the central area of the face (forehead, lower portions of the eyelids, nasolabial folds, and perioral areas) these had evolved over a period of about 1 year. A skin biopsy, taken from a lesion on the forehead, revealed an epithelioid cell granuloma with central necrosis and surrounding lymphocytic infiltrate with multinucleate giant cells. The chest X-ray and the results of the laboratory studies were within normal limits; the Mantoux test was negative. The patient was treated with minocycline 100 mg/day for 4 months. There was significant clinical improvement, but papular lesions remained on the forehead. Later on, treatment with systemic steroids for 7 months resulted in the resolution of most lesions. Comment: Lupus miliaris disseminatus faciei (LMDF) is an uncommon, chronic, inflammatory dermatosis characterized by red-to-yellow or yellow-brown papules of the central face, particularly on and around the eyelids. Originally, LMDF was considered to be a variant of lupus vulgaris or a tuberculid because of the histology, but there has been no evidence to date supporting a link to tuberculosis. Some authors consider LMDF to be a granulomatous forms of rosacea. However, our case supports the concept that it is a distinct entity. PMID: 20492827 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20492827&dopt=Abstract = URL to article

Related ArticlesAllergy to pumpkin and crossreactivity to pollens and other foods. Ann Allergy Asthma Immunol. 2010 Feb;104(2):178-80 Authors: La Shell MS, Otto HF, Whisman BA, Waibel KH, White AA, Calabria CW PMID: 20306822 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20306822&dopt=Abstract = URL to article

Related Articles[Erythematotelangiectatic skin--diagnostic difficulties] Ann Acad Med Stetin. 2009;55(1):58-65; discussion 65 Authors: Ratajczak-Stefańska V, Maleszka R, Boer M, Kiedrowicz M Erythematotelangiectatic skin is a common cosmetic and medical problem. Flushing or persistent erythema, teleangiectasias, and occasionally other inflammatory skin lesions can be caused by internal or environmental factors. Certain physiologic reactions and systemic or dermatologic diseases represent internal conditions leading to visible skin flushing in the blush area. Erythematotelangiectatic skin is found in body areas which are particularly exposed to various environmental factors and perform important esthetic functions at the same time. Determination of the main etiopathologic factor responsible for flushing in the blush area precedes the selection of an adequate method of care, correction or treatment of the erythematotelangiectatic skin. The main aim of this study was to analyze fundamental mechanisms of flushing or persistent erythema and their sequellae basing on the literature. Another aim was to review current diagnostic options useful in examining the etiology and severity of erythematotelangiectatic skin symptoms. PMID: 20349593 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20349593&dopt=Abstract = URL to article

Related ArticlesIntense pulsed light in the treatment of non-aesthetic facial and neck vascular lesions: report of 85 cases. J Eur Acad Dermatol Venereol. 2010 May 7; Authors: Campolmi P, Bonan P, Cannarozzo G, Bruscino N, Troiano M, Prignano F, Lotti T Abstract Background Intense pulsed light (IPL) treatment is one of the most effective procedures for patients with non-aesthetic vascular lesions in addition to signs of skin photoageing, and it has been reported as very successful in the treatment of telangiectasias, spider nevi, erythrosis, and above all, rosacea and poikiloderma. Its use is based on the principle of selective photothermolysis, which exploits the haemoglobin absorption peak among its range of wavelengths. Objective The aim of this study is to assess the efficacy and safety of intense pulsed light in treating non-aesthetic vascular skin lesions, especially with regard to poikiloderma of Civatte and rosacea. Methods A total of eighty-five patients, 64 women and 21 men, with 63 non-aesthetic vascular lesions (28 Poikiloderma of Civatte and 35 rosacea), 22 pigmented lesions (UV-related hyperpigmentation of solar lentigo-type) and four precancerous lesions (actinic keratosis, AKs), were treated repeatedly with IPL for 2 years. The patients received a mean of five treatments (range 4-6) at 3-weekly intervals. They were evaluated via clinical observations and professional photographs were taken before each treatment and after 2 weeks, 4 weeks, 3 months, 6 months and 12 months. The outcome of the IPL treatments was evaluated by four independent dermatologists, who were not informed about the study protocol, and who assessed the performance of IPL by dividing the results into four categories: no results, slight improvement, moderate improvement and marked improvement. Results All the patients showed improvements in their overall lesions: 72 lesions (80.9%) achieved a marked improvement, 14 lesions (15.7%) achieved a moderate improvement and three lesions (3.4%) achieved a slight improvement. The results of the 63 non-aesthetic vascular lesions in Rosacea and Poikiloderma of Civatte were: 51 with a marked improvement, 10 with moderate improvement, whereas only two lesions achieved a slight improvement. The improvement of all four actinic keratoses was marked whereas the 22 pigmented lesions obtained a marked improvement in 17 cases, a moderate improvement in four cases and a slight improvement in one case. No undesirable effects were observed. Conclusions Our study confirms how by minimizing side-effects, time and costs, IPL can be effective and safe for the treatment of non-aesthetic facial and neck vascular lesions. PMID: 20477927 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20477927&dopt=Abstract = URL to article

Related ArticlesAcne Rosacea: Effectiveness of 532 nm Laser on the Cosmetic Appearance of the Skin. J Otolaryngol Head Neck Surg. 2010 Jun;39(3):292-6 Authors: Maxwell EL, Ellis DA, Manis H AbstractOBJECTIVE:The aim of the study was to perform a prospective blinded trial to compare the improvement of midface acne rosacea using 532 nm laser therapy with and without a retinaldehyde-based topical application.SETTING:A private clinic and surgicentre specializing in facial plastic surgery.DESIGN:A prospective randomized blinded clinical trial.METHODS:Fourteen patients with type 1 erythematotelangiectatic acne rosacea were enrolled in the study. The side of the face to be treated was chosen randomly. The opposite side of the face served as the control. Patients underwent six treatments with the 532 nm laser, with four sets of photodocumentation over a period of 3 months. Following each treatment, patients were asked to rate their degree of improvement based on a 5-point improvement scale. A final assessment was performed by five separate blinded evaluators.MAIN OUTCOME MEASURES:Final photographic evaluation to assess (1) reduction in overall redness, (2) reduction in visible telangiectasia, (3) difference between left and right sides of the face, and (4) degree of overall skin texture improvement.RESULTS:Three men and eight women completed the study. Six right hemifaces and five left hemifaces were treated. One hundred percent of patients noted a mild to moderate improvement in all signs of type 1 acne rosacea, including overall redness of the face, telangiectasia, and skin texture. The blinded evaluators were able to note a difference between the treated and untreated sides 47% of the time.CONCLUSION:The 532 nm laser combined with the topical retinaldehyde improved overall redness, telangiectasia, and skin texture in acne rosacea patients. The degree of improvement was greater when compared to using the laser alone as the sole treatment modality. PMID: 20470675 [PubMed - in process] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20470675&dopt=Abstract = URL to article