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Related Articles Facial Erythema in an Elderly Man. JAMA Dermatol. 2020 05 01;156(5):587-588 Authors: Navarrete-Dechent C, Busam KJ, Markova A PMID: 32211818 [PubMed - in process] Abstract {url} = URL to article

Related ArticlesOVERVIEW OF TIKTOK'S MOST VIEWED DERMATOLOGIC CONTENT AND ASSESSMENT OF ITS RELIABILITY. J Am Acad Dermatol. 2020 Dec 21;: Authors: Villa-Ruiz C, Kassamali B, Mazori DR, Min M, Cobos G, LaChance A PMID: 33359080 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesInvestigating the relationship between rosacea and use of vasodilatory medications in a hospital-wide population. J Am Acad Dermatol. 2020 Dec 23;: Authors: Abid R, Reid AT, Zafar F, Powers EM, Powers JG PMID: 33359782 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesPediatric rosacea in a patient with a dark phototype: Clinical and dermoscopic features. Clin Case Rep. 2020 Dec;8(12):3257-3259 Authors: Chabchoub I, Litaiem N, Zeglaoui F Abstract Rosacea is rare in children and patients with dark phototype. Dermoscopy helps make the correct diagnosis. Positive family history of rosacea is reported in affected children, which suggests a strong familial inheritance of the disorder. PMID: 33363916 [PubMed] {url} = URL to article

Related ArticlesDoxycycline-Associated Dual Cutaneous Adverse Reaction to the Drug (CARD): Case Report of Concurrent Photosensitivity and Morbilliform Exanthem to Doxycycline. Cureus. 2020 Nov 18;12(11):e11546 Authors: Jacob JS, Cohen PR Abstract Antibiotics have been observed to cause drug-induced reactions. These can include a cutaneous adverse reaction to the drug (CARD) such as photosensitivity. A 51-year-old woman initiated doxycycline monohydrate for rosacea. Within nine days, she developed two different, simultaneous skin rashes: a phototoxic reaction and a morbilliform drug eruption. The medication was stopped; topical and oral corticosteroids were initiated. Within two weeks, her rashes resolved. Common cutaneous adverse reactions to doxycycline include photosensitivity and morbilliform exanthem. Less common skin side effects include bullous eruptions, lupus-like eruptions, pigmentary disorders, and vasculitis. Albeit uncommon, doxycycline-associated dual CARD - such as the photosensitivity and morbilliform exanthem - may occur. PMID: 33365215 [PubMed] {url} = URL to article

Related ArticlesSafety and Efficacy of an Augmented Intense Pulse Light Protocol for Dry Eye Syndrome and Blepharitis. Photobiomodul Photomed Laser Surg. 2020 Dec 28;: Authors: Zhang-Nunes S, Guo S, Lee D, Chang J, Nguyen A Abstract Objective: We evaluated the safety and efficacy of an augmented BroadBand Light (BBL™) protocol on the upper and lower eyelids in improving meibomian gland dysfunction (MGD) and/or dry eye disease (DED). Background: DED, often associated with MGD, can cause significant morbidity and accounts for 3.54 billion U.S. dollars of health care spending yearly. Intense pulsed light (IPL) has been used to treat MGD DED with some success. BBL therapy, a high-quality IPL machine, shows much promise for decreasing inflammation and redness in rosacea, as well as hyperpigmentation from sun damage. Methods: A retrospective medical chart review was performed for MGD DED and/or hyperpigmentation patients who received BBL therapy between January 1, 2015, and February 28, 2020. Inclusion criteria included patients who underwent at least one BBL treatment. Each treatment involved the upper and lower eyelids, as well as cheeks, nose, and face. Each MGD DED subject completed the Ocular Surface Disease Index (OSDI) and underwent pre- and post-treatment standard clinical examinations. Results: Forty-seven patients had treatment without significant adverse effects; all patients with MGD DED reported improvement in their dry eye or blepharitis. BBL was determined to be a safe and effective treatment. There were no changes in visual acuity (p = 0.555) and OSDI scores were improved (p = 0.016). There was one case each of mild corneal/conjunctival abrasion, temporary hyperpigmentation, and two of temporary eyelash thinning. Patients with MGD also showed significant improvement in blepharitis and reduced hordeolum frequency after BBL treatment. Conclusions: This novel IPL/BBL protocol appears safe and effective for treating dry eye and blepharitis. PMID: 33370543 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesAssociation between rosacea and cardiovascular disease: A systematic review and meta-analysis. J Cosmet Dermatol. 2020 Dec 21;: Authors: Zhang J, Yan Y, Jiang P, Liu Z, Liu Y, Liu Y, Wang X, Li M, Xu Y Abstract BACKGROUND: Rosacea and cardiovascular diseases (CVD) are chronic inflammatory disorders. While CVD is the leading cause of mortality globally, increasing evidence indicates that CVD prevalence could be higher among patients with rosacea. AIMS: This review aimed to determine the association between the prevalence of CVD and rosacea. PATIENTS/METHODS: A systematic review of observational studies with controls available in MEDLINE, EMBASE, PubMed, Cochrane, and Web of Science databases was conducted. We performed a pooled meta-analysis using random-effects weighting. Overall, 11 studies met the inclusion criteria, which indicated increased odds for at least one risk factor of CVD, including diabetes, high blood pressure, or dyslipidemia. RESULTS: The pooled meta-analysis indicated an association of rosacea with higher odds of insulin resistance or diabetes (odds ratio [OR], 1.18; 95% confidence interval [CI], 0.97-1.45), high systolic blood pressure (OR, 1.96; 95% CI, 1.35-2.84), dyslipidemia (OR, 1.50; 95% CI, 1.19-1.88), and CVD (OR, 6.65; 95% CI, 2.80-15.76). No publication bias was detected. The effect of confounding factors due to overlapping symptoms and lack of individual-level data were limitations of this review. CONCLUSION: Patients with rosacea have a high risk of CVD. However, further studies are warranted to confirm the association between rosacea and CVD. PMID: 33350031 [PubMed - as supplied by publisher] {url} = URL to article

Related Articles Contact sensitization to cosmetic series of allergens in female patients with rosacea: A prospective controlled study in China. J Cosmet Dermatol. 2020 Dec 22;: Authors: Chen B, Yu F, Chen W, Yao Z, Yang X, Zhang D, Hao F Abstract BACKGROUND: Allergic contact dermatitis to cosmetics (ACDC) complicates the diagnosis and treatment of rosacea, and is increasingly observed in daily practice. AIMS: The present study aimed to identify the contact allergens responsible for ACDC in Chinese female rosacea patients with or without suspected ACDC (SACDC). METHODS: From a total of 1267 women with rosacea, 122 with SACDC, 145 without SACDC, and 100 age-matched healthy controls without rosacea or SACDC were examined on a voluntary basis. Skin patch tests with C-1000 cosmetic series (Chemotechnique Diagnostics, Malmo, Sweden) were conducted, including 20 selected allergens. RESULTS: Positive allergic reaction was found in 85.2% and 33.8% of SACDC and non-SACDC (P < .001), respectively, and 27.0% of healthy volunteers. Most reactions occurred at day 3, and the majority of all the examinees including normal controls reacted to more than 1 allergen. In SACDC patients, leading allergens were methylchloroisothiazolinone/methylisothiazolinone (28.7%), linalool hydroperoxide (27.1%), fragrance mix I (21.3%), methylisothiazolinone (17.2%), limonene hydroperoxides (16.4%), formaldehyde (14.8%), myroxylon pereirae (13.9%), and propolis (10.7%); the overall allergic reaction rate positively correlated with new onset of facial pruritus (P < .001). The occurrence of irritant contact reactions correlated with positive allergic reactions in rosacea patients with or without SACDC (P = .032 or P < .001, respectively). CONCLUSIONS: Preservatives and fragrances are primary culprits for ACDC in Chinese female rosacea patients. Patch testing should be considered in the suspected patients. PMID: 33350569 [PubMed - as supplied by publisher] {url} = URL to article MORE INFORMATION ON COSMETICS

Related Articles Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin. J Drugs Dermatol. 2020 Dec 01;19(12):1181-1183 Authors: Draelos ZD, Gunt H, Zeichner J, Levy S Abstract BACKGROUND: Patients with sensitive skin find topical retinoid use for anti-aging purposes challenging due to irritation. Bakuchiol, a meroterpene from the Psoralea corylifolia seed, has retinol functionality through retinol-like regulation of gene expression. OBJECTIVE: This research examined the tolerability, efficacy, and barrier effects of a nature-based bakuchiol-containing cleanser and moisturizer in subjects with sensitive skin. METHODS: 60 female subjects Fitzpatrick skin types I&ndash;V age 40&ndash;65 years with sensitive mild to moderate photodamaged skin were enrolled in this 12 week study. A sensitive skin panel was constructed: 1/3 eczema/atopic dermatitis, 1/3 rosacea, 1/3 cosmetic intolerance syndrome. Subjects used a nature-based cleanser and moisturizer twice daily and underwent transepidermal water loss (TEWL), corneometry, tolerability assessments, and efficacy assessments at baseline, 5&ndash;10 minutes post-application, and week 4. RESULTS: The skin care products were well tolerated and efficacious (P&lt;0.001) in terms of investigator assessed improvement in visual smoothness, tactile smoothness, clarity, radiance, overall appearance, and global anti-aging. Cheek corneometry measurements demonstrated a statistically significant 16% increase in skin moisture content (P&lt;0.001). CONCLUSION: A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective in individuals with sensitive skin.J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5522. PMID: 33346506 [PubMed - as supplied by publisher] {url} = URL to article Sensitive Skin vs Rosacea

Related Articles Helicobacter pylori and skin disorders: a comprehensive review of the available literature. Eur Rev Med Pharmacol Sci. 2020 Dec;24(23):12267-12287 Authors: Guarneri C, Ceccarelli M, Rinaldi L, Cacopardo B, Nunnari G, Guarneri F Abstract Helicobacter pylori is a Gram-negative bacterium identified for the first time about 30 years ago and commonly considered as the main pathogenic factor of gastritis and peptic ulcer. Since then, it was found to be associated with several gastrointestinal and extra-gastrointestinal diseases. Helicobacter pylori is also associated with many skin disorders including, but not limited to, chronic urticaria, rosacea, lichen planus, atopic dermatitis, psoriasis, pemphigus vulgaris, vitiligo, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, primary cutaneous marginal zone B-cell lymphomas and cutaneous T-cell pseudolymphoma. Literature up to September 2020 shows that clear evidence exists only for some of the mentioned associations, while in the majority of cases, data appear contrasting. The aim of this review is to summarize the available studies on the topic and draw possible conclusions. Further clinical and laboratory studies are needed to assess the real plausibility and relevance of these associations, as well as the possible role of Helicobacter pylori with the underlying pathogenic mechanisms. PMID: 33336746 [PubMed - in process] {url} = URL to article More info on HP

Related ArticlesThe basics of baggy eyelids. Dis Mon. 2020 Oct;66(10):101037 Authors: Khanna S, Phelps PO PMID: 32622676 [PubMed - indexed for MEDLINE] {url} = URL to article

Related ArticlesCarbon Dioxide Laser Resurfacing for Rhinophyma: A Case Report and Discussion of the Literature. J Oral Maxillofac Surg. 2020 Dec;78(12):2296.e1-2296.e7 Authors: Graves LL, Hoopman J, Finn R Abstract Rhinophyma, an unsightly and obstructive skin lesion of the nasal area, can be difficult to treat. Numerous modalities have been tried, including medical, excision, and ablation, with various tools and results. In the present report, we have demonstrated the use of the carbon dioxide (CO2) laser on the nose of a 56-year-old man, with excellent cosmetic results even at 59 months after treatment. Discussion of the disease entity and the advantages and disadvantages of the different treatment options are presented. Given the results shown in our patient, we believe that CO2 laser ablation should be a standard treatment of rhinophyma, given its practicality, predictability, and excellent outcomes. PMID: 32640206 [PubMed - indexed for MEDLINE] {url} = URL to article

Related Articles Flare-up of Rosacea due to Face Mask in Healthcare Workers During COVID-19. Maedica (Bucur). 2020 Sep;15(3):416-417 Authors: Chiriac AE, Wollina U, Azoicai D Abstract COVID-19 (SARS-COV-2) pandemic is associated with aggravation of facial dermatoses caused by professional prophylactic measures, mostly face masks, especially reported in healthcare workers, such as irritant and contact dermatitis, seborrheic dermatitis, rosacea, acne. We present a case of flare-up of rosacea in a nurse working in an Intensive Care Unit for COVID-19 patients, using FFP1 type mask at work and textile or paper mask outside the hospital. PMID: 33312262 [PubMed] {url} = URL to article More Information

Related ArticlesAdenoid Cystic Basal Cell Carcinoma Arising in Rhinophyma. Curr Health Sci J. 2020 Jul-Sep;46(3):309-314 Authors: TaslÎca R, Georgescu CV, PĂtraŞcu V Abstract Adenoid cystic is a rare histological subtype of basal cell carcinoma. Basal cell carcinoma (BCC), the most common form of skin cancer is a slow-spreading tumor with local malignancy, with a high cure rate and favorable prognosis when is diagnosed in the early stages. Rhinophyma is one of the four subtypes of rosacea and it is histopathologically characterized by sebaceous glands hypertrophy. Disseminated annular granuloma (GAD) is a rare inflammatory dermatosis with uncertain etiopathogenesis, clinically represented by papules with annular or arciform aspect. UV radiations aggravates rosacea and are involved in the etiopathogenesis of BCC and can have a triggering or an aggravating effect on GAD. The association of adenoid cystic BCC with rhinophyma it is rare and more than that, the presence of both in association with GAD is not described in medical literature. We present the case of a 78-year old male patient, with personal history of prolonged exposure to UV radiations, that was admitted to the Dermatology for 4 nodular tumors, located on the face. The skin of the nose and menton with thickened, hypertrophied, irregular, red appearance and dilated pores. Also, on the upper limbs and trunk, the patient had, erythematous papules with arciform and ring shape with hypopigmented centers. We performed surgical excision of the tumors and biopsied an annular lesion. Microscopic examination showed nodular basal cell carcinoma with areas of adenoid cystic carcinoma and actinic degeneration of collagen and gigantocellular granulomatous inflammation. The skin biopsied from the upper limb showed annular granuloma appearance. PMID: 33304635 [PubMed] {url} = URL to article

Related Articles Gold photothermal therapy for refractory papulopustular rosacea: A case series. Photodermatol Photoimmunol Photomed. 2020 Dec 11;: Authors: Park KY, Han HS, Park JW, Lee HW, Seo SJ Abstract Rosacea is a common chronic inflammatory cutaneous disease that can severely impair the quality of life. However, despite various treatment options, treatment results are often unsatisfactory, and relapses are common. Thus, new and more effective treatment options are desirable. Photothermal therapy (PTT) is a therapeutic method whereby cancers are ablated by the heat generated from absorbed near-infrared light energy.1 PTT can also be used to treat inflammatory diseases, including acne vulgaris. However, little is known about the efficacy and safety of PTT for treating rosacea. Therefore, we performed a prospective pilot study to evaluate the efficacy and safety of gold nanoshell-mediated PTT for the treatment of refractory papulopustular rosacea (PPR). PMID: 33305395 [PubMed - as supplied by publisher] {url} = URL to article More Information

Related Articles[Pediatric ocular rosacea effectively treated with topical 1.5% azithromycin eye drops]. Ophthalmologe. 2020 Dec 09;: Authors: Starosta DA, Lorenz B Abstract Ocular rosacea in children is a rare but often underdiagnosed condition. It is typically associated with chronic blepharoconjunctivitis, chalazia, corneal opacity and corneal neovascularization. The recommended treatment consists of topical (eyelid hygiene, steroids, cyclosporin, lubricants) and systemic (antibiotics e.g. erythromycin) measures. This case series of 8 children demonstrates the efficacy of local 1.5% azithromycin treatment together with eyelid hygiene in pediatric ocular rosacea. A further advantage of this topical treatment is that the required application of only twice daily for 3 days followed by 7 days without treatment is convenient and improves adherence to treatment. PMID: 33296015 [PubMed - as supplied by publisher] {url} = URL to article

Rosettes in T-cell pseudolymphoma: a new dermoscopic finding. An Bras Dermatol. 2020 Nov 16;: Authors: Alves RG, Ogawa PM, Enokihara MMSES, Hirata SH Abstract Rosettes are small white structures visible with polarized light dermoscopy, whose exact morphological correlation is not yet defined. These small shiny structures are found in several conditions such as scarring, dermatofibroma, molluscum contagiosum, squamous cell carcinoma, basal cell carcinoma, melanoma, melanocytic nevus, discoid lupus erythematosus, and papulopustular rosacea. In this novel report, the authors describe the presence of rosettes in a T-cell pseudolymphoma lesion. PMID: 33288369 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesOpen-label Extension Study Evaluating Long-term Safety and Efficacy of FMX103 1.5% Minocycline Topical Foam for the Treatment of Moderate-to-Severe Papulopustular Rosacea. J Clin Aesthet Dermatol. 2020 Nov;13(11):44-49 Authors: Stein Gold L, Del Rosso JQ, Kircik L, Bhatia ND, Hooper D, Nahm W, Stuart I Abstract BACKGROUND: Efficacy and safety of FMX103 1.5% for papulopustular rosacea were previously demonstrated in two 12-week, Phase 3 studies. OBJECTIVE: We sought to evaluate the safety and efficacy of FMX103 1.5% foam for up to 52 weeks of treatment. METHODS: Following the completion of two 12-week, double-blind, vehicle-controlled, Phase 3 studies, subjects were invited to enter a 40-week open-label extension study in which all subjects applied FMX103 1.5% once daily. Efficacy endpoints were the reduction in inflammatory lesions and the rate of IGA treatment success from the double-blind baseline. Safety assessments included adverse events, vital signs, laboratory tests, and facial tolerability signs and symptoms. RESULTS: The favorable safety profile of FMX103 1.5% observed in the double-blind studies was maintained over extended treatment lasting up to one year. There were no serious treatment-related adverse events. Long-term treatment with FMX103 1.5% was associated with a greater than 82-percent reduction in inflammatory lesions from baseline and with over 79 percent of subjects achieving treatment success. At the end of the open-label treatment period, over 82 percent of subjects indicated they were overall "satisfied" or "very satisfied" with FMX103 1.5%. All facial local tolerability symptoms improved through Week 52. LIMITATIONS: Due to the nature of the open-label study, lacking a vehicle-treated control, no statistical comparisons can be made. CONCLUSION: FMX103 1.5% demonstrated a favorable safety and tolerability profile for up to 52 weeks. Long-term efficacy was demonstrated by progressive reductions in inflammatory lesions and increasing IGA treatment success, suggesting that FMX103 1.5% may be a suitable option for the treatment for papulopustular rosacea. PMID: 33282103 [PubMed] {url} = URL to article

Related ArticlesUpdate on the Management of Rosacea from the American Acne & Rosacea Society (AARS). J Clin Aesthet Dermatol. 2020 Jun;13(6 Suppl):17-24 Authors: Del Rosso JQ, Tanghetti E, Webster G, Stein Gold L, Thiboutot D, Gallo RL Abstract Importance: Previous consensus articles on rosacea from the American Acne and Rosacea Society (AARS) have focused on pathophysiology, clinical assessment based on phenotypic expressions of rosacea, management guidelines, discussions of individual medical therapies, and reviews of physical modalities. Pathophysiologic mechanisms believed to be operative in rosacea have been covered extensively in the literature. Objective: This article updates the previously published consensus recommendations from the AARS on the management of rosacea, including systematic literature and evidence-based reviews of available therapeutic agents and physical modalities. Observations: This article includes discussions of available published data on topical ivermectin, topical oxymetazoline, combination therapy approaches, and physical devices for the management of rosacea. Consistent with what many publications on rosacea currently emphasize, clinicians are encouraged to define the clinical manifestations present in the patient and to select therapies that correlate with the optimal treatment of those manifestations. There are less data available on how to optimally integrate therapies; however, it appears that rationally selected medical therapies can be utilized concurrently. Conclusion: Due to the multifactorial pathogenesis of rosacea, its clinical presentation is heterogeneous. Rosacea is a chronic and recurrent inflammatory disorder, and clinical manifestations often vary in nature and severity over time, which might necessitate an adjustment in treatment. As new data become available, rosacea management approaches should be updated. PMID: 33282106 [PubMed] {url} = URL to article

Immune-mediated diseases and risk of Crohn's disease or ulcerative colitis: a prospective cohort study. Aliment Pharmacol Ther. 2020 Dec 05;: Authors: Lo CH, Khalili H, Lochhead P, Song M, Lopes EW, Burke KE, Richter JM, Chan AT, Ananthakrishnan AN Abstract BACKGROUND: Although immune-mediated diseases (IMDs) including inflammatory bowel diseases (IBDs) are known to cluster, to what extent this is due to common environmental influences is unknown. AIM: To examine the incidence of IBD in individuals with another IMD. METHODS: We used data from the prospective Nurses' Health Study II cohort (1995-2017) to examine the effect of diagnoses of several common IMDs on subsequent risk of Crohn's disease (CD) or ulcerative colitis (UC) using Cox proportional hazards models, adjusting for detailed diet and lifestyle confounders. RESULTS: We documented 132 cases of CD and 186 cases of UC over 2 016 163 person-years of follow-up (median age at IBD diagnosis 50 years). Compared to participants with no history of IMD, the HRs of CD for those with 1 and ≥ 2 IMDs were 2.57 (95% CI 1.77-3.74) and 2.74 (95% CI 1.36 to 5.49), respectively (Ptrend < 0.0001). This association was only modestly attenuated by adjustment for environmental risk factors (HR 2.35 and 2.46, respectively). The risk of UC was not increased, with multivariable-adjusted HRs of 1.22 (95% CI 0.85-1.76) and 1.33 (95% CI 0.67-2.65) for those with 1 and ≥ 2 IMDs, respectively, compared to those with none (Ptrend 0.16) (Pheterogeneity comparing CD and UC 0.037). Asthma, atopic dermatitis, psoriasis and rosacea were individually associated with higher risk of CD (HR ranging from 2.15 to 3.39) but not UC. CONCLUSIONS: Individuals with one or more IMDs are at an increased risk for CD but not UC. PMID: 33280139 [PubMed - as supplied by publisher] {url} = URL to article

investigation of thyroid blood tests and thyroid ultrasound findings of patients with rosacea. Dermatol Ther. 2020 Dec 05;: Authors: Gönülal M, Teker K, Öztürk A, Yaşar FY Abstract BACKGROUND: We aimed to investigate the relationship between rosacea and thyroid diseases by analyzing thyroid blood tests and ultrasound findings of our patients recently diagnosed with rosacea. METHODS: This study was designed as a prospective, single-center study. Dermatological examination findings, lesion locations were recorded, and rosacea clinical scores were calculated for all study group patients. The control group consisted of completely healthy women presented to our hospital during the study period for check-up purposes. Serum free thyroxine, free triiodothyronine, thyroid-stimulating hormone, anti-thyroglobulin antibody, anti-thyroid peroxidase antibody levels were measured, and thyroid ultrasound examinations were performed for all study participants. RESULTS: The entire study cohort consisted of 123 patients (63 cases and 60 controls). There was no significant difference between the groups in terms of mean patient age (p<0,05). Cheek was the most common lesion location (96.8%). There was no difference between the groups in terms of thyroid-related laboratory parameters. However, anti-TPO levels differed significantly with increasing disease severity (i.e., RCSs). There were significant relationships between cheek lesions and fT4 (p=0.021), while nose and chin lesions were associated with fT3 (p=0.01, p=0.001). Thyroid ultrasound findings revealed that rosacea patients tended to have larger thyroid nodules and more heterogeneous thyroid parenchymas than controls. CONCLUSIONS: Our findings indicate that thyroid blood tests, including thyroid autoantibodies, should be tested and thyroid ultrasounds should be performed in patients diagnosed with rosacea. However, these findings need to be validated by prospective studies conducted in larger patient series with more extended follow-up periods. This article is protected by copyright. All rights reserved. PMID: 33280224 [PubMed - as supplied by publisher] {url} = URL to article More Information on Dual-frequency Ultrasound for Rosacea

Related Articles Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment. Sci Adv. 2020 Dec;6(49): Authors: Madhvapathy SR, Wang H, Kong J, Zhang M, Lee JY, Park JB, Jang H, Xie Z, Cao J, Avila R, Wei C, D'Angelo V, Zhu J, Chung HU, Coughlin S, Patel M, Winograd J, Lim J, Banks A, Xu S, Huang Y, Rogers JA Abstract Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication-compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (P AD = 0.0034) and its ability to study impact of topical treatments on skin diseases. PMID: 33277260 [PubMed - as supplied by publisher] {url} = URL to article Wouldn't it be incredible if a non profit patient advocacy grassroots organization sponsored say 1000 rosacea sufferers and another 1000 control group using this new low-cost SHS tool to see if this actually would improve rosacea diagnosis independently from the status quo pharmaceutical sponsored rosacea research being done? What if say, 10K members each donated one dollar and we used the RRDi MAC to help us in sponsoring such an investigation? Rosacea Research in Perspective of Funding

Related Articles Adipokines in the Skin and in Dermatological Diseases. Int J Mol Sci. 2020 Nov 28;21(23): Authors: Kovács D, Fazekas F, Oláh A, Törőcsik D Abstract Adipokines are the primary mediators of adipose tissue-induced and regulated systemic inflammatory diseases; however, recent findings revealed that serum levels of various adipokines correlate also with the onset and the severity of dermatological diseases. Importantly, further data confirmed that the skin serves not only as a target for adipokine signaling, but may serve as a source too. In this review, we aim to provide a complex overview on how adipokines may integrate into the (patho) physiological conditions of the skin by introducing the cell types, such as keratinocytes, fibroblasts, and sebocytes, which are known to produce adipokines as well as the signals that target them. Moreover, we discuss data from in vivo and in vitro murine and human studies as well as genetic data on how adipokines may contribute to various aspects of the homeostasis of the skin, e.g., melanogenesis, hair growth, or wound healing, just as to the pathogenesis of dermatological diseases such as psoriasis, atopic dermatitis, acne, rosacea, and melanoma. PMID: 33260746 [PubMed - in process] {url} = URL to article Cytokines and Rosacea

Related Articl Coptis chinensis Franch Directly Inhibits Proteolytic Activation of Kallikrein 5 and Cathelicidin Associated with Rosacea in Epidermal Keratinocytes. Molecules. 2020 Nov 26;25(23): Authors: Roh KB, Ryu DH, Cho E, Weon JB, Park D, Kweon DH, Jung E Abstract Rosacea is a common and chronic inflammatory skin disease that is characterized by dysfunction of the immune and vascular system. The excessive production and activation of kallikerin 5 (KLK5) and cathelicidin have been implicated in the pathogenesis of rosacea. Coptis chinensis Franch (CC) has been used as a medicinal herb in traditional oriental medicine. However, little is known about the efficacy and mechanism of action of CC in rosacea. In this study, we evaluate the effect of CC and its molecular mechanism on rosacea in human epidermal keratinocytes. CC has the capacity to downregulate the expression of KLK5 and cathelicidin, and also inhibits KLK5 protease activity, which leads to reduced processing of inactive cathelicidin into active LL-37. It was determined that CC ameliorates the expression of pro-inflammatory cytokines through the inhibition of LL-37 processing. In addition, it was confirmed that chitin, an exoskeleton of Demodex mites, mediates an immune response through TLR2 activation, and CC inhibits TLR2 expression and downstream signal transduction. Furthermore, CC was shown to inhibit the proliferation of human microvascular endothelial cells induced by LL-37, the cause of erythematous rosacea. These results demonstrate that CC improved rosacea by regulating the immune response and angiogenesis, and revealed its mechanism of action, indicating that CC may be a useful therapeutic agent for rosacea. PMID: 33256158 [PubMed - in process] {url} = URL to article Full Text: molecules-25-05556.pdf Et Cetera Cathelicidin Peptide LL-37 and Vitamin D3

Related ArticlesParkinson's disease and skin. Parkinsonism Relat Disord. 2020 Nov 20;82:61-76 Authors: Niemann N, Billnitzer A, Jankovic J Abstract Parkinson's disease is associated with a variety of dermatologic disorders and the study of skin may provide insights into pathophysiological mechanisms underlying this common neurodegenerative disorder. Skin disorders in patients with Parkinson's disease can be divided into two major groups: 1) non-iatrogenic disorders, including melanoma, seborrheic dermatitis, sweating disorders, bullous pemphigoid, and rosacea, and 2) iatrogenic disorders related either to systemic side effects of antiparkinsonian medications or to the delivery system of antiparkinsonian therapy, including primarily carbidopa/levodopa, rotigotine and other dopamine agonists, amantadine, catechol-O-methyl transferase inhibitors, subcutaneous apomorphine, levodopa/carbidopa intestinal gel, and deep brain stimulation. Recent advances in our understanding of the role of α-synuclein in peripheral tissues, including the skin, and research based on induced pluripotent stem cells derived from skin fibroblasts have made skin an important target for the study of Parkinson's disease pathogenesis, drug discovery, novel stem cell therapies, and diagnostics. PMID: 33248395 [PubMed - as supplied by publisher] {url} = URL to article