rss

Related ArticlesEvaluation of Botulinum Toxin A as an Optional Treatment for Atopic Dermatitis. J Clin Aesthet Dermatol. 2020 Jul;13(7):32-35 Authors: Khattab FM Abstract OBJECTIVE: Botulinum toxin (BTX) A has different biological activities, including anti-inflammatory and antipruritic behavior. Studies on humans and animals have shown that BTX is efficient in treating itch caused by histamine, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar avoidance. OBJECTIVE: This study sought to assess the impact of BTX-A in patients with atopic dermatitis using scores of SCORAD and to identify parameters linked to greater improvements. METHODS: This was a prospective, intrapatient, left-to-right, randomized, placebo-controlled study of BTX-A for the treatment of atopic dermatitis. The study included 26 patients with atopic dermatitis (12 males and 14 females) with an average age of 37.8 years. Responses to therapy were assessed using SCORAD, Dermatology Quality of Life Index (DLQI), and the worldwide clinical reaction score evaluation. RESULTS: Mean SCORAD values dropped from 50.5 to 11 points (p<0.001); meanwhile, 64.1 percent of patients reported an excellent response, including 78.9 percent of patients with severe AD. The DLQI score fell by 10.15 points (43.5%) in patients treated with BTX-A. A statistically significant reduction in SCORAD and DLQI scores occurred relative to in the placebo group (p<0.001). CONCLUSION: Based on the results of this study, BTX-A appears to be a safe and effective therapy for atopic dermatitis of all grades (mild, moderate, and severe). However, BTX-A appears to be best suited for patients with severe atopic dermatitis. PMID: 32983334 [PubMed] {url} = URL to article

Related Articles Rosacea and Associated Comorbidities: A Google Search Trends Analysis. J Clin Aesthet Dermatol. 2020 Jul;13(7):36-40 Authors: Marchitto MC, Chien AL Abstract BACKGROUND: There is recent evidence linking rosacea to systemic disease. OBJECTIVE: We sought to identify correlations in Google searches (Google LLC, Mountain View, California) for rosacea and comorbid conditions to assess whether the public is seeking information regarding these trends. METHODS: Google search data from January 1, 2004, to February 28, 2018, for rosacea and search terms representing common comorbid conditions were investigated. This analysis included searches occurring in the United States (US), Canada, the United Kingdom (UK), and Australia. Search volume index (SVI) data were plotted over time and Pearson correlation coefficients were calculated from search data to assess for correlations between search terms. RESULTS: The level of interest in rosacea was highest in the spring and lowest in the winter in the US, Canada, and UK. Seasonal search trends in Australia were the inverse of those in northern hemisphere nations. Significant correlations were found between depression and rosacea SVI in the US (R=0.481; p<0.001), dementia and rosacea SVI in the UK (R=0.774; p=0.011), and hypothyroidism and rosacea SVI (R=0.752; p<0.001) in the UK. Additionally, search trends for irritable bowel syndrome (R=0.399; p<0.001) and ulcerative colitis (R=0.514; p=0.032) correlated significantly with rosacea in Canada and the UK, respectively. In Australia, search trends for osteoporosis significantly correlated with rosacea (R=0.394; p<0.001). CONCLUSIONS: Our findings indicate growing interest among the general public regarding rosacea and comorbid diseases, which behooves clinicians to adopt a more comprehensive approach in managing rosacea patients. PMID: 32983335 [PubMed] {url} = URL to article See also Systemic Cormorbidities in Rosacea

Related ArticlesParkinson's Disease and Its Dermatological Associations: Is Your Skin Whispering You a Diagnosis? Cureus. 2020 Aug 22;12(8):e9933 Authors: Shah P, Sagar PR, Alhumaidi N, Bollampally VC, Malik BH Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized clinically by the triad of resting tremor, rigidity, and bradykinesia. Although PD is primarily known for motor disturbance, 98.6% of patients experience one or more non-motor symptoms at all stages of the disease. Dermatological disorders are discussed as common non-motor associations of PD since the 20th century. Many studies have shown that patients of PD are predisposed to skin disorders. This article is a traditional review done to analyze the association between PD and its dermatological manifestations. We did a literature search using six keywords in the PubMed database and took the relevant articles published in the last 10 years. We reviewed more than 100 articles, which also included animal studies. On meticulous review, we observed an increased incidence of certain skin disorders like seborrheic dermatitis, bullous pemphigoid, rosacea, and melanoma in patients of PD. These disorders share either common risk factors or underlying mechanisms revolving around genetics, immunology, inflammation, and pathophysiology of PD, but the exact causation yet seems obscured. We believe that this opens a horizon for more research in the link between the skin and nervous system. We also emphasize that the dermatologists, neurologists and general physicians should address the cutaneous disorders in PD timely, educate their patients, help them lessen the psychosocial distress, and improve their quality of life. PMID: 32968594 [PubMed] {url} = URL to article

Related ArticlesEvolution of surgical modalities in the management of rhinophyma: our experience. Br J Oral Maxillofac Surg. 2020 Aug 22;: Authors: Goh M, Gönen ZB, Sayan A, Ilankovan V Abstract Rhinophyma is a progressive disease of the nose, which is characterised by skin thickening and sebaceous hyperplasia. Patients with rhinophyma are often stigmatised due to worsening disfigurement of their nose. This can also result in functional impairment such as reduced nasal patency. Severe cases of rhinophyma are best managed with varied surgical interventions, as there is no clear 'gold standard' treatment that has been described. We present our experiences in the management of rhinophyma and the evolution of treatment modalities that have been employed over a nine-year period. PMID: 32951923 [PubMed - as supplied by publisher] {url} = URL to article

Occupational Dermatoses Among Frontline Healthcare Workers During the COVID-19 Pandemic: A Cross-Sectional Survey. J Am Acad Dermatol. 2020 Sep 17;: Authors: Trepanowski N, Larson AR, Evers-Meltzer R PMID: 32950541 [PubMed - as supplied by publisher] {url} = URL to article Journal Pre-proof

Related Articles Paired Transcriptomic and Proteomic Analysis Implicates IL-1β in the Pathogenesis of Papulopustular Rosacea Explants. J Invest Dermatol. 2020 Sep 14;: Authors: Harden JL, Shih YH, Xu J, Li R, Rajendran D, Hofland H, Chang ALS Abstract Papulopustular rosacea (PPR) is a chronic inflammatory skin disease with limited treatment options. Although multiple pathways have been described to be upregulated in PPR, a mechanistic understanding of the key drivers and interaction between pathways in PPR pathology is lacking. In this study, we utilized PPR biopsy explants to integrate both differentially expressed genes (DEGs) and differently expressed proteins (DEPs) in paired non-lesional (NL) and lesional (LS) PPR tissue (n=5 patients). The results of this study identified 92 DEGs and 20 DEPs between paired PPR LS and NL explants. MAPK and TNF signaling pathways were the most significantly upregulated pathways in PPR LS tissue and aligned with DEPs identified in this study. Both MAPK and TNF signaling pathways highlighted IL-1β as a potential central mediator to PPR pathogenesis. In support of this, stimulation of NL explants with IL-1β resulted in a transcriptomic and proteomic profile similar to LS PPR. In this integrative transcriptomic and quantitative protein analysis, we identified several inflammatory genes, proteins, and pathways which may be contributing to PPR, as well as highlighted a potential role of IL-1β in driving inflammation in PPR. PMID: 32941918 [PubMed - as supplied by publisher] Full Text {url} = URL to article Interleukin 1 beta (IL-1β) is a cytokine. Cytokines and Rosacea Reply to this TopicThere is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

Fluorescence-advanced videodermatoscopy characterization of demodex mites. A comparison with reflectance confocal microscopy. J Eur Acad Dermatol Venereol. 2020 Sep 14;: Authors: Fernandez-Nieto D, Segurado-Miravalles G, Gonzalez-Cantero A, Ortega-Quijano D, Jimenez-Cauhe J, Boixeda P Abstract Demodex mites (namely D. folliculorum and D. Brevis) are commonly considered commensals of human pilosebaceous units. However, they are thought to play a pathogenic role in several skin conditions, specially pityriasis folliculorum, rosacea, perioral dermatitis and hair folliculitis.1 Several studies report an increased density of demodex mites in patients with rosacea (papulopustular and erythematotelangiectatic forms. PMID: 32924177 [PubMed - as supplied by publisher] {url} = URL to article

Ocular rosacea. Curr Opin Ophthalmol. 2020 Sep 08;: Authors: Redd TK, Seitzman GD Abstract PURPOSE OF REVIEW: To revisit ocular rosacea as an underappreciated condition which can cause permanent blindness if inadequately treated, and to review data supporting improved diagnostic and treatment strategies. RECENT FINDINGS: Ocular rosacea has an underrecognized prevalence in children and individuals with darker skin tone. Rosacea has several associations with other significant systemic diseases. Variations in local and systemic microbiome, including demodex infestation, may play a role in pathogenesis, severity, and in explaining the different phenotypes of rosacea. The National Rosacea Society Expert Committee established an updated classification system of rosacea in 2017. New treatment algorithms based on these clinical subtypes are suggested. SUMMARY: With continued advancements in the understanding of the epidemiology and pathogenesis of rosacea, randomized controlled trials specific for ocular rosacea remain lacking. There is overall consensus that rosacea and ocular rosacea require chronic maintenance treatment strategies involving combination topical and systemic therapies. PMID: 32925255 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesDiagnostic and Therapeutic Challenges. Retina. 2019 Dec;39(12):2419-2422 Authors: Zago LA, Lima LH, Zett C, Sato M, Shiokawa N, Bhatt N PMID: 30461539 [PubMed - indexed for MEDLINE] {url} = URL to article

Ocular Symptoms of Rosacea. Cesk Slov Oftalmol. 2020;75(6):329-333 Authors: Beran D, Stepanov A, Studnička J, Jirásková N Abstract The authors present case reports of two women, who were hospitalized in Department of Ophthalmology, University hospital Hradec Králové for ocular symptoms of rosacea. In the beginning there were relatively severe objective findings in the anterior segment of the eye in both cases - significant cornea graying with superficial and deep cornea vascularization in both eyes. On faces of both patients there were more or less typical sings of general illness. Especially in the first case there were severe papulopustules with crust all over the face. Subjectively Patients describe characteristic symptoms of dry eye. After dermatological consultation local and general anti-inflammatory treatment was set with consequent condition improving in both cases patients. In both cases we use two different general therapy formula according to literature (Azitromycin x Doxyhexal). In one case report, we found distinctive non-compliance during aftercare on our department with serious consequences. The purpose of our report is to point out ocular complications of rosacea and importance of oftalmologist´s and dermatologist´s cooperation during therapy of this illness with can lead to permanent damage of front segment of the eye and significant loss of visual acuity. PMID: 32911949 [PubMed - in process] {url} = URL to article

Microbiota in Rosacea. Am J Clin Dermatol. 2020 Sep 10;: Authors: Kim HS Abstract Rosacea is a complex facial skin condition associated with abnormal inflammation and vascular dysfunction. Next to the known trigger factors, the role of microbiota in the development and aggravation of rosacea continues to raise interest. Demodex folliculorum mites, Helicobacter pylori, Staphylococcus epidermidis, Chlamydia pneumoniae, and the Demodex-associated bacterium, Bacillus oleronius are microbes that have been linked with rosacea. However, the results of studies which assessed their involvement in the disease have been inconsistent and inconclusive. Microbiological research in many different disciplines exploded in recent years as methods to analyze complex microbial communities at the taxonomic and phylogenetic levels became available. Here, we provide an update on the microorganisms implicated in rosacea and review the potential pathogenic role of microbes in the development of rosacea. PMID: 32914214 [PubMed - as supplied by publisher] {url} = URL to article

Severe phymatous rosacea of the nose, cheeks, and chin treated with hydrosurgery. Cutis. 2020 Jul;106(1):37-39 Authors: Bittar JM, Kovach SJ, Ditre CM Abstract Phymatous rosacea is a rare and severe form of rosacea that manifests as disfiguring soft-tissue hypertrophy and sebaceous gland hyperplasia and fibrosis. Most cases are surgically treated; surgical modalities vary, however, ranging from cryosurgery to conventional excision, and consensus guidelines for surgical management do not exist. The Versajet II Hydrosurgery System (Smith-Nephew) is a high-pressure, pulsatile lavage system. We present the case of a 75-year-old man with severe phymatous rosacea of the nose, cheeks, and chin who was successfully treated with the Versajet II Hydrosurgery System, yielding excellent contouring. PMID: 32915934 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesSevere rhinophyma treated by shave excision and electrocautery. BMJ Case Rep. 2020 Jan 13;13(1): Authors: Gupta M, Singh G, Gupta M Abstract Rhinophyma is a rare disease, causing disfiguring soft-tissue hypertrophy of the nose. Various medical and surgical treatment modalities have been tried, with limited success. We report a case of a 76-year-old man, where shave excision of the rhinophymatous tissue was done with satisfactory cosmetic outcome. PMID: 31937630 [PubMed - indexed for MEDLINE] {url} = URL to article

Related ArticlesHormonal Contraceptives and Dermatology. Am J Clin Dermatol. 2020 Sep 07;: Authors: Williams NM, Randolph M, Rajabi-Estarabadi A, Keri J, Tosti A Abstract Hormones play a significant role in normal skin physiology and many dermatologic conditions. As contraceptives and hormonal therapies continue to advance and increase in popularity, it is important for dermatologists to understand their mechanisms and dermatologic effects given the intricate interplay between hormones and the skin. This article reviews the dermatologic effects, both adverse and beneficial, of combined oral contraceptives (COCs), hormonal intrauterine devices (IUDs), implants, injections, and vaginal rings. Overall, the literature suggests that progesterone-only methods, such as implants and hormonal IUDs, tend to trigger or worsen many conditions, including acne, hirsutism, alopecia, and even rosacea. Therefore, it is worthwhile to obtain detailed medication and contraceptive histories on patients with these conditions. There is sufficient evidence that hormonal contraceptives, particularly COCs and vaginal rings, may effectively treat acne and hirsutism. While there are less data to support the role of hormonal contraceptives in other dermatologic disorders, they demonstrate potential in improving androgenetic alopecia and hidradenitis suppurativa. PMID: 32894455 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesTLR3 augments glucocorticoid-synthetic enzymes expression in epidermal keratinocytes; Implications of glucocorticoid metabolism in rosacea epidermis. J Dermatol Sci. 2020 Aug 29;: Authors: Shimada-Omori R, Yamasaki K, Koike S, Yamauchi T, Aiba S Abstract BACKGROUND: While most skin diseases benefit from topical steroids, rosacea symptoms are exacerbated by topical steroids. In the rosacea pathogenesis, abnormal innate immune mechanisms including overexpression of the Toll-like receptor (TLR) have been proposed. However, the links between glucocorticoid metabolism and innate immunity in the epidermis have not been elucidated. OBJECTIVE: In order to understand the pathology by which rosacea symptoms are exacerbated by steroids and environment stimuli, we examined the molecular links between the innate immune system and glucocorticoid synthesis in epidermis. METHODS: We examined the expression of glucocorticoid-synthetic enzymes in rosacea skin. We stimulated epidermal keratinocytes by TLR ligands and examined the regulation of glucocorticoid-synthetic enzymes. We also employed siRNA and adenovirus vectors to knockdown and transduce TLR molecules, respectively. RESULTS: Rosacea epidermis showed high HSD11B1 in the granular layer. Among TLR ligands, TLR3 ligand Poly(I:C) enhanced the expression of multiple glucocorticoid-synthetic enzymes including HSD11B1 and CYP11A1, and increased cortisol in the cultured media. Induction of HSD11B1 by Poly(I:C) was abolished by pretreatment with TLR3 siRNA. Transfection with an adenoviral vector incorporating TLR3 enhanced HSD11B1 and CYP11A1 protein expression by Poly(I:C). In addition, cell staining revealed increased expression of HSD11B1 and CYP11A1 proteins in the group transfected with TLR3 under the same conditions. CONCLUSION: TLR3-stimulated epidermal keratinocytes and rosacea epidermis enhance the expression of glucocorticoid-synthetic enzymes, which would promote cortisol activation in the epidermis. The innate immunity modulates glucocorticoid-synthetic enzymes expression via the TLR3 pathway in epidermal keratinocytes. PMID: 32888783 [PubMed - as supplied by publisher] {url} = URL to article

Related Articles Efficacy and tolerability of a cream containing modified glutathione (GSH-C4), beta-Glycyrrhetic and azelaic acids in mild-to-moderate rosacea: A pilot, assessor-blinded, VISIA and ANTERA 3-D analysis, two-center study (The "Rosazel" Trial). J Cosmet Dermatol. 2020 Sep 03;: Authors: Dall'Oglio F, Puviani M, Milani M, Micali G Abstract INTRODUCTION: Rosacea is a very common, chronic inflammatory disease characterized by flushing, erythema and inflammatory lesions. Increased oxidative stress plays a relevant pathogenetic role in Rosacea. Intracellular Glutathione (GSH) is the main scavenger protective mechanism against increased oxidative stress. An altered GSH metabolism in Rosacea has been described. GSH-C4 is a modified GSH molecule characterized by a better intracellular bioavailability and longer half-life. A daily cream (E-AR) containing GSH-C4 (0.1%) with beta-Glycyrrhetic (0.5%) and azelaic acids (10%), with an SPF of 30, is available. STUDY AIM AND METHODS: In a pilot, prospective, two-center, assessor-blinded study we evaluate the efficacy and the tolerability of E-AR cream in subjects with mild to moderate Rosacea treated for 8 weeks. The main outcomes were the Investigator Global Assessment (IGA) 7-point score (from 0, completely clear; to 6, severe) and the clinical and instrumental erythema severity score (ESS) (from 0 to 4) evaluated in a blinded fashion (randomly coded photographs) at baseline, after 4 (only clinical) and 8 weeks (clinical and instrumental). VISIA evaluation for erythema and lesion counts and ANTERA 3D analysis for skin haemoglobin concentration (a parameter associated with inflammation) were also performed at the same time points. Analysis of primary outcomes was performed on an intention-to-treat basis. Tolerability was evaluated at week 4 and 8 recording spontaneously reported side effects. RESULTS: Thirty subjects (22 women and 8 men; mean age 38 years) were enrolled after their written informed consent. Twenty-six (87%) subjects completed the study phases. Four subjects stopped prematurely the trial due to low skin tolerability (n=3) or lost to follow-up (n=1). At baseline, mean (SD) IGA score was 2.6(0.9). At week 4, IGA score decreased (NS) to 2.3(1.2). IGA score decreased significantly (p=0.0001) at week 8 to 1.2(1) (mean difference 1.3; 95% CI of the difference from 0.9 to 1.7) in comparison with the baseline. The inflammatory mean (SD) lesion count, evaluated clinically, were 5.1(2.5) at baseline, 2.8(1.9) at week 4, and 1.9 (1.7) at week 8 (p=0.0001; ANOVA Test), representing a 63% reduction. This reduction was confirmed by inflammatory lesions count performed on VISIA pictures (from 4.5 at baseline to 1.7 lesions at week 8). Similar evolution was observed for the clinical and instrumental ESS with a reduction of 56% (clinical) and 48% (VISIA), respectively, at week 8 in comparison with the baseline. ANTERA 3D photographs confirmed the positive evolution observed clinically with a significant reduction (-24%) in hemoglobin content: from 1.88 at baseline to 1.44 at week 8. CONCLUSION: This new GSH-C4, beta-glycyrrethic and azelaic acids cream has shown to be efficacious in mild to moderate rosacea subjects. Local tolerability is in line with other anti-rosacea treatments. PMID: 32885541 [PubMed - as supplied by publisher] {url} = URL to article Full text

Related ArticlesA case of primary cutaneous marginal zone lymphoma presenting with rosacea-like eruption. JAAD Case Rep. 2020 Sep;6(9):902-904 Authors: Agnihotri T, Adotama P, Kalowitz-Bieber A, Stokar E, Meehan SA, Latkowski JA PMID: 32875041 [PubMed] {url} = URL to article

Related Articles Morbihan Disease - An Old and Rare Entity Still Difficult to Treat. Acta Dermatovenerol Croat. 2020 Aug;28(2):118-119 Authors: Jerković Gulin S, Ljubojević Hadžavdić S Abstract Morbihan disease (MD), also known as Morbihan syndrome, "solid persistent facial edema and erythema", "rosacea lymphedema", and "solid facial edema in acne", is a rare and often unrecognizable entity, that presents with a slow occurrence of persistent lymphoedema of the upper two-thirds of the face (1,2). A 30-year-old woman presented to our Department with persistent, asymptomatic face edema and erythema lasting for 18 months. She was previously treated for rosacea with doxycycline (100 mg/day for four months) without improvement. Dermatological examination revealed erythematous, nonpitting, solid edema located on the mid-forehead, nose, and cheeks with sparse erythematous papules and pustules on the entire face including the chin and comedones, papules, and pustules on the back (Figure 1 and Figure 2). She was otherwise healthy and was not taking any medication. Laboratory tests with immunological tests and Quantiferon test together with MRI of the orbits, chest X-ray, chest high-resolution computed tomography, cranial X-ray, and abdominal ultrasound were all within normal limits. Histopathology revealed dermal edema, perivascular and peri-adnexal lymphohistiocytic infiltrate, and sebaceous gland hyperplasia. Based on the typical clinical picture, histopathological findings, and the exclusion of several differentials the diagnosis of MD was established. The patient was treated with oral isotretinoin (20 mg/day for eight months) without regression of solid edema and erythema on the face but with complete regression of acne on the trunk. She was started on oral corticosteroids (prednisolone, 20 mg/day for two months followed by reduction of the dose over three months), again with only slight short transient improvement and rapid relapse of facial erythema and edema. The patient refused any other suggested treatment. We treated our patient for a total 2 years and followed up for 5 years. The pathogenesis of MD is still unknown. It is considered a clinical variety or a complication of rosacea or acne which does not tend to regress spontaneously. It is believed that chronic inflammation in patients with MD is due to acne or rosacea causing structural damage to blood and lymph vessels (1,3,4). However, cases of MD without previous history of rosacea and acne have been reported supporting the distinct disease theory (3,4). Edema and erythema are localized on the upper half of the face affecting the forehead, glabella, eyelids, nose, and cheeks. Although the symptoms may come and go, MD usually does not improve without treatment (5). Several therapeutic options have been reported, although there is no established standard treatment for MD. Reported therapy includes short-term oral isotretinoin (0.5 mg/kg/day), long-term oral isotretinoin (40-80 mg/day, 10-24 months), long-term doxycycline, combination of systemic corticosteroids and antibiotic (prednisolone 20 mg/day for 2 weeks and doxycycline 200 mg/day for 12 weeks), slow-releasing doxycycline monohydrate (40 mg/day for 6 months), long-term minocycline (50 mg/day for 4 months), and a combination of both oral retinoid and ketotifen (isotretinoin 0.7 mg/kg/day for 4 months, ketotifen 2 mg/day for 4 months) (1,2,6,8). The disease is frequently recalcitrant to therapy, and only several cases of successfully treated patients with MD have been reported (1,2,4, 6-8). We presented a patient with characteristic features of MD, which is a persistent, cosmetically disturbing condition, unfortunately mostly refractory to therapeutic measures. PMID: 32876040 [PubMed - in process] {url} = URL to article More on Morbihan disease

Related Articles Surgical treatment of rhinophyma using an ordinary bur. Arch Craniofac Surg. 2020 Aug;21(4):264-267 Authors: Kang JK, Lee JS, Choi JH, Shin MS, Yun BM Abstract Rhinophyma is a painless benign tumor of the skin of the nose. It is the most severe form of rosacea. Rhinophyma is particularly rare among Asians. It can be treated with surgical resection using various methods, including scalpel excision, dermabrasion, cryosurgery, argon laser, carbon dioxide laser, and electrocautery. However, the gold standard treatment of rhinophyma remains unknown. In the present case, we debulked a giant rhinophyma with a scalpel and contoured it using a bur. Along with a relevant literature review, we present a case of rhinophyma in an Asian patient who was treated at no additional cost using a bur widely used in general plastic surgery. PMID: 32867419 [PubMed] {url} = URL to article image courtesy of Wikimedia Commons

Related ArticlesEyelid nodules in idiopathic facial aseptic granuloma. Arch Soc Esp Oftalmol. 2020 Aug 28;: Authors: Galindo-Ferreiro A, Marqués-Fernández VE, Juárez Martín Á, González-Márquez PI, Vega-Gutiérrez J Abstract Idiopathic facial aseptic granuloma (IFAG) is a recently described and rare condition. It is considered a form of infantile granulomatous rosacea. IFAG with facial and eyelid nodules is very rare. A description is presented of 3cases of IFAG eyelid nodules. They concern healthy children with no history of trauma. Biopsy examination revealed non-caseating inflammatory granulomas. Different medical treatments have been tried that seem to accelerate its healing, although its tendency is spontaneous resolution within several months. Painless recurrent eyelid nodules can be confused with chalazion. The diagnosis of IFAG should be considered in chronic eyelid nodules. PMID: 32868084 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesRetrospective Study of Factors Affecting Efficacy of Therapy with Dye Pulsed Light for Erythematotelangiectatic Rosacea. Dermatol Ther (Heidelb). 2020 Aug 31;: Authors: Zhao L, You C, Chen H, Wang J, Cao J, Qi M, Hou S, Zheng X, Shao L, Liu Q Abstract INTRODUCTION: Dye pulsed light (DPL) was proven to be effective at treating erythematous and telangiectatic skin disorders. However, there are limited data on the efficacy of DPL treatment for erythematotelangiectatic rosacea (ETR), and researchers do not fully understand the factors that may affect the efficacy. Here, we performed a study to investigate the efficacy of DPL treatment for ETR and determine the factors affecting that efficacy. METHODS: Sixty-five patients with ETR underwent three treatment sessions with DPL at 4-week intervals and were followed up at 4 weeks after the last treatment session. Skin type, sex, age, lesion site, severity of erythema and telangiectasia, VISIA percentile ranking, clinical photographs and red area images were recorded at baseline. The post-treatment erythematous and telangiectatic scores and VISIA percentile rankings were recorded, and the effects of different personal and clinical factors on the efficacy were statistically analysed. RESULTS: The erythema and telangiectasia scores and VISIA percentile rankings showed significant improvement after the DPL procedures (p < 0.01). With regard to erythema, treatment efficacy was not affected by any of the investigated variables, including pre-treatment erythema scores, skin type, pre-treatment VISIA percentile ranking, sex, age and lesion site (p > 0.05). With regard to telangiectasia, the treatment efficacy was greater for mild telangiectasia than for severe telangiectasia (odds ratio = 4.14, p < 0.05). There was no significant difference in treatment efficacy between the moderate and severe categories (odds ratio = 4.00, p > 0.05). CONCLUSION: DPL is not the optimal procedure for treating severe telangiectasia in patients with ETR, whereas the efficacy of the treatment for erythema was not affected by the severity of the condition. PMID: 32865718 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesSerum zinc levels and efficacy of zinc treatment in acne vulgaris: a systematic review and meta-analysis. Dermatol Ther. 2020 Aug 29;:e14252 Authors: Yee BE, Richards P, Sui JY, Marsch AF Abstract BACKGROUND: Oral and topical zinc have been used for the treatment of acne, but there is a lack of definitive evidence for their efficacy. OBJECTIVES: To (1) determine if mean serum zinc levels differ between acne patients and controls and (2) to determine the efficacy of zinc preparations in the treatment of acne. METHODS: A systematic review and meta-analysis was performed according to recommended PRISMA [Preferred Reporting Items for Systematic Reviews and Meta-Analyses] guidelines. RESULTS: Subjects with acne had significantly lower serum zinc levels compared to controls. Patients who were treated with zinc had a significant improvement in mean inflammatory papule count compared to those who were not treated with zinc. There was no significant difference in the incidence of side effects in zinc supplementation versus comparators. CONCLUSIONS: Acne patients have decreased serum zinc levels. Zinc is effective for the treatment of acne, particularly at decreasing the number of inflammatory papules, when used as monotherapy or as an adjunctive treatment. This article is protected by copyright. All rights reserved. PMID: 32860489 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesReadability, quality, and timeliness of online health resources for rosacea. Int J Dermatol. 2020 Aug 28;: Authors: Yee D, Modiri O, Shi VY, Hsiao JL PMID: 32857386 [PubMed - as supplied by publisher] {url} = URL to article

Related ArticlesRhinophyma: Prevalence, Severity, Impact and Management. Clin Cosmet Investig Dermatol. 2020;13:537-551 Authors: Chauhan R, Loewenstein SN, Hassanein AH Abstract Rhinophyma is an advanced stage of rosacea affecting the nasal soft tissues and resulting in disruption of the nasal architecture, airway obstruction, and disfigurement of the nasal aesthetic units. Rhinophyma presents with hypertrophy of the nasal soft tissues, erythema, telangiectasias, nodules, and lobules with a bulbous appearance. Significant psychosocial morbidity is associated with the disease. Understanding of this disease has improved and multiple treatment options exist. The article is a review of the literature to evaluate the pathophysiology, clinical presentation, and epidemiology of keywords "rhinophyma" and "rosacea" using an OVID Medline and PubMed search along with a systematic review of outcomes pertaining to treatment of rhinophyma with laser therapy, scalpel excision, and the subunit method using an OVID Medline search. The subunit method has the highest complication and revision rates followed by carbon dioxide laser therapy. Outcomes between carbon dioxide laser and scalpel therapy and electrocautery are equivalent. Scalpel excision is a more cost-effective treatment modality with less post-operative complications; however, it risks poor hemostasis intraoperatively. Patient satisfaction is common post-therapy regardless of the treatment method. Over 89% of patients would recommend undergoing treatment for rhinophyma irrespective of treatment type. Treatment options vary, and choice of treatment can be dependent on practitioner and patients' treatment goals. PMID: 32848439 [PubMed] {url} = URL to article

Related ArticlesCutaneous angiosarcoma of the head and neck resembling rosacea: A case report. SAGE Open Med Case Rep. 2020;8:2050313X20940419 Authors: Wong A, Flores J Abstract Angiosarcoma is a malignant endothelial cell tumor that involves a variety of anatomic sites with the skin being the most common. Cutaneous angiosarcoma is a diagnostic challenge as it can be confused with lesions such as rosacea, hemangiomas and hematomas. Since the tumor has a propensity for early metastasis and extensive intradermal spread, early diagnostic intervention via punch biopsy may prevent delays in diagnosis and improve tumor resectability and prognosis. We present a case of cutaneous angiosarcoma on the nose and cheeks of a 75-year-old male that resembled rosacea. PMID: 32850127 [PubMed] {url} = URL to article