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    The RRDi Medical Advisory Consultants list (46 RRDi MAC Members) is in alphabetical order by last name. For more information.

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    • rss
      PubMed RSS Feed - -Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics

      By rss · Posted

      Ecotoxicol Environ Saf. 2025 Jun 30;302:118587. doi: 10.1016/j.ecoenv.2025.118587. Online ahead of print. ABSTRACT The increasing environmental detection of antidepressants such as amitriptyline (AT) has raised toxicological concerns, yet its long-term safety profile remains poorly characterized. We applied an integrative strategy combining phenome-wide association studies (PheWAS), Mendelian randomization (MR), network toxicology, and molecular docking to systematically evaluate potential adverse effects of AT. PheWAS analyses were performed across 784 phenotypes using UK Biobank and FinnGen (R10). Among these, loss-of-function mutations in AT targets SLC6A2 and SLC6A4 showed significant associations after multiple-testing correction with pancreatic cancer and erythematous conditions, respectively. Complementary MR analyses using GTEx v8 tissue-specific cis-expression quantitative trait loci (eQTLs) and multiple autoimmune and inflammatory genome-wide association study (GWAS) datasets demonstrated that elevated expression of SLC6A2 and SLC6A4 conferred protective effects against systemic lupus erythematosus, psoriasis, rosacea, and erythema nodosum across tissues, supporting the causal relevance of these pathways. Network toxicology based on protein-protein interactions (STRING v11.5, Cytoscape v3.10.1) and functional enrichment (ClusterProfiler v4.10.0) highlighted immunoinflammatory, neuroendocrine, and ion channel regulatory mechanisms potentially involved in AT-induced toxicity. Finally, molecular docking simulations (AutoDock Vina v1.2.7, AlphaFold structures) provided structural evidence for AT interactions with key targets including TRPV1. Collectively, these findings suggest that pharmacological inhibition or environmental accumulation of AT may contribute to inflammatory skin reactions and pancreatic tumorigenesis through multiple converging molecular pathways. PMID:40592148 | DOI:10.1016/j.ecoenv.2025.118587 {url} = URL to article
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      PubMed RSS Feed - -Marginal zone lymphoma masquerading as phymatous acne rosacea: a case study

      By rss · Posted

      Skin Health Dis. 2025 Apr 11;5(3):231-235. doi: 10.1093/skinhd/vzaf026. eCollection 2025 Jun. ABSTRACT Marginal zone lymphoma (MZL) is an indolent B-cell lymphoma characterized by considerable heterogeneity in clinical presentation. Cutaneous MZL typically manifests as papules, plaques or nodules, often affecting the trunk and arms. Rare cases of MZL presenting as acne rosacea have been reported; however, these have been primarily reported as granulomatous rosacea. Specific evidence of MZL presenting as phymatous acne rosacea is extremely rare and not well documented in the medical literature. We report a rare case of primary systemic nodal MZL manifesting alongside cutaneous extra-nodal MZL, mimicking rhinophymatous and otophymatous acne rosacea. An 84-year-old White man with a 13-year history of nodal MZL, under active monitoring, presented with erythematous, swollen lesions on the ears and nose. This was initially diagnosed as acne rosacea; however, conventional treatment proved ineffective, and the patient was referred for dermatological evaluation. A skin biopsy from the earlobe revealed a diffuse infiltrate of small lymphoid B cells, positive for CD20, CD79a and BCL2, and negative for CD5 and CD23, consistent with cutaneous MZL. Further imaging revealed systemic involvement, with enlarged lymph nodes above and below the diaphragm and splenomegaly. The patient was started on R-CVP chemotherapy (rituximab, cyclophosphamide, vincristine and prednisolone), leading to significant improvement in both the skin lesions and systemic disease. However, due to chemotherapy intolerance, treatment was discontinued after four cycles. This case highlights a rare presentation of MZL, mimicking the features of phymatous acne rosacea, particularly rhinophyma and otophyma. The resemblance to rosacea, particularly phymatous subtypes, leads to initial misdiagnosis and delays in appropriate treatment. This underlines the importance of considering alternative diagnoses in patients with atypical or nonresponsive dermatological conditions, especially when conventional therapies fail. Early biopsy and histological evaluation are critical for ensuring timely diagnosis and treatment, potentially improving patient outcomes. PMID:40584956 | PMC:PMC12202875 | DOI:10.1093/skinhd/vzaf026 {url} = URL to article
    • rss
      PubMed RSS Feed - -AI-augmented differential diagnosis of granulomatous rosacea and lupus miliaris disseminatus faciei: A 23-year retrospective pilot study

      By rss · Posted

      PLoS One. 2025 Jun 30;20(6):e0326763. doi: 10.1371/journal.pone.0326763. eCollection 2025. ABSTRACT Granulomatous rosacea (GR) and lupus miliaris disseminatus faciei (LMDF) exhibit overlapping clinical features, making their differentiation challenging. While histopathological examination remains the gold standard, it is invasive and time-consuming, highlighting the need for non-invasive diagnostic approaches. This study evaluates artificial intelligence (AI)-based models for differentiating between GR and LMDF and assess their impact on clinician performance. This retrospective pilot study included 96 patients (62 GR, 34 LMDF) with histopathologically confirmed diagnoses. Neural network models, including convolutional neural networks and vision transformers (ViT), were applied to cropped lesion images while a transformer-based multiple instance learning (TransMIL) approach was used for whole-image analysis. Diagnostic accuracy was also compared between clinicians with and without AI assistance. ViT_base_patch16_224 achieved the highest accuracy (93.0%) and reliability (κ = 0.81) on cropped images, while the TransMIL reached 70% accuracy on whole images. AI augmentation significantly improved clinicians' diagnostic accuracy from 64.7% to 70.3% (p = 0.0136), with the greatest improvement observed among general practitioners. Additionally, mean diagnostic time decreased from 10.7 to 6.4 minutes. These findings highlight the potential of AI models, particularly ViT, in facilitating the differential diagnosis of GR and LMDF. AI-augmented diagnosis improved accuracy and efficiency across all clinician expertise levels, supporting its integration as a complementary tool in dermatological practice. PMID:40587564 | PMC:PMC12208491 | DOI:10.1371/journal.pone.0326763 {url} = URL to article
    • rss
      PubMed RSS Feed - -3D-printed hydrogel patch for controlled topical release: Gelatin/tannic acid formulation meets additive manufacturing

      By rss · Posted

      Eur J Pharm Biopharm. 2025 Jun 25:114802. doi: 10.1016/j.ejpb.2025.114802. Online ahead of print. ABSTRACT Prolonged use of protective masks can cause skin issues like rosacea and "maskne," particularly among healthcare workers. Poorly fitting commercial dressings often worsen these problems. A novel solution involves 3D-printing personalized hydrogel patches with active ingredients, with customizable designs, concentrations, and controlled release rates. This study explores customizable 3D-printed gelatin/ tannic acid hydrogel patches containing metronidazole for rosacea or salicylic acid for maskne treatment. Rheological properties, including gelation temperature, viscosity at gelation temperature, gelation time, and viscosity during printing, were analysed. Optimal printing conditions were determined using a Quality by Design approach with Design of Experiments framework. Three patch designs-occlusive, grid, and triangular infill-were 3D-printed. Mechanical properties were assessed via tensile strength tests, and in vitro studies evaluated the release profiles and permeation of the active ingredients. The gelatin/tannic acid and gelatin/tannic acid-metronidazole hydrogels had similar gelation temperatures, while the salicylic acid hydrogel gelled at a lower temperature. All formulations had comparable viscosities at gelation, and gelation times (∼20 s). Optimal print conditions were 42 °C, 25 Psi, and 30 mm/s gelatin/tannic acid and metronidazole hydrogels, and 36 °C and 30 Psi for the salicylic acid formulation. Infill patterns affected mechanical properties and drug release, with grid patterns showing stronger structures and higher drug release rates compared to triangular patterns. In vitro permeation tests revealed salicylic acid penetrated the epidermal barrier and accumulated within the skin, despite low overall retention of both active ingredients. These findings highlight the potential of personalized 3D-printed patches for treating mask-related skin conditions. PMID:40578492 | DOI:10.1016/j.ejpb.2025.114802 {url} = URL to article
    • rss
      PubMed RSS Feed - -Comorbidities Associated With Lichen Planopilaris: A Systematic Review and Meta-Analysis

      By rss · Posted

      Int J Dermatol. 2025 Jun 27. doi: 10.1111/ijd.17925. Online ahead of print. ABSTRACT Lichen planopilaris (LPP) is a primary cicatricial alopecia suggested to be associated with various comorbid medical conditions, including autoimmune, endocrine, and metabolic disorders. However, there is conflicting data regarding these associations. This study quantitatively evaluated the prevalence and odds of comorbidities among patients with LPP. PubMed/MEDLINE, EMBASE, Cochrane Library, and Web of Science were searched from inception to December 25, 2023, to include observational studies reporting prevalent/incident cases of at least one comorbidity in LPP patients. The study adhered to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). Risk-of-bias assessment was performed using the Newcastle-Ottawa scale. Random-effect models were utilized to analyze available data. Of the 2535 studies screened, 59 studies were included for meta-analysis, comprising 15,178 LPP patients and 64,735,181 non-LPP controls. Among LPP patients, comorbidities with the highest risk (odds ratio, OR [95% confidence interval, Cl]; prevalence) compared with non-LPP controls and data available from more than one study included lichen planus (15.78 [1.79-139.30]; 6.5%), psoriasis (3.55 [1.10-11.51]; 4.3%), rosacea (3.15 [2.25-4.40]; 10.4%), melanoma (3.11 [1.41-6.87]; 2.3%), systemic lupus erythematosus (3.06 [2.29-4.09]; 1.8%), cutaneous squamous cell carcinoma (3.04 [1.64-5.66]; 4.8%), vitiligo (2.89 [1.60-5.24]; 2.0%), coronary artery disease (1.66 [1.46-1.88]; 7.6%), rheumatoid arthritis (1.50 [1.22-1.84]; 3.5%), hypothyroidism (1.48 [1.12-1.96]; 17.8%), thyroiditis (1.26 [1.08-1.48]; 3.9%), and iron deficiency anemia (1.18 [1.05-1.33]; 9.1%). LPP is significantly associated with autoimmune disorders, thyroid diseases, and skin cancer. Further investigation is required to elucidate the underlying pathogenesis and establish appropriate screening criteria. PMID:40579650 | DOI:10.1111/ijd.17925 {url} = URL to article
    • rss
      PubMed RSS Feed - -Novel Molecular Subtyping Revealed Molecular Pathways That Contribute to the Pathogenesis of Rosacea

      By rss · Posted

      J Dermatol. 2025 Jun 26. doi: 10.1111/1346-8138.17798. Online ahead of print. ABSTRACT The latest progress in rosacea research over the past two decades has revealed important limitations of the current clinical subtyping approach. A new framework of rosacea molecular subtyping is urgently needed to gain insight into the pathogenesis of rosacea. Here, we propose a novel molecular subtype of rosacea based on pathogenetic progression using gene set enrichment analysis (GSEA) and consensus clustering analysis. We identified molecular pathways that contribute to the severity of rosacea. Specifically, the renin angiotensin system (RAS) pathway contributes to erythema and flushing in the mild stage, and the gradual activation of inflammatory pathways and decreased metabolism and biosynthesis were found to be correlated with the severity of rosacea. In addition, angiogenesis and neutrophil activation may contribute to persistent erythema and a large number of papules and pustules in the severe stage of rosacea. Finally, the transcription factor (TF) regulatory network revealed that the key TFs (ETV4, ETS1, USF1, IFR1, NFKB1, and STAT1) and their targets regulated the RAS, inflammatory, and angiogenesis pathways, contributing to the pathogenesis of rosacea. This work correlated molecular subtyping of rosacea with its pathogenetic progression, which provided insight into the pathogenesis and therapeutic strategies for rosacea patients of different severity. PMID:40567003 | DOI:10.1111/1346-8138.17798 {url} = URL to article
    • rss
      PubMed RSS Feed - -Exploring the neural basis of rosacea: altered brain activity and its links with social anxiety

      By rss · Posted

      Clin Exp Dermatol. 2025 Jun 25:llaf291. doi: 10.1093/ced/llaf291. Online ahead of print. ABSTRACT BCAKGROUND: Rosacea is a chronic dermatological condition primarily affecting the face, known for its links to the central nervous system and significant social impact. However, the specific neurological underpinnings remain largely unexplored. OBJECTIVE: To investigate the brain activity changes of rosacea and their links with clinical symptoms and psychosocial measurements. METHODS: This cross-sectional study included 32 treatment-naïve female patients with rosacea and 29 age- and gender-matched healthy controls. Neuroimaging, clinical, and psychosocial assessments were conducted. Resting-state functional magnetic resonance imaging (rs-fMRI) data were analyzed for amplitude of low-frequency fluctuations (ALFF). We examined associations between ALFF and clinical symptoms and psychosocial measures. RESULTS: Increased ALFF was observed in the prefrontal cortex (PFC) of patients with rosacea, particularly in the right superior frontal gyrus (SFG) and left orbital middle frontal gyrus (ORBmid) (voxel level P < 0.001, cluster level P < 0.05). The right SFG's ALFF values were positively correlated with erythema scores (r = 0.395; P < 0.05). Meanwhile, activity in the left ORBmid correlated significantly with Social Avoidance and Distress Scale (SADS) (r = 0.528; P < 0.01) and Social Appearance Anxiety Scale (SAAS) (r = 0.535, P < 0.01) scores. Mediation analysis showed that appearance anxiety mediates the association between left ORBmid's ALFF values and social avoidance (indirect effect = 0.217, 95% CI, (0.022, 0.440); P < 0.05). CONCLUSIONS: This study offers novel insights into rosacea's neuropathology, linking PFC activity with physical and psychosocial symptoms. The findings underscore the potential of targeting neuro-psycho-social aspects in comprehensive rosacea management. PMID:40561524 | DOI:10.1093/ced/llaf291 {url} = URL to article
    • rss
      PubMed RSS Feed - -Efficacy of Widely Used Topical Drugs for Rosacea: A Systematic Review and Meta-Analysis

      By rss · Posted

      Actas Dermosifiliogr. 2025 Jun 17:S0001-7310(25)00443-0. doi: 10.1016/j.ad.2025.06.004. Online ahead of print. ABSTRACT Topical interventions for rosacea are often used to relieve local symptoms. However, currently, there are few articles to systematically analyze the efficacy profile of topical drugs for rosacea. This study aimed to investigate the efficacy profile of widely used topical drugs. To acquire appropriate information from related literature, we looked into 4 databases. Efficacy was appraised with the Investigator Global Assessment, Clinician's Erythema Assessment, Patient's Self-Assessment and Subject Self-Assessment of Rosacea Facial Redness scales. Treatment-emergent adverse events and dermal tolerability were also recorded. According to 21 randomized controlled trials included, a total of 6 topical drugs including minocycline, ivermectin, azelaic acid, metronidazole, brimonidine and oxymetazoline were reported. These drugs are well-tolerated and safe. Ivermectin is more effective than azelaic acid and metronidazole. Azelaic acid has a better efficacy profile than metronidazole according to included studies. Minocycline turned out to be effective improving the symptoms of rosacea. Brimonidine and oxymetazoline both have significant effects on reducing facial redness. PMID:40553721 | DOI:10.1016/j.ad.2025.06.004 {url} = URL to article
    • rss
      PubMed RSS Feed - -Epidemiology of Skin Diseases in Poland: Analysis of Prevalence and Risk Factors: A Cross-Sectional Study

      By rss · Posted

      Dermatol Ther (Heidelb). 2025 Jun 21. doi: 10.1007/s13555-025-01464-5. Online ahead of print. ABSTRACT INTRODUCTION: Although skin diseases are a significant public health concern, epidemiological data for Poland is still lacking. This study aimed to fill this scientific gap by analyzing the prevalence of skin diseases and associated risk factors in the Polish population. METHODS: A cross-sectional study was conducted using data from the National Healthy Skin Test (2023), an online questionnaire distributed via the Medonet health platform, involving 27,000 adult Polish internet users. Participants self-reported physician-diagnosed skin conditions. The prevalence of these conditions was assessed, and statistical analysis, including logistic regression, was used to evaluate associations with demographic and socioeconomic factors (age, gender, education level, and urbanization). RESULTS: The most prevalent skin conditions were herpes labialis (40.6%), dandruff (37.6%), hair loss (34.8%), and acne (32.7%), with 89.5% of participants reporting at least one condition. Striking gender differences were observed, with psoriasis (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.80-2.30) and tinea pedis (OR = 2.10, 95% CI: 1.90-2.30) in men, while women were more prone to rosacea (OR = 0.6, 95% CI: 0.50-0.70) and hair loss (OR = 0.70, 95% CI: 0.60-0.70). Higher education was unexpectedly associated with an increased risk of multiple conditions, including acne (OR = 1.50, 95% CI: 1.40-1.60) and non-melanoma skin cancer (OR = 1.40, 95% CI: 1.20-1.80), but a decreased risk of psoriasis (OR = 0.90, 95% CI: 0.80-1.00). Urban residents of cities with > 500,000 inhabitants showed a significantly higher prevalence of atopic dermatitis/eczema (OR = 1.20, 95% CI: 1.00-1.30) and non-melanoma skin cancer (OR = 2.00, 95% CI: 1.40-2.90) compared with other areas. CONCLUSIONS: This first overview of skin disease epidemiology in Poland reveals significant variations in prevalence based on demographic and socioeconomic factors. These findings have important public health implications, suggesting the need for: (1) gender-specific dermatological education campaigns, (2) age-targeted skin cancer screening programs for those over 65 years, (3) improved access to dermatological care in rural areas, and (4) educational interventions addressing the observed socioeconomic disparities in disease prevalence and detection. PMID:40543011 | DOI:10.1007/s13555-025-01464-5 {url} = URL to article
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      PubMed RSS Feed - -Efficacy and safety of repetitive transcranial magnetic stimulation in treating erythematotelangiectatic rosacea: a single-center, randomized, double-blind, sham-controlled device trial

      By rss · Posted

      J Am Acad Dermatol. 2025 Jun 19:S0190-9622(25)02367-9. doi: 10.1016/j.jaad.2025.06.040. Online ahead of print. NO ABSTRACT PMID:40543669 | DOI:10.1016/j.jaad.2025.06.040 {url} = URL to article
    • rss
      PubMed RSS Feed - -N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease

      By rss · Posted

      Diabetes Metab Res Rev. 2025 Jul;41(5):e70060. doi: 10.1002/dmrr.70060. ABSTRACT N-lactoyl amino acids (Lac-AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various biochemical processes. This narrative review aims to provide a comprehensive overview of the current understanding of Lac-AA, emphasising their biosynthesis, physiological roles, and potential implications in various diseases. We discuss the discovery of Lac-AA as signalling molecules, and their involvement in exercise-induced appetite suppression, energy metabolism, and other pathways. This review explores the complex relationship between Lac-AA and various pathological conditions, including mitochondrial disorders, type 2 diabetes, phenylketonuria, cancer, and rosacea. We also examine the interplay between Lac-AA and the gut microbiota, as well as their association with metformin treatment. Furthermore, we address the ongoing debate regarding whether Lac-AA are merely reflections of lactate and amino acid levels or independent signalling molecules. This review synthesises the latest research findings, highlights the significance of Lac-AA in metabolic research, and identifies promising avenues for future investigation in this rapidly evolving field. PMID:40534243 | PMC:PMC12177442 | DOI:10.1002/dmrr.70060 {url} = URL to article
    • rss
      PubMed RSS Feed - -RETRACTION: Correlation between Cigarette Smoking and Alcohol Consumption and Rosacea: A Two-Sample Mendelian Randomization Study

      By rss · Posted

      Skin Res Technol. 2025 Jun;31(6):e70194. doi: 10.1111/srt.70194. NO ABSTRACT PMID:40534590 | PMC:PMC12177413 | DOI:10.1111/srt.70194 {url} = URL to article
    • rss
      PubMed RSS Feed - -Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment

      By rss · Posted

      Clin Cosmet Investig Dermatol. 2025 Jun 12;18:1459-1470. doi: 10.2147/CCID.S525787. eCollection 2025. ABSTRACT Rosacea is a common dermatological disease, and the complexity of its etiology and pathogenesis makes conventional treatment of rosacea difficult. Small-molecule drugs are a new option for the treatment of rosacea. Based on its good efficacy, convenience of use, affordable price and other advantages, more and more small-molecule drugs are used in the treatment and management of rosacea, involving a variety of molecular pathways, including JAK/STAT signaling pathway, TRPV, TLR2-KLK5-LL37 and mTOR pathways, Th1/Th17-IL17, PED-4, AhR and MRGPRX2. However, the specific treatment mechanism and research progress have not been systematically elucidated. This review summarizes the latest advances in small molecules targeting key inflammatory pathways in rosacea, provides new ideas for the treatment of rosacea and new directions for the clinical management of rosacea. In addition, we need to pay attention to individual differences in patients, the side effects of drugs and formulations. Therefore, further research on small-molecule drugs for the treatment of rosacea is very necessary. PMID:40529547 | PMC:PMC12170860 | DOI:10.2147/CCID.S525787 {url} = URL to article
    • rss
      PubMed RSS Feed - -Lupus miliaris disseminatus faciei: A unique presentation with extrafacial involvement

      By rss · Posted

      Dermatol Online J. 2025 Feb 15;31(1). doi: 10.5070/D331164979. ABSTRACT Lupus miliaris disseminatus faciei is a rare papular eruption primarily affecting the face, but extrafacial involvement can occur, which poses diagnostic challenges. We present a young woman with both facial and axillary involvement of lupus miliaris disseminatus faciei and review the literature to highlight less common extrafacial locations. Despite its rarity, lupus miliaris disseminatus faciei should be considered in the differential diagnosis of persistent papular eruptions. Histopathologic confirmation is essential, particularly in cases lacking facial involvement. Early recognition and treatment can minimize scarring, but a uniformly successful treatment option is lacking. Our report emphasizes the importance of biopsy to establish a diagnosis, especially in the absence of facial involvement given the misleading nature of the current nomenclature. PMID:40526935 | DOI:10.5070/D331164979 {url} = URL to article
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      PubMed RSS Feed - -Treatment of Erythematotelangiectatic Rosacea With Collateral Puncture Therapy: Protocol for a Randomized Controlled Trial

      By rss · Posted

      JMIR Res Protoc. 2025 Jun 17;14:e59682. doi: 10.2196/59682. ABSTRACT BACKGROUND: Erythematotelangiectatic rosacea (ETR) is the most common subtype of rosacea, characterized by persistent facial erythema and telangiectasia of varying calibers. It causes significant aesthetic impairment and is often accompanied by uncomfortable symptoms, such as burning, stinging, dryness, and itching, profoundly affecting patients' quality of life. Intense pulsed light (IPL) therapy demonstrates notable improvement in persistent erythema and telangiectasia; however, it is associated with issues such as a prolonged treatment course and high costs. Collateral puncture therapy involves rapid puncturing of specific acupuncture points followed by gentle squeezing around the needle holes to induce minor bleeding. Previous studies have shown that collateral puncture therapy for ETR offers advantages such as rapid onset of effect, a simple procedure, and low cost. Nevertheless, more high-quality clinical research data are needed to confirm these findings. OBJECTIVE: This study aims to observe the clinical efficacy and safety of collateral puncture therapy in treating ETR. METHODS: This study enrolled 60 patients diagnosed with ETR. The patients were randomly divided into 2 groups: one group underwent 4 sessions of collateral puncture therapy with 1-week intervals between treatments, and the other group received a single session of IPL therapy. The primary efficacy end points were the clinician's erythema assessment and the clinician's telangiectasia assessment. The secondary efficacy end points included the investigator's global assessment, patient's self-assessment, Flushing Assessment Tool results, Dermatology Life Quality Index, and Rosacea-specific Quality-of-Life instrument. The evaluation points were before treatment, immediately after treatment, and during follow-up. The data were statistically analyzed using SPSS (version 25.0; IBM Corp) to compare intragroup and intergroup differences between the 2 sets of data before and after treatment, with a significance level of α=.05 for hypothesis testing. RESULTS: Recruitment began on June 1, 2023. All participants have been recruited. Data analysis will be complete by the end of August 2025, with study findings available by December 2025. CONCLUSIONS: This study has the potential to verify the clinical efficacy and safety of collateral puncture therapy in the treatment of ETR, supplement rosacea treatment methods, standardize treatment protocols, and fill a current clinical gap in treating rosacea. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2200062639; https://www.chictr.org.cn/showproj.html?proj=177100. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/59682. PMID:40527501 | DOI:10.2196/59682 {url} = URL to article
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      PubMed RSS Feed - -Effect of Intense Pulsed Light Combined With 3% Tranexamic Acid for Facial Erythema Associated With Acne Vulgaris and Rosacea

      By rss · Posted

      Lasers Surg Med. 2025 Jun 15. doi: 10.1002/lsm.70029. Online ahead of print. ABSTRACT BACKGROUND: Current treatment options for facial erythema associated with acne and rosacea include oral and topical treatments. Physical modalities are also commonly used recently. Combination therapy usually works better than a single therapy. There are few studies on the therapeutic effect of IPL combined with TXA on facial erythema. OBJECTIVE: To study the efficacy of intense pulsed light combined with 3% tranexamic acid in the treatment of facial erythema associated with acne and rosacea. METHODS: A total of 56 patients were included in the study. They were randomly divided into the observation group and the control group, with 28 cases in each group. The observation group was treated with intense pulsed light combined with 3% tranexamic acid for external use, while the control group was treated with intense pulsed light only. The clinical efficacy, erythema degree, and skin disease quality of life index score before and after treatment were observed in the two groups, and the results were compared. RESULTS: After treatment, both groups showed improvement; the observation group exhibited a significantly higher overall effective rate than the control group (p < 0.05). The scores of erythema index and skin quality of life index in the observation group were lower than those in the control group, and the differences were statistically significant (p < 0.05). There were no obvious adverse reactions in both groups. CONCLUSION: Intense pulsed light combined with 3% tranexamic acid can effectively improve the degree of acne and rosacea erythema without serious adverse effects. PMID:40518702 | DOI:10.1002/lsm.70029 {url} = URL to article
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      PubMed RSS Feed - -Extemporaneous dermatological compounding in hospital pharmacies, Northwest Ethiopia

      By rss · Posted

      Front Public Health. 2025 May 30;13:1486936. doi: 10.3389/fpubh.2025.1486936. eCollection 2025. ABSTRACT BACKGROUND: Dermatological problems are among the leading causes of hospital visits in Ethiopia. Extemporaneous compounded products are currently used by many patients with different disorders. The aim of the study was to evaluate the most commonly prescribed extemporaneously compounded products compounding practice and applicability of compounding guidelines at five randomly selected hospitals in Northwest Ethiopia. METHODS: A hospital-based multicenter descriptive cross-sectional study was conducted by retrospectively analyzing prescription records for dermatological compounding from January to April 2023. A total of 423 prescriptions from hospital pharmacies were systematically selected. Data related to skin condition patterns, product selection, and dosage form types were extracted using a semi-structured data extraction tool and analyzed using SPSS version 25.0 at a significance level of 5%. RESULTS: A total of 423 prescriptions containing dermatological products for compounding were analyzed. Most patients were female (82.1%) and aged 30-64 years (46.3%). Melasma (82.9%), acne vulgaris (68.6%), acute dermatitis (63.27%), and Rosacea (61.54%) were the four top dermatological diseases for which compounding preparations were prescribed. More than half of the prescriptions (56.26%) contained a combination of two drugs. Most compounded dosage form was semisolid preparations (95.98%), while the remaining 17 (4.02%) were liquids. Salicylic acid (35.39%) was the most frequently prescribed active ingredient, followed by Clobetasone (13.03%) and Betamethasone (10.01%). Vaseline (47.62%) and Nivea cream (44.3%) were the most commonly used excipients for compound preparations. Hydroquinone (4%) with Nivea cream (30gm) (17.0%), followed by salicylic acid (5%) + Betamethasone (75 g) + Vaseline (20 g) (10.6%) were the most commonly prescribed dermatological formulations. CONCLUSION: Dermatological disease is more prevalent in the study area. and extemporaneous compounding is a common element of pharmaceutical care. Extemporaneous and topical semisolid preparations containing two or more active ingredients are the most widely compounded and prescribed products. This study suggests the application of good manufacturing practices and componding guidelines for extemporaneous compounding of dermatological formulations to ensure efficacy, quality, and safety. PMID:40520300 | PMC:PMC12162544 | DOI:10.3389/fpubh.2025.1486936 {url} = URL to article
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      PubMed RSS Feed - -Ocular rosacea : Clinical aspects, diagnostics, management and treatment

      By rss · Posted

      Ophthalmologie. 2025 Jul;122(7):566-580. doi: 10.1007/s00347-025-02265-z. Epub 2025 Jun 16. ABSTRACT Ocular rosacea is a chronic inflammatory disease that affects the surface of the eye and the eyelids. It often occurs in conjunction with rosacea in the facial area but can also occur independently. It is characterized by bilateral chronic posterior blepharitis and meibomitis, which can involve the entire surface of the eye, including the cornea, during the course of the disease. The diagnosis is largely based on clinical findings. The main symptoms include reddened, burning and itchy eyes, dryness, sensitivity to light and blurred vision. The exact etiology of ocular rosacea is not fully understood. A genetic predisposition, dysregulation of the immune system, environmental factors and microbial factors are involved. Treatment usually includes a combination of eyelid hygiene, topical and, if necessary, systemic agents. The prognosis is generally considered favorable; however, in the case of untreated ocular rosacea, severe progressive courses can also lead to blindness. PMID:40522449 | DOI:10.1007/s00347-025-02265-z {url} = URL to article
    • Guide
      Grassroots Non Profit for Rosacea

      By Guide · Posted

      What is your view of a non profit organization? Please reply to this post and tell us what you think a non profit for rosacea in your view should be doing for rosacea sufferers.  The fact is that most non profit organizations involved with rosacea are sponsored and administered by businessmen and dermatologists, with support mainly from the skin industry. The RRDi was founded on one of the core principles of engaging in rosacea research sponsored by rosacea sufferers. Read the Mission Statement.  What social media group for rosacea has united to sponsor their own rosacea research? Any rosacea group at Reddit, Facebook or other rosacea social media group has united to sponsor their own rosacea research?  Should a non profit organization have staff that is paid or should they be volunteers?  How are most non profit organizations run? Who makes the decisions?  Do you know what a grassroots rosacea non profit is all about?  If you were to recommend a non profit organization for rosacea, what non profit would you recommend to your favorite rosacea social media group?  Do you think it would be a good idea to gather 10K rosacea sufferers together in a united non profit organization and each one donate $1 US dollar so the non profit organization could sponsor their own novel rosacea research rather than the current status quo rosacea research sponsored by the skin industry? What is your view of the forum style website the RRDi has been using for over twenty years? 
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      PubMed RSS Feed - -Effect of compound glycyrrhizin combined with fractional CO2 laser on the improvement of skin lesions and skin barrier function in rosacea

      By rss · Posted

      Pak J Pharm Sci. 2025 Mar-Apr;38(2):407-411. ABSTRACT Rosacea is a chronic facial inflammatory disease affecting quality of life, with complex causes including psychological, lifestyle and immune factors. This study examines the use of compound glycyrrhizin with fractional CO2 laser treatment for rosacea patients. From January 2018 to January 2022, 108 patients with rosacea lesions were randomly assigned to a control group (conventional treatment) and an observation group (glycyrrhizin plus laser treatment). Both groups received 12 weeks of therapy. Analysis using SPSS26.0 and GraphPad Prism 8.0 showed improvement in skin lesions and barrier function post-treatment. The observation group had fewer lesions and better skin hydration compared to the control group (P<0.05). Adverse reactions were higher in the observation group but not significantly different (P>0.05). The combination treatment enhances therapeutic effects, improves skin lesions, and strengthens the skin barrier, warranting promotion. PMID:40501239 {url} = URL to article
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      PubMed RSS Feed - -Evaluating the Efficacy and Safety of Poly-d,l-lactic Acid Administered via Cannula Technique in the Treatment of Moderate Rosacea

      By rss · Posted

      Plast Reconstr Surg Glob Open. 2025 Jun 11;13(6):e6855. doi: 10.1097/GOX.0000000000006855. eCollection 2025 Jun. ABSTRACT Rosacea is a chronic skin condition typically managed with treatments targeting surface symptoms such as erythema. Long-term solutions may require addressing deeper skin alterations. This study explored the efficacy and safety of poly-d,l-lactic acid (PDLLA, Juvelook, VAIM Inc., Seoul, Korea) administered via a cannula technique for moderate rosacea treatment. Four participants (32-62 years of age) with moderate rosacea unresponsive to conventional therapies underwent 3 PDLLA treatments at 3-week intervals. A 25G blunt-tip cannula was used to administer PDLLA into the subdermal layer. Erythema was assessed at baseline, 4 weeks, and 12 weeks using the Clinician's Erythema Assessment scale. Patient satisfaction was measured on a 4-point scale. PDLLA showed significant efficacy in reducing erythema and improving skin structure. All participants reported improved Clinician's Erythema Assessment scores with sustained effects at the 12-week follow-up. Patient satisfaction was high, and adverse effects were minimal (mild edema resolving spontaneously). PDLLA via cannula shows promise for treating refractory rosacea by addressing both superficial and deeper skin factors. Further research is needed to validate long-term efficacy and explore mechanisms of action. PMID:40502431 | PMC:PMC12153276 | DOI:10.1097/GOX.0000000000006855 {url} = URL to article
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      PubMed RSS Feed - -Advances in Genetic Polymorphism Research in Rosacea: Mechanisms and Clinical Implications

      By rss · Posted

      Clin Cosmet Investig Dermatol. 2025 Jun 5;18:1423-1429. doi: 10.2147/CCID.S524611. eCollection 2025. ABSTRACT Rosacea is a chronic inflammatory skin disease primarily affecting the central region of the face. Typical manifestations include erythema, papules, or pustules on the cheeks, glabella, chin, and nose, with some patients experiencing ocular involvement. The pathogenesis of this disease is influenced by both polygenic inheritance and environmental factors, with abnormalities in innate immunity and neurovascular regulation playing a leading role. Recent genetic studies have identified several key genes, including Human Leukocyte Antigen (HLA), Toll-Like Receptor 2 (TLR2), Interleukin-17 (IL-17), Cathelicidin Antimicrobial Peptide (CAMP), and others, that are closely associated with rosacea onset and progression. This review summarized recent advances in rosacea-related genetic researches, aiming to reveal the genetic basis of the disease and provide support for early intervention and precision management of high-risk populations. PMID:40496604 | PMC:PMC12148945 | DOI:10.2147/CCID.S524611 {url} = URL to article
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      PubMed RSS Feed - -A Case of Intense Pulsed Light Aggravated Rosacea Successfully Treated by Abrocitinib

      By rss · Posted

      Clin Cosmet Investig Dermatol. 2025 Jun 5;18:1417-1421. doi: 10.2147/CCID.S522317. eCollection 2025. ABSTRACT Rosacea is a chronic inflammatory skin condition characterized by facial erythema, papules, pustules, telangiectasia, and flushing. Currently, various treatment options are available, but no definitive cure has been established. Phototherapy is primarily effective for treating telangiectatic rosacea because it helps alleviate erythema and telangiectasia. However, it can also pose risks; when applied inappropriately, phototherapy may worsen rosacea symptoms, making the condition more difficult to manage. This case report presents a patient with rosacea who experienced acute exacerbation after intense pulsed light therapy, characterized by persistent erythema, edema, pustules, exudation, and a burning sensation with pain. Subsequent treatment with oral abrocitinib for 12 weeks led to a gradual resolution of the patient's facial symptoms. Therefore, we hypothesized that the oral JAK-1 inhibitor abrocitinib not only serves as a promising new treatment option for rosacea but also offers therapeutic benefits in cases of inappropriate phototherapy. PMID:40491845 | PMC:PMC12147815 | DOI:10.2147/CCID.S522317 {url} = URL to article
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      PubMed RSS Feed - -Niclosamide Alleviated Skin Inflammation and Restored the Balance between Effector and Regulatory T Cells in Skin

      By rss · Posted

      Biomol Ther (Seoul). 2025 Jun 10. doi: 10.4062/biomolther.2024.210. Online ahead of print. ABSTRACT Niclosamide is an oral anthelmintic agent and was reported to also have anti-inflammatory effects by suppressing STAT3 signaling pathways. In this study, we investigated the effect of niclosamide on skin inflammatory diseases to determine its potential as a therapeutic drug. We investigated the effects of niclosamide on two models of skin inflammatory diseases: imiquimod -induced psoriasis-like skin inflammation and LL-37-induced rosacea mouse models. Our experimental results showed that niclosamide ameliorated the psoriasis-like skin inflammation and reduced proinflammatory cytokine production in the psoriasis mouse model. Moreover, niclosamide restored the imbalance between IL-17-expressing γδT cells and Tregs in the psoriasis model. Topical application of niclosamide significantly decreased the abundance of IL-17A+ γδT cells, which was increased by imiquimod. Moreover, niclosamide significantly increased the abundance of CD4+Foxp3+ Tregs. In the LL-37-induced rosacea mouse model, niclosamide significantly reduced the number of inflammatory cells including neutrophils and mast cells that play major roles in initiating inflammation and inducing uncontrolled dermal vessel function in rosacea. Lastly, niclosamide significantly reduced the number of p-STAT3-positive cells in mouse skin, which was increased by treatment with imiquimod or LL-37. We found an anti-inflammatory effect of niclosamide in psoriasis and rosacea mouse models and demonstrated the ability of niclosamide in controlling skin inflammation by recalibrating T cell differentiation and restoring T cell regulatory function. Niclosamide, as a STAT3 inhibitor, is a promising therapeutic for skin inflammation, particularly for preventing the relapse of disease by restoring regulatory cell functions. PMID:40492423 | DOI:10.4062/biomolther.2024.210 {url} = URL to article
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      PubMed RSS Feed - -A Case-Control Study Examining the Differences in Vitamin D Levels Between Individuals With Rosacea and Healthy Individuals

      By rss · Posted

      J Cosmet Dermatol. 2025 Jun;24(6):e70141. doi: 10.1111/jocd.70141. ABSTRACT BACKGROUND: Rosacea is an inflammatory and chronic skin condition that may be affected by many factors. The purpose of this study is to compare the level of vitamin D in two groups of cases (suffering from rosacea) and controls (healthy). METHODS: This case-control study was conducted in 2022 on 62 patients referred to Sedigheh Tahereh dermatology clinic, Isfahan, Iran. The criteria for entering the case group are to have rosacea based on the updated phenotype-based diagnosis and classification system. Demographic variables such as age and gender as well as vitamin D levels were recorded for both case and control groups. RESULTS: The mean of vitamin D level among patients with rosacea (29.9 ± 2.95) was higher than the control group (24.5 ± 2.14), but the difference was not statistically significant (p > 0.05). There was no significant difference in the mean of vitamin D level between rosacea patients and controls in gender or severity subgroups. CONCLUSION: There is no significant difference in vitamin D levels between patients with rosacea and healthy individuals. PMID:40492444 | PMC:PMC12150255 | DOI:10.1111/jocd.70141 {url} = URL to article
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      PubMed RSS Feed - -Sequential combination treatment with doxycycline and isotretinoin in association with topical calcineurin inhibitors and metronidazole cream for the treatment of rosacea fulminans

      By rss · Posted

      Ital J Dermatol Venerol. 2025 Jun;160(3):284-285. doi: 10.23736/S2784-8671.25.08096-X. NO ABSTRACT PMID:40485578 | DOI:10.23736/S2784-8671.25.08096-X {url} = URL to article
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      PubMed RSS Feed - -Efficacy and safety of non-fractional ablative carbon dioxide laser resurfacing for the treatment of rhinophyma - a retrospective cohort and questionnaires-based study

      By rss · Posted

      Lasers Med Sci. 2025 Jun 9;40(1):261. doi: 10.1007/s10103-025-04442-7. ABSTRACT PURPOSE: Phymatous rosacea is a chronic and disfiguring subtype of rosacea, mainly affecting the nose and leading to the development of rhinophyma. This condition manifests with erythema, enlarged pores and increased sebum secretion, progressing to textural alterations and nasal hypertrophy. Ablative CO2 laser resurfacing has emerged as a preferred approach, offering hemostatic control and favorable cosmetic outcomes. This case series presents our treatment experience with a non-fractional ablative CO2 laser resurfacing under local anesthesia for severe rhinophyma patients. METHODS: A Retrospective case series of patients with severe rhinophyma treated with an ablative CO2 laser between December 2010 and March 2020 in our laser unit. Post-procedure aesthetic outcome was assessed by the treating physician 3 months following treatment and patients were asked to complete a long-term follow-up questionnaire. RESULTS: Sixteen patients (15 males) were included, of which 13 patients (81%) had completed the questionnaire on an average of 15 months following treatment (range 2-24 months). Patient satisfaction following treatment was high, with an average satisfaction score of 7.9 out of 10 (range 4-10). Post-procedure aesthetic outcome was rated as very good or excellent in 13 patients (81%, with 75% or greater improvement). Among the 13 patients who completed the questionnaire, 11 (85%) indicated that they would recommend this treatment to others with a similar condition. CONCLUSION: Non-fractional, ablative CO2 laser resurfacing performed under local anesthesia, has proven to be a safe, effective and well-tolerated treatment for severe rhinophyma, yielding sustainable results and high satisfaction rate. PMID:40484919 | DOI:10.1007/s10103-025-04442-7 {url} = URL to article
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      PubMed RSS Feed - -Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations

      By rss · Posted

      Front Pharmacol. 2025 May 22;16:1586829. doi: 10.3389/fphar.2025.1586829. eCollection 2025. ABSTRACT INTRODUCTION: Rosacea is a common chronic inflammatory skin disorder and dysregulation of neuroimmune functions and neurovascular loops play critical roles in the development of rosacea. Huperzine A (Hup A) has several bioactive properties, including anti-inflammatory, antioxidant, and neuroprotective effects. However, the potential roles of Hup A in treating rosacea is unknown. METHODS: Network pharmacology, molecular docking, and molecular dynamics simulation techniques has been used to investigate the anti-rosacea mechanisms of Hup A in rosacea. RESULTS: Our results predicted 21 potential anti-rosacea targets of Hup A through public databases. KEGG pathway enrichment analysis revealed that these key targets participated in the regulation of MAPK signaling, NF-kappa B signaling, and PI3KAKT signaling pathways. Further machine learning analysis identified six core targets (BCL2, RXRA, PKN2, XDH, PRKCA, and FAP). Analysis of the GSE65914 dataset showed that XDH was upregulated in rosacea lesions, while BCL2 and RXRA were downregulated, with no significant expression changes of the other genes. Molecular docking results indicated that Hup A could bind to key targets (XDH, BCL2, and RXRA), which were further confirmed by molecular dynamics simulations. DISCUSSION: This study systematically elucidates the potential mechanisms of Hup A in the treatment of rosacea and provides a theoretical basis for its application in rosacea therapy. PMID:40474977 | PMC:PMC12137240 | DOI:10.3389/fphar.2025.1586829 {url} = URL to article
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      PubMed RSS Feed - -Red Scalp Disease: An Underdiagnosed Entity

      By rss · Posted

      Skin Appendage Disord. 2025 Jun;11(3):291-295. doi: 10.1159/000542573. Epub 2024 Nov 19. ABSTRACT INTRODUCTION: Red scalp disease or scalp rosacea, an inflammatory dermatosis, is frequently misdiagnosed as scarring alopecia due to nonspecific trichoscopic findings and limited case reports. While facial rosacea is well-documented, rosacea affecting extrafacial sites, such as the scalp, remains underrecognized. Accurate diagnosis is crucial to avoid unnecessary treatments and to establish an appropriate prognosis. CASE REPORT: A 70-year-old male with an asymptomatic red scalp for 1 year, unresponsive to topical treatments, presented to our clinic. Examination revealed diffuse erythema with papules and pustules. Trichoscopy showed vascular polygons, "caterpillar hair" vessels, linear arterial branching, and hairpin vessels. Diagnosis of scalp rosacea was made, and significant improvement was observed after 2 months of oral tetracycline therapy. DISCUSSION/CONCLUSION: Red scalp disease is characterized by diffuse erythema, inflammatory lesions, and vascular changes. Patients often exhibit mild facial photosensitivity but may not show prominent facial rosacea symptoms. Distinct trichoscopic patterns can assist in accurate diagnosis. Early recognition and treatment with systemic antibiotics, such as tetracyclines, are crucial to prevent progression to more severe inflammation. Increased awareness among dermatologists and trichologists is essential to enhance the diagnosis and management of this condition. PMID:40475104 | PMC:PMC12136549 | DOI:10.1159/000542573 {url} = URL to article
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      PubMed RSS Feed - -No Thromboembolic Events Observed in RCTs of Oral Tranexamic Acid: A Systematic Review and Descriptive Synthesis

      By rss · Posted

      J Am Acad Dermatol. 2025 Jun 4:S0190-9622(25)02229-7. doi: 10.1016/j.jaad.2025.06.001. Online ahead of print. NO ABSTRACT PMID:40480374 | DOI:10.1016/j.jaad.2025.06.001 {url} = URL to article

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