Root Admin Guide Posted February 11, 2022 Root Admin Report Share Posted February 11, 2022 "Natural coumarins present in a variety of foods and herbs are a class of chemically diverse compounds with important biological effects, useful for health promotion and the prevention of various diseases. The most important adverse effects of coumarins are represented by hepatotoxicity favored by the ingestion of large doses and possible genetic polymorphism of CYP2A6 and dermatological phototoxic reactions. A better understanding of the safety profile of coumarins present in nutraceuticals is necessary for a safer use of these valuable natural compounds." Front Pharmacol. 2022; 13: 803338.Safety Profile of Nutraceuticals Rich in Coumarins: An Update Simona Codruta Heghes, Oliviu Vostinaru, Cristina Mogosan, Doina Miere, Cristina Adela Iuga, Lorena Filip Link to comment Share on other sites More sharing options...
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