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Targeting the gut-skin axis - probiotics as new tools for skin disorder management?

Exp Dermatol. 2019 Aug 06;:

Authors: Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P

Abstract
The existence of a gut-skin axis is supported by increasing evidence, but its translational potential is not widely recognized. Studies linked inflammatory skin diseases to an imbalanced gut microbiome, hence, the modulation of the gut microbiota to improve skin condition seems to be a promising approach. Today there is a growing interest in natural products as alternatives to synthetic drugs. In this respect, oral probiotics could be a simple, safe and cheap modality in the therapeutic management of skin inflammation. Unfortunately, very few studies have looked how probiotic supplementation influence inflammatory skin disorders. The results of probiotic use, although beneficial, are difficult to implement into clinical practice due to the heterogeneity of the applied supplemental regimen. In this Viewpoint we aim to encourage the conduction of more research in that direction to explore unambiguously the therapeutic potential of oral probiotics in dermatology. We focus on the most common inflammatory skin diseases (atopic dermatitis, psoriasis, rosacea, acne vulgaris) with gut dysbiosis, but we also discuss some less common and very serious skin pathologies (e.g. erythema nodosum, pyoderma gangrenosum, hidradenitis suppurativa) that are possibly linked to an imbalanced gut microbiome. We dissect the possible mechanisms along the gut-skin axis and highlight novel points where probiotics could interfere in this communication in the diseased state. This article is protected by copyright. All rights reserved.

PMID: 31386766 [PubMed - as supplied by publisher]

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