Guide

"It is most important to use a nonirritating cleanser that helps to lock in moisture." Ingredients such as ceramides, hyaluronic acid, and glycerin help hydrate the skin, while it is best to avoid alcohol-based products." Red in the face: What to do about rosacea, Ellen Warren, Chicago Tribune

bakersmt, Can you share your papers here in this thread?

Allergan has announced the Rhofade Savings Card program. Just fill out the online form.

"According to the researchers, while both the 532 and 940nm wavelength lasers are effective for facial telangiectasias, they lacked evidence to support whether one wavelength was superior to the other until now.....Given the efficacy and safety of the 940nm wavelength laser, the researchers recommend this wavelength be added to the standard treatment facial vasculature." Better Laser For Treating Facial Spider Veins Identified By BUSM Researchers, Medical News Today Apparently the Cadillac of these type laser machines is the V+ laser

"I have one other suggestion. One of my patients finds that when she follows a strict sugar-free diet, her facial redness fades almost completely. But if she has so much as a chocolate biscuit, the redness flares up again the next day. There’s no evidence to back this up, but I’ve seen that it works for her. Why not try it?" How CAN I banish my embarrassing rosacea? DR MARTIN SCURR answers questions from readers, Martin Scurr, Daily Mail

"Dermatologist Mara Weinstein says, "Rose hip oil is packed full of vitamins (vitamin A, vitamin C) and antioxidants. It has anti-inflammatory properties, which can help reduce the redness associated with rosacea and acne-prone skin, which is sensitive skin. Just make sure that whatever formulation you pick up is noncomedogenic (doesn't clog pores)." Red in the face: What to do about rosacea, Ellen Warren, Chicago Tribune

JAAD Alcohol intake and risk of rosacea in US women Suyun Li, BA, Eunyoung Cho, ScD, Aaron M. Drucker, MD, Abrar A. Qureshi, MD, MPH, Wen-Qing Li, PhD

"Overall, women who drank alcohol had an elevated risk of developing rosacea and that risk increased as their alcohol consumption increased. Even just one to three drinks per month led to a 14% increased risk. Five or more in a week – the risk increased by 28 % to 49%!" Alcohol May Increase Risk of Skin Condition in Women, By Denise Reynolds, EMaxHealth "As if Nutella wasn't enough to take away from us (or try, it didn't work), a study conducted by the Journal of the American Academy of Dermatology has found a link between drinking white wine and the development of rosacea, a skin condition that often presents as a red rash. Although this isn't the first time alcohol has been linked to bringing on rosacea, it was previously thought that red wine was the culprit." DO THEY HAVE TO RUIN EVERYTHING? BY CATHY DONOHUE. Her "Possibly bad news if your summer plans include sitting in sidewalk cafes sipping chardonnay all day: A new study just found that drinking white wine could up your risk of developing rosacea." Studies Show Pinot Grigio Could Trigger Rosacea and We Are Extremely Sad About It, BY MACAELA MACKENZIE, Allure "Researchers have found that women who consume alcohol may be more likely to develop rosacea than non-drinking women, with white wine and liquor being the biggest offenders." White wine linked to rosacea: study, New York Daily News White wine, liquor may raise women's risk of rosacea, by Honor Whiteman, Medical News Today Your Favorite Drink May Increase Your Risk of This Skin Condition, by Brittany Burhop, Senior Editor, NewBeauty Drinking White Wine Raises Your Risk of Developing Rosacea By Ashley Weatherford,The Cut, NY Mag White wine may do no favors for a woman's skin, By CBS News, KZBK Alcohol consumption increases rosacea risk in women, Science Daily White Wine Raises Women's Risk for Rosacea, NewsMax Study: Risk of Rosacea higher with White Wine, Indian Wine Academy Like White Wine? You Might Be at a Higher Risk of Developing Rosacea, Elizabeth Chambers, Paste

""We also tell our patients to avoid certain ingredients in skin care and cosmetics, such as retinol, alpha hydroxy acids, and beta hydroxy acids, which can be too harsh for sensitive rosacea-prone skin." Concerned your skin care might be making symptoms worse? Read up on the signs your products are secretly damaging your face."" Got Rosacea? These Makeup Tricks Will Make It Disappear, by Lindsay Cohn, Readers Digest

"We found white wine and liquor were significantly associated with a higher risk of rosacea," said study senior author Wen-Qing Li. He's an assistant professor of dermatology and epidemiology at Brown University. White wine may increase risk for rosacea in women, study says, By Kathleen Doheny, HealthDay News, UPI

Tom Busby, poster extraordinaire, posted at RF a pdf containing two interesting articles. The first is, "What’s all the craze about demodex?" and the second is "Factors in rosacea pathogenesis clearer." Worth the read. What's all the craze about demodex-Gadie-2016.pdf What's all the craze about demodex-Gadie-2016.pdf

Answer.

The ROSCO panel that created the phenotype classification which the RRDi has endorsed are from all over the world (by last name, first name initial, country) read the panel list.

Dr. Tan Study on the Psychological Impact of Rosacea

"People look at someone with rosacea and conclude the red face is from anger, embarrassment or boozing — it’s little wonder that sufferers of this common skin condition feel stigmatized. Now recently published research co-authored by Windsor dermatologist Dr. Jerry Tan confirms what he regularly hears from his rosacea patients: Having this condition — characterized by facial redness, pimples and sometimes thickened red skin in the nasal area — frequently leads to embarrassment, loss of confidence, sadness, depression and despair." Study confirms the emotional pain rosacea inflicts, says Windsor dermatologist, by Brian Cross, Windsor Star

Natural Remedies for Rosacea? (the link no longer works) By THE NEW YORK TIMES The wayback machine shows the article which is reproduced in a series of screen shots below for posterity:

Hydroxychloroquine (HCQ), sold under the brand name Plaquenil among others (Hydroquin, Axemal, Dolquine, Quensyl, Quinoric), is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. It is frequently sold as a sulfate salt known as hydroxychloroquine sulfate. Wikipedia Treatment for Rosacea There are reports that this treatment has worked for rosacea. Since Hydroxychlorquine is available in a generic prescription and is available around the world in such brand names as Plaquenil, Hydroquin, Axemal, Dolquine, Quensyl, and Quinoric rosaceans can refer to this paper and ask their physician for a prescription for an eight week course. We should be hearing reports whether others report success with this treatment. Please post your experience in this thread. Clinical Papers on Hydroxychloroquine and Rosacea "Finally, the 8-week HCQ treatment exerted satisfactory therapeutic effects on erythema and inflammatory lesions of rosacea patients, indicating that it is a promising drug for rosacea in clinical treatment." Hydroxychloroquine is a novel therapeutic approach for rosacea. Efficacy and safety of hydroxychloroquine for treatment of patients with rosacea: a multi-center, randomized, double-blind, double-dummy, pilot study. Hydroxychloroquine Suppresses LL37-induced Mast Cells "Interestingly, hydroxychloroquine, an antimalarial medication and disease-modifying antirheumatic drug (DMARD), demonstrated effectiveness in treating symptoms in a subgroup of the neurogenic rosacea patients."Neurogenic Rosacea: What Pharmacists Should Know, Pharmacy Times Thanks to David Pascoe at RSG, "A pre-proof version of an article to appear in the Journal of the American Academy of Dermatology details a small double blind study that found that oral hydroxychloroquine 200 mg twice a day offered similar benefits to rosacea sufferers compared to doxycycline 100 mg a day." [1] Anecdotal Reports ---------------------------Duff Man reports: "I tried every cream imaginable; the list of creams I didn't try is shorter. I went for 13 years without a full remission; started getting the rash really bad when I was a handsome young man, and it really was tough on my self esteem. It did a number on my face, and began to cover my scalp too. The only thing that finally worked for me with long lasting, real remission, is plaquenil. My only regret is that I didn't try it sooner. Much, much sooner. In hindsight, I think it was likely lupus all along, and my experience really has me questioning how many other people with "rosaceae" are just lupus sufferers. I would encourage folks here to do an honest self audit to reconcile any symptoms that may be similar to lupus and connect the dots. And whatever you do, whatever your gut tells you, please don't give up on finding a lasting resolution. Even if I don't have lupus, the treatment for it resolved my horrible, red, burning, painful, embarrassing rash. I don't really care what we call it because I'm able to look in the mirror again. And Im feeling my age again. I hope everyone here finds a lasting remission. Don't stop until you do." Duff Man post no 221 on 4/17/2017 (scroll down to next post for more info). -------------------------------------end Duff Man report "hydroxychloroquine has been the first drug that actually feels like it's starting to help the instability on my face a bit." owldog post no 79 Scarlet Letters has an interesting article discussing using mepacrine and plaquenil in treating rosacea. Jamoverton [post no 7] reports hydroxychloroquine was part of his regimen that puts him "in a much better place due to medications." Anti-Parasitic Treatment for Rosacea Plaquenil (Hydroxychloroquine) is listed as one of the Anti-parasitic Prescription Agents For Rosacea. Etcetera Mepacrine Hydroxychloroquine has been listed as one of the treatments considered for coronavirus. Virus has never been ruled out in rosacea. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post. End Notes [1] A report published in the Journal of the American Academy of Dermatology reports that oral hydroxychloroquine is just as effective as oral doxycycline in treating rosacea. [see post no 7 in this thread by scrolling down for the clinical paper source associated with this which is David Pascoe] Am Acad Dermatol. 2020 May 18;S0190-9622(20)30915-4. doi: 10.1016/j.jaad.2020.05.050. Online ahead of print.Efficacy and Safety of Hydroxychloroquine for Treatment of Patients With Rosacea: A Multi-Center, Randomized, Double-Blind, Double-Dummy, Pilot StudyBen Wang, Xin Yuan, Xin Huang, Yan Tang, Zhixiang Zhao, Bin Yang, Baoqi Yang, Yue Zheng, Chao Yuan, Hongfu Xie, Ji Li

"It’s also important to take a holistic approach to your lifestyle if you suffer from rosacea. Eating an anti-inflammatory diet can help reduce flare-ups. And beauty blends, like The Beauty Chef’s Inner Glow Powder, can nourish your skin from the inside out." Everything You Need To Know About Rosacea, By Emily Waight, sporteluxe

Mistica at RF reported about Dawn M Lamako who posted her treatment for PD using Sugardyne (sugar as an antimicrobial) which she explains with incredible detailed references to documents and photos. Be sure to scroll all the way down to see Dawn's photos of the treatment. "Sucrose monocaprate showed the strongest antibacterial activity against all tested bacteria, especially Gram-positive bacteria." Food Chem. 2015 Nov 15;187:370-7. doi: 10.1016/j.foodchem.2015.04.108. Epub 2015 Apr 24. In vitro antibacterial activities and mechanism of sugar fatty acid esters against five food-related bacteria. Zhao L, Zhang H, Hao T, Li S. "There are several ways in which salt and sugar inhibit microbial growth. The most notable is simple osmosis, or dehydration." "In summary, we presented in this report a simple and efficient approach for the preparation of sugar derived Schiff bases. The synthesized D-glucosamine derivatives were shown to possess biological activity when evaluated for antimicrobial activity against Gram-positive and Gram-negative bacterial and fungi strains." International Journal of Carbohydrate Chemistry Volume 2013 (2013), Article ID 320892, 5 pages Synthesis and Antimicrobial Activity of Carbohydrate Based Schiff Bases: Importance of Sugar Moiety Helmoz R. Appelt, Julieta S. Oliveira, Roberto C. V. Santos, Oscar E. D. Rodrigues,4 Maura Z. Santos, Elisiane F. Heck, and Líria C. Rosa How do salt and sugar prevent microbial spoilage?, Scientific American "Studies showed that solutionof appropriate sugar concentration incubated at pH 7.0 and 35° C were lethal to the bacterial species studied." In Vitro Study of Bacterial Growth Inhibition in Concentrated Sugar Solutions: Microbiological Basis for the Use of Sugar inTreating Infected Wounds "Sugars have been used as wound dressings for at least 4,000 years in many parts of the world." The Antimicrobial Activity of Sugar Against Pathogens of Wounds and Other Infections of Man S. Selwyn, J. Durodie

Jane Chertoff, Brit+Co, wrote an article about an 'All-in-One Skincare Product' called Rozatrol which is developed by Board-certified dermatologist Zein Obagi which is sold on Dr. Obagi's website, Zo Skin Health, Inc., which describes the product as "An enzymatic exfoliator provides ultra-mild exfoliation, while amino acids support optimal microcirculation to prevent the signs of premature aging." Watch this promotion video by Zo Skin Health, Inc. UK: Ingredients Water (Aqua, Eau), Glycerin, Cetyl Alcohol, Helianthus Annuus (Sunflower) Seed Oil, C12-15 Alkyl Benzoate, Palmitoyl Glycine, Neopentyl Glycol Diethylhexanoate, Dimethicone, Panthenol, Potassium Cetyl Phosphate, PEG-100 Stearate, Glyceryl Stearate, Lactose, PEG-36 Castor Oil, PEG-12 Glyceryl Laurate, Phenoxyethanol, Xanthan Gum, Magnesium Aluminum Silicate (Argilla), Brassica Oleracea Italica (Broccoli) Extract, Panthenyl Triacetate, Farnesyl Acetate, Farnesol, Aminomethyl Propanol, Caprylyl Glycol, Milk Protein/Protéine du lait, Chlorphenesin, Neopentyl Glycol Diisostearate, Hydrolyzed Algin, Papain, Marrubium Vulgare Meristem Cell Culture, Leontopodium Alpinum Meristem Cell Culture, Benzalkonium Chloride, Stearyl Alcohol, Myristyl Alcohol, Disodium EDTA, Lactic Acid, Titanium Dioxide, Carbomer, 1,2-Hexanediol, Citric Acid, Lecithin, Algin, Alcohol, Tocopherol.

Violetsareblue started a thread at RF about this special type flushing and Lizzy added her thoughts, while elegantsquatlobster said she also suffers from this phenomenon so I started this thread to list the different treatment protocols offered and will continue to update this list here. If you have something to offer please reply to this thread with your thoughts. BraceYourself started another thread about nose pain which you may also be interested in investigating. Treatments Offered Accutane Anafranil (see post #10 elegantsquatlobster) Beta blocker for two months and it made cheeks calm but nose gradually worse Capsaicin (see post #4 elegantsquatlobster) Clonidine (lower the dose - high dose causes nose flushing) Cold Gel packs Erythromycin gel Ice Chips (eating) Low Dose Naltrexone Metronidazole gel Paxil Probiotics Steroids Treatments for Phymatous (Rhinophyma) - Phenotype 5 Etcetera Rosacea and Chronic Rhinosinusitis: A Case-Controlled Study

A noted authority on rosacea, Dr. Frank Powell "insists that episodes of flushing are not a prerequisite for making a diagnosis of rosacea, and that some patients can develop the full-blown disease without a prior history of frequent flushing. Rebora too, another investigator, says that flushing is not a necessary stage in the sequence leading up to the full-blown 'red face'." Powell in his book wrote a chapter on Flushing and Blushing and confirms what other clinicians have found that while both are seen 'sufficiently often enough' in rosacea patients and both flushing and/or blushing are the 'first features of rosacea to appear in some patients," nevertheless, "flushing and blushing are not necessarily a component of the clinical picture in all patients with rosacea." Source Phenotype 1 is flushing. Not all rosaceans have Phenotype 1. List of Anecdotal Reports of Rosaceans Who Report No Flushing "I run each morning and don't really seem to flush aside from being hot. My face is back to the way it was when I woke up within 5 minutes after stopping. I had a few cups of coffee and no change. The only change in redness seems to come from applying my Lotion which subsides. What are some general thoughts on Flushing?" clfergus (post no 1) 21st April 2009 03:16 PM "Flushing seems to be a critical symptom to the dx of rosacea and I don't think I flush. I don't even blush." Rhea (post no 1) 24th August 2012 01:58 PM "Meanwhile, my sister, who has rosy cheeks/rosacea but no flushing, sits in front of a heater all day, which would give me a panic attack + flushing." beherenow (post no 1) If you don't flush please post in this thread to add your experience to the list.

Mechanism of free radical toxicity induced by xenobiotics (Image courtesy of Wikimedia Commons) Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Wikipedia "These findings clearly show that in the mild involvement phase of rosacea patients, superoxide dismutase activity was stimulated to protect the skin against reactive oxygen species so that the malondialdehyde levels were maintained. In contrast, in more severe disease, due to a decrease in the capacity of the antioxidant defence system, the malondialdehyde levels were increased. These findings support the 'antioxidant system defect hypothesis' in rosacea patients." [4] Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including algae, bacteria, higher plants, and animals. In humans, it acts as a buffer against iron deficiency and iron overload.[3] Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body, hence serum ferritin is used as a diagnostic test for iron-deficiency anemia. Wikipedia These results support the role of oxidative stress and affected metabolism of iron in etiology of rosacea. The higher presence of ferritin in skin cells of rosacea patients explains the exacerbation of symptoms by exposure to UV light, that releases ferritin free iron, which is fundamental in the generation of oxidative stress. [1] The statistically significant differences in the expression of ferritin, higher peroxide levels, and lower antioxidative potential support the onset of systemic oxidative stress in patients with rosacea. [2] Iron and/or ferritin accumulation are known to occur under pathological conditions in many inflammatory skin diseases or in human skin chronically exposed to UV light. [3] Antioxidant System Defect Hypothesis For more info since this post is related to the ASDH theory on rosacea. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post. End Notes [1] Lijec Vjesn. 2011 Jul-Aug;133(7-8):288-91. The role of oxidative stress and iron in pathophysiology of rosacea. Tisma VS, Poljak-Blazi M. [2] J Am Acad Dermatol. 2009 Feb;60(2):270-6. doi: 10.1016/j.jaad.2008.10.014. Epub 2008 Nov 25. Oxidative stress and ferritin expression in the skin of patients with rosacea. Tisma VS, Basta-Juzbasic A, Jaganjac M, Brcic L, Dobric I, Lipozencic J, Tatzber F, Zarkovic N, Poljak-Blazi M. [3] J Photochem Photobiol B. 2000 Jan;54(1):43-54. Contrasting effects of excess ferritin expression on the iron-mediated oxidative stress induced by tert-butyl hydroperoxide or ultraviolet-A in human fibroblasts and keratinocytes. Giordani A, Haigle J, Leflon P, Risler A, Salmon S, Aubailly M, Mazière JC, Santus R, Morlière P. [4] Clin Exp Dermatol. 2003 Mar;28(2):188-92. The role of free oxygen radicals in the aetiopathogenesis of rosacea. Oztas MO, Balk M, Ogüs E, Bozkurt M, Ogüs IH, Ozer N.

The 32-year-old blogger suffers rosacea, which causes red flushing to the face – similar to when a person blushes. 'I LOOKED LIKE A TOMATO' Who is Lex Gillies? Beauty blogger who ditched gluten and dairy to combat rosacea flare ups, By Lizzie Parry, The Sun Lex Gillies, Beauty Blogger, British Skin Foundation Ambassador image courtesy of Caters News Agency, The Sun "Lex's blog first gained popularity when she began posting about her treatments for the skin condition rosacea, which she says left her face 'looking like a tomato'." By MOLLY ROSE PIKE FOR MAILONLINE, Daily Mail I Have Chronic Rosacea – This Is The Only Skincare Routine That Helps, Refinery29 Lex Gillies' Instagram Post About Her Rosacea Twitter (the classic butterfly) Facebook Talonted Lex Lucy Abbersteen Interviews Lex Gillies About Rosacea Famous Rosaceans

Van Gogh - Trauernder alter Mann (image courtesy of Wikimedia Commons) "Rosacea was associated with a disease severity-dependent, increased risk of depression and anxiety disorders. The findings may call for increased awareness of psychiatric morbidity in patients with rosacea." Dermatology. 2016;232(2):208-13. doi: 10.1159/000444082. Epub 2016 Mar 9. Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders: A Danish Nationwide Cohort Study. Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Alexander Egeberg, M.D., Ph.D., the lead author in the above study is a member of the RRDi MAC. Rosacea Causes Emotional Pain