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Rosacea Linked to Slightly Increased Risk for Alzheimer's Disease By Jody Smith, EmpowHER, June 3, 2016 Daily Mail • Health24 • Fox News • "Recently, an increased interest has been shown in the potential associations between neurodegenerative diseases and rosacea. For example, a nationwide cohort study from Denmark explored the relationship between rosacea and neurodegenerative diseases such as Parkinson’s disease. MMPs are believed to be associated with the neurodegenerative diseases and an increased expression of MMP-1 and MMP-9 has also been observed in rosacea. In addition, another Danish study found that rosacea was significantly associated with dementia, especially Alzheimer disease. AMPs, MMP, and inflammatory cascades, which have a shared impact on both rosacea and Alzheimer disease, are considered to be involved in the underlying mechanism. Together, these findings suggest that a pathogenic link might therefore exist between rosacea and neurodegenerative diseases."Int J Mol Sci. 2016 Sep; 17(9): 1562.Published online 2016 Sep 15. doi: 10.3390/ijms17091562, PMCID: PMC5037831Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory ConditionYu Ri Woo, Ji Hong Lim, Dae Ho Cho, and Hyun Jeong Park, "Rosacea is significantly associated with dementia, particularly AD. Increased focus on symptoms of cognitive dysfunction in older patients with rosacea may be relevant." Ann Neurol. 2016 Jun;79(6):921-8. doi: 10.1002/ana.24645. Epub 2016 Apr 28. Patients with rosacea have increased risk of dementia. Egeberg A, Hansen PR, Gislason GH, Thyssen JP.

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The RRDi is please to announce that Alexander Egeberg, M.D., Ph.D., has joined the RRDi MAC and is volunteering to answer questions in our forum. Dr. Egeberg has been in the news recently with his team looking at 1997-2012 data from the Danish national health registry system. The nation's entire population -- roughly 5.6 million men and women -- were included. About 82,000 had rosacea. The results are a series of medical papers linking rosacea with Glioma, autoimmune diseases, dementia, Alzheimer's Disease and Parkinson's disease. For example, Nature, Dermatology Times, MedLinePlus, HealthDay have articles quoting Dr. Egeberg.

Older Patients with Rosacea are Likely to be Diagnosed with Dementia

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People with rosacea could be more prone to developing Alzheimer's disease Rosacea and Alzheimer's have similar proteins KSHB, Kansas City, Candi Carney 10:48 AM, Apr 28, 2016

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Rosacea is linked to a number of systemic cormobidities including dementia. The number of diseases linked to rosacea continues to grow. Below are some links to dementia and rosacea. Medical Xpress • EurekAlert • ScienceDaily • JAMA Network • The Hospitalist • TechTimes • McKnight's • "Recently, an increased interest has been shown in the potential associations between neurodegenerative diseases and rosacea. For example, a nationwide cohort study from Denmark explored the relationship between rosacea and neurodegenerative diseases such as Parkinson’s disease. MMPs are believed to be associated with the neurodegenerative diseases and an increased expression of MMP-1 and MMP-9 has also been observed in rosacea. In addition, another Danish study found that rosacea was significantly associated with dementia, especially Alzheimer disease. AMPs, MMP, and inflammatory cascades, which have a shared impact on both rosacea and Alzheimer disease, are considered to be involved in the underlying mechanism. Together, these findings suggest that a pathogenic link might therefore exist between rosacea and neurodegenerative diseases."Int J Mol Sci. 2016 Sep; 17(9): 1562.Published online 2016 Sep 15. doi: 10.3390/ijms17091562, PMCID: PMC5037831Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory ConditionYu Ri Woo, Ji Hong Lim, Dae Ho Cho, and Hyun Jeong Park More Information on Systemic Cormobidities in Rosacea

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KWGN Report Revolutionary Treatment for Wrinkles, Acne, & Rosacea

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New evidence for a pathogenic link between rosacea and Parkinson disease

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