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Of the 15 subjects that have completed 12 weeks of treatment in the study, 100% have IGA scores of clear (0) or almost clear (1), compared to their baseline scores of moderate (3) or severe (4). Investigators also observed a 93% reduction in total inflammatory lesions from baseline to week 12 in the same subjects who have completed the 12-week study.....BPX-011 is a hydrophilic (non-oil-based) topical gel with fully solubilized minocycline that has been shown to penetrate the skin to deliver the antibiotic to its target. Following positive results from its previously announced phase 2b study of BPX-01 in acne, BioPharmX continues with phase 3 clinical study plans for BPX-01 for the treatment of acne. BioPharmX Announces Preliminary Data from Rosacea Feasibility Study, by BioPharmX Corporation, PharmPro

"LAUSANNE, Switzerland, Sept. 11, 2017 /PRNewswire/ -- Today, the results of a study evaluating the combined use of topical rosacea treatments ivermectin 1% cream and brimonidine 0.33% gel were published in the Journal of Drugs in Dermatology." Galderma: Combined Use of Rosacea Therapies Ivermectin 1% Cream and Brimonidine 0.33% Gel Evaluated in MOSAIC Study, PRNewswire, MarketsInsider, BusinessInsider

"Following fourteen years of follow-up analysis, this study showed that increased alcohol intake was associated with a significantly higher risk of rosacea when compared to individuals who never consumed alcohol. Of the individual types of alcohol beverages, the consumption of white wine or liquor showed an even higher association with rosacea risk. Interestingly, white wine and liquor are the only two types of alcoholic beverages that lack anti-inflammatory components such as flavonoids which are present in red wine. Importantly, this study adds to the growing body of evidence in implicating alcohol consumption as a factor in the development of rosacea." Does Alcohol Intake Lead to an Increased Rate of Rosacea?, Written by Neeti Vashi, BSc, Medical News Bulletin

"New research shows that keeping these microorganisms in balance may help to protect skin from certain conditions. For example, acne, eczema, and rosacea are now attributed to a lack of diversity in the skin microbiome, Dr. Levin explains. Eczema patients, for instance, were found to have a microbiome that's different from the microbiomes of those who do not suffer from the telltale inflammation and skin rashes. Often, skin conditions occur because the microorganisms found on the skin have changed significantly from optimal levels, she adds." Everything You Need to Know About Your Skin Microbiome, By Alina Dizik, Shape For more information on this subject

"Rosacea has always been a subtle, yet outwardly facing part of my identity—one I've never truly come to terms with. Growing up I would always be asked, "Why are your cheeks so red?" Or "Why are you blushing so much? Are you embarrassed?" No Karen, I have rosacea, my skin is overly sensitive to the sun. Of course I never said that—I simply shrugged it off." What It's Really Like Living with Rosacea, by RACHEL EPSTEIN, marie claire

LENA DUNHAM REVEALS BATTLE WITH ROSACEA 10:51 AM PDT 8/22/2017 by Stephanie Chan, Hollywood Reporter Lena Dunham Is Seriously Bummed She Suddenly Has Rosacea at 31. Here's Why That Happens. Amanda MacMillan August 25, 2017, Health

"We report a unique case of facial erythema of rosacea that responded to brimonidine gel with effective blanching for two years until the patient developed a paradoxical erythema reaction. This is an adverse reaction physicians should be aware of with continued prescription of brimonidine gel for their rosacea patients." Paradoxical Erythema Reaction of Long-term Topical Brimonidine Gel for the Treatment of Facial Erythema of Rosacea June 2016 | Volume 15 | Issue 6 | Case Report | 763 | Copyright © 2016 • PubMed Erin Lowe MSIV and Scott Lim DO

Stanford Secukinumab Clinical Trial (posted by David Pascoe) Update June 15, 2020: "Patients treated with secukinumab for papulopustular rosacea saw significant improvements in quality of life and reduction of severity markers, according to a study presented at the American Academy of Dermatology virtual meeting." Secukinumab demonstrates clinical improvement in rosacea patients, Healio

"Considering the significant improvement in the patient’s condition after appropriate diet and appropriate use of herbal medicines, it seems that traditional medicinal therapies have great results in the treatment of rosacea." Treatment Measures to Protect Health and Nutrition: Health and nutrition regimes were recommended at first because of gastrointestinal problems are, prohibited concentrated foods and due to the type of skin lesions that is a sign of increased virulent yellow bile the prohibition of bile stimulating and producing foods. Pharmaceutical Measures: Aftimoni whey protein with Sisymbrium irio should be consumed hot at fasting, Liver capsule (coriander seed, fumaria, lettuce seed, chicory seed, Jujube, Rhubarb root, cassia leaf, thyme), sekanjabin (fennel, chicory seed, celery seed, Tribulus terrestris, cumin, Khyarin seed, chicory root bark, fennel root bark, capparis root bark), and local mask containing mallow, mallow flowers, and chamomile flowers were administered along with milk and two drops of lemon juice. Conclusion Owing to the significant improvement in our patient’s condition, it seems that temperament reform through recommendations and regimens, as well as herbal medicines prescribed according to sources of Iranian traditional medicine, play an important role in the development of rosacea symptoms. This study should be a useful guide for future clinical studies of this disease. Asian Journal of Clinical Case Reports for Traditional and Alternative Medicine Improvement of Rosacea Symptoms in a 62-year-old Man with the Treatment of Iranian Traditional Medicine Article 4, Volume 1, Issue 1, Winter 2017, Page 29-36 • Abstract • Akramosadat Atyabi (M.D., Ph.D. Candidate), Fatemeh Eghbalian (M.D., Ph.D. Candidate) , Mehrdad Karimi (M.D., Ph.D.)

"The researchers also noted that a very low intake of saturated fats (below 3 percent of daily diet) was associated with a higher risk of death in the study, compared to diets containing up to 13 percent daily. At the same time, high-carb diets -- containing an average 77 percent carbohydrates -- were associated with a 28 percent increased risk of death versus low-carb diets, Dehghan said. "The study showed that contrary to popular belief, increased consumption of dietary fats is associated with a lower risk of death," Dehghan said. "We found no evidence that below 10 percent of energy by saturated fat is beneficial, and going below 7 percent may even be harmful. Moderate amounts, particularly when accompanied with lower carbohydrate intake, are probably optimal," she said. These results suggest that leading health organizations might need to reconsider their dietary guidelines, Dehghan noted." Large diet study suggests it's carbs, not fats, that are bad for your health, By DENNIS THOMPSON HEALTHDAY, CBS News

This post has been promoted to an article: Do You Have A Gut Feeling About Your Rosacea?

"While assessment of available clinical trial data indicates that the medication is as effective as other available treatment for controlling rosacea-associated erythema with minimal risk of adverse effects, studies of long-term duration and direct comparison will be necessary to establish its place in treatment guidelines and clinical practice." Oxymetazoline hydrochloride cream for facial erythema associated with rosacea. Expert Rev Clin Pharmacol. 2017 Aug 24;:1-6 Authors: Patel NU, Shukla S, Zaki J, Feldman SR

"Patients with rosacea were significantly more likely than controls to have Demodex mite infestation, according to findings from a literature review and meta-analysis." Demodex mite infestation present in patients with rosacea, Healio Dermatology What are the numbers?

Q&As What Can I Do for My Rosacea? The Short Answer from a dermatologist —Dermatologist Christine Poblete-Lopez, MD healthessentials, Cleveland Clinic

"In the recent study, Di Nardo and colleagues have found that transient receptor potential vanilloid 4 (TRPV4) activates mast cells in people with rosacea." Researchers discover rosacea treatment pathway, Healio For more information on this read the post, Trigeminal sensory malfunction theory

"It didn't take long to be diagnosed with rosacea and told that "there is not much known about it and no known cure". All four of the dermatologists I visited (yes, four - I was determined to find one who would offer a glimmer of hope) explained that it was chronic inflammation where blood vessels dilate too easily. It occurs most commonly in women (check) with fair skin (check) who are prone to blushing (check). So, at an age when I assumed I was well beyond my "skin-issue" years, I was suddenly a textbook case. All the doctors told me to treat it with oral and topical antibiotics." Dealing With Rosacea: Under My Skin, Calgary Avansino, Vogue

"Lena Dunham has spoken out in the past about her mental health difficulties, her endometriosis and her battles with social-media trolls, but this time she has turned her attention to a skin issue that plagues people all over the world: rosacea." Lena Dunham Speaks Out About Rosacea, Vogue image courtesy Wikicommons Lena Dunham Reveals Her Struggle With Rosacea, And For A Great Reason, Huff Post LENA DUNHAM REVEALS A SUDDEN STRUGGLE WITH ROSACEA HAS "RUINED" HER SKIN, Harpers Bazaar Lena Dunham Is Not Happy That She Suddenly Has Rosacea, Self Lena Dunham Reveals How Rosacea Ruined Her 'Perfect ****** Skin', Allure Lena Dunham Is Seriously Bummed She Suddenly Has Rosacea at 31. Here's Why That Happens, Health 9 Celebrities Who Also Deal With Annoying Skin Issues, By Zahra Barnes, Self Famous Rosaceans

Originally intended for those suffering from rosacea and eczema, this redness-neutralizing cream comes in three shades and has an irritation-soothing, sensitive-skin-comforting formula made up of colloidal oatmeal, peptides, hydrolyzed collagen, aloe, and avocado to calm, smooth, and hydrate the skin. This Concealer Was Made For Rosacea, but Is Baller at Covering Acne Scars, by MEGAN MCINTYRE, Popsugar IT Cosmetics Bye Bye Redness Neutralizing Correcting Cream

Tom Busby, poster extraordinair at RF, posted the following which is worth reading and reproduced below (post no 2 in this thread. "Hi Stephan, you're right that demodex can cause dry eye symptoms, and plugging of the meibomian glands. Your photo shows a small whitish plug inside the margins of the eyelashes, which is where the meibomian glands are located. I suggest you read as much as you can, and use google search terms like "inspissated meibomian glands," which is the medical term for plugged meibomian glands, and your description of dry eyes upon waking is called "saponification." "Meibomian Gland Dysfunction" (MGD) is the general term, and demodicosis or demodectic blepharitis would be more specific terms.The medical profession is obsessed with the naming of things, and you'll eventually learn more if you go through the steep learning curve of learning the medical terms. I did all this when I found I had conditions very similar to yours.Plus, the eyes have extremely complicated anatomy, which you will need to learn. To get you started, the function of the meibomian glands is to release a tiny bit of oil each time you blink (from the blink pressure) and the oil floats on top of the tear film, and slows down the evaporation of the aqueous component. The Glands of Moll and the Glands of Zeiss also release oil. The lack of oil is the problem, and is why eye drops don't do anything at all.The plug that is outside the margin of the eyelashes, in your photo, is most like a plugged up Gland of Moll. These plugs are mostly a cosmetic problem, and are the result of dead demodex decaying and causing an allergic reaction. A prominent rosacea MD refers to them as "the gravestone of a dead demodex." The crusty skin below your eyes appears to be a combination of demodex-induced and malassezia-induced reactions. Climbazole treats against malassezia, but does nothing against demodex.You can gently express the meibomian glands, and you'll learn a lot by examining the quality and quantity of fluid that comes out. You'll need to read a lot more about this, but in very general terms, it's easier to start with the lower lid, and roll a finger gently up. Don't do this over and over, because the amount of oil in the mebomian glands is tiny, and there's no point to emptying the glands by doing it over and over. Most likely, nothing will come out of your meibomian glands, which is not what you want to see, at all, but it will show how bad the situation is. Perhaps the fluid will be discolored, or thickened -- this is also showing the need for treatment.The best current medically accepted treatment is 25% Tea Tree Oil (TTO), or preferably, a derivative of it called terpinen 4-ol. These procedures and products are patented. The main problem is that these treatments can't be self-administered, because both products burn the cornea, and generally require about a weekly one-hour office visit to an ophthalmologist. Worse yet, in the US these treatments aren't covered by insurance, but I'd like to know if they are covered in Canada. Treatments would cost tens of thousands of dollars. The condition, if it is indeed and allergic reaction, is most likely recurring. You could self-treat with Cliradex wipes, which are 5% TTO, or terpinen 4-ol, but the concept could also be imitated by making your own Cliradex wipes, with 5% TTO and 95% MCT oil. Use before bedtime. Demodex males move around at night, and they're easier to kill. TTO is a contact-killer.I never used TTO or terpinen 4-ol as a treatment, because the idea of putting any essential oil near my eyes seemed to being inviting a disaster. My eyes are too important to me, as I read a lot. However, after two years of effectively treating against seb derm induced by an allergic reaction to malassezia, using climbazole as the active ingredient, I found that my eyes were becoming more dry and bloodshot, so a year and a half ago, I went through a second incredibly steep learning curve to find out how I could treat MGD and demodectic blepharitis. As I had previously learned how to make an MCT lotion and an MCT shampoo/shower gel with climbazole, I decided to test other compounds -- only safe ones -- and I found that piroctone olamine suppressed or eradicated demodex. Now my meibomian glands are unblocked, and have remained unblocked for over a year. I use piroctone olamine at a concentration of 0.14%, and climbazole at 0.09%. Neither of these products is applied directly to the cornea or onto an open eye, which would be ridiculously dangerous in my opinion.However, my method of trying something to see if it works, is generally called "foraging research" and is not considered scientifically acceptable today, but it's how most discoveries were made before medicine became so incredibly complex and expensive. Nevertheless, I was so exhausted by the expense and futility of the medical system, that I did my own research and experimentation both as to malassezia and then as to demodex.Expect to use daily treatment with topical piroctone olamine for 23 days to see initial results, and 120 days for about 99% treatment, and 180 days for full treatment. The process of taking a shower, lathering up with the shower off for 3-5 minutes, then rinsing off and towel drying, and then applying a lotion, is very simple, so the time involved is not oppressive because the treatment is merely ordinary, daily hygiene, using an effective ingredient.There's a larger list of things that either don't work, or don't treat against demodex, and they're listed here, and in many other medical articles: http://www.reviewofophthalmology.com/content/c/36944/ You can't buy piroctone olamine-based cosmetics in the US or Canada because there isn't a Final Monograph approved by the FDA, and Canada follows the FDA in these matters. However, there is a Preliminary Monograph on Octopirox, another name for piroctone olamine, and one can see that piroctone olamine has a 3000 to 1 safety ratio, which is huge. With climbazole, the EU considers a 100 to 1 safety margin acceptable, so it's clear that piroctone olamine is much safer.There is no reason for a manufacturer to spend the millions of dollars necessary for a Final Monograph on piroctone olamine, because there are many OTC products overseas and already on the market, making the expense unrecoverable. The same reasoning shows the futility of a patented prescription product, although it would be possible, but it would be undercut by consumers who are willing to buy OTC products from overseas web-vendors.You could find some of these OTC piroctone olamine products on eBay or Amazon, but I'm not certain if they would ship them to the US or Canada. It would be worth your time and effort to try to obtain these products, as they aren't very expensive.Keep in mind that I'm merely a guy that reads a lot and is willing to try to figure things out, so you'll need to form your own conclusions. Good Luck! Tom Busby" ------------------------------------- Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

In a recent interview, Sai Pallavi clarified that it is not acne and it’s an atypical disease she is suffering with. ‘It is Rosacea. I am photo sensitive. Whenever I am exposed to camera and light, my face turns pink,’ the actress said. Fidaa Girl Sai Pallavi suffers with skin disease – Rosacea, Celebs Cinema Image Wikipedia Commons Famous Rosaceans

“The Antirougeurs line is targeted as redness relief,” Malinowski said. “It is clinically proven to reduce the redness associated with rosacea.” The Antirougeurs Dermo-Cleansing fluid is a gentle, soothing formula which cleanses and comforts the skin while reducing heat sensations. The Antirougeurs Redness Relief soothing cream contains an SPF of 25. “The cream moisturizes, protects, neutralizes and alleviates existing redness with a broad spectrum UVA/UVB protection,” Malinowski said. Eterna MedSpa offers help for those battling rosacea, [Sponsored] by Eterna Medspa & Laser Vein Center, The Herald-News, Shaw Media Eau Thermale Avène Antirougeurs Fort Relief Concentrate Eau Thermale Avène Antirougeurs Dermo Cleansing Milk Eau Thermale Avène Cicalfate Restorative Skin Cream Eau Thermale Avène Antirougeurs Day Redness Relief Soothing SPF 25 Cream

Demodex Solutions, one of our sponsors, is experimenting with a new improved ZZ like cream that hopefully will help with dry skin and is seeking six (6) willing volunteers who will provide before and after photos for this trial and details of your experience. You will receive free trial samples shipped to your address at no charge to you for shipping or the samples. However, you must provide before and after photos to be selected for this trial. If you are interested, you must follow these steps: (1) Join the RRDi and be sure to confirm by clicking on the validation email sent to you so you are a registered member. (2) After logging to your RRDi account, use the contact form and request an application which will be sent to you after you join the RRDi in step one. In the contact form request to be part of the Demodex Solutions trial that you want the samples mailed to you. Remember, only six will be chosen so please follow the directions we send you. If you have dry skin that would be a plus for your being selected. Demodex Solutions will choose from among the applicants the final six trial members. You may live anywhere in the world since the samples will be mailed to your address at no cost to you. The ingredients of the dry skin version will be different (something for dry skin) but will be similar to the ZZ cream which is listed as follows: ZOSSO Incredients Zinc oxide 7.1% Sulfur Sublimate 7.1% Mint (Herba menthae) 2% Boric acid 2% Salicylic Acid 0.5% Dimethiconum Composite Java Brucea And 2 more herbs which are a secret... There are no steroids, no hormones, no pesticides, no antibiotics, etc.

Please do.

Mahalo Mistica for your post. The new Trigeminal sensory malfunction theory involving the TRPV4 expression I originally put in 'other theories' but it is logical to put under the Nervous System Theory. Really appreciate your posting here.

"Due to the design of the gelator, drug release was up to 10 times faster and retention of the drug within the skin was up to 20 times more effective than that observed for commercial products." Source We will learn more about these new 'Cationic Supramolecular Hydrogels' in the future. Kate Lawrence, Chemistry Views, writes, "Effective drug delivery using cationic supramolecular gels could be associated with intermolecular reactions as well as the lack of coulombic attraction between the gelator and the drug. A rabbit model was developed based on the decrease of erythema (redness of the skin) after inducing vasodilation (widening of blood vessels), and in vivo experiments demonstrated the efficacy of the hydrogels. This, combined with the straightforward preparation of thermoreversible supramolecular hydrogels at room temperature, provides an option for industrial-scale production of dermatological formulations to treat rosacea and other chronic skin diseases." Langmuir, American Chemistry Society, reports that "hybrid peptide hydrogels show antibacterial activity." Another design "novel supramolecular gels in ethanol-water mixtures...seem to promote the retention of the drug inside the skin....effective in vivo anti-inflammatory activity was observed, especially with the indomethacin-incorporated gel, which indicates that these supramolecular hydrogels are a good option for the delivery of poor water soluble drugs for the treatment of acute inflammation or other skin diseases." Novel nanostructured supramolecular hydrogels for the topical delivery of anionic drugs. The good news about these new supramolecular hydrogels is "the potential opening up of alternative strategies in therapy." Cationic nioplexes in supramolecular hydrogels as hybrid materials to deliver nucleic acids