Guide

"Terpinen-4-ol is used in multiple skin related diseases including blepharitis, rosacea, Demodex, meibomian gland dysfunction, chalazion and dry eye., as well as lid margin diseases. The compound exhibits miticidal, anti-inflammatory, antibacterial and antifungal effects. Terpinen-4-ol is the main component of tea tree oil,[2] which is steam-distilled from the leaves of the Australian native plant Melaleuca alternifolia. Because of its beneficial effects, the oil has long been used by the Aborigines for wounds and minor skin infections." Wikipedia "Using a reported in vitro killing assay to measure the survival time of adult Demodex folliculorum up to 150 minutes, we have screened serial concentrations of 13 of the 15 known ingredients of TTO [Tea Tree Oil] (ISO4730:2004) that were soluble in mineral oil and examined their synergistic relationships in killing mites. The most potent ingredient was then tested for its efficacy in killing Demodex in vivo. Results All ingredients exhibited a dose-dependent killing effect. Besides Terpinen-4-ol, the order of relative potency did not correlate with the order of relative abundance in TTO for the remaining 12 ingredients. Terpinen-4-ol was the most potent ingredient followed by α-Terpineol, 1,8-Cineole and Sabinene. Terpinen-4-ol, the most abundant ingredient in TTO, was more potent than TTO at equivalent concentrations and its killing effect was even observable at a mere concentration of 1%. Terpinen-4-ol exhibited a significant synergistic effect with Terpinolene, but an antagonistic effect with α-Terpineol in killing mites (both P < 0.05). In vivo, Terpinen-4-ol was shown to eradicate mites. Conclusions The above finding suggests that deployment of Terpinen-4-ol alone should enhance its potency in killing Demodex mites by reducing the adverse and antagonistic effects from other ingredients in TTO." Transl Vis Sci Technol. 2013 Nov; 2(7): 2. Published online 2013 Nov 13. doi: 10.1167/tvst.2.7.2 PMCID: PMC3860352 Terpinen-4-ol is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites Sean Tighe, Ying-Ying Gao, and Scheffer C. G. Tseng "When these components were examined individually, only terpinen-4-ol suppressed the production after 40 h of TNFalpha, IL-1beta, IL-8, IL-10 and PGE2 by LPS-activated monocytes. CONCLUSION: The water-soluble components of tea tree oil can suppress pro-inflammatory mediator production by activated human monocytes." Inflamm Res. 2000 Nov;49(11):619-26. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Hart PH, Brand C, Carson CF, Riley TV, Prager RH, Finlay-Jones JJ. "Terpinen-4-ol suppresses inflammatory mediator production by activating human monocytes. Monocytes are a type of white blood cell–part of the human body’s immune system." Loving Terpinen-4-ol by ANDREA "Not all tea tree oils are created equal and as George Orwell might say, some tea tree oils 'are created more equal than others.' ” Confessions Of A Tea Tree Oil Snob, Michelle Glover Shop

This is a forum to share your experiences of living with rosacea with fellow sufferers and those interested to learn more. As a condition where many suffer in silence, here we encourage you to share your thoughts, fears, hopes, frustrations and advice amongst a community of those who understand. Through the support of our community and the sharing of one united voice, together we can raise awareness of the impact of living with rosacea and breakdown the common and often damaging misconceptions surrounding the condition Experience My Rosacea UK Campaign Sponsored by Galderma

Before you go in with a heavy camouflage, soothe skin from the outset to create a smoother, more uniform base for makeup. Dr Anthony Bewley, Consultant Dermatologist at Whipps Cross and Barts Hospitals, London, recommends taking five with a redness reducing treatment to help both skin and mind cool off (incidentally, stress is thought to trigger 79% of flare-ups, which has more of the touch of the ‘vicious circle’ about it). THE MAKEUP MANIAC: MAKEUP FOR ROSACEA, Anna Hunter, Get the Gloss

Altogether, our results show that IVM is endowed with topical anti-inflammatory properties that could have important applications for the treatment of T-cell mediated skin inflammatory diseases. Experimental Allergy and Immunology doi: 10.1111/all.13118 Topical ivermectin improves allergic skin inflammation Erwan Ventre, Aurore Rozières, Vanina Lenief, Floriane Albert, Patricia Rossio, Léo Laoubi, David Dombrowicz, Bart Staels, Lauriane Ulmann, Valerie Julia, Emmanuel Vial, André Jomard, Fériel Hacini-Rachinel, Jean-François Nicolas, Marc Vocanson

So how long were you on Soolantra total Rory?

"Pharmaceutical compounding (done in compounding pharmacies) is the creation of a particular pharmaceutical product to fit the unique need of a patient. To do this, compounding pharmacists combine or process appropriate ingredients using various tools. This may be done for medically necessary reasons, such as to change the form of the medication from a solid pill to a liquid, to avoid a non-essential ingredient that the patient is allergic to, or to obtain the exact dose(s) needed or deemed best of particular active pharmaceutical ingredient(s). It may also be done for more optional reasons, such as adding flavors to a medication or otherwise altering taste or texture. Compounding is most routine in the case of intravenous/parenteral medication, typically by hospital pharmacists, but is also offered by privately owned compounding pharmacies and certain retail pharmacies for various forms of medication. Whether routine or rare, intravenous or oral, etc., when a given drug product is made or modified to have characteristics that are specifically prescribed for an individual patient, it is known as "traditional" compounding." Wikipedia There is a difference between a pharmacist and a compounding pharmacist. Whether your insurance covers a compounding pharmacist is another matter you will need to investigate. A prescription from a medical doctor is usually required for the compounding pharmacy to make the prescription. The base ointment can be any type the pharmacist has available or prescribed by the physician. This is like the old fashioned pharmacist who has a motar and pestal. image courtesy of Wikipedia commons Links Professional Compounding Centers of America Find a Local Compounding Pharmacy Near You Walgreens Pharmacy Compounding Services How do I Find a Compounding Pharmacy Near Me? FDA Human Drug Compounding FDA Registered Outsourcing Facilities Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

Kalamazoo reports that her dermatologist in Spain prescribed a compounding pharmacist formula for rosacea that includes the following: 30 gram 'crema glucidica' (Spanish) for sensitive skin containing: 1% metronidazol 1% ivermectin 0.5% hyaluronic acid 5% vitamin PP (pellagra-preventive factor - vitamin B3 [niacin]) 0.5% glyceral acid Apply 1 to 2 times a day. In addition to the compounding formula above the dermatologist prescribed the following: 7 milligrams of isotretinoin taken orally once a day metronidazole drops for ocular rosacea SPF 50 topical in gel format to prevent sunburn If any member tries this please post here.

The impact of other potential pathogens remains unsettled. For example, said Dr. Webster, European physicians accept completely that the Demodex folliculorum mite is the root of rosacea. "If you ask me, or many American dermatologists, it's less decided." Although D. folliculorum levels are elevated in rosacea, he explained, people can have heavy D. folliculorum colonization, but no rosacea, and vice versa. The fact that Demodex levels are highest in ETT rosacea counters the assumption that mites attack the hair follicles, causing inflammation and pimple formation, he added. "The issue is confounded by the fact that the anti-mite drug Soolantra (topical ivermectin, Galderma) works well in rosacea. But no one has fulfilled Koch's postulates by showing that killing the Demodex improves rosacea; that Soolantra lowers Demodex levels; and that patients who resist Soolantra have Demodex levels that don't decrease with treatment." One cannot assume that topical ivermectin works in rosacea by killing Demodex, he said, because antibiotics such as doxycycline work in rosacea through many non-antibiotic effects. Topical ivermectin also has anti-inflammatory activity, he noted. Also unclear, he said, is the contribution of Bacillus oleronius. This bacterium has been found to have antigens (chaperonin GroEL and aconitate hydratase) that excited the lymphocytes of patients with rosacea, but not in normal subjects.6 "It sounds like something's going on there. Also, the immune response to B. oleronius was found to be especially elevated in ocular rosacea. But we don't know that the antigens in this bug are unique to this bug. Much remains to be worked out. It's a stretch to conclude that the bug isolated from one mite of 40 studied is relevant. I'd be more convinced if these antigens are in Propionibacterium acnes or some known skin resident" that causes disease. Factors in rosacea pathogenesis clearer By John Jesitus Dermatology Times, Dermatology, Clinical dermatology

While there has been in the past discussion about classifying demodicosis as a disease sui generis or demodectic rosacea as a rosacea variant, there is overwhelming evidence that demodex mites are involved in some cases of rosacea. Therefore, the RRDi has now recognized demodectic rosacea as a rosacea variant. Demodectic Rosacea posts have moved.

On the horizon, another α-adrenergic agonist, oxymetazoline 1% cream, likely will earn FDA approval in early 2017, predicted Drs. Harper and Webster. Allergan submitted the drug for FDA approval in mid-2016 and expects its Prescription Drug User Fee Act date in the first half of 2017, according to the company. 12th Annual Women's & Pediatric Dermatology Symposium 2016, Dermatology Times Rosacea treatments Dermatologists welcome antibiotics, α-adrenergic agonists and more

There is an interesting thread at RF started by HunkeyMonkey about a cheap and easy home test for demodex. It is good that rosaceans are figuring out novel ways to view demodex mites. Here is a video uploaded by HunkeyMonkey at Vimeo. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

"This meta-analysis gives strong evidence that IVM 1% cream is the most effective topical treatment above other alternatives and it satisfies the impairment of social and working life with a sustained better QoL." [1] "Topical ivermectin cream 1% given daily is an effective and safe therapy against rosacea." [2] Gets Worse Before it Gets Better In many anecdotal reports from users of Soolantra [ivermectin] complain that it gets worse before it gets better. This may cause some to stop the treatment. It is not uncommon for Soolantra users to say the first week or more of Soolantra use their rosacea actually got worse. This might be the result of the ivermectin killing the mites. However, in time, usually within a month, you will know whether or not Soolantra is improving your rosacea. If you do stop the treatment you should notify your physician. If you think you may be allergic to Soolantra, a good test is to dab a little Soolantra on the inside of your wrist and see if within a few hours whether your skin turns red and gets inflamed. If so, you may be allergic to Soolantra and you should notify your physician of this fact. If not, then just because your facial treatment of rosacea using Soolantra gets worse before it gets better, the only way is to continue your facial treatment of topical Soolantra and usually within a month you will see some improvement. However, total clearance takes time, at least 12 weeks or longer. "After 16 weeks, blepharitis (P = .004), and conjunctival redness (P = .008) had strongly improved, and grade 1 was seen in all patients until the end of follow-up." "The follow-up was 8 months (range: 5-12 months)." [2] On the Soolantra web site there are clinical studies indicating that it may take at least 12 weeks or longer to see positive results from Soolantra. Look for the following: Reply to this TopicThere is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post. End Notes [1] Dermatol Ther. 2019 Dec 20;:e13203Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta-analysis.Husein-ElAhmed H, Steinhoff M [2] Ocul Immunol Inflamm. 2020 Apr 07;:1-5 Efficacy of Topical Ivermectin for the Treatment of Cutaneous and Ocular Rosacea. Sobolewska B, Doycheva D, Deuter CM, Schaller M, Zierhut M

Traumatic brain injury (TBI) is one of the leading causes of disability and death in infants and children in the United States, with more than half a million affected annually, according to the Centers for Disease Control and Prevention. Those under age 4 who experience brain trauma can suffer lifelong problems with memory, attention and other executive functions. While there are no drugs available to treat these injuries, scientists have shown that certain antibiotics -- which inhibit the brain's inflammatory response -- can improve outcomes for adult animal models that have suffered a blow to the head. However, this treatment seems to negatively affect brains that have not yet developed, according to a new study from Drexel University College of Medicine. When administered to newborn rats immediately after head injury, the FDA-approved antibiotic minocycline exacerbated cognitive deficits, says the study, which was published in the journal Experimental Neurology. Antibiotics targeting brain’s inflammatory response may exacerbate cognitive deficits in children, Published on January 11, 2017, Drexel University, News-Medical.Net

The Regenlite Transform Laser is now available in Colorado at Aria Integrative Health. Many other lasers purposely do harm to your skin, forcing your body to heal. This laser actually stimulates your body's natural ability to produce healthy regeneration. It helps with fine lines and wrinkles, rosacea, eczema, and acne. Change your skin from the inside out POSTED 11:51 AM, JANUARY 10, 2017, BY TRAVIS DOOLEY HARRISON, Fox 31 Denver

A 52-year-old Colombian woman, a patient with psoriasis, undergoing phototherapy with (ultraviolet B narrowband) UVBnb, presented with a symptomless solitary diffuse erythaematous plaque on her nose for 3 months. Initially, she was treated with pimecrolimus 1% cream for 8 weeks, which was then combined with metronidazole cream for 4 weeks, with the initial diagnosis of UV-triggered rosacea, without improvement. A punch biopsy was performed and the histology showed a pseudolymphomatous reaction. The diagnosis of nasal pseudolymphoma of borreliosis was confirmed with PCR. The lesion completely resolved following oral doxycycline therapy. BMJ Case Rep. 2015; 2015: bcr2014205688. Published online 2015 Jan 7. doi: 10.1136/bcr-2014-205688 PMCID: PMC4289773 Case Report Borrelial pseudolymphoma of the nose Mosab Tariq Mohanna, Jivko Kamarashev, and Günther F L Hofbauer

I know it's tempting to slather flaky skin in moisturizing oil, but a lot of oil blends feature fragrances, which can cause flare-ups, resulting in itchy, red, inflamed skin. The same goes for rosacea. Someone with rosacea should just be using mild non-soap cleansers and fragrance-free moisturizers. Essential oils and botanicals, though natural, can make the skin angrier and redder. Should You Stop Using Argan Oil On Your Skin?, By Mona Gohara, MD | Lifestyle/Beauty, Shape

Rory, Thanks for the encouragement. I guess you are probably right. 90 days simply isn't enough time. I do see a little improvement but it is a tough regimen to go through. Breaking out with rosacea after using it isn't exactly my cup of tea, but I have read several other anecdotal reports that many go through similar flareups after applying Soolantra. One year is a long time to be patient for results. Did you go through all this with Soolantra?

You Have an Untreated Skin Condition Feel like you’ve tried everything and your red, sensitive skin still isn’t calling it quits? Zeichner recommends a visit to your dermatologist to see if an undiagnosed skin condition like rosacea might be the cause. “Rosacea is a condition characterized by facial flushing and redness, burning and stinging, and bumps and pus pimples,” he says. “Genetically, the skin is more sensitive to the environment and overreacts to triggers like spicy food and changes in temperature. If you think you have rosacea, visit your dermatologist to discuss treatment options.” Why your skin is suddenly so sensitive, Health Tips, Pulse.com.gh

There are anecdotal reports that oil of oregano helps heal rosacea. Anecdotal Reports I have the papulopustular subtype, I find oregano oil has worked super well for me as well...I take 6 super strength P73 Oreganol gelcaps a day (I had to work up to that, it made me sick at first). I find that I can skip several days without my rosacea coming back; I think the OO stops some sort of inflammatory process. I've experimented, and after about a week and a half my skin starts to flare again if I don't take the OO. - Michelle - post #6 Last september i went on heavy dose of oregano oil - 6 times a day x 7 drops. i noticed significant improvement ...added heavy dose of ginger tea(mushed up ginger in hot water) and pau darco tea. Now my symptoms are almost all gone.....thats continuous since late october....I really think oregano oil is doing main work. My wife almost forgot i had that disorder.....Michael - post # 1 more info on oil of oregano

I spoke to expert Dr. Craig Kraffert, Board Certified Dermatologist and President of Amarte about the benefits of sulfur, and here's what he said: "Sulfur is a periodic table element that is an essential part of all living organisms. A broad spectrum antimicrobial with unique anti-inflammatory and exfoliative properties, purified sulfur is very effective in the treatment of acne, rosacea, and seborrheic dermatitis. A multi-tasker, this element is also a skin brightener that helps decrease sebum production." I Tried Adding Sulfur To My Skin Care Routine To Reduce The Redness On My Face, By KELLY DOUGHER, Bustle

Christine123 recommends using Nu-Stock, tea tree oil and zinc oxide cream to eradicate demodex in a thread at RF.

It is difficult for rosacea patients to discern which products and ingredients will be beneficial to their skin and which products will lead to an exacerbation of the signs and symptoms of rosacea. In this paper, the authors provide a brief overview of rosacea, its pathogenesis, signs and symptoms, and the management of the two major rosacea subtypes—erythematotelangiectatic rosacea and papular pustular rosacea. Reviewed in greater detail are the common ingredients used in over-the-counter cleansers and moisturizers with discussion of how these ingredients potentially benefit or harm the skin of patients with rosacea. J Clin Aesthet Dermatol. 2011 Aug; 4(8): 31–49. PMCID: PMC3168246 A Guide to the Ingredients and Potential Benefits of Over-the-Counter Cleansers and Moisturizers for Rosacea Patients Jacquelyn Levin, DO and Richard Miller, DO Rosacea.pdf Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post.

People who often tilt their heads low for long hours and whose blood vessels in the skin are more prone to vasodilation (widening of blood vessels) may suffer from facial skin redness because of poor blood circulation caused by bad posture, Liu said. “Not all facial redness is caused by rosacea, although many people seek medical treatment because they are worried that they might have rosacea,” Liu said. A 2014 US study showed that only 31 percent of cases of red-face syndrome are due to rosacea, Liu added. Your phone might be making your face red: doctor, By Lee I-chia , Taipei Times

It has been two months now using Soolantra, every night at bedtime. There is some improvement after sixty days. I just got my third tube of Soolantra which lasts about a month and will give it one more month.

A chronic condition that’s more common after age 30, rosacea can lead to redness, bumps and pustules, usually on the face. Some people experience dryness, stinging, itching and burning. “The skin of rosacea patients is very sensitive,” says John Wolf, chair of dermatology at Houston’s Baylor College of Medicine. Triggers include cold or hot weather, indoor heat, stress, sun, wind, alcohol, hot baths, vigorous exercise and spicy food. What to do about dry, itchy skin?, By Consumer Reports, The Washington Post