Guide

"I looked it up and thought I would try a new supplement (and very expensive, unfortunately) called Histame which is supposed to help those who have trouble eating histamine rich foods. Well, guess what? My skin is not only clear but much, much less puffy. My eyes are not bloodshot but white. I look so much healthier. For me, it was Histamine Intolerance all along. That is probably why my skin and my diet were so interrelated, and why taking a mast cell inhibitor like quercetin helped me. Anyway, I am now one happy camper. I still stick to a low histamine diet, which most docs who treat Histamine Intolerance seem to recommend, but my face looks great. My whole appearance has improved. If you seem to react to high histamine foods (tomatoes, smoked fish, aged cheese, etc.) you might want to give it a whirl. Histame is very expensive, though, but I don't have much choice for myself. My body really seems to be lacking in DAO, one of the enzymes that helps the body deal with histamine. Regards, Queta" Histame 30 caps Dietary Supplement Food Intolerance Support. Clinically Shown To Degrade Histamine From Food Naturally helps discomfort from: Pizza, Tomatoes, Wine/Beer, Fish, Aged Cheeses, Bananas, Chocolate, More.. Supplement Facts Serving Size: 1 Capsule Servings per Container: 30 Amount per Serving Vitamin C 10 mg Calcium (as calcium carbonate) 100 mg Diamine Oxidase Enzyme 4000 HDU 0.3 mg (as porcine kidney protein concentrate pellets) Other Ingredients: Cellulose, water. HDU = Histamine Digesting Units Lactose-free Wheat-free Gluten-free Soy-free RECOMMENDED: For best results, take one (1) or two (2) capsules within 15 minutes of consuming products causing food intolerance. The RRDi is an Amazon Affiliate. By clicking below on the link and purchasing the item, the RRDi receives a small fee. Thanks. Please post your experience using this product in this thread.

"The panel agreed on phenotype-based treatments for signs and symptoms presenting in individuals with rosacea." Dr. Martin Schaller serves on the ROSCO panel as well as the RRDi MAC. Br J Dermatol. 2016 Nov 12. doi: 10.1111/bjd.15173. Rosacea treatment update: Recommendations from the global ROSacea COnsensus (ROSCO) panel. Schaller M, Almeida L, Bewley A, Cribier B, Dlova N, Kautz G, Mannis M, Oon H, Rajagopalan M, Steinhoff M, Thiboutot D, Troielli P, Webster G, Wu Y, van Zuuren E, Tan J.

ORACEA is indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. No meaningful effect was demonstrated for generalized erythema (redness) of rosacea. Limitations of Use: This formulation of doxycycline has not been evaluated in the treatment or prevention of infections. ORACEA should not be used for treating bacterial infections, providing antibacterial prophylaxis, or reducing the numbers or eliminating microorganisms associated with any bacterial disease. To reduce the development of drug-resistant bacteria as well as to maintain the effectiveness of other antibacterial drugs, ORACEA should be used only as indicated." Source

Usually you read that Soolantra is for Phenotype 4, however, the report below shows that Soolantra may improve Phenotype 2 and Phenotype 3. "Our series demonstrates better results with moderate to severe papulopustular rosacea as in the cases studied in trials. Nevertheless, we have also observed some response in mild cases of erythematotelangiectatic rosacea as well. Tolerance of ivermectin cream is high and produces quick results." Dermatol Online J. 2016 Aug 15;22(8). pii: 13030/qt9ks1c48n. Treatment of rosacea with topical ivermectin cream: a series of 34 cases. Mendieta Eckert M1, Landa Gundin N.

"Minocycline 100mg is non-inferior to doxycycline 40mg in efficacy over a 16- week treatment period. Furthermore, at follow up, RosaQoL scores and PaGA were statistically significantly more improved in the minocycline group than in the doxycycline group, and minocycline 100mg gives longer remission than doxycycline 40mg. In this study there was no significant difference in safety between these treatments, however, based on previous literature minocycline has a lower risk/benefit ratio than doxycycline. Minocycline 100mg may be a good alternative treatment for those patients who, for any reason, are unable or unwilling to take doxycycline 40mg." Br J Dermatol. 2016 Oct 31. doi: 10.1111/bjd.15155. DOMINO, doxycycline 40mg vs minocycline 100mg in the treatment of rosacea: a randomised, single blinded, non-inferiority trial, comparing efficacy and safety. van der Linden MM, van Ratingen AR, van Rappard DC, Nieuwenburg SA, Spuls PI. Monocycline "is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group....Minocycline is the most lipid-soluble of the tetracycline-class antibiotics, giving it the greatest penetration into the prostate and brain, but also the greatest amount of central nervous system (CNS)-related side effects, such as vertigo." Wikipedia Orał Minocycline (minolira) has been approved for treating acne which is a timed released minocycline hydrochloride. Oracea, a frequently prescribed timed released doxycycline (another tetracycline), by Galderma, is reportedly used by many rosacea sufferers to control their rosacea. It may be possible that minolira may be approved for rosacea. Topical Minocycline There have been a number of pharmaceutical companies in clinical trials with developing a monocycline topical which we have been following for some time now in this thread, and Zilxi has been announced as the front runner in this race. Minocycline-Induced Lupus If you are not aware of minocycline-induced lupus, you are now informed.

The RRDi endorses the phenotype based treatment for rosacea proposed by the ROSCOE Panel in November 2016. “Given the overlap of rosacea features across subtypes and the fact that no single treatment completely addresses all rosacea features, the current approach of diagnosing and treating rosacea by subtype may hinder individualised patient management. A new approach is needed to bring us closer to helping each and every rosacea patient receive the right treatment according to their signs and symptoms.” Jerry Tan, MD “While the rosacea management landscape has advanced, the current subtype-based view of the disease can hinder progress by limiting the way we consider treatment options. These new ROSCO recommendations should help to make a positive impact on future treatment development and ultimately help improve the lives of people with rosacea through a symptom-led approach.” Esther J. van Zuuren, MD Global ROSacea COnsensus (ROSCO) expert panel calls for new approach to diagnosis and treatment of rosacea to improve outcomes for patients, BusinessWire Br J Dermatol. First published 2016 Oct 8. doi: 10.1111/bjd.15122. Full Text published 2017 Feb;176(2):465-471. doi: 10.1111/bjd.15173. Wiley Updating the diagnosis, classification and assessment of rosacea: Recommendations from the global ROSacea COnsensus (ROSCO) panel. Tan J, Almeida L, Bewley A, Cribier B, Dlova N, Gallo R, Kautz G, Mannis M, Oon H, Rajagopalan M, Steinhoff M, Thiboutot D, Troielli P, Webster G, Wu Y, van Zuuren E, Schaller M. For more info on this subject, read the articles, Classification Of Rosacea Remains Controversial • Shortcomings in rosacea diagnosis and classification • Who is the ROSCO Panel? • Phenotype Classification, How does it work? Download: pdf

Souris24 (Marie) claims that she followed the liver and gallbladder flush discussed in this book and it improved her rosacea. This was in December 2015. Marie's last post was on August 15, 2016 where she states, "I believe that it made my rosacea better because it cleared some inflammation that was making my rosacea worse but the root cause of my rosacea is something else." By clicking below on the link and purchasing the item, the RRDi receives a small fee. Thanks. Please post your experience using this product in this thread.

The RRDi is pleased to announce that Greg K. Sakamoto, MD, has been appointed to serve on the RRDi and has graciously volunteered to assist us with his busy schedule. The RRDi appreciates Dr. Sakamoto's volunteer spirit.

Washing face with dandriff shampoo can combat rosacea, By Joe and Teresa Graedon, November 12, 2016, Houston Chronicle

Diet doesn't just effect acne or rosacea, it also effects depression. Diet is associated with the risk of depression UNIVERSITY OF EASTERN FINLAND Ruusunen, Anu. Diet and depression. Publications of the University of Eastern Finland. Dissertations in Health Sciences 2013; no 185. ISSN: 1798-5714 ISBN: 978-952-61-1201-5

"Mindfulness, defined as purposively and nonjudgementally paying attention in the present moment, could be used within psychosocial interventions to reduce the distress associated with social anxiety and avoidance found in many skin conditions....The findings indicate that higher levels of mindfulness are associated with lower distress. This suggests that facilitating mindfulness may be helpful in reducing distress in dermatology patients, and the use of mindfulness techniques warrants further investigation." Br J Dermatol. 2016 Nov; 175(5): 930–936. Published online 2016 Sep 18. doi: 10.1111/bjd.14719 PMCID: PMC5091630 The importance of mindfulness in psychosocial distress and quality of life in dermatology patients K. Montgomery, P. Norman, A.G. Messenger, and A.R. Thompson

Dry Winter Skin: Eczema, Psoriasis, and Rosacea Explained, By Catherine Winters, Consumer Reports

"Low-dose isotretinoin was an effective therapeutic option for difficult-to-treat papulopustular rosacea." A Randomized-Controlled Trial of Oral Low-Dose Isotretinoin for Difficult-To-Treat Papulopustular Rosacea Presented in part at the Journées Dermatologiques de Paris Congress, Paris, 7–11 December 2010. Emilie Sbidian, Éric Vicaut, Henri Chidiack, Elie Anselin, Bernard Cribier, Brigitte Dréno6, Olivier Chosidow To Continue Reading About Low Dose Isotretinoin Click Here

It has now been over one week since I started using Soolantra. I apply it in the evening just before bed. After the fourth day I had about four or five white capped papules appear on my cheeks which I removed. On the eighth day I have noticed an improvement. I apply it over the red spots on my forehead and cheeks. Attached are photos on day eight.

Abstract Erythromelanosis follicularis faciei et colli (EFF) is an unusual condition characterized by the triad of hyperpigmentation, follicular plugging and erythema of face and neck. This is less common in women and familial case reports are few. We report EFF in three siblings in an Indian family, two of whom are females. The possibility of this condition being genetically related to keratosis pilaris as well as being a variant of keratosis rubra pilaris is also discussed. IDJVL 2008 | Volume : 74 | Issue : 1 | Page : 47-49 Erythromelanosis follicularis faciei et colli: Relationship with keratosis pilaris M Augustine, E Jayaseelan Department of Dermatology, St. John's Medical College Hospital, Bangalore, India ---------------------- Abstract The thirteenth case of erythromelanosis follicularis of the face and neck is reported and attention is called to this entity. Characteristically, it affects males in adolescence or young adulthood. It begins symmetrically on the preauricular cheeks and imperceptibly spreads onto the temples and lateral aspects of the neck. It presents as an irregularly marginated, red-brown pigmentation with fine telangiectasia, small, pale, slightly scaly, follicular papules, and patchy alopecia of vellus hair. The histologic features, although nondiagnostic, correlate well with the clinical features. The possible relationship to keratosis pilaris rouge is discussed. JAAD, November 1981 Volume 5, Issue 5, Pages 533–534 Erythromelanosis follicularis faciei et colli A case report Thomas L. Watt, M.D., John S. Kaiser, M.D. Bangor, ME, USA From the Departments of Medicine (Section of Dermatology) and Pathology of the Eastern Maine Medical Center. --------------------------------------------------------------------------------------------------------------------- "In view of its association with keratosis pilaris at arms and shoulders, this condition may be more common than previously thought but prevalence studies are lacking. Rosacea is a chronic facial dermatosis characterized by central facial erythema and flushing with varying presentations comprising papules, pustules, phymatous features and ocular irritation. Childhood and adolescent rosacea has been noted in case reports and case series." Indian Journal of Dermatology, Venereology and Leprology 74(1):47-January 2008 Erythromelanosis follicularis faciei et colli: Relationship with keratosis pilaris -------------------------------------- Images

"The dysasthesia can be very disturbing for many patients and improved with amytriptyline or gabapentin." Rosacea: Choosing Among the Topical and Systemic Therapeutic Options As the field of therapies available for rosacea has expanded, clinicians must weigh the topical and oral treatment options on a case-by-case basis By Mark Bechtel, MD and Ann Bechtel, BSN, Practical Dermatology "Dysesthesia (or dysaesthesia) means "abnormal sensation". Its etymology comes from the Greek word "dys," meaning "bad," and "aesthesis," which means "sensation" (abnormal sensation). It is defined as an unpleasant, abnormal sense of touch. It often presents as pain[1] but may also present as an inappropriate, but not discomforting, sensation. It is caused by lesions of the nervous system, peripheral or central, and it involves sensations, whether spontaneous or evoked, such as burning, wetness, itching, electric shock, and pins and needles....It is sometimes described as feeling like acid under the skin. Burning dysesthesia might accurately reflect an acidotic state in the synapses and perineural space. Some ion channels will open to a low pH, and the acid sensing ion channel has been shown to open at body temperature, in a model of nerve injury pain. Inappropriate, spontaneous firing in pain receptors has also been implicated as a cause of dysesthesia." Wikipedia "Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder and a variety of pain syndromes from neuropathic pain to fibromyalgia to migraine and tension headaches." Wikipedia "Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat partial seizures and neuropathic pain." Wikipedia

"The dysasthesia can be very disturbing for many patients and improved with amytriptyline or gabapentin." Rosacea: Choosing Among the Topical and Systemic Therapeutic Options As the field of therapies available for rosacea has expanded, clinicians must weigh the topical and oral treatment options on a case-by-case basis By Mark Bechtel, MD and Ann Bechtel, BSN, Practical Dermatology

"What are the key drugs marketed for Rosacea and their clinical attributes? How are they positioned in the Global Rosacea market? What are the unit prices and annual treatment cost for Rosacea therapies in different countries?" Global Rosacea Drugs Price Analysis and Strategies Report 2016:Treatment Options, Attributes, Market Positioning, Reimbursement Landscape & New Drug Pricing 2012-2021 - Research and Markets, BusinessWire

"A number of studies in the psychodermatological literature show that skin disorders have a negative impact on the psychological and emotional health of some of those affected. These effects include depression, a decreased sense of body image and self-esteem, sexual and relationship difficulties and a general reduction in quality of life." "The Face Values: Global Perceptions Survey aimed primarily to assess the impact of facial erythema associated with rosacea on the subconscious perceptions and initial reactions of others, including those affected by the condition. It assessed how these perceptions may affect their attitudes and choices about people with rosacea in relation to work, in relationships and in general social settings. This approach builds on a previous US study in people who had signs of mild to moderate papular/pustular rosacea and which highlighted consistent differences in attitudes toward those with rosacea versus images of people with clear skin (Kelton Research 2009, data on file)." [1] There was a YouTube video about this but it has been removed. End Note [1] Dermatol Ther (Heidelb). 2015 Jun; 5(2): 117–127. Published online 2015 May 29. doi: 10.1007/s13555-015-0077-2, PMCID: PMC4470961 Perceptions on the Psychological Impact of Facial Erythema Associated with Rosacea: Results of International Survey Thomas Dirschka,corresponding author Giuseppe Micali, Linda Papadopoulos, Jerry Tan, Alison Layton, and Simon Moore

"There are few validated methods of assessing improvement in rosacea, possibly due to the multiplicity of outcomes collected. Selective outcome reporting bias, defined as results-based selection of outcomes for publication, is a problem in many clinical trials and affects the conclusions of a significant proportion of systematic reviews." [1] Nevertheless, here are a number of resources for your consideration if you are contemplating entering a rosacea clinical trial. Resources ClinicalTrials.gov A service of the U.S. National Institutes of Health NHS Clinical Trials CenterWatch Clinical Trials Multiple Nationwide Clinical Research Studies of an Investigational Gel for Severe ROSACEA are being conducted near you, Cutanea ResearchTrials.org IRF Centerwatch Clinical Trials Autocruitment Clinical Research Associates of Tidewater ClinicalConnection Wilmington Dermatology Center Sinclair Dermatology MayoClinic Patient SGS Sterling Group Rosacea Research Open Label Study to Assess the Effect of Secukinumab in Moderate to Severe Papulopustular Rosacea End Notes [1] Trials 201617:429, DOI: 10.1186/s13063-016-1554-3 Development of a core outcome set for clinical trials in rosacea: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey Sanjana Iyengar, Paula R. Williamson, Jochen Schmitt, Lena Johannsen, Ian A. Maher, Joseph F. Sobanko, Todd V. Cartee, Daniel Schlessinger, Emily Poon and Murad Alam

“In the study population, Oracea Capsules reduced the inflammatory biomarkers associated with rosacea,” said Dr. Philip Brown, MD, JD, Senior Vice President, Medical and Regulatory Affairs, Galderma Laboratories, L.P. “Those with the best treatment outcomes showed a greater reduction in the associated biomarkers. This information could help us continue to develop even more effective treatments for meaningful, lasting relief of the symptoms associated with this common skin condition.” Research is clearing up the understanding of rosacea, a common skin condition, Brandpoint (BPT), Bloomer Advance Research is clearing up the understanding of rosacea, a common skin condition, Brandpoint (BPT), Wayne County Journal-Banner Online, Piedmont, MO

Please note: This review was sometime back and you can see the dates of each post in this thread. My current regimen for rosacea can be viewed in my Rosacea Blog. However, in the spirit of 'everything rosacea' I have posted my experience using Soolantra for a number of months in this thread for your enjoyment and education. ---------------------------------------------------------- Just got my prescription for Soolantra* today and applied it all over every red spot I have on my face and forehead just before bed. It took over eleven days for my insurance company to approve the prescription drug. I will be posting in this thread my experience using Soolantra. Hoping this works. *My insurance initially would not approve it. I called the insurance company and asked for a second review and after the eleven days of waiting it was approved. Walmart posts that the cost is $346.62 for 30 gram tube. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

"...studies from the dermatology department at Stanford University provide evidence that supports the use of broad-band light (BBL™) therapy to reduce rosacea symptoms and rejuvenate skin cells." Laser therapy reduces rosacea symptoms, rejuvenates skin, Sponsored Content, In Your Neighborhood, Waterloo Region Record, TheRecord

Reduces visible redness & broken capillaries with this cooling formula that has antioxidants shielding skin from external aggressors. Calms, evens and leaves a flawless complexion. Oil-free & talc-free. By clicking below on the link and purchasing the item, the RRDi receives a small fee. Thanks. Please post your experience using this product in this thread.

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