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    • Clin Exp Dermatol. 2021 Oct 20. doi: 10.1111/ced.14987. Online ahead of print. ABSTRACT For several decades, there has been a significant growth in the incidence of autoimmune diseases. Studies indicate that genetic factors may not be the only trigger for disease development and that dysbiosis of the microbiome may be another mechanism involved in the pathogenesis of autoimmune diseases. The role of the microbiome in the development of common skin disorders such as psoriasis, atopic dermatitis, acne, and rosacea is increasingly well understood. However, few studies have focused on lichen planus and the rare acquired immunobullous diseases (AIBD), both mucocutaneous groups of disorders linked to skin, oral and gut microbiomes. This review provides an insight into the current understanding of how the microbiome may contribute to the development of autoimmunity as well as themaintenance and exacerbation of acquired immunobullous and lichenoid diseases. These mechanisms may have implications for future preventive and therapeutic approaches. PMID:34669983 | DOI:10.1111/ced.14987 {url} = URL to article
    • Dermatol Ther. 2021 Oct 19. doi: 10.1111/dth.15162. Online ahead of print. ABSTRACT With the recent interest in medical marijuana, research into cannabinoids is regaining wider attention. Cannabinoids are collectively a group of active compounds that can be produced by animals (endocannabinoids), plants (phytocannabinoids) or synthetically. By acting on a number of different receptors like cannabinoids receptors and transient receptor potential ion channel family, cannabinoids are known to modulate cutaneous inflammation, pain and itch. Rosacea is a highly prevalent disease and can be associated with a significant degree of morbidity associated with its symptom. Transient receptor potential ion channels are known to be triggered in rosacea and may underlie a portion of rosacea's pathophysiology. This article aims to detail the TRP channel pathways in rosacea and the known effects of cannabinoids on these pathways and further discussing the potential role of cannabinoids in treating rosacea. This article is protected by copyright. All rights reserved. PMID:34664381 | DOI:10.1111/dth.15162 {url} = URL to article
    • Dermatol Ther (Heidelb). 2021 Oct 18. doi: 10.1007/s13555-021-00613-w. Online ahead of print. ABSTRACT INTRODUCTION: Depression and anxiety are common among people with rosacea. However, the exact magnitude of the prevalence rate and odds ratios (ORs) for depression and anxiety, respectively, in rosacea patients is unclear, and no systematic review or meta-analysis of published data has yet been performed. We therefore performed as systematic review and meta-analysis to determine the prevalence rates and ORs for depression and anxiety in rosacea patients. METHODS: We performed a systematic search of the PubMed, Embase and Medline databases for all observational studies published up to October 2020 that reported the prevalence rates and ORs for depression and anxiety in patients with rosacea. The primary outcome measures were prevalence rates and ORs for depression and anxiety in patients with rosacea. Heterogeneity across studies was assessed with the I2 statistic. Sources of heterogeneity were explored through subgroup and meta-regression analyses. RESULTS: A total of 14 studies involving 14,134,021 patients with rosacea were included in the systematic review and meta-analysis. The pooled prevalence of depression was 19.6% (95% confidence interval [CI] 15.0-24.3%) and that of anxiety was 15.6% (95% CI 11.8-19.3%). The prevalence of depression and anxiety was significantly lower in studies using clinical criteria to diagnose depression and anxiety (9.2 and 10.2%, respectively) than in those studies using screening tools (26.2% [P < 0.01] and 22.7% [P = 0.03], respectively). The methodological quality of the included studies greatly contributed to the heterogeneity. Patients with rosacea were more likely to experience depression (OR 2.21, 95% CI 1.79-2.72) and anxiety (OR 2.31, 95% CI 1.56-3.44) than healthy controls. CONCLUSIONS: This systematic review and meta-analysis indicates that patients with rosacea are at a higher risk of experiencing depression and anxiety. More efforts are warranted to recognize and manage depression and anxiety in patients with rosacea. PMID:34657997 | DOI:10.1007/s13555-021-00613-w {url} = URL to article
    • Postepy Dermatol Alergol. 2021 Aug;38(4):590-596. doi: 10.5114/ada.2021.108917. Epub 2021 Sep 17. ABSTRACT INTRODUCTION: Inflammation, immune system disorders, Demodex infestation, neurovascular dysregulation and oxidative stress are thought to be contributory factors in the pathogenesis of rosacea. AIM: To evaluate the presence of Demodex mites, the morphologic features of the nailfold capillaries, and the systemic oxidative stress status in patients with rosacea. MATERIAL AND METHODS: Thirty-one patients diagnosed with rosacea and 37 healthy age- and gender-matched subjects were included in this prospective case-control study. The presence of Demodex infestation, the findings of nailfold capillaroscopy (NFC), and the status of systemic oxidative stress measured by total oxidant capacity (TOC), total antioxidant capacity (TAC) and oxidative stress index (OSI) were evaluated. RESULTS: Demodex infestation rates were significantly higher in rosacea patients than in controls (p = 0.001). Increases in the diameters of the capillaries and the presence of avascular areas and crossing and abnormal structures were significantly more common in rosacea patients than in the healthy controls (p < 0.01, p = 0.016, p = 0.02, p < 0.001, respectively), and hairpin structures were significantly less common in rosacea patients than in the controls (p < 0.001). The presence of crossing capillaries was positively correlated with higher TOC levels (p = 0.05), while abnormal structures were found to be correlated with lower levels of TAC (p = 0.045). CONCLUSIONS: Oxidative status and NFC may play diagnostic and prognostic roles in rosacea, which should be confirmed by studies with larger sample sizes. PMID:34658699 | PMC:PMC8501418 | DOI:10.5114/ada.2021.108917 {url} = URL to article
    • J Eur Acad Dermatol Venereol. 2021 Oct 17. doi: 10.1111/jdv.17758. Online ahead of print. ABSTRACT Few studies have investigated the relationship between rosacea and upper gastrointestinal (GI) disorders, with two studies reporting conflicting data that patients with rosacea are at higher risk for gastroesophageal reflux disease (GERD).1, 2 Here, we conducted a case-control study to investigate a potential relationship between rosacea and GI disorders with a focus on the upper GI tract defined as the esophagus, stomach, and small intestine. PMID:34661953 | DOI:10.1111/jdv.17758 {url} = URL to article
    • Cureus. 2021 Aug 31;13(8):e17617. doi: 10.7759/cureus.17617. eCollection 2021 Aug. ABSTRACT BACKGROUND: The multifactorial nature of rosacea and chronic spontaneous urticaria (CSU) pathogenesis complicates the achievement of satisfactory treatment outcomes. 13C urea breath test (UBT) has been identified as an accurate, non-invasive, and quick procedure to detect the presence of Helicobacter pylori (H. pylori) with high sensitivity and specificity. OBJECTIVE: In this study, we aim to assess the correlation between H. pylori infection and rosacea and CSU patients. METHODS: A cross-sectional, observational study was conducted on patients with rosacea and CSU in the dermatology clinic at King Khalid University Hospital in Riyadh, Saudi Arabia. History and physical examination were performed by a dermatologist. H. pylori 13C-UBT detection was performed in all subjects. RESULTS: In total, 114 patients were included in this current study, with 41 rosacea and 73 urticaria patients. The vast majority of our subjects were females (96.5%). The mean (±SD) age was 42.3 (±12.7). More than half (58.8%) of the examined samples were positive for 13C-UBT; however, positive results were significantly higher in the rosacea patients (73.2%) compared to the urticaria group (50.7%), with a p-value of 0.019. CONCLUSION: Our findings underline the significant association of H. pylori with rosacea and CSU regardless of the presence or absence of gastrointestinal symptoms. We thus recommend the inclusion of H. pylori testing in the routine workup of CSU and rosacea patients. PMID:34646668 | PMC:PMC8483814 | DOI:10.7759/cureus.17617 {url} = URL to article
    • Acta Derm Venereol. 2021 Oct 13. doi: 10.2340/actadv.v101.356. Online ahead of print. ABSTRACT Rosacea, a chronic condition usually recognized by its visible presentation, can be accompanied by invisible symptoms, such as burning and stinging. This aim of this review is to gather the most recent evidence on burning and stinging, in order to further emphasize the need to address these symptoms. Inflammatory pathways can explain both the signs and symptoms of rosacea, but available treatments are still evaluated primarily on their ability to treat visible signs. Recent evidence also highlights the adverse impact of symptoms, particularly burning and stinging, on quality of life. Despite an increasing understanding of symptoms and their impact, the management of burning and stinging as part of rosacea treatment has not been widely investigated. Clinicians often underestimate the impact of these symptoms and do not routinely include them as part of management. Available therapies for rosacea have the potential to treat beyond signs, and improve burning and stinging symptoms in parallel. Further investigation is needed to better understand these benefits and to optimize the management of rosacea. PMID:34643244 | DOI:10.2340/actadv.v101.356 {url} = URL to article More Information on Burning and Stinging in Rosacea
    • If you have been diagnosed with Phenotype 5, it usually responds to treatment quite well. We have a list of treatment options to consider listed in this post which requires you join the RRDi as an active member to view. Have you been diagnosed with Phenotype 5? What 2 prescription treatments have you used?
    • Clin Cosmet Investig Dermatol. 2021 Oct 2;14:1393-1400. doi: 10.2147/CCID.S322876. eCollection 2021. ABSTRACT PURPOSE: Although acne vulgaris (AV) is a common disease and can persist into adulthood, there are few large-scale epidemiological studies on the prevalence of acne vulgaris in adults. The aim of our study was to characterise the epidemiology and comorbidity of acne vulgaris in working adults in Germany. PATIENTS AND METHODS: Within the framework of a cross-sectional study, a total of 161,269 employees underwent dermatological whole-body examinations in more than 500 German companies between 2001 and 2016. Point prevalence rates for acne vulgaris and further skin diseases and their 95% confidence intervals were calculated and differences between participants with and without acne vulgaris were tested with chi-squared tests. RESULTS: Mean age was 43.2 years ± 10.9, 55.5% were male. In total, n = 5311 people (3.3%) with acne vulgaris were identified. Prevalence decreased by age. Controlling for age and gender, acne was significantly associated with folliculitis (OR = 1.91; CI: 1.76-2.07), contact dermatitis (OR = 1.74; CI: 1.08-2.81), rosacea (OR = 1.74; CI: 1.40-2.15), pyoderma (OR = 1.58; 1.22-2.06), seborrheic dermatitis (OR = 1.47; CI: 1.27-1.71), hand eczema (OR = 1.34; CI: 1.00-1.76), verruca vulgaris plantaris (OR = 1.29; CI: 1.09-1.51), tinea pedis (OR = 1.27; CI: 1.10-1.47), spider veins (OR = 1.26; CI: 1.16-1.38) and telangiectasia (OR = 1.15; CI: 1.02-1.30). CONCLUSION: These data underline the importance of acne vulgaris in the adult population. Further studies to better understand the pathophysiology of AV and its comorbidity in different phases of adulthood would be desirable to develop appropriate guidelines and therapy concepts. PMID:34629884 | PMC:PMC8495148 | DOI:10.2147/CCID.S322876 {url} = URL to article
    • first you stop consuming alcohol completely and see the result after one month. I am not saying that alcohol is causing your rosacea getting worsen but Sometimes it happens that any trigger which causes flare-ups, if we consume them only once would immediately cause flare-ups. This is only to see whether alcohol is your trigger or not and please share your results.
    • Guest Jennifer
      I have rosacea on my nose.  I have had it for 3 years, with little notice, but now it is getting really bad with bigger pores and bumps getting bigger and bigger on top and sides of my nose.  I have taken the  2 prescription medications recommended with poor results.  I have had it scraped 1 time 2 years ago but it did nothing.  I have alcohol a couple times a month.  Does anyone know what can slow down the process on the nose please?
    • Arch Soc Esp Oftalmol (Engl Ed). 2021 Oct;96(10):556-560. doi: 10.1016/j.oftale.2020.07.008. Epub 2021 Sep 24. ABSTRACT Idiopathic facial aseptic granuloma (IFAG) is a recently described and rare condition. It is considered a form of infantile granulomatous rosacea. IFAG with facial and eyelid nodules is very rare. A description is presented of three cases of IFAG eyelid nodules. They concern healthy children with no history of trauma. Biopsy examination revealed non-caseating inflammatory granulomas. Different medical treatments have been tried that seem to accelerate its healing, although its tendency is spontaneous resolution within several months. Painless recurrent eyelid nodules can be confused with chalazion. The diagnosis of IFAG should be considered in chronic eyelid nodules. PMID:34620487 | DOI:10.1016/j.oftale.2020.07.008 {url} = URL to article
    • Skin Appendage Disord. 2021 Aug;7(5):382-386. doi: 10.1159/000514565. Epub 2021 Apr 26. ABSTRACT INTRODUCTION: Scalp rosacea is scarcely reported in the literature, but it is probably not uncommon. Trichoscopic findings have not been specifically established for this entity. CASE PRESENTATION: We report 4 cases of chronic scalp rosacea with trichoscopic evidence of peripilar scaling that resolved without scarring after treatment. DISCUSSION/CONCLUSION: Chronic and persistent inflammation around the isthmus produced in scalp rosacea may form peripilar scaling resembling that found in lichen planopilaris. PMID:34604328 | PMC:PMC8436626 | DOI:10.1159/000514565 {url} = URL to article
    • Only little group study with 14 candidates will not suffice the result of alcohol consumption not as a risk factor in rosacea and we over and over say that every rosacea person has different triggers associated with them and depends on the the degree of alcohol consumption just like any other intake triggers.
    • Yes it is a growing concern because it could be possible that no antibiotic will be left to cure the diseases in future because bacteria could develop resistance to every antibiotic since we are using antibiotics without any concern and knowledge and antibiotic stewardship programs make aware people and physicians of antibiotic prescription and use. I have covered these topics earlier here and here.
    • Yes it is likely possible that following mohs surgery, rosacea can exacerbate in patient because in mohs surgery, the cancer skin is excised and removed and the normal skin tissue is not disturbed but following skin excision and removal, the normal skin environment is disturbed and so it can cause rosacea exacerbation.
    • Yes because anything which comes into contact with skin, skin has resident immune cells and they are primarily come into rescue just like army men and mast cells are one of them. They play a key role as army men. So it would be a better immunotherapy if we target mast cells.
    • and anything which you are consuming a lot may cause trigger. Drink but one or two times a day and see if it changes anything because you need to watch what triggers you or what not.
    • Green tea hasn't been on an rosacea trigger list. What is on most rosacea trigger lists is HOT BEVERAGES may cause a flush, whether it is green tea, black tea, white tea, coffee, hot water, etc.  FOR MORE INFORMATION
    • If you are a RRDi member, you need to login to your account. Then simply post anywhere guests are able to post, like this thread where you asked this question. That reactivates your account. Once you are reactivated, under your display name it shows 'Active Member.' This gives you 30 days of access to our website where guests are restricted. If you haven't posted in the last thirty days your account is then deactivated. Repeat the process to re-activate your account.  If you remember the email address you used to register your account but forgot the password, use the forgot password tool to reactivate your account:  https://irosacea.org/lostpassword/ If you don't remember your login credentials, our volunteers can assist. Use the contact form and give us what you remember you used to register your account, i.e., your display name?  We can then reset your password for you if we can figure out what EMAIL you used to register your account.   
    • Is green tea a trigger?  I drink a lot every day.  I don't seem to notice a difference after I drink it.  Could it just be affecting my baseline redness?
    • I'm trying to activate my account.  Any help?
    • J Cosmet Dermatol. 2021 Sep 28. doi: 10.1111/jocd.14483. Online ahead of print. ABSTRACT BACKGROUND: Rosacea is a chronic inflammatory skin disease that affects people's life quality. It has been found to be related to many detrimental factors including ultraviolet exposure. However, the association between alcohol consumption and rosacea has long been debated. AIMS: To elucidate this association, we conducted a systematic review and meta-analysis. METHODS: We performed a systematic search of the literature published before February 16, 2021 on PubMed, Embase, and the Cochrane database and used a meta-analytic approach to calculate the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). RESULTS: Finally, 14 eligible studies were identified, and alcohol consumption was not found to be a risk factor for rosacea. However, in subgroup analysis, alcohol consumption increased the risk of phymatous rosacea (PhR) and the pooled OR was 4.17 (95% CI = 1.76-9.91). CONCLUSION: Overall, our study showed that alcohol consumption was a risk factor in phymatous rosacea (PhR). More studies of rosacea investigating sex distribution, alcohol intake levels, and types of alcoholic beverages consumed are needed in the future. PMID:34582097 | DOI:10.1111/jocd.14483 {url} = URL to article More information on Alcohol and Rosacea
    • Br J Dermatol. 2021 Sep 28. doi: 10.1111/bjd.20768. Online ahead of print. ABSTRACT Rosacea is a chronic, symptomatic and potentially disfiguring inflammatory skin condition with high prevalence, particularly among women.1 Quantitative research into the psychosocial factors associated with rosacea has consistently reported the presence of anxiety, depression, decreased quality of life and feelings of stigmatisation.2,3 Such factors may be challenging to identify in clinical practice, since the objective severity of a visible difference does not always correlate with the lived experience.4. PMID:34582568 | DOI:10.1111/bjd.20768 {url} = URL to article
    • Life (Basel). 2021 Sep 14;11(9):962. doi: 10.3390/life11090962. ABSTRACT Many relatively common chronic inflammatory skin diseases manifest on the face (seborrheic dermatitis, rosacea, acne, perioral/periorificial dermatitis, periocular dermatitis, etc.), thereby significantly impairing patient appearance and quality of life. Given the yet unexplained pathogenesis and numerous factors involved, these diseases often present therapeutic challenges. The term "microbiome" comprises the totality of microorganisms (microbiota), their genomes, and environmental factors in a particular environment. Changes in human skin microbiota composition and/or functionality are believed to trigger immune dysregulation, and consequently an inflammatory response, thereby playing a potentially significant role in the clinical manifestations and treatment of these diseases. Although cultivation methods have traditionally been used in studies of bacterial microbiome species, a large number of bacterial strains cannot be grown in the laboratory. Since standard culture-dependent methods detect fewer than 1% of all bacterial species, a metagenomic approach could be used to detect bacteria that cannot be cultivated. The skin microbiome exhibits spatial distribution associated with the microenvironment (sebaceous, moist, and dry areas). However, although disturbance of the skin microbiome can lead to a number of pathological conditions and diseases, it is still not clear whether skin diseases result from change in the microbiome or cause such a change. Thus far, the skin microbiome has been studied in atopic dermatitis, seborrheic dermatitis, psoriasis, acne, and rosacea. Studies on the possible association between changes in the microbiome and their association with skin diseases have improved the understanding of disease development, diagnostics, and therapeutics. The identification of the bacterial markers associated with particular inflammatory skin diseases would significantly accelerate the diagnostics and reduce treatment costs. Microbiota research and determination could facilitate the identification of potential causes of skin diseases that cannot be detected by simpler methods, thereby contributing to the design and development of more effective therapies. PMID:34575111 | DOI:10.3390/life11090962 {url} = URL to article
    • J Invest Dermatol. 2021 Sep 23:S0022-202X(21)01313-0. doi: 10.1016/j.jid.2021.04.024. Online ahead of print. ABSTRACT Microbes and commensal mites contribute to the development of inflammation and neurovascular dysregulation in rosacea. Cathelicidin family proteins are epithelial antimicrobial peptides expressed in higher-order mammals. In humans, mature LL-37 is cleaved from its precursor in response to microbial infection, UV light, and injury. In their new article in the Journal of Investigative Dermatology, Yoon et al. expand on existing evidence supporting LL-37 proinflammatory activity in lipopolysaccharide (LPS)- and UV-primed models of rosacea. They show in vitro that LL-37 promotes NLRP3-mediated inflammasome activation through lysosomal destabilization in the presence of LPS and that the injection of LL-37 in vivo leads to skin inflammation that is abrogated by direct NLRP3 inhibition and homozygous knockout in a murine model. PMID:34565561 | DOI:10.1016/j.jid.2021.04.024 {url} = URL to article More information on Cathelicidin Peptide LL-37
    • Clin Epidemiol. 2021 Sep 18;13:845-851. doi: 10.2147/CLEP.S323744. eCollection 2021. ABSTRACT BACKGROUND: Seborrhea is a skin condition characterized by abundant production of sebum associated with typical dermatological conditions such as rosacea and acne. Little is known about the prevalence of seborrhea and the frequency of concurrent skin diseases in the general population. OBJECTIVE: To investigate the epidemiology and comorbidity of seborrhea in the adolescent and adult working population. METHODS: In large-scale examinations by dermatologists in 343 German companies, the seborrheic skin type and the occurrence of skin findings were documented electronically. Odds ratios (OR) and their 95% confidence intervals (95% CI) of further skin diseases were computed. Logistic regression analyses were conducted for each disease using seborrhea as dependent variable. RESULTS: A total of 48,630 employees were examined. About 6.0% showed seborrhea (6.6% in men, 5.4% in women). Seborrhea strongly predicted acne (OR 3.59; CI 3.18-4.05), trichilemmal cysts (OR 1.99; CI 1.25-3.18) and rosacea (OR 1.45; CI 1.17-1.81). Regression analyses controlling for age, gender and phototype confirmed significant associations of seborrhea with acne and rosacea. CONCLUSION: Only a minor proportion of the working population shows meaningful seborrheic skin. However, this condition predicts distinct skin diseases and thus needs attention, in particular, with respect to consulting and secondary prevention. PMID:34566435 | PMC:PMC8459174 | DOI:10.2147/CLEP.S323744 {url} = URL to article
    • J Cosmet Dermatol. 2021 Sep 26. doi: 10.1111/jocd.14477. Online ahead of print. ABSTRACT BACKGROUND: Rosacea is a chronic inflammatory cutaneous disease that can be associated with cardiometabolic disorders. Oxidative stress is included in the pathogenesis of rosacea, and thiol-disulfide homeostasis (TDH) acts as antioxidants. OBJECTIVE: To evaluate the TDH and metabolic parameters in patients with rosacea. MATERIAL AND METHODS: A total of 42 rosacea patients and 50 controls participated in this prospective study. Demographic data, clinical entities, anthropometric measurements, and laboratory findings were recorded. Additionally, TDH was measured by an automated spectrophotometric method. RESULTS: Rosacea patients had greater body mass index values (27.9 ± 5.2 kg/m² vs. 23 ± 1.4 kg/m², p < 0.001), waist-hip ratios (0.87 ± 0.1 vs. 0.77 ± 0.8, p < 0.001), and insulin resistance (3.0 ± 2.0 vs. 1.3 ± 0.5, p < 0.001) compared with controls. Disulfide levels, the disulfide/native thiol ratio (DNTR), and the disulfide/total thiol ratio (DTTR) were increased (p < 0.05) in rosacea patients. Native thiol and total thiol levels and the native/total thiol ratio (NTTR) were decreased in rosacea patients (p < 0.05). Different rosacea subtypes had no effect on oxidative stress markers. The duration of illness and insulin resistance values significantly correlated with DNTR and DTTR in the rosacea group (p < 0.05). CONCLUSION: Rosacea has a metabolic milieu with increased oxidative stress and insulin resistance. Note This adds to the list found at  PMID:34564928 | DOI:10.1111/jocd.14477 {url} = URL to article
    • J Cosmet Dermatol. 2021 Sep 26. doi: 10.1111/jocd.14436. Online ahead of print. ABSTRACT BACKGROUND: While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper knowledge of the role of nutritional supplements in dermatological diseases can be a useful tool in advising the patients and in certain cases ameliorating the disorder. PATIENTS/METHODS: Literature review of last 15 years was made using the terms "diet in dermatology," "nutrition and skin," "nutritional supplements in dermatology," "nutritional agents and acne," "nutritional agents and alopecia," and "nutritional agents and psoriasis." RESULTS: While there are multiple publications on the use of nutritional supplements for amelioration of skin diseases, most of them are based on either associations or in vitro studies, but very few transcend the rigors of a clinical trial or the holey grail of a double-blinded randomized controlled trial. There seem to be some evidence in acne, psoriasis, telogen effluvium, urticaria & vitiligo. Coeliac disease and dermatitis herpetiformis have a strong link with diet. Rosacea has a strong link with certain foods, but the other disorders like melasma, aphthous stomatitis do not have any scientifically validated association with diet. CONCLUSIONS: Our updated review examines the role of nutritional supplements and antioxidants in various dermatological disorders. We have found that there are varying levels of evidence with notable associations of low glycemic diet & acne, fish oil & weight loss with psoriasis, fish oils & probiotics with atopic dermatitis & vitamins & botanical extracts with vitiligo. The evidence for diet and nutrition in bullous disorders and photoageing is scarce. The role of low histamine diet in urticaria is useful in select cases of episodic urticaria. Rosacea is triggered by hot and spicy food . Apart from gluten and Dermatitis Herpetiformis, no diet can be considered disease modifying in our reveiw. The lack of comparison of nutritional or dietary modiffication with conventional validated agents, makes the data difficult to translate in real world patient management. PMID:34564936 | DOI:10.1111/jocd.14436 {url} = URL to article
    • J Am Heart Assoc. 2021 Sep 24:e020671. doi: 10.1161/JAHA.120.020671. Online ahead of print. ABSTRACT Background There is emerging evidence that rosacea, a chronic cutaneous inflammatory disease, is associated with various systemic diseases. However, its association with cardiovascular disease (CVD) remains controversial. We aimed to investigate whether patients with rosacea are at increased risk of developing CVD. Methods and Results This retrospective cohort study from the Korean National Health Insurance Service-Health Screening Cohort included patients with newly diagnosed rosacea (n=2681) and age-, sex-, and index year-matched reference populations without rosacea (n=26 810) between 2003 and 2014. The primary outcome was subsequent CVD including coronary heart disease and stroke. Multivariable Cox regression analyses were used to evaluate adjusted hazard ratios for subsequent CVD adjusted for major risk factors of CVD. Compared with the reference population (13 410 women; mean [SD] age, 57.7 [9.2] years), patients with rosacea (1341 women; mean [SD] age, 57.7 [9.2] years) displayed an increased risk for CVD (adjusted hazard ratios, 1.20; 95% CI, 1.03-1.40) and coronary heart disease (adjusted hazard ratios, 1.29; 95% CI, 1.05-1.60). The risk for stroke was not significantly elevated (adjusted hazard ratios, 1.12; 95% CI, 0.91-1.37). Conclusions This study suggests that patients with rosacea are more likely to develop subsequent CVD. Proper education for patients with rosacea to manage other modifiable risk factors of CVD along with rosacea is needed. PMID:34558290 | DOI:10.1161/JAHA.120.020671 {url} = URL to article
    • J Cosmet Dermatol. 2021 Sep 24. doi: 10.1111/jocd.14469. Online ahead of print. NO ABSTRACT PMID:34559462 | DOI:10.1111/jocd.14469 {url} = URL to article
    • Dermatol Clin. 2021 Oct;39(4):555-568. doi: 10.1016/j.det.2021.05.009. Epub 2021 May 31. ABSTRACT The recent coronavirus disease 2019 (COVID-19) pandemic has led to the dramatic increase in use of personal protective equipment (PPE) among health care providers and the general public. Herein the authors discuss the various occupational dermatoses including allergic and irritant contact dermatitis, acne, seborrheic dermatitis, and rosacea related to frequent handwashing, disinfecting of surfaces, and prolonged wear of various PPE including face masks, gloves, and gowns. The authors provide an overview of published PPE-associated occupational dermatoses during the COVID-19 pandemic and also discuss prevention strategies and treatment options to help patients with these complaints. PMID:34556245 | DOI:10.1016/j.det.2021.05.009 {url} = URL to article
    • J Am Acad Dermatol. 2021 Sep 20:S0190-9622(21)02502-0. doi: 10.1016/j.jaad.2021.09.024. Online ahead of print. ABSTRACT Antibiotic resistance is a growing health concern that has attracted increasing attention from clinicians and scientists in recent years. While resistance is an inevitable consequence of bacterial evolution and natural selection, misuse and overuse of antibiotics plays a significant role in its acceleration. Antibiotics are the mainstay of therapy for common dermatoses, including acne and rosacea, as well as skin and soft tissue infections. Therefore, it is critical for dermatologists and physicians across all disciplines to identify, appropriately manage, and prevent cases of antibiotic resistance. This review explores dermatologic conditions in which development of antibiotic resistance is a risk and discusses mechanisms underlying the development of resistance. We discuss disease-specific strategies for overcoming resistant strains and improving antimicrobial stewardship along with recent advances in the development of novel approaches to counter antibiotic resistance. PMID:34555484 | DOI:10.1016/j.jaad.2021.09.024 {url} = URL to article More Info
    • J Am Acad Dermatol. 2021 Sep 18:S0190-9622(21)02495-6. doi: 10.1016/j.jaad.2021.09.020. Online ahead of print. NO ABSTRACT PMID:34547357 | DOI:10.1016/j.jaad.2021.09.020 {url} = URL to article
    • Arch Rheumatol. 2021 Jan 14;36(2):252-257. doi: 10.46497/ArchRheumatol.2021.8280. eCollection 2021 Jun. ABSTRACT OBJECTIVES: This study aims to investigate the frequency of fibromyalgia syndrome (FMS) in rosacea patients and the relationship between disease disability score of FMS and quality of life score of rosacea. PATIENTS AND METHODS: This cross-sectional controlled clinical trial was performed between December 2017 and December 2018. One hundred female rosacea patients (mean age 43.2±10.1; range, 21 to 65 years) and 100 age- and sex-matched control subjects (mean age 41.2±11.1; range, 22 to 68 years) with no history of skin disease and systemic diseases including diabetes, cardiovascular, renal and hepatic diseases were recruited. Dermatology Life Quality Index (DLQI) scores were calculated using a 10-item self-administered questionnaire. The diagnosis of FMS was established according to 2010 American College of Rheumatology diagnostic criteria. Fibromyalgia Impact Questionnaire (FIQ) was used to determine the clinical severity and functional disability, while Visual Analog Scale (VAS) was used to determine pain severity in the patients with FMS. RESULTS: The frequency of FMS in patient group was significantly higher than control group (p=0.019). The mean duration of FMS in patient group was significantly higher than control group (p=0.001). There was no significant difference in terms of the age of onset of FMS, FIQ and VAS scores between groups (p=0.53, p=0.54, p=0.07, respectively). DLQI scores were significantly correlated with FIQ scores in the patient group (r=0.43, p=0.008). CONCLUSION: The frequency of FMS in rosacea patients was significantly higher than control subjects without any skin disease and there was a correlation between disability score of FMS and quality of life score of rosacea. Investigating fibromyalgia symptoms in rosacea patients may be helpful for providing patient-based therapeutic approaches where neurologically based treatments may also be beneficial for rosacea. PMID:34527930 | PMC:PMC8418776 | DOI:10.46497/ArchRheumatol.2021.8280 {url} = URL to article Other Systemic Comorbidities in Rosacea
    • Arch Dermatol Res. 2021 Sep 14. doi: 10.1007/s00403-021-02277-0. Online ahead of print. ABSTRACT Botulinum toxin A (BTX-A) injections have become the most popular noninvasive cosmetic procedures performed worldwide. With growing interest, investigators continue to uncover an expanding array of aesthetic indications for BTX-A. Botulinum toxin A has been used off-label in the management of masseter hypertrophy for facial slimming, platysmal bands, nasal 'bunny' lines, perioral rhytides, gummy smile and scars, to name a few. Interestingly, the injection of multiple microdroplets of dilute BTX-A into the dermis, sometimes referred to as 'microbotox', has been investigated as a tool for facial rejuvenation. A handful of prospective studies and case series have demonstrated the benefit of BTX-A in the treatment of facial erythema and improving skin texture. The aim of this review is to summarize and appraise currently available data on the role of BTX-A in treating facial erythema and skin quality, with a special focus on potential pathophysiologic mechanisms. PMID:34519860 | DOI:10.1007/s00403-021-02277-0 {url} = URL to article
    • Dermatology. 2021 Sep 7:1-6. doi: 10.1159/000518220. Online ahead of print. ABSTRACT BACKGROUND: The prevalence and impact of pruritus, pain, and other sensory symptoms in skin diseases are poorly known. OBJECTIVE: To assess the frequency of these symptoms with dermatoses and their association with depression using data from the "Objectifs Peau" survey. METHODS: A representative sample of 20,012 French individuals was created using the usual quota method. RESULTS: When patients suffered from both pruritus and skin pain, they had a higher relative risk of psychological suffering (2.9) than those who suffered only from pruritus (1.4) or skin pain (1.2). Pruritus was reported in 48.55% of patients with acne, 43.24% with mycoses, 44.35% with warts, and 36.51% with rosacea. For skin pain, the results were 11.22%, 27.59%, and 16.13% for atopic dermatitis, acne, and warts, respectively. Other unpleasant sensations, such as tingling or burning, were also frequently reported. CONCLUSION: Pruritus, pain, or other sensory symptoms were found to be common not only in classic pruritic skin diseases but also in acne, rosacea, or warts. The association of pruritus and pain dramatically increased psychological suffering. These symptoms must be systematically searched for in patients, especially since new therapeutic possibilities are emerging for the symptomatic treatment of pruritus. PMID:34515100 | DOI:10.1159/000518220 {url} = URL to article
    • Arch Dermatol Res. 2021 Sep 12. doi: 10.1007/s00403-021-02279-y. Online ahead of print. ABSTRACT Rosacea is a chronic inflammatory skin condition that is associated with multiple systemic comorbidities, with the strongest evidence linking rosacea to hypertension, dyslipidemia, inflammatory bowel disease, and anxiety and depression. To assess dermatologists' awareness of and screening practices for rosacea comorbidities, we developed a survey that was distributed to attendings and residents across four academic dermatology departments in Massachusetts. A total of 73 dermatologists with varying experience participated in the study. Findings demonstrated significant knowledge and practice gaps among academic dermatologists in managing systemic comorbidities in rosacea. In addition, dermatologists' awareness of rosacea comorbidities was negatively correlated with number of years out of residency training, highlighting the need to address this knowledge gap through increased continuing medical education. Importantly, we observed a low screening frequency despite a high awareness of the association between rosacea and ocular comorbidities, suggesting that additional financial, institutional, or practice barriers likely contribute to the low screening rate. PMID:34510277 | DOI:10.1007/s00403-021-02279-y {url} = URL to article
    • J Cosmet Dermatol. 2021 Sep 12. doi: 10.1111/jocd.14454. Online ahead of print. NO ABSTRACT PMID:34510704 | DOI:10.1111/jocd.14454 {url} = URL to article
    • Vestn Otorinolaringol. 2021;86(4):95-98. doi: 10.17116/otorino20218604195. ABSTRACT One of the frequent causes of a significant increase in the external nose, forming a persistent deformity of the face, as well as leading to a non-standard clinical picture is rhinophyma disease. The article considers some historical data, epidemiology, peculiarities of pathogenesis, as well as the basics of surgical treatment tactics along with possible preventive measures against rhinophyma. At present, the treatment of this pathology presents great difficulties. Despite the many surgical methods, rhinophyma is poorly treatable, often relapses and leaves no less noticeable disfigurement of the face in the postoperative period. In this regard, there is a constant search for new surgical methods, which has not only medical but also important social significance. PMID:34499455 | DOI:10.17116/otorino20218604195 {url} = URL to article MORE INFORMATION ON PHENOTYPE 5
    • Australas J Dermatol. 2021 Sep 7. doi: 10.1111/ajd.13711. Online ahead of print. NO ABSTRACT PMID:34490894 | DOI:10.1111/ajd.13711 {url} = URL to article
    • Dermatol Ther (Heidelb). 2021 Sep 4. doi: 10.1007/s13555-021-00605-w. Online ahead of print. ABSTRACT INTRODUCTION: At present, some studies have reported that nasal rosacea may be an independent disease, but phenotypic characteristics and risk factors for nasal rosacea remain unknown. This study aimed to clarify the clinical features and explore the risk factors for nasal rosacea. METHODS: A hospital-based retrospective study was conducted, including 1615 rosacea patients and 1501 healthy individuals. The patients were divided into three groups based on the involved areas of the lesions (non-nasal, intermediate and nasal rosacea group). Their demographic data and clinical features were obtained from patients' medical records, and risk factors of nasal rosacea were analyzed. RESULTS: There were 927 (57.4%), 647 (40.1%) and 41 (2.5%) cases in the non-nasal, intermediate and nasal rosacea groups, respectively. Of 41 patients with nasal rosacea, all (100.0%) had fixed erythema and 17 cases (41.5%) had phymatous changes. Compared with control group, male gender (adjusted odds ratio [aOR] = 2.39, 95% confidence interval [CI] = 1.14, 4.99), obesity (aOR = 3.19, 95% CI 1.86, 11.79) and alcohol use (aOR = 1.58, 95% CI 1.22, 5.40) were risk factors for nasal rosacea, but these three factors were not risk factors for non-nasal rosacea and intermediate rosacea groups. Among patients with nasal lesions (compared with patients without nasal phymatous changes), family history of rosacea was a risk factor (aOR = 2.12, 95% CI 1.01, 4.46) for nasal phymatous changes and Fitzpatrick IV skin type was a protective factor (aOR = 0.49, 95% CI 0.28, 0.86). CONCLUSION: Nasal rosacea has relatively specific clinical features and independent risk factors, suggesting that it may be a special type of rosacea. PMID:34480736 | DOI:10.1007/s13555-021-00605-w {url} = URL to article
    • Ocul Surf. 2021 Sep 1:S1542-0124(21)00099-9. doi: 10.1016/j.jtos.2021.08.017. Online ahead of print. ABSTRACT Rosacea is a common chronic skin disease affecting mostly people aged 40 and above, with currently no cure. When it affects the eyelids and periocular skin, it leads to dry eye and potentially corneal damage. Research performed over the last decade shed light into the potential mechanisms leading to skin hypersensitivity and provided promising avenues for development of novel, rational therapeutics aimed at reducing the skin inflammatory state. In this review, we discuss the current knowledge on the mechanisms of rosacea in general and of periocular skin-affecting disease in particular, identify key questions that remain to be answered in future research, and offer a disease model that can explain the key characteristics of this disease, with particular emphasis on a potential positive feedback loop that could explain both the acute and chronic features of rosacea. PMID:34481075 | DOI:10.1016/j.jtos.2021.08.017 {url} = URL to article
    • Dermatol Ther (Heidelb). 2021 Sep 2. doi: 10.1007/s13555-021-00597-7. Online ahead of print. ABSTRACT Rosacea is a chronic inflammatory skin disease characterized by centrofacial erythema, papules, pustules, and telangiectasias. The onset of rosacea typically occurs after 30 years of age. It is estimated that approximately 2-5% of adults worldwide are affected. While the exact etiology of rosacea remains unknown, its pathogenesis is thought to be multifactorial with both environmental and genetic factors implicated. Ultraviolet radiation, heat, steam, ingested agents, including spicy foods and alcohol, host vasculature, dermal matrix degeneration, genetic susceptibility, and microbial organisms, including Demodex mites and Heliobacter pylori, have been implicated in the development of rosacea. Recently, mast cells (MCs) have emerged as key players in the pathogenesis of rosacea through the release of pro-inflammatory cytokines, chemokines, proteases, and antimicrobial peptides leading to cutaneous vasodilation, angiogenesis, and tissue fibrosis. Several existing and emerging topical, oral, and injectable therapeutics have been associated with improvement of rosacea symptoms based on their ability to stabilize and downregulate activated MCs. Herein, we review the data implicating MCs in the pathogenesis of rosacea and discuss interventions that may stabilize this pathway. PMID:34476755 | DOI:10.1007/s13555-021-00597-7 {url} = URL to article More Info
    • Just saw a new page on the NRS website designated, 'key staff' and you can see a screen shot below:  If you will note in the above paragraph, Mr Huff is stated as 'president of the Glendale Communications Group, which provides infrastructure and personnel for for the NRS program services at no cost to its members.' If this is correct, why do the past 22 years of public Form 990s (1998 thru 2019) show that over $10 million of the donations to the NRS have been spent on private contractors that are owned by Mr. Huff, including Glendale Communications Group? For example, in 2019 the NRS spent $285,871 on 'private contractors' including Glendale Communications Group which happens to be 94% of the donations given to the NRS in 2019. If this is 'no cost to its members' then why report this expense on Form 990 for 2019?  In the previous year, 2018, the NRS spent $432,408 on private contractors, one of which is Glendale Communications Group, which happens to be 93% of the total donations given to the NRS in 2018. For a complete list of these Form 990s click here.  For a breakdown of how the NRS spends its donations click here. 
    • J Cosmet Dermatol. 2021 Sep 2. doi: 10.1111/jocd.14428. Online ahead of print. ABSTRACT INTRODUCTION: This study aims to compare the choroidal thickness (CT) of patients with rosacea with healthy individuals. METHODS: This study was conducted with 42 patients with Papulopustular Rosacea (PPR), 38 patients with Erythematotelangiectatic Rosacea (ETR), and gender and age-matched 37 healthy individuals in the control group. CT measurements were done using the spectral-domain optical coherence tomography. RESULTS: Choroidal thickness means were measured as 352 ± 78 μm, 331 ± 67 μm, and 346 ± 83 μm at the subfoveal region; 323 ± 72.3 μm, 303.5 ± 68.4 μm, and 314 ± 80.3 μm at 1000 μm nasal; and 325.2 ± 71 μm, 304.4 ± 52.2 μm, and 309 ± 67 μm at 1000 μm temporal in the PPR, ETR, and control groups, respectively (p > 0.05). CONCLUSION: Although rosacea is a common chronic skin disease that could have systemic findings, CT is not affected by this disease. PMID:34473882 | DOI:10.1111/jocd.14428 {url} = URL to article
    • Metabol Open. 2021 Aug 13;11:100118. doi: 10.1016/j.metop.2021.100118. eCollection 2021 Sep. ABSTRACT BACKGROUND: The prevalence of diabetes mellitus is on the inexorable rise despite the promises of a wide range of conventional medications. Thus, there is a need to scientifically investigate plants for antidiabetic effect. METHODS: After the Rubus Erlanrige Engl (Rosaceae) leaf has been decocted, the plant extract's antidiabetic activity was first investigated in vitro and then in vivo. The in vitro activity was assessed using 3, 5-Dinitrosalicylic acid, and 2,2-diphenyl-1-picrylhydrazine method for α-amylase inhibition and antioxidant effect respectively. On the other hand, the in vivo antidiabetic activity was carried out in normoglycemic, glucose loaded (2.5 g/kg) and single dose streptozotocin (200 mg/kg) induced diabetic mice. RESULTS: Acute toxicity study showed the extract is safe with ≥2 g/kg. The in vitro results demonstrated the extract has an IC50 of 7.34 ± 0.02 and 10.38 ± 0.0.62 μg/ml for antioxidant and α-amylase inhibition activity respectively. On the other hand, the in vivo study revealed that the extract significantly reduced blood glucose level following glucose loading. The extract did not, however, produce a significant reduction of glucose level in normal mice indicating low risk of hypoglycemia. The extract also significantly decreased blood glucose levels in streptozotocin-induced diabetic mice. In the single dose study, the extract lowered blood glucose level all except by lower dose at the 3rd and 4th h (p < 0.05). In repeated dose studies, the reduction in fasting blood glucose was significant with all doses of the extract from the 2nd week onwards. In addition, the extract produced less reduction in body weight after diabetic induction. CONCLUSION: The findings collectively indicate that the extract has an antidiabetic activity, with low risk of hypoglycemia, probably mediated by various secondary metabolites that act in synergy. PMID:34466798 | PMC:PMC8384911 | DOI:10.1016/j.metop.2021.100118 {url} = URL to article
    • J Cosmet Laser Ther. 2021 Aug 30:1-2. doi: 10.1080/14764172.2021.1957114. Online ahead of print. ABSTRACT Lately it has been established that intra-dermal botulinum toxin is also effective in treating many dermatological conditions including refractory erythematous-telangiectatic rosacea, post - menopausal facial flushing and other similar conditions.However, the desired effect of treating the reddening in patients suffering from facial flushing can become an undesirable and embarrassing side effect when these same patients present to the clinic for esthetic concerns such as upper face rhytids. In this case, intramuscular botulinum toxin injections used for wrinkles treatment will also secondarily treat the facial reddening in their localized skin diffusion zones and result in embarrassing white patches all over the face. The patchy appearance following botulinum toxin injections for esthetic purposes could be bothersome for some patients and could be a tell-tale sign of botulinum toxin injections. PMID:34459693 | DOI:10.1080/14764172.2021.1957114 {url} = URL to article
    • World J Gastrointest Oncol. 2021 Aug 15;13(8):835-844. doi: 10.4251/wjgo.v13.i8.835. ABSTRACT Helicobacter pylori (H. pylori) is an infectious agent influencing as much as 50% of the world's population. It is the causative agent for several diseases, most especially gastric and duodenal peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach. A number of other, extragastric manifestations also are associated with H. pylori infection. These include neurological disorders, such as Alzheimer's disease, demyelinating multiple sclerosis and Parkinson's disease. There is also evidence for a relationship between H. pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma. Generally little is known about the relationship between H. pylori infection and diseases of the pancreas. Most evidence about H. pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis. There is data (albeit not fully consistent) indicating modestly increased pancreatic cancer risk in H. pylori-positive patients. The pathogenetic mechanism of this increase is not yet fully elucidated, but several theories have been proposed. Reduction of antral D-cells in H. pylori-positive patients causes a suppression of somatostatin secretion that, in turn, stimulates increased secretin secretion. That stimulates pancreatic growth and thus increases the risk of carcinogenesis. Alternatively, H. pylori, as a part of microbiome dysbiosis and the so-called oncobiome, is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation. The role of H. pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins (mostly enzymes) of H. pylori and pancreatic tissue. Patients with autoimmune pancreatitis often show positivity for antibodies against H. pylori proteins. H. pylori, as a part of microbiome dysbiosis, also is viewed as a potential trigger of autoimmune inflammation of the pancreas. It is precisely these relationships (and associated equivocal conclusions) that constitute a center of attention among pancreatologists, immunologists and pathologists. In order to obtain clear and valid results, more studies on sufficiently large cohorts of patients are needed. The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research. Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer. PMID:34457189 | PMC:PMC8371525 | DOI:10.4251/wjgo.v13.i8.835 {url} = URL to article
    • Thanks for your insight into all this. Very few, as you have pointed out, are motivated to express any thought on this subject. The RRDi has social media accounts. Would you like to volunteer to moderate and manage one or more of them?  
    • Hi, I have just come across this forum today (via the following page: https://rosacea-support.org/book-reviews#rosaceadiet) and became quite interested in the community. In terms of what the RRDI stands for today (this being patient-led and supported): the mission sounds great and quite admirable. As someone who is in my early 30's and got properly assessed and diagnosed with rosacea just back in 2017... I find the condition does not get nearly enough attention (especially considering that there is mild research that had taken place on important topics such as the possibility of a link between rosacea and autoimmune conditions: https://www.dermatologytimes.com/view/more-evidence-rosacea-autoimmune-link). This being said, as a new member it seems there are two main things missing: lack of awareness of the organization and therefore, lack of engagement. The first issue might be solved by collaboration with other grass-roots groups in either adjacent / related conditions or another dermatological condition of high prominence (for example, atopic dermatitis has been quite popular in recent years). The vehicle for collaboration and engagement could be as simple as social media (posting of recent articles on either topic and soliciting feedback that way).  Thanks again for keeping this community alive. It is impressive to learn that RRDI has been going on since 2004 and I hope it will remain so. This condition is truly under-represented but the last thing patients need is another big group (such as the aforementioned NRS and AARS) that simply unites 'thought leaders' (in this case, physicians with clout) and the pharmaceutical manufacturers.
    • Every dermatological disease assessed had a significant increase in TME when compared to the prior year. This increase was most significant for acne vulgaris (808%), psoriasis (792%), malignant skin neoplasms (716%), atopic dermatitis (609%), rosacea (566%) and contact dermatitis (529%).  Published online 2021 Aug 19. doi: 10.1016/j.jid.2021.07.109 LB767 A multicenter analysis of patients using telemedicine for dermatological conditions during the COVID-19 pandemic
    • Rosacea-like eruptions following COVID-19 vaccination More Information
    • Rosacea-like eruptions following COVID-19 vaccination More Information
    • Clin Exp Dermatol. 2021 Aug 25. doi: 10.1111/ced.14905. Online ahead of print. ABSTRACT BACKGROUND: Hidradenitis suppurativa (HS) is a devastating chronic inflammatory skin disease with frequent recurrences. Various systemic treatments and procedures have been used but the efficacy of fractional microneedling radiofrequency (FMR) has not been reported. AIM: To evaluate the clinical and histological efficacy of FMR in the treatment of HS lesions. METHODS: An 8-week, prospective, split-body, unblinded study was conducted, which enrolled 10 adult patients with mild to moderate HS to receive 3 sessions of FMR treatment biweekly. HS severity was assessed using the number and type of lesions, HS Physician Global Assessment (HS-PGA) and the modified Sartorius score (mSS). Skin biopsies were performed on participants to assess change in inflammation before and after FMR. RESULTS: Severity of HS was significantly reduced on the FMR-treated side of the body, but not on the control side. Inflammatory HS lesions were significantly reduced after 4 weeks, while HS-PGA and mSS were significantly decreased after 6 weeks. Immunohistochemistry staining showed decreased expression of inflammatory markers including neutrophil elastases, interleukin (IL)-8 and IL-17, tumour necrosis factor-α, transforming growth factor-β1 and matrix metalloproteinases. CONCLUSION: FMR may be a viable treatment option for mild to moderate HS. PMID:34431555 | DOI:10.1111/ced.14905 {url} = URL to article
    • Indian Dermatol Online J. 2021 Jul 14;12(4):500-514. doi: 10.4103/idoj.idoj_298_21. eCollection 2021 Jul-Aug. ABSTRACT Ivermectin is a broad-spectrum antiparasitic drug with anti-inflammatory, anti-viral, anti-bacterial, and anti-tumor effects. In this review, we discuss the history, pharmacology, multimodal actions, indications in dermatology and tropical medicine, therapeutic and prophylactic use of ivermectin in COVID-19, safety, adverse effects, special considerations, and drug interactions of ivermectin. PMID:34430453 | PMC:PMC8354388 | DOI:10.4103/idoj.idoj_298_21 {url} = URL to article
    • Clin Exp Dermatol. 2021 Aug 24. doi: 10.1111/ced.14910. Online ahead of print. ABSTRACT BACKGROUND: Particulate matter (PM) is a mixture of solid and liquid particles suspended in air which originates from industrial plants or vehicle emission. Although skin primarily contacts with air pollutants, the associations between PM and chronic inflammatory skin diseases has not been well established. OBJECTIVE: To investigate associations between PM and atopic dermatitis as well as other chronic inflammatory dermatoses using Korea Health Insurance Review & Assessment Service data. METHODS: Monthly disease statistics from seven largest cities (Seoul, Busan, Daegu, Incheon, Gwangju, Daejeon, Ulsan) and Jeju Island of South Korea of 23,288,000 people were included. Based on daily air pollution level and weather forecast from 2015 to 2019, multivariate negative binomial regression analysis was conducted to estimate monthly visits of atopic dermatitis with respect to outdoor air pollutants (PM2.5 , PM10 , O3 , NO2, SO2 , CO). RESULTS: Every 10 μg/m3 increase in PM2.5 and PM10 was significantly associated with 2.71% (95% confidence interval (CI)=0.76%-4.71%; P = 0.0063) and 2.01% (95% CI=0.92%-3.11%, P = 0.0003) increase in monthly patient visits of atopic dermatitis, respectively. Every 1 ppb increase in SO2 and 100 ppb increase in CO was significantly associated with 2.26% (95% CI=1.35%-3.17%; P < 0.0001) and 2.86% (95% CI=1.35%-4.40%; P = 0.0002) increase in patient visits of atopic dermatitis, respectively, while O3 and NO2 were not associated. On the other hand, increases in PM2.5 and PM10 concentrations were significantly associated with increases of patient visits of psoriasis, seborrheic dermatitis, and rosacea. CONCLUSION: Our data suggest PM is associated with atopic dermatitis and chronic inflammatory skin diseases. PMID:34426985 | DOI:10.1111/ced.14910 {url} = URL to article
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