PubMed RSS Feed - - A Case of Acne Fulminans in a Patient with Ulcerative Colitis Successfully Treated with Prednisolone and Diaminodiphenylsulfone: A Literature Review of Acne Fulminans, Rosacea Fulminans and Neutrophilic Dermatoses Occurring in the

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A Case of Acne Fulminans in a Patient with Ulcerative Colitis Successfully Treated with Prednisolone and Diaminodiphenylsulfone: A Literature Review of Acne Fulminans, Rosacea Fulminans and Neutrophilic Dermatoses Occurring in the Setting of Inflammatory Bowel Disease.

Dermatology. 2011 Apr 30;

Authors: Wakabayashi M, Fujimoto N, Uenishi T, Danno K, Tanaka T

A 19-year-old Japanese man had been treated for ulcerative colitis for 2 years. He was admitted to our hospital with nodulocystic inflammatory papules and pustules on his face and chest, high-grade fever, arthralgia and general malaise. A biopsy specimen from a pustule showed prominent infiltration of neutrophils in the epidermis and dermis, particularly around hair follicles. We made a diagnosis of acne fulminans. The systemic administration of prednisolone at 30 mg daily for 1 week immediately improved his skin lesions and other symptoms; however, during tapering of prednisolone at 20 mg daily, skin lesions flared up. The addition of oral diaminodiphenylsulfone improved the skin lesions. Although there have been a few reports of acne fulminans associated with Crohn's disease, this is the first case report of acne fulminans in a patient with ulcerative colitis. It is noteworthy that the addition of diaminodiphenylsulfone was effective for treating the relapse of acne fulminans in this case.

PMID: 21540556 [PubMed - as supplied by publisher]

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