rss Posted November 23, 2011 Report Share Posted November 23, 2011 Demodex-associated bacterial proteins induce neutrophil activation. Br J Dermatol. 2011 Nov 19; Authors: O'Reilly N, Bergin D, Reeves EP, McElvaney NG, Kavanagh K Abstract Background:â€‚ Patients with rosacea demonstrate a higher density of Demodex mites in their skin than controls. A bacterium isolated from a Demodex mite from a patient with papulopustular rosacea (PPR) was previously shown to provoke an immune response in patients with PPR or ocular rosacea thus suggesting a possible role for bacterial proteins in the etiology of this condition. Objectives:â€‚ To examine the response of neutrophils to proteins derived from a bacterium isolated from a Demodex mite. Methods:â€‚ Bacterial cells were lysed and proteins were partially purified by AKTA-FPLC. Isolated neutrophils were exposed to bacterial proteins and monitored for alterations in migration, degranulation and cytokine production. Results:â€‚ Neutrophils exposed to proteins from Bacillus cells demonstrated increased levels of migration and elevated release of MMP-9, an enzyme known to degrade collagen and cathelicidin, an antimicrobial peptide. In addition neutrophils exposed to the bacterial proteins demonstrated elevated rates of Il-8 and TNF-alpha production. Conclusions:â€‚ Proteins produced by a bacterium isolated from a Demodex mite have the ability to increase the migration, degranulation and cytokine production abilities of neutrophils. These results suggest that bacteria may play a role in the inflammatory erythema associated with rosacea.PMID: 22098186 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22098186&dopt=Abstract = URL to article Link to comment Share on other sites More sharing options...
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