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Clinical and non-invasive instrumental evaluation of the efficacy of a non-steroid anti-inflammatory 8-beta Glycyrrhetinic Acid cream for the treatment of erythema in rosacea.

Dermatol Ther. 2020 Aug 24;:e14224

Authors: Cameli N, Mariano M, Zanniello R, Berardesca E

Abstract
BACKGROUND: Rosacea is a very common chronic facial dermatosis characterized by a multiphase evolution. Inflammation is an important compound in rosacea, due to inflammatory reactions to cutaneous microorganisms such as Demodex Follicolorum but also to ultraviolet damage that generates reactive oxygen species.
OBJECTIVE: To evaluate the efficacy and tolerability of a non-steroid anti-inflammatory 18-beta Glycyrrhetinic Acid cream for the treatment of mild rosacea by means of non-invasive methods.
METHODS: A total of 24 subjects suffering from erythemato-telangiectatic or mild papulo-pustular rosacea were recruited to enter the trial. 12 patient applied an anti-inflammatory cream with 18-beta Glycyrrhetinic acid twice daily for 20 days, 12 patient recruited as control, applied the same formulation without 18-beta Glycyrrhetinic acid.
RESULTS: After 10 days treatment, in the patient sample who applied the 18-beta Glycyrrhetinic acid cream a significant reduction of erythema was recorded, the mean change from baseline showed an increase in hydration level of the skin surface but it was not statistically significant.
CONCLUSIONS: The use of 18-beta Glycyrrhetinic Acid cream can be helpful in managing symptoms and condition of rosacea skin, especially in the management of erythema. This article is protected by copyright. All rights reserved.

PMID: 32833275 [PubMed - as supplied by publisher]

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"Enoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice." Wikipedia