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Clindamycin phosphate 1.2% and tretinoin 0.025% gel for rosacea: summary of a placebo-controlled, double-blind trial.

J Drugs Dermatol. 2012 Dec 1;11(12):1410-4

Authors: Freeman SA, Moon SD, Spencer JM

Abstract
Rosacea is a common, chronic, and poorly understood dermatological condition characterized by an in"ammatory component composed of papules and pustules and a vascular component composed of "ushing and erythema. Current treatment options include topical, systemic, and light-based methods, each of which focuses on either the in"ammatory or the vascular component. Retinoids are not routinely indicated as treatment because of the common conception that they would be too in"ammatory for the sensitive rosacea patient. However, photodamage may play a role in rosacea and tretinoin is well-known to repair photodamage. Thirty rosacea subjects were enrolled to assess their response to the use of clindamycin phosphate 1.2% and tretinoin 0.025% gel (ZIANA; Medicis Pharmaceutical Corporation, Scottsdale, AZ) for a period of 12 weeks. The results showed a dramatic decrease in pustules and papules without any signi!cant in"ammation or overall intolerance. No improvement in facial redness was achieved. Based on our results, more investigation of topical retinoids for rosacea treatment is prudent. J Drugs Dermatol. 2012;11(12):1410-1414.

PMID: 23377509 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/PubMed/23377509?dopt=Abstract = URL to article

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