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Dermadexin (also known as Pruridexin or Helioclin® Dermatitis SD Cream) is a topical treatment for dermatitis and seborrhoeic dermatitis developed by Astion Pharma with a unique mechanism of action using a Fatty acid amide hydrolase (FAAH) inhibitor and a NF-kappa B (NF-kB) inhibitor designated as pyridine-3-carboxamide glyceryl monocaprylate (P3CGM), which has an excellent topical safety profile demonstrating a broad range in pre-clinical studies. [1]

It was announced in August 2015 that the FDA accepted 510(k) submission for Dermadexin. [2]

There is now available an over the counter topical, Astion Face Cure (active ingredient Dermadexin), available at Amazon UK or on the Astion Pharma website.  


Astion Face Cure contains the active ingredient Dermadexin [Pruridexin] and the inactive ingredients water, liquid paraffin, cetostearyl alcohol, glycerol, niacinamide, sodium cetostearyl sulphate, glyceryl monocaprylate and benzyl alcohol. 

Anecdotal Reports 

There are at least a couple of positive reports of using the Astion Face Cure, Boris started a thread on this, and post no 141 by freixinet

End Notes 

[1] Dermadexin Executive Summary

[2] FDA Accepts Dermadexin 510(k) Submission, Aug 6th, 2015, Medesthetics

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