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Acute irritant threshold correlates with barrier function, skin hydration and contact hypersensitivity in atopic dermatitis and rosacea.

Exp Dermatol. 2013 Sep 23;

Authors: Darlenski R, Kazandjieva J, Tsankov N, Fluhr JW

Abstract
The aim of the study was to disclose interactions between epidermal barrier, skin irritation and sensitization in healthy and diseased skin. Transepidermal water loss (TEWL) and stratum corneum hydration (SCH) were assessed in adult patients with atopic dermatitis (AD), rosacea, and healthy controls. A 4-hour patch test with 7 concentrations of sodium lauryl sulfate was performed to determine the irritant threshold (IT). Contact sensitization pattern was revealed by patch testing with European baseline series. Subjects with a lower IT had higher TEWL values and lower SCH. Subjects with positive allergic reactions had significantly lower IT. In AD, epidermal barrier deterioration was detected on both volar forearm and nasolabial fold, while in rosacea impeded skin physiology parameters were observed on the facial skin only, suggesting that barrier impediment is restricted to the face in rosacea, in contrast with AD where the abnormal skin physiology is generalized. This article is protected by copyright. All rights reserved.

PMID: 24112695 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24112695?dopt=Abstract = URL to article