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Gold Nanoshell-mediated Photothermal Therapy for Rosacea


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Gold nanoshell-mediated Photothermal therapy (PTT) has been used to treat acne. [1] There is a paper on using PTT for rosacea. [2] Photothermal therapy "is an extension of photodynamic therapy, in which a photosensitizer is excited with specific band light. This activation brings the sensitizer to an excited state where it then releases vibrational energy (heat), which is what kills the targeted cells. Unlike photodynamic therapy, photothermal therapy does not require oxygen to interact with the target cells or tissues. Current studies also show that photothermal therapy is able to use longer wavelength light, which is less energetic and therefore less harmful to other cells and tissues." [3] Gold nanoparticle-mediated PTT has been used to target cancer so there are more papers on this subject. [4]

Naomi Halas (Rice University, TX, USA) created the gold-silica nanoshells in 1997 demonstrating by varying the thickness of the gold shell that the nanoshells interactions with specific wavelengths of light could be tuned. These gold nano shells are 150 nm in thickness. At least one company, Nanospectra, manufactures Auroshell. [5]


Auroshell is an inert, non toxic particle fifty times smaller than a red blood cell. 


One paper on using gold nanoshell-mediated PTT for acne states, "The treatment of enlarged facial pores with gold nanoshell-mediated PTT produced excellent results with no side effects." [6]

The paper on using gold nano shell-mediated PTT for rosacea full text is available for purchase by Wiley Online as seen below but the RRDi is broke and we can't even purchase this to review the research paper full text. So do you understand why the RRDi needs donations to keep going?  But you will always have Facebook, Reddit and the other rosacea social media groups when the RRDi dissolves due to lack of funds since we will be out of funds soon.  


More Research on Gold nanoshell-mediated PTT 

Do you want more research on this for rosacea?  Could a non profit rosacea patient advocacy grassroots organization collect donations and sponsor such an investigation?  Could 10K members each donate ONE DOLLAR to do this?  

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There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please. 

End Notes 

[1] Dermatol Ther. 2020 Jan;33(1):e13189.  doi: 10.1111/dth.13189. Epub 2019 Dec 23.
Gold nanoshell-mediated photothermal therapy for acne vulgaris
Kui Young Park, Hye Sung Han, Ji Yeon Hong, Seong Jun Seo, Sang Ju Lee 

Lasers Surg Med. 2019 Oct;51(8):686-693.  doi: 10.1002/lsm.23099. Epub 2019 May 14.
Acne Treatment With Light Absorbing Gold Microparticles and Optical Pulses: An Open-Label European Multi-Centered Study in Moderate to Moderately Severe Acne Vulgaris Patients
Christine Sofie Krohn Fuchs, Christiane Bay, Maurice Adatto, Hans Lomholt, Merete Haedersdal  

[2] Photodermatol Photoimmunol Photomed. 2020 Dec 11;:
Gold photothermal therapy for refractory papulopustular rosacea: A case series.
Park KY, Han HS, Park JW, Lee HW, Seo S

[3] Photothermal Therapy, Wikipedia

[4] 592,000 results for “Gold nanoparticle-mediated” in Semantic Scholar

[5] Nanospectra

[6] Med Laser 2019;8(2):97-100 https://doi.org/10.25289/ML.2019.8.2.97 pISSN 2287-8300ᆞeISSN 2288-0224 
Gold Nanoshell-Mediated Photothermal Therapy for Facial Pores
Sang Ju Lee, Jeanne Jung, Seung Hui Seok, Dong Hyun Kim


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