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Association between Rosacea and Smoking: A Systematic Review and Meta-Analysis.

Dermatol Ther. 2021 Jan 06;:e14747

Authors: Yuan X, Yin D

Abstract
Rosacea is a chronic inflammatory disease of the centrofacial region. However, the association between rosacea and smoking remains controversial. To evaluate the association between rosacea and smoking, we performed a systematic review and meta-analysis. A comprehensive systematic search of literature published before October 15, 2020 on online databases (including Web of Science, PubMed, Cochrane Library, and Embase) was performed. The pooled odds ratios (ORs) were calculated. Twelve articles were included, covering 80 156 controls and 54 132 patients with rosacea. Tobacco consumption was not found to increase the risk of rosacea. However, using subtype analysis (involving five articles), we found there was a decreased risk of rosacea in current smokers but an increased risk in ex-smokers. In addition, smoking appears to increase the risk of papulopustular rosacea (PPR) and phymatous rosacea (PhR). Analysis of all included studies also showed that ex-smoking was associated with an increased risk, while current smoking was associated with a reduced risk of rosacea. In order to prevent many diseases, including rosacea, the public should be encouraged to avoid smoking. This article is protected by copyright. All rights reserved.

PMID: 33406295 [PubMed - as supplied by publisher]

{url} = URL to article

Other Systemic Cormorbidities in Rosacea

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