Skin Microbiome and Rosacea

[Guide]

Microorganisims of the skin microbiome is now being researched more than ever and a recent article elucidates this subject and discusses rosacea: 

"Rosacea has also been linked to a dysbiosis of the skin microbiome. An increased abundance of Demodex mites are observed in this disease. An interesting suggestion was made by Parodi et al. who reported an interplay between the skin and bacterial overgrowth in the small intestine. Rosacea patients had a significantly higher overgrowth of gut bacteria than controls and elimination of the overgrowth, using an antibiotic, resulted in an almost complete regression of the skin pathology for a prolonged time. These findings support the pathogenetic role of the gut microbiome in rosacea lesions, although the exact relationship remains to be elucidated. Additionally, research even investigated the microbiota of the Demodex mites, but final conclusions are still outstanding." [1]

Transplant Treatment Methods
"Transplantation of a complete microbiome or application of single strains has demonstrated beneficial therapeutic application." [1]

The first method discusses skin microbiome transplantation, where "the skin microbiome of a healthy individual is transferred to the washed and/or disinfected skin area of another person with the aim of improving the skin condition of the latter." [1] A second method is "skin bacteriotherapy, where one or multiple pure cultures with health-promoting properties are placed on the washed and/or disinfected skin area of a person." [1]

"A third method of changing the skin microbiome is through prebiotic stimulation. In this process, prebiotics are supplemented to the skin to stimulate the growth of specific health-promoting microbes. A prebiotic is an ingredient with a bioselective activity that exerts a beneficial effect on the host and attempts to improve the host's health." [1]

The fourth method has been around for some time now which is, "Microbiome transplantation for humans is not new and is best known by the example of faecal microbiota transplantation (FMT) for the treatment of gastric Clostridium difficile infections." [1] We have discussed this before in a post, Baby You Can Drive My Gut. 

Bacteria is the Main Focus
While this article focuses mainly on bacteria, as most papers on this subject do the same, it does refer to a token mention of fungus, demodex and virus and ignores protozoa, archea, helminths, or any other microbe.

It is worth reading. We should make a TikTok video on this subject, because reading the article is a deep dive for most rosaceans. 

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End Notes

[1] Comput Struct Biotechnol J. 2021; 19: 624–631.
Skin microbiome transplantation and manipulation: Current state of the art
Chris Callewaert, Nastassia Knödlseder, Ante Karoglan, Marc Güell, and Bernhard Paetzolde,