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Experience in managing glaucoma filtration surgery complications with oral doxycycline: A case series.

Eur J Ophthalmol. 2021 Feb 07;:1120672121992953

Authors: Yong GY, Mohamed-Noor J, Ong PY, Suliman NB, Lim CW, Zahari M

Abstract
PURPOSE: To report the clinical profile and effectiveness of oral doxycycline as a non-invasive treatment for glaucoma filtering surgery complications.
METHOD: Prospective case series.
RESULTS: Doxycycline is widely used in treating corneal melts, ocular surface diseases, meibomian gland disease, recurrent epithelial cell erosion, rosacea, and keratitis sicca. This prospective case series highlights the successful treatment of five patients with leaking blebs and conjunctiva erosion from glaucoma filtration surgery with the use of oral doxycycline. There was no adverse event reported in our cases.
CONCLUSIONS: This study suggests that oral doxycycline may be a feasible non-surgical treatment modality due to its ability to inhibit collagenolysis, restore the Meibomian gland function, thereby stopping breakdown and promote conjunctival tissue healing.

PMID: 33550831 [PubMed - as supplied by publisher]

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