rss Posted March 25, 2014 Report Share Posted March 25, 2014 Comparative analysis of rosacea and cutaneous lupus erythematosus: Histopathologic features, T-cell subsets, and plasmacytoid dendritic cells. J Am Acad Dermatol. 2014 Mar 19; Authors: Brown TT, Choi EY, Thomas DG, Hristov AC, Chan MP Abstract BACKGROUND: Distinction of rosacea and cutaneous lupus erythematosus (LE) can be challenging because of significant clinical and histologic overlap. A controlled study comparing these conditions is lacking. OBJECTIVE: We compared the histologic features, T-cell subsets, and plasmacytoid dendritic cells in rosacea and LE. METHODS: Biopsy specimens of rosacea (n = 27) and facial LE (n = 30) were retrospectively reviewed and reacted with Alcian blue and periodic acid-Schiff stains, and CD4, CD8, CD25, and CD123 immunostains. RESULTS: LE demonstrates a lower CD4:CD8 ratio (1.74 vs 2.80, P = .0064), fewer CD4(+)CD25(+) regulatory T cells (13% vs 31%, P < .0001), and more CD123(+) plasmacytoid dendritic cells (18% vs 6%, P = .0137) than rosacea. The plasmacytoid dendritic cells in LE are more likely to form clusters (P = .0137) and comprise at least 20% of the infiltrate (P = .0340). Also associated with LE are follicular plugging (P = .0039), perineural lymphocytic infiltrate (P = .0211), abundant mucin deposition (P = .0031), and conspicuous basement membrane thickening (P = .0073), whereas Demodex infestation (P = .0064) and sebaceous hyperplasia (P = .0029) are significantly associated with rosacea. LIMITATIONS: Although statistically significant, the immunophenotypic differences are rather small and limited for routine use. CONCLUSION: The infiltrates in rosacea and LE differ immunophenotypically, and may aid in their distinction in addition to conventional histologic examination.PMID: 24656728 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/pubmed/24656728?dopt=Abstract = URL to article Link to comment Share on other sites More sharing options...
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