rss Posted February 20, 2021 Report Share Posted February 20, 2021 Related ArticlesRosacea with persistent facial erythema and high Demodex density effectively treated with topical ivermectin alone or combined with oral carvedilol. Dermatol Ther. 2021 Feb 18;:e14899 Authors: Huang HP, Hsu CK, Lee JY Abstract Topical ivermectin is effective in treating papulopustular rosacea, but its effect on persistent facial erythema of rosacea with high Demodex densities has not been well documented. We retrospectively reviewed 39 rosacea patients with persistent facial erythema and high Demodex densities. Clinician's erythema assessment (CEA) and Demodex density were evaluated before and after topical ivermectin alone or combined with oral carvedilol. Three patients (all with papulopustular rosacea, in ivermectin group) dropped out due to early ivermectin-induced local flare of rosacea. In the remaining patients (ivermectin group n=14; ivermectin-carvedilol group n=22), the CEA grade and Demodex density were significantly reduced, both p<0.01. There was no statistically significant difference between the two groups in CEA before and after treatment (p=0.07 and p=0.23, respectively), and in Demodex density (p=0.82 and 0.10, respectively). Both regimens markedly improved the persistent facial erythema with response being excellent in 26 of 36 patients (72%), good in 2, fair in 4 and none in 4. There was a correlation between the reduction of CEA and Demodex density after treatment (rho=0.50, p=0.002). The results showed that topical ivermectin was effective in reducing persistent facial erythema of rosacea with Demodex overgrowth. This article is protected by copyright. All rights reserved.PMID: 33605018 [PubMed - as supplied by publisher] {url} = URL to article Link to comment Share on other sites More sharing options...
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