Tetracycline for Coronavirus

[Guide]

Tetracycline has been around for over sixty years and has been used to treat rosacea for at least as long a period. Recently, tetracycline has been used to treat coronavirus. "Remarkably, tetracyclines (TetraC) were candidate as promising drugs to fight against COVID‐19 pandemics due to their potential antiviral effect." [1] We have added tetracycline to the list of treatments for rosacea which are being used to treat coronavirus. [2]

"Among TetraC in daily practice, Doxycycline (DOX) and Minocycline (MIN) are the most prescribed ones due to their safety profile, availability and efficacy, adequate to treat in an outpatient setting. Their profiles together with their antiviral property make TetraC an encouraging candidate to treat dermatological outpatients with mild forms of COVID‐19 (Table S2)." [1]

"Taken together, data presented here highlight that the antiviral, anti-inflammatory, immune-modulatory, and cardioprotective abilities of TCs, mainly doxycycline or minocycline, make them potential partners in the management of COVID-19–derived pneumonia and related complications, such as ALI and ARDS. In addition, both doxycycline and minocycline have noteworthy therapeutic and prophylactic effects against SARS-CoV-2 infection." [3]

End Notes

[1] Dermatol Ther. 2021 Jan-Feb; 34(1): e14694.
Tetracyclines in COVID‐19 patients quarantined at home: Literature evidence supporting real‐world data from a multicenter observational study targeting inflammatory and infectious dermatoses
Laura Cristina Gironi, Giovanni Damiani, Elisa Zavattaro, Alessia Pacifico, Pierachille Santus, Paolo Daniele Maria Pigatto, Ottavio Cremona, and Paola Savoia 

[2] Coronavirus and Rosacea

[3] Front Pharmacol. 2021; 12: 642822.
Pleiotropic Effects of Tetracyclines in the Management of COVID-19: Emerging Perspectives
Hayder M. Al-kuraishy,  Ali I. Al-Gareeb,  Mohammed Alqarni,  Natália Cruz-Martins, and Gaber El-Saber Batiha