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"Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections." [1] 

A paper in June 2014 published in Clinical and Experimental Dermatology magazine states that Perioral Dermatitis Severity Index (PODSI) "was significantly lower in the praziquantel group than in the placebo (vehicle) group." [2]

In April 2015, another paper, published in the Int J Dermatol by some of the same authors, mentions successful treatment not with POD, instead mentioning rosacea, using a 3% topical ointment of praziquantel, that concluded, "Use of 3% PZQ ointment twice daily for 12 weeks resulted in significantly better effects than a placebo treatment in improving rosacea and the patient's quality of life." [3] 

The possibility of using this treatment for rosacea was discussed in a couple of threads at RF [4] so without a doubt we will be hearing more about this eventually. 

Praziquantel is included in with the Anti-parasitic Prescription Agents used to treat rosacea. 


[1] Wikipedia

[2] Clin Exp Dermatol. 2014 Jun;39(4):448-53. doi: 10.1111/ced.12342.
Topical praziquantel as a new treatment for perioral dermatitis: results of a randomized vehicle-controlled pilot study.
Bribeche MR, Fedotov VP, Jillella A, Gladichev VV, Pukhalskaya DM.

[3] Int J Dermatol. 2015 Apr;54(4):481-7. doi: 10.1111/ijd.12552. Epub 2014 Jul 11.
Clinical and experimental assessment of the effects of a new topical treatment with praziquantel in the management of rosacea.
Bribeche MR, Fedotov VP, Gladichev VV, Pukhalskaya DM, Kolitcheva NL.

[4] First thread at RF that mentions praziquantel

Second thread at RF that mentions praziquantel


You may be throwing out the baby with bath water using this treatment.

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