Root Admin Guide Posted April 27, 2021 Root Admin Report Share Posted April 27, 2021 Researchers have attempted to create a new cocrystal of metronidazole (MTZ) with ethyl gallate (EG) to an enhance solubility and dissolution to evaluate its potential application in improving the bioavailability of metronidazole. The results concluded, "Compared to MTZ, the MTZ-EG cocrystal exhibits a higher solubility, faster dissolution and higher bioavailability. Additionally, MTZ-EG is physically stable in water for at least 24 h. Overall, the improved solubility and solid-state stability during dissolution make MTZ-EG a suitable candidate for further development into an oral solid dosage form with an improved biopharmaceutical performance." Pharmaceutics. 2021 Apr; 13(4): 546.Improving the Solubility, Dissolution, and Bioavailability of Metronidazole via Cocrystallization with Ethyl Gallate Jinhui Li, Xinghui Hao, Chenguang Wang, Haiyan Liu, Lianchao Liu, Xin He, and Changquan Calvin Sun Space-filling model of ethyl gallate image courtesy of Wikimedia Commons Link to comment Share on other sites More sharing options...
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