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Cutaneous Paraneoplastic Granulomatous Eruptions Secondary to Metastatic Carcinoid Tumour.

Br J Dermatol. 2014 Nov 11;

Authors: Cohen JM, Nambudiri VE, Kulke MH, Todd DJ, Murphy GF, LeBoeuf NR

Abstract
Cutaneous granulomatous eruptions comprise a rare subset of paraneoplastic dermatitides most commonly associated with haematologic malignancies. The pathogenesis of these eruptions remains poorly understood. Carcinoid tumours are uncommon neuroendocrine neoplasms that most often arise in the gastrointestinal tract and produce excess serotonin leading to diarrhoea and flushing. Metastases can result in elevated systemic neuroendocrine mediator levels causing carcinoid syndrome, with cutaneous manifestations including flushing, rosacea, pellagra, and rarely sclerodermatous changes (1). This article is protected by copyright. All rights reserved.

PMID: 25388104 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25388104?dopt=Abstract = URL to article