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Reflectance confocal microscopy for monitoring the density of demodex mites in rosacea patients before and after treatment.

Br J Dermatol. 2015 Mar 20;

Authors: Sattler EC, Hoffmann VS, Ruzicka T, Maier T, Berking C

BACKGROUND: Demodex mites seem to serve as pathogenic trigger in many Demodex-associated diseases like rosacea. In facial skin of rosacea patients significantly higher numbers of Demodex mites have been shown compared to healthy controls. Reflectance confocal microscopy (RCM) allows the detection and quantification of Demodex mites in vivo non-invasively. It is hypothesized that a reduction of Demodex mites under rosacea therapy can be monitored by RCM.
MATERIAL AND METHODS: In 25 patients with facial rosacea RCM was performed before and after therapy. Mosaics of 5x5 mm(2) and 8x8 mm(2) were scanned and the total number of mites per follicle and per area as well as of the follicles per area were counted.
RESULTS: In all patients Demodex folliculorum could be detectedand quantified using RCM.. RCM showed significant differences pre- and post-treatment (p-value =0.0053 for 5x5 mm(2) and 0.0003 for 8x8 mm(2) ): The mean number of mites per follicle was 0.632 (range 0.157 - 2.276) per 8x8 mm(2) area and 0.704 (range 0.106 - 2.200) per 5x5 mm(2) area before treatment and 0.405 (range 0.074 - 1.745) and 0.505 (range 0.094 - 1.704), respectively, after treatment. The corresponding mean number of mites was 155.2 (range 45-446) and 86.2 (range 12 - 286), respectively, before treatment and 96.2 (range 18-363) and 58.5 (12-230), respectively, after treatment.
CONCLUSION: By RCM a reduction of the density of Demodex mites in facial skin of rosacea patients under therapy, correlating to clinical improvement, can be quantified and monitored non-invasively. Possible reasons for this therapeutic effect are discussed. This article is protected by copyright. All rights reserved.

PMID: 25801631 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25801631?dopt=Abstract = URL to article

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