15% Azelaic Acid and 1% Dihydro Avenanthramide D

[Guide]

There is  "a novel formulation cream containing 15% AzA (anti‐inflammatory/anti‐oxidant/anti‐microbial agent) combined with 1% dihydroavenanthramide D (anti‐inflammatory/anti‐itch)" that was evaluated using an instrumental "erythema‐directed digital photography (EDDP)." The study concluded "that this new non‐irritating product represents a valid therapeutic option for mild/moderate inflammatory rosacea."

J Cosmet Dermatol. 2021 Apr; 20(Suppl 1): 28–31.
A novel azelaic acid formulation for the topical treatment of inflammatory rosacea: A multicentre, prospective clinical trial
Federica Dall’Oglio, MD, PhD,  Aurora Tedeschi, MD, PhD,  Francesco Lacarrubba, MD,  Gabriella Fabbrocini, MD, PhD,  Nevena Skroza, MD, PhD,  Paolo Chiodini, MS, Giuseppe Micali, MD

"It was found that the synthetic analog dihydroavenanthramide D (DHAvD) can interact with the neurokinin-1 receptor (NK1R) and inhibit mast cell degranulation."

Experimental Dermatology 26(8) November 2016
Dihydroavenanthramide D inhibits mast cell degranulation and exhibits anti-inflammatory effects through the activation of neurokinin 1 receptor
Tobias Lotts, Konstantin Agelopoulos, Ngoc Quan Phan, Karin Loser

"Avenanthramides (anthranilic acid amides, formerly called "avenalumins") are a group of phenolic alkaloids found mainly in oats (Avena sativa), but also present in white cabbage butterfly eggs (Pieris brassicae and P. rapae), and in fungus-infected carnation (Dianthus caryophyllus). A number of studies demonstrate that these natural products have anti-inflammatory, antioxidant, anti-itch, anti-irritant, and antiatherogenic activities." Wikipedia

Closeup of oat florets (small flowers) image courtesy of Wikimedia Commons