Keratinocyte Pattern in the Pathogenesis of Rosacea.

[Guide]

"Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells." [1]

"These findings reveal the specific epithelial differentiation in normal central facial skin, and epithelial–immune crosstalk in lesions providing insight into an initial keratinocyte pattern in the pathogenesis of rosacea." [2]

"In conclusion, we extensively and comprehensively investigated the characteristics of central facial skin and rosacea lesions in a stepwise manner. We potentially revealed the communication between the skin barrier and innate immune system, keratinocyte–immune crosstalk, and provided insights into the initial keratinocyte pattern for the pathogenesis of rosacea. Finally, our findings suggested STAT1 might be a potential therapeutic target for rosacea." [2]

"Epidermal RNA-seq and immunohistochemistry analysis further validated the epithelial-derived STAT1 signature in rosacea lesions." [2]

"Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. " [3]

"Bacterial peptidoglycan (PGN) stimulates toll-like receptor 2 (TLR2) on the surface of keratinocytes (KCs), triggering signaling pathways that promote an innate immune response. " [4]

End Notes

[1] Keratinocyte, Wikipedia - image courtesty of Wikimedia Commons

[2] Front Immunol. 2021; 12: 674871.
Keratinocyte-Immune Cell Crosstalk in a STAT1-Mediated Pathway: Novel Insights Into Rosacea Pathogenesis

[3] STAT1, Wikipedia - STAT1 image courtesy of Wikimedia Commons

[4] AhR Regulates Peptidoglycan-Induced Inflammatory Gene Expression in Human Keratinocytes