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PubMed RSS Feed - -Associations of particulate matter with atopic dermatitis and chronic inflammatory skin diseases in South Korea


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Clin Exp Dermatol. 2021 Aug 24. doi: 10.1111/ced.14910. Online ahead of print.


BACKGROUND: Particulate matter (PM) is a mixture of solid and liquid particles suspended in air which originates from industrial plants or vehicle emission. Although skin primarily contacts with air pollutants, the associations between PM and chronic inflammatory skin diseases has not been well established.

OBJECTIVE: To investigate associations between PM and atopic dermatitis as well as other chronic inflammatory dermatoses using Korea Health Insurance Review & Assessment Service data.

METHODS: Monthly disease statistics from seven largest cities (Seoul, Busan, Daegu, Incheon, Gwangju, Daejeon, Ulsan) and Jeju Island of South Korea of 23,288,000 people were included. Based on daily air pollution level and weather forecast from 2015 to 2019, multivariate negative binomial regression analysis was conducted to estimate monthly visits of atopic dermatitis with respect to outdoor air pollutants (PM2.5 , PM10 , O3 , NO2, SO2 , CO).

RESULTS: Every 10 μg/m3 increase in PM2.5 and PM10 was significantly associated with 2.71% (95% confidence interval (CI)=0.76%-4.71%; P = 0.0063) and 2.01% (95% CI=0.92%-3.11%, P = 0.0003) increase in monthly patient visits of atopic dermatitis, respectively. Every 1 ppb increase in SO2 and 100 ppb increase in CO was significantly associated with 2.26% (95% CI=1.35%-3.17%; P < 0.0001) and 2.86% (95% CI=1.35%-4.40%; P = 0.0002) increase in patient visits of atopic dermatitis, respectively, while O3 and NO2 were not associated. On the other hand, increases in PM2.5 and PM10 concentrations were significantly associated with increases of patient visits of psoriasis, seborrheic dermatitis, and rosacea.

CONCLUSION: Our data suggest PM is associated with atopic dermatitis and chronic inflammatory skin diseases.

PMID:34426985 | DOI:10.1111/ced.14910

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